Lovastatin Induces a Pronounced Differentiation Response in Acute Myeloid Leukemias

References

• Mitus A. J., Miller K. B., Schenkein D. P., Ryan H. F., Parsons S. K., Wheeler C., Antin J. H. Improved survival for patients with acute myelogenous leukemia. J. Clin. Oncol. 1995; 13: 560–569
   PubMed Web of Science ®Google Scholar
• Cripe L. D. Adult acute leukemia. Curr. Probl. in Cancer 1997; 21: 1–64
   PubMed Web of Science ®Google Scholar
• Tallman M. S. Differentiation therapy with all-trans retinoic acid in acute myeloid leukemia. Leukemia 1996; 10: S12–S15
   PubMed Web of Science ®Google Scholar
• Deluca L. Retinoids and their receptors in differentiation, embryogenesis and neoplasia. Faseb J. 1991; 5: 2924–2933
   PubMed Web of Science ®Google Scholar
• Huang M., Ye Y. C., Chen S. R., Chai J. R., Lu J. X., Zhoa L., Gu L. J., Wang Z. Y. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988; 72: 567–572
   PubMed Web of Science ®Google Scholar
• Sacchi S., Russo D., Avvisati G., Dastoli G., Lazzarino M., Pelicci P. G., Bonora M. R., Visani G., Grassi C., Iacona I., Luzzi L., Vanzanelli P. All-trans retinoic acid in hematological malignancies, an update. GER (Gruppo Ematologica Retinoidi). Haematologica 1997; 82: 106–121
   PubMed Web of Science ®Google Scholar
• Kakizuka A., Miller W. H. J., Umesono K., Warrell R. P. J., Frankel S. R., Murty V., Dmitrovsky E., Evans R. M. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARrx with a novel putative transcription factor, PML. Cell 1991; 66: 663–674
   PubMed Web of Science ®Google Scholar
• Warrell R. P. J., Frankel S. R., Miller W. H. J., Scheinberg D. A., Itri L. M., Hittelman W. N., Vyas R., Andreeff M., Tafuri A., Jakubowski A. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans retinoic acid). N. Engl. J. Med. 1991; 324: 1385–1393
   PubMed Web of Science ®Google Scholar
• Grignani F., Ferucci P. F., Testu U., Talamo G., Fagioli M., Alcalay M., Mencarelli A., Grignani F., Peschle C., Nicoletti I., Pelicci P. G. The acute promyelocytic leukemia- specific PML-RARrx fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 1993; 74: 423–431
   PubMed Web of Science ®Google Scholar
• Dimitroulakos J., Pienkowska M., Sun P., Farooq S., Ziel-Enska M., Squire J. A., Yeger H. Identification of a novel zinc finger gene, zf5-3, as a potential mediator of neuroblastoma differentiation. Int J Cancer 1999; 81: 970–8
   PubMed Web of Science ®Google Scholar
• Dimitroulakos J., Yeger H. HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: Lovastatin specifically targets P-glyco-protein-expressing cells. Nature Med. 1996; 2: 326–333
   PubMed Web of Science ®Google Scholar
• Goldstein J. L., Brown M. S. Regulation of the mevalonate pathway. Nature 1990; 343: 425–430
   PubMed Web of Science ®Google Scholar
• Corsini A., Maggi P. M., Catapano A. L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacological Research 1995; 31: 9–27
   PubMed Web of Science ®Google Scholar
• Dimitroulakos J., Nohynek D., Backway K. L., Hedley D. W., Yeger H., Preedman M. H., Minden M. D., Penn L. Z. Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach. Blood 1999; 93: 1308–1318
   PubMed Web of Science ®Google Scholar
• Hu Z. B., Minden M. D., McCulloch E. A. Phosphorylation of BCL-2 after exposure of human leukemic cells to retinoic acid. Blood 1998; 92: 1768–75
   PubMed Web of Science ®Google Scholar
• Ahmed N., Laverick L., Sammons J., Baumforth K. R., Hassan H. T. Effect of all-trans retinoic acid on chemotherapy induced apoptosis and down-regulation of Bcl-2 in human myeloid leukaemia CD34 positive cells. Leak Res 1999; 23: 741–9
   PubMed Web of Science ®Google Scholar
• Agura E. D., Howard M., Collins S. J. Identification and sequence analysis of the promoter for the leukocyte integrin b-subunit (CD 18) A retinoic acid-inducible gene. Blood 1992; 79: 602–609
   PubMed Web of Science ®Google Scholar
• Park J. R., Robertson K., Hickstein D. D., Tsai S., Hocken-Berry D. M., Collins S. J. Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid- induced HL-60 granulocytes. Blood 1994; 84: 440–445
   PubMed Web of Science ®Google Scholar
• Freedman M. H., Grunberger T., Correa P., Axelrad A. A., Dube I. D., Cohen A. Autocrine and paracrine growth control by granulocyte-monocyte colony-stimulating factor of acute lymphoblastic leukemia cells. Blood 1993; 81: 3068–3075
   PubMed Web of Science ®Google Scholar
• Wang C., Curtis J. E., Minden M. D., McCulloch E. A. Expression of a retinoic acid receptor gene in myeloid leukemia cells. Leukemia 1989; 3: 264–269
   PubMed Web of Science ®Google Scholar
• Keyomarsi K., Sandoval L., Band V., Pardee A. B. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res. 1991; 51: 3602–3609
   PubMed Web of Science ®Google Scholar
• Zhu W., Cowie A., Wasfy G. W., Penn L. Z., Leber B., Andrews D. W. Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J. 1996; 15: 4130–4141
   PubMed Web of Science ®Google Scholar
• Lee S. T., Hoeflich K. P., Wasfy G. W., Woodgett J. R., Leber B., Andrews D. W., Hedley D. W., Penn L. Z. Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts. Oncogene 1999; 18: 3520–8
   PubMed Web of Science ®Google Scholar
• Gray-Bablin J., Rao S., Keyomarsi K. Lovastatin induction of cyclin-dependant kinase inhibitors in human breast cells occurs in a cell cycle dependent fashion. Cancer Res. 1997; 57: 604–609
   PubMed Web of Science ®Google Scholar
• Dimitroulakos J., Squire J., Pawlin G., Yeger H. NUB-7: A stable I-type human neuroblastoma cell line inducible along N- and S-type cell lineages. Cell Growth and Diff. 1994; 5: 373–384
   PubMedGoogle Scholar
• Thibault A., Samid D., Tompkins A. C., Figg W. D., Cooper M. R., Hohl R. J., Trepel J., Liang B., Patronas N., Venzon D. J., Reed E., Myers C. E. Phase 1 study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin. Cancer Res. 1996; 2: 483–491
   PubMed Web of Science ®Google Scholar
• Masciulli R., Testa U., Barberi T., Samoggia P., Tritarelli E., Pustorino R., Mastroberardino G., Camagna A., Peschle C. Combined vitamin D3/retinoic acid induction of human promyelocytic cell lines: enhanced phagocytic cell maturation and hybrid granulomonocytic phenotype. Cell Growth Differ 1995; 6: 493–503
   PubMedGoogle Scholar
• Miyauchi J. All-trans retinoic acid and hematopoietic growth factors regulating the growth and differentiation of blast progenitors in acute promyelocytic leukemia. Leuk Lymphoma 1999; 33: 267–80
   PubMed Web of Science ®Google Scholar
• Hu Z., Minden M. D., McCulloch E. A. Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells. Leukemia 1995; 9: 1667–1673
   PubMed Web of Science ®Google Scholar
• Delia D., Aiello A., Soligo D., Fontanella E., Melani C., Pezzella F., Pierotti M., Delia Porta G. Bcl-2 proto-ongogene expression in normal and neoplastic human myeloid cells. Blood 1992; 79: 1291–1298
   PubMed Web of Science ®Google Scholar
• Introna M., Barbui A. M., Golay J., Bambacioni F., Schiro R., Bernasconi S., Breviario F., Erba E., Borleri G., Barbui T., Biondi A., Rambaldi A. Rapid retroviral infection of human haemopoietic cells of different lineages: efficient transfer in fresh T cells. Br J Haematol 1998; 103: 449–61
   PubMed Web of Science ®Google Scholar
• Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol. Methods 1983; 65: 55–63
   PubMed Web of Science ®Google Scholar
• Darzynkiewicz Z., Bruno S., Del Bino G., Gorezyca W., Holz M. A., Lassota P., Traganos F. Features of apoptotic cells measured by flow cytometry. Cytometry 1992; 13: 795–808
   PubMedGoogle Scholar
• Kroemer G., Petit P., Zamzami N., Vayssiere J. L., Mignotte B. The biochemistry of programmed cell death. Faseb J. 1996; 9: 1277–1287
   Web of Science ®Google Scholar