110
Views
22
CrossRef citations to date
0
Altmetric
Original Article

Proliferation of Immature Myeloma Cells by Interleukin-6 Is Associated with CD45 Expression in Human Multiple Myeloma

, , , &
Pages 51-55 | Received 24 Dec 1999, Published online: 01 Jul 2009

References

  • Hirano T, Yasukawa K, Harada H. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986.; 324, 73-76
  • Kawano M, Hirano T, Matsuda T. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988.; 332, 83-85
  • Kawano MM, Huang N, Harada H. Identification of immature and mature myeloma cells in the bone marrow of human myeloma. Blood 1993.; 82, 564-570
  • Suematsu S, Matsusaka T, Matsuda T. Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. Proc Natl Acad Sci USA 1992.; 89, 232-235
  • Hilbert DM, Kopf M, Mock BA. Interleukin 6 is essential for in vivo development of B lineage neoplasms. J Exp Med 1995.; 182, 243-248
  • Lattanzio G, Libert C., Aquilina M. Defective development of pristane-oil-induced plasmacytomas in inter-leukin-6-deficient BALB/c mice. Am J Pathol 1997.; 151, 689-696
  • Rettig MB, Ma HJ, Vesico RA. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 1997.; 276, 1851-1854
  • Murakami M, Hibi M, Nakagawa N. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 1993.; 260, 1808-1810
  • Narazaki M, Witthuhn B, Yoshida K. Activation of JAK2 kinase by the interleukin 6 signal transducer gp130. Proc Natl Acad Sci USA 1994.; 91, 2285-2289
  • Lutticken C., Wegenka UM, Yuan I. Association of transcription factor APRF and protein kinase Jakl with the inter-leukin-6 signal transducer gp130. Science 1994.; 263, 89-92
  • Stahl N, Boulton T, Farruggella T. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6P receptor components. Science 1994.; 263, 92-95
  • Kumar G, Gupta S, Wang S. Involvement of Janus kinases, p52 She, Raf-1, and MEK-1 in the IL-6 induced mitogen-activated protein kinase cascade of a growth-responsive B cell line. J Immunol 1994.; 153, 4436-4447
  • Ihle JN, Witthuhn BA, Quelle FW. Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Bio-chem Sci 1994.; 19, 222-227
  • Shuai K, Schindler C., Prezioso VR. Activation of transcription by IFN-y: Tyrosine phosphorylation of a 91-kD DNA binding protein. Science 1992.; 258, 1808-1812
  • Schindler C., Shuai K, Prezioso VR. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 1992.; 257, 809-813
  • Neumann C., Zehentmaier G, Danhauser-Riedl S. IL-6 induces tyrosine phosphorylation of the Ras activating protein She, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1. Eur J Immunol 1996.; 26, 379-384
  • Nakafuku M, Satoh T, Kaziro Y. Differentiation factors, including nerve growth factor, fibroblast growth factor, and Interleukin-6, induce an accumulation of an active Ras-GTP complex in rat pheochromocytoma PC12 cells. J Biol Chem 1992.; 267, 19448-19454
  • Hata H, Matsuzaki H, Sonoki T. Establishment of a CD45-positive immature plasma cell line from an aggressive multiple myeloma with high serum lactate dehydrogenase. Leukemia 1994.; 8, 1768-1773
  • Witzig TE, Kimlinger TK, Ahmann GJ. Detection of myeloma cells in the peripheral blood by flow cytometry. Cytometry 1996.; 26, 113-120
  • Joshua D, Peterson A, Brown R. The labelling index of primitive plasma cells determines the clinical behaviour of patients with myelomatosis. Br J Haematol 1996.; 94, 76-81
  • Schneider U, van Lessen A, Huhn D. Two subsets of peripheral blood plasma cells defined by differential expression of CD45 antigen. Br J Haematol 1997.; 97, 56-64
  • Fujii R, Ishikawa H, Mahmoud MS. MPC-1-CD49e- immature myeloma cells include CD45+ subpopulations that can proliferate in response to IL-6 in human myelomas. Br J Haematol 1999.; 105, 131-140
  • Mahmoud MS, Ishikawa H, Fujii R. Induction of CD45 expression and proliferation in U-266 myeloma cell line by interleukin-6. Blood 1998.; 92, 3887-3897
  • Streuli M, Hall LR, Saga Y. Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens. J Exp Med 1987.; 166, 1548-1566
  • Trowbridge IS, Thomas ML. CD45: an emerging role as a protein phosphatase required for lymphocyte activation and development. Annu Rev Immunol 1994.; 12, 85-116
  • Kishihara K, Penninger J, Wallace VA. Normal B lymphocyte development but impaired T cell maturation in CD45-exon 6 protein tyrosine phosphatase-deficient mice. Cell 1993.; 74, 143-156
  • Cyster JG, Healy JI, Kishihara K. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature 1996.; 381, 325-328
  • Mahmoud MS, Fujii R, Ishikawa H. Enforced CD19 expression leads to growth inhibition and reduced tumorigenicity. Blood 1999.; 94, 3551-3558

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.