Clinical and Biologic Diversity of Leukemias Occurring in Patients with Mastocytosis

References

• Kirshenbaum A. S., Goff J. P., Kessler S. W., Mican J. M., Zsebo K. M., Metcalfe D. D. Effects of IL‐3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells. Journal of Immunology 1992; 148: 772–777
   PubMed Web of Science ®Google Scholar
• Agis H., Willheim M., Sperr W. R., Wilfing A., Krömer E., Kabrna E., Spanblöchl E., Strobl H., Geissler K., Spittler A., Boltz‐Nitulescu G., Majdic O., Lechner K., Valent P. Monocytes do not make mast cells when cultured in the presence of SCF. Characterization of the circulating mast cell progenitor as a c‐kit+, CD34+, Ly−, CD14−, CD17−, colony forming cell. Journal of Immunology 1993; 151: 4221–4227
   PubMed Web of Science ®Google Scholar
• Rottem M., Okada T., Goff J. P., Metcalfe D. D. Mast cells cultured from peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/Fc&RI− cell population. Blood 1994; 84: 2489–2496
   PubMed Web of Science ®Google Scholar
• Valent P. The Riddle of The Mast Cell: c‐kit Ligand as Missing Link?. Immunology Today 1994; 15: 111–114
   PubMedGoogle Scholar
• Galli S. J. New insights into “the riddle of the mast cells”: microenvironmental regulation of mast cell development and phenotypic heterogeneity. Laboratory Investigation 1990; 62: 5–33
   PubMed Web of Science ®Google Scholar
• Valent P., Sillaber C., Bettelheim P. The growth and differentiation of human mast cells. Progress in Growth Factor Research 1991; 3: 27–41
   PubMedGoogle Scholar
• Valent P., Bettelheim P. Cell surface structures on human basophils and mast cells: Biochemical and functional characterization. Advances in Immunology 1992; 52: 333–421
   PubMed Web of Science ®Google Scholar
• Scheck O., Horny H. ‐P., Ruck P., Schmelzle R., Kaiserling E. Solitary mastocytoma of the eyelid. A case report with special reference to the immunocytology of human tissue mast cells, and a review of the literature. Virchows Archiv 1987; 412: 31–36
   Web of Science ®Google Scholar
• Valent P., Ashman L. K., Hinterberger W., Eckersberger E., Majdic O., Lechner K., Maurer D., Bettelheim P. Mast cell typing: Demonstration of a distinct hemopoietic cell type and evidence for immunophenotypic relationship to mononuclear phagocytes. Blood 1989; 73: 1778–1785
   PubMed Web of Science ®Google Scholar
• Agis H., Füreder W., Bankl H. C., Kundi M., Sperr W. R., Willheim M., Boltz‐Nitulescu G., Butterfield J. H., Kishi K., Lechner K., Valent P. Comparative phenotypic analysis of human mast cells, blood monocytes and blood basophils: Dissection of three distinct myeloid cell lineages. Immunology 1996; 87: 535–543
   PubMed Web of Science ®Google Scholar
• Födinger M., Fritsch G., Winkler K., Emminger W., Mitterbauer G., Gadner H., Valent P., Mannhalter C. Origin of human mast cells: development from transplanted hematopoietic stem cells after allogeneic bone marrow transplantation. Blood 1994; 84: 2954–2959
   PubMed Web of Science ®Google Scholar
• Irani A. M., Nilsson G., Miettinen U., Craig S. S., Ashman L. K., Ishizaka T., Zsebo K. M., Schwartz L. B. Recombinant human stem cell factor stimulates differentiation of human mast cells from dispersed fetal liver cells. Blood 1992; 80: 3009–3016
   PubMed Web of Science ®Google Scholar
• Valent P., Spanblöchl E., Sperr W. R., Sillaber C., Zsebo K. M., Agis H., Strobl H., Geissler K., Bettelheim P., Lechner K. Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor (SCF)/kit ligand in long term culture. Blood 1992; 80: 2237–2245
   PubMed Web of Science ®Google Scholar
• Mitsui H., Furitsu T., Dvorak A. M., Irani A. M., Schwartz L. B., Inagaki N., Takei M., Ishizaka K., Zsebo K. M., Gillis S., Ishizaka T. Development of human mast cells from umbilical cord blood cells by recombinant human and murine c‐kit ligand. Proceedings of the National Academy of Sciences of the United States of America 1993; 90: 735–739
   PubMed Web of Science ®Google Scholar
• Sillaber C., Strobl H., Bevec D., Ashman L. K., Butter‐field J. H., Lechner K., Maurer D., Bettelheim P., Valent P. IL‐4 regulates c‐kit proto‐oncogene product expression in human mast and myeloid progenitor cells. Journal of Immunology 1991; 147: 4224–4228
   PubMed Web of Science ®Google Scholar
• Lennert K., Parwaresch M. R. Mast cells and mast cell neoplasia: a review. Histopathotogy 1979; 3: 349–356
   PubMed Web of Science ®Google Scholar
• Parwaresch M. R., Horny H. ‐P., Lennert K. Tissue mast cells in health and disease. Pathology Research and Practice 1985; 179: 439–461
   PubMed Web of Science ®Google Scholar
• Metcalfe D. D. Classification and diagnosis of mastocytosis: current status. Journal of Investigative Dermatology 1991; 96: 2S–4S
   Web of Science ®Google Scholar
• Valent P. Biology, classification and treatment of human mastocytosis. Wiener Klinische Wochenschrifr 1996; 108: 385–397
   PubMed Web of Science ®Google Scholar
• Nagata H., Worobec A. S., Oh C. K., Chowdhury B. A., Tannenbaum S., Suzuki Y., Metcalfe D. D. Identification of a point mutation in the catalytic domain of the protooncogene c kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proceedings of the National Academy of Sciences of the United States of America 1995; 92: 10560–10564
   PubMed Web of Science ®Google Scholar
• Longley B. J., Tyrrell L., Lu S. Z., Ma Y. S., Langley K., Ding T. G., Duffy T., Jacobs P., Tang L. H., Modlin I. Somatic c‐kit activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nature Genetics 1996; 12: 312–314
   PubMed Web of Science ®Google Scholar
• Worohec A. S., Semere T., Nagata H., Metcalfe D. D. Clinical correlates of the presence of the Asp816Val c‐kit mutation in the peripheral blood mononuclear cells of patients with mastocytosis. Cancer 1998; 83: 2120–2129
   PubMed Web of Science ®Google Scholar
• Pignon J. M., Giraudiers S., Duquesnoy P., Jouault H., Imhert M., Vainchenker W., Vernant J. P., Tuliez M. A new c‐kit mutation in a case of aggressive mast cell disease. British Journal of Haematology 1997; 96: 374–376
   PubMed Web of Science ®Google Scholar
• Buttner C., Henz B. M., Welker P., Sepp N. T., Grabbe J. Identification of activating c‐kit mutations in adult‐, but not childhood‐onset indolent mastocytosis: a possible explanation for divergent clinical behaviour. Journal of Investigative Dermatology 1998; 111: 1227–1231
   PubMed Web of Science ®Google Scholar
• Longley B. J., Metcalfe D. D., Tharp M., Wang X., Tyrrell L., Lu S. ‐Z., Heitjan D., Ma Y. Activating and dominant inactivating c‐kit catalytic domain mutations in distinct forms of human mastocytosis. Proceedings of the National Academy of Sciences of the United States of America 1999; 96: 1609–1614
   PubMed Web of Science ®Google Scholar
• Escrihano L., Orfao A., Villarrubia J., Martin F., Madruga J. I., Cuevas M., Velasco J. L., Rios A., San Miguel J. F. Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia. Cytometry 1997; 30: 98–102
   PubMedGoogle Scholar
• Escribano L., Orfao A., Villarrubia J., Diaz‐Agustin B., Cerveró C., Rios A., Velasco J. L., Ciudad J., Navarro J. L., San Miguel J. F. Immunophenotypic characterization of human bone marrow mast cells. A flow cytometric study of normal and pathologic bone marrow samples. Analytical Cellular Pathology 1998; 16: 151–159
   PubMed Web of Science ®Google Scholar
• Escribano L., Orfao A., Diaz‐Agustin B., Villarmbia J., Cerveró C., López A., Marcos M. A., Bellas C., Fernández‐Canadas S., Cuevas M., Sánchez A., Velasco J. L., Navarro J. L., Miguel J. F. Indolent systemic mast cell disease in adults: imrnunophenotypic characterization of bone marrow mast cells and its diagnostic implications. Blood 1998; 91: 2731–2736
   PubMed Web of Science ®Google Scholar
• Prokocimer M., Polliack A. Increased bone marrow mast cells in preleukemic syndromes, acute leukemia, and lymphoproliferative disorders. American Journal of Clinical Pathology 1981; 75: 34–38
   PubMed Web of Science ®Google Scholar
• Yoo D., Lessin L. S., Jensen W. N. Bone marrow mast cells in lymphoproliferative disorders. Annals of Internal Medicine 1978; 88: 753–757
   PubMed Web of Science ®Google Scholar
• Yoo D., Lessin L. S. Bone marrow mast cells content in preleukemic syndrome. American Journal of Medicine 1982; 73: 539–542
   PubMed Web of Science ®Google Scholar
• Horny H. ‐P., Panvaresch M. R., Lennert K. Bone marrow findings in systemic mastocytosis. Human Pathology 1985; 16: 808–814
   PubMed Web of Science ®Google Scholar
• Brunning R. D., McKenna R. W., Rosai J., Parkin J. L., Risdall R. Systemic mastocytosis, extracutaneous manifestations. American Journal of Surgical Pathology 1983; 7: 425–438
   PubMed Web of Science ®Google Scholar
• Horny H. ‐P., Kaiserling E. Lymphoid cells and tissue mast cells of hone marrow lesions in systemic mastocytosis: a histological and immunohistological study. British Journal of Haematology 1988; 69: 449–455
   PubMed Web of Science ®Google Scholar
• Horny H. ‐P., Ruck M. T., Kaiserling E. Spleen findings in generalized mastocytosis. A clinicopathologic study. Cancer 1992; 70: 459–468
   PubMed Web of Science ®Google Scholar
• Horny H. ‐P., Kaiserling E., Panvaresch M. R., Lennert K. Lymph node findings in generalized mastocytosis. Histopathology 1992; 21: 439–446
   PubMed Web of Science ®Google Scholar
• Caplan R. M. The natural course of urticaria pigmentosa. Analysis and follow up of 112 cases. Archives of Dermatology 1963; 87: 146–157
   PubMed Web of Science ®Google Scholar
• Horan R. F., Austen K. F. Systemic mastocytosis: retrospective review of a decade's clinical experience at the Brigham and Women's hospital. Journal of Investigative Dermatology 1991; 96: 5–13
   Web of Science ®Google Scholar
• Travis W. D., Li C. Y., Bergstralh E. J., Yam L. T., Swee R. G. Systemic mast cell disease. Analysis of 58 cases and literature review. Medicine 1988; 67: 345–368
   PubMed Web of Science ®Google Scholar
• Friedman B. I., Will J. J., Freiman D. G., Braunstein H. Tissue mast cell leukemia. Blood 1958; 13: 70–78
   PubMed Web of Science ®Google Scholar
• Efrati P., Klajman A., Spitz H. Mast cell leukemia? Malignant mastocytosis with leukemia‐like manifestations. Blood 1957; 12: 869–882
   PubMed Web of Science ®Google Scholar
• Travis W. D., Li C. Y., Hoagland H. C., Travis L. B., Banks P. M. Mast cell leukemia: report of a case and review of the literature. Mayo Clinic Proceedings 1986; 61: 957–966
   PubMed Web of Science ®Google Scholar
• Dalton R., Chan L., Batten E., Eridani S. Mast cell leukaemia: evidence for hone marrow origin of the pathological clone. British Journal of Haematology 1986; 64: 397–406
   PubMed Web of Science ®Google Scholar
• Baghestanian M., Bankl H. C., Sillaber C., Beil W. J., Radaszkiewicz Th., Füreder W., Preiser J., Veselly M., Schernthaner G., Lechner K., Valent P. A case of malignant mastocytosis with circulating mast cell precursors: biologic and phenotypic characterization of the malignant clone. Leukemia 1996; 10: 159–166
   PubMed Web of Science ®Google Scholar
• Horny H. ‐P., Parwaresch M. R., Kaiserling E., Müller K., Olhermann M., Mainzer K., Lennert K. Mast cell sarcoma of the larynx. Journal of Clinical Pathology 1986; 39: 596–602
   PubMed Web of Science ®Google Scholar
• Kojima M., Nakamura S., Itoh H., Ohno Y., Masawa N., Joshita T., Suchi T. Mast cell sarcoma with tissue eosinophilia arising in the ascending colon. Modern Pathology 1999; 12: 739–743
   PubMed Web of Science ®Google Scholar
• Guenther P. P., Huebner A., Sobottka S. B., Neumeister V., Weissbach G., Todt H., Parwaresch R. Intracranial mast cell sarcoma: what do we treat?, submitted
   Google Scholar
• Lawrence J. B., Friedman B. S., Travis W. D., Chinchilli V. M., Metcalfe D. D., Gralnick H. R. Hematologic manifestations of systemic mast cell disease: a prospective study of laboratory and morphologic features and their relation to prognosis. American Journal of Medcine 1991; 91: 612–624
   PubMed Web of Science ®Google Scholar
• Travis W. D., Li C. Y., Yam L. T., Bergstralh E. J., Swee R. G. Significance of systemic mast cell disease with associated hematologic disorders. Cancer 1988; 62: 965–972
   PubMed Web of Science ®Google Scholar
• Horny H. ‐P., Ruck M., Wehrmann M., Kaiserling E. Blood findings in generalized mastocytosis: evidence of frequent simultaneous occurrence of myeloprolif‐erative disorders. British Journal of Haematology 1990; 76: 186–193
   PubMed Web of Science ®Google Scholar
• Hutchinson R. M. Mastocytosis and co‐existent Non‐Hodgkin's lymphoma and myeloproliferative disorders. Leukemia and Lymphoma 1992; 7: 29–36
   PubMed Web of Science ®Google Scholar
• Travis W. D., Li C. Y., Bergstralh E. J. Solid and hematologic malignancies in 60 patients with systemic mast cell disease. Archives of Pathology and Laboratory Medicine 1989; 113: 365–368
   PubMed Web of Science ®Google Scholar
• Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A. G., Gralnick H. R., Sultan C. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French‐American‐British group. Annals of Internal Medicine 1985; 103: 626–629
   PubMed Web of Science ®Google Scholar
• Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A. G., Gralnick H. R., Sultan C. Proposal for the recognition of minimally differentiated acute myeloid leukemia. British Journal of Haematology 1991; 78: 325–329
   PubMed Web of Science ®Google Scholar
• Horny H. ‐P., Sillaber C., Menke D., Kaiserling E., Wehrmann M., Stehberger B., Chott A., Lechner K., Lennert K., Valent P. Diagnostic value of immunostaining for tryptase in patients with mastocytosis. American Journal of Surgical Pathology 1998; 22: 1132–1140
   PubMed Web of Science ®Google Scholar
• Valent P. Mast cell differentiation antigens: Expression in normal and malignant cells and use for diagnostic purposes. European Journal of Clinical Investigation 1995; 25: 715–720
   PubMed Web of Science ®Google Scholar
• Fukuda T., Kamishima T., Tsuura Y., Suzuki T., Kakihara T., Naito M., Kishi K., Matsumoto K., Shibata A., Saito T. Expression of the c‐kit gene product in normal and neoplastic mast cells but not in neoplastic basophil / mast cell precursors from chronic myelogenous leukaemia. Journal of Pathology 1995; 177: 139–146
   PubMed Web of Science ®Google Scholar
• Valent P., Escribano L., Parwaresch R., Schemmel V., Schwartz L. B., Sotlar K., Sperr W. R., Horny H. ‐P. Recent advances in mastocytosis research. International Archives of Allergy and Immunology 1999; 120: 1–7
   PubMed Web of Science ®Google Scholar
• Li W. V., Kapadia S. B., Sonmez‐Alpan E., Steven M. S., Swerdlow S. H. Immunohistochemical characterization of mast cell disease in paraffin sections using tryptase, CD68, myeloperoxidase, lysozyme, and CD20 antibodies. Modern Pathology 1996; 9: 982–988
   PubMed Web of Science ®Google Scholar
• Sagher F., Liban E., Ungar H., Schorr S. Urticaria pigmentosa with bone marrow involvement, mast cell aggregates in bones and myelosclerosis found at autopsy in a case dying of monocytic leukemia. Journal of Investigative Dermatology 1956; 27: 355–368
   PubMed Web of Science ®Google Scholar
• Pennacchio L., Mele G. Forma intermedia fra leucemia acuta a promielociti basofili e mastocitosi sistemica. Minerva Medica 1970; 62: 3747–3749
   Google Scholar
• Cains L. J. Systemic mastocytosis. Australasian Journal of Dermatology 1972; 13: 111–113
   PubMedGoogle Scholar
• Vilter R. W., Wiltse D. Preleukemia and urticaria pigmentosa followed by acute myelomonoblastic leukemia. Archives of Internal Medicine 1985; 145: 349–352
   PubMed Web of Science ®Google Scholar
• Wong K. F., Chan J. K., Chan J. C., Kwong Y. L., Ma S. K., Chow T. C. Concurrent acute myeloid leukemia and systemic mastocytosis. American Journal of Hematology 1991; 38: 243–244
   PubMed Web of Science ®Google Scholar
• Lindner P. S., Pardanani B., Angadi C., Frieri M. Acute nonlymphocytic leukemia in systemic mastocytosis with biclonal gammopathy. Journal of Allergy and Clinical Immunology 1992; 90: 410–412
   PubMed Web of Science ®Google Scholar
• Kyriakou D., Kouroumalis E., Konsolas J., Oekonomaki H., Tzardi M., Kanavaros P., Manoussos O., Eliopoulos G. D. Systemic mastocytosis: a rare cause of noncirrhotic portal hypertension simulating autoimmune cholangitis‐report of four cases. American Journal of Gastroenterology 1998; 93: 106–108
   PubMed Web of Science ®Google Scholar
• Sperr W. R., Walchshofer S., Horny H. ‐P., Födinger M., Simonitsch I., Fritsche‐Polanz R., Schwarzinger I., Tschachler E., Sillaber C., Hagen W., Geissler K., Chott A., Lechner K., Valent P. Systemic mastocytosis associated with acute myeloid leukaemia: report of two cases and detection of the c‐kit mutation Asp‐816 to Val. British Journal of Haematology 1998; 103: 740–749
   PubMed Web of Science ®Google Scholar
• Shaw D. W., Hocking W., Ahmed A. R. Generalized cutaneous mastocytosis and acute myelogenous leukemia. International Journal of Dermatology 1983; 22: 109–112
   PubMed Web of Science ®Google Scholar
• Safyan E. L., Veerabagu M. P., Swerdlow S. H., Lee R. G., Rakela J. Intrahepatic cholestasis due to systemic mastocytosis: a case report and review of literature. American Journal of Gastroenterology 1997; 92: 1197–1200
   PubMed Web of Science ®Google Scholar
• Cooper A. J., Winkelmann R. K., Wiltsie J. C. Hematologic malignancies occumng in patients with urticaria pigmentosa. Journal of the American Academy of Dermatology 1982; 7: 215–220
   PubMed Web of Science ®Google Scholar
• Parwaresch M. R., Horny H. ‐P., Bödewadt‐Radzun S. Mast cell disease. In Neoplastic Hematopathology, D. M. Knowles. William. & Wilkins, New York 1992; 1485–1515
   Google Scholar
• Petit A., Pulik M., Gaulier A., Lionnet F., Mahe A., Sigal M. Systemic mastocytosis associated with chronic myelomonocytic leukemia: clinical features and response to interferon alpha therapy. Journal of the American Academy of Dermatology 1995; 32: 850–853
   PubMed Web of Science ®Google Scholar
• Lewis J. P., Welbom J. L., Meyers F. J., Levy N. B., Roschak T. Mast cell disease followed by leukemia with clonal evolution. Leukemia Research 1987; 11: 769–773
   PubMed Web of Science ®Google Scholar
• Smith J. D., Lazarchick J. Systemic mast cell disease with marrow and splenic involvement associated with chronic myelomonocytic leukemia. Leukemia and Lymphoma 1999; 32: 391–394
   PubMed Web of Science ®Google Scholar
• Pulik M., Lionnet F., Petit A., Genet P., Gaulier A. Long term response to interferon alpha in a patient with systemic mastocytosis and chronic myelomonocytic leukemia [letter]. American Journal of Hematology 1992; 47: 66
   Web of Science ®Google Scholar
• Agis H., Beil W. J., Bankl H. ‐C., Füreder W., Sperr W. R., Ghannadan M., Baghestanian M., Sillaber C., Bettelheim P., Lechner K., Valent P. Basophil‐ versus mast cell lineage involvement in myelodysplastic and leukemic disorders. Leukemia and Lymphoma 1996; 22: 187–204
   PubMed Web of Science ®Google Scholar
• Wakem C. J., Bennett J. M. Acute mast cell leukemia: cytochemical and clinical features (abstract). Clinical Research 1970; 16: 687
   Google Scholar
• Daniel M. ‐T., Flandrin G., Bernard J. Leucémie aigue a mastocytes: etude cytochimique et ultrastructurale, à propos d'une observation. Nouvelle Revue Francaise d Hematologie 1975; 15: 319–332
   PubMedGoogle Scholar
• Clancy R. T., Gauldie J., Vallieres M., Bienenstock J., Day R. P., Pineo R. F. An approach in immunotherapy using antibody to IgE in mast cell leukemia. Cancer 1976; 37: 673–696
   Web of Science ®Google Scholar
• Popa G., Iordacheanu L. Leucémie a mastocytes. Revista Medico Chirurgicala Societatii Medici Naturalisti Din hasi. 1977; 81: 519–520
   PubMedGoogle Scholar
• Kimura A., Tanaka R., Taketomi Y., Dohi H., Fujimura K., Kamada N., Kuramoto A., Kajihara H., Aoki Y., Yamamoto S. A case of mastocytoma with leukemic manifestation of its immature form in the terminal stage. Rinsho Ketsueki 1979; 20: 1137–1146
   PubMedGoogle Scholar
• Coser P., Quaglino D., De Pasquale A., Colombetti V., Prinoth O. Cytobiological and clinical aspects of tissue mast cell leukemia. British Journal of Haematology 1980; 45: 5–12
   PubMed Web of Science ®Google Scholar
• Pauls J. D., Brems J., Pockros P. J., Saven A., Wagner R. L., Weber R., Metcalfe D., Christiansen S. C. Mastocytosis: diverse presentations and outcomes. Archives of Internal Medicine 1999; 159: 401–405
   PubMed Web of Science ®Google Scholar
• Butterfield J. H., Weiler D., Dewald G., Gleich G. J. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leukemia Research 1988; 12: 345–355
   PubMed Web of Science ®Google Scholar
• Szweda J. A., Abraham J. P., Fine G., Nixon R. K., Rupe C. E. Systemic mast cell disease: A review and report of three cases. American Journal of Medicine 1962; 32: 227–239
   Web of Science ®Google Scholar
• Treske U., Altenähr E., Lindner J. Histomorphologische und cytologische Befunde bei einem Fall von Gewebsmastzell‐Retikulose mit akutem leukämieartigem Verlauf. Blut 1968; 17: 287–293
   PubMedGoogle Scholar
• Mutter R. D., Tannenbaum M., Ultmann J. E. Systemic mast cell disease. Annals of Internal Medicine 1963; 59: 887–906
   PubMed Web of Science ®Google Scholar
• Toney E., Simpson K., Wilbur S., Munoz P., Skikne B. Malignant mastocytosis with circulating mast cells. American Journal of Hematology 1990; 34: 283–286
   PubMed Web of Science ®Google Scholar
• Valent P., Spanblochl E., Bankl H. C., Sperr W. R., Marosi C., Pirc Danoewinata H., Virgolini I., Eichler H. G., Agis H., Sillaber C., Bettelheim P., Lechner K. Kit ligand/mast cell growth factor independent differentiation of mast cells in myelodysplasia and chronic myeloid leukemic blast crisis. Blood 1994; 84: 4322–4332
   PubMed Web of Science ®Google Scholar
• Wimazal F., Sperr W. R., Horny H. ‐P., Carroll V., Binder B. R., Fonatsch C., Walchshofer S., Födinger M., Schwar‐zinger I., Samorapoompichit P., Chott A., Dvorak A. M., Lechner K., Valent P. Hyperfibrinolysis in a case of myelodysplastic syndrome with leukemic spread of mast cells. American Journal of Hematology 1999; 61: 66–77
   PubMed Web of Science ®Google Scholar
• Nagata H., Worobec A. S., Semere T., Metcalfe D. D. Elevated expression of the proto oncogene c kit in patients with mastocytosis. Leukemia 1998; 12: 175–181
   PubMed Web of Science ®Google Scholar
• Cox J. V., Balaban E. P., Demian S. E., Sheehan R. G. An eosinophilic fibrohistolytic lesion of bone marrow in a patient with Hodgkin's disease. Cancer 1991; 68: 1824–1827
   PubMed Web of Science ®Google Scholar
• Saletti P. H., Ghielmini M., Scali G., Pedrinis E., Guéneau M., Cavalli F. Hodgkin's and Castleman's disease in a patient with systemic mastocytosis. Annals of Hematology 1999; 78: 97–100
   PubMed Web of Science ®Google Scholar
• Petrella T., Depret O., Arnould L., Maynadie M., Guy H., Dalac S., Caillot D., Casasnovas O., Lombard J. N. Systemic mast cell disease associated with hairy cell leukaemia. Leukemia and Lymphoma 1997; 25: 593–595
   PubMed Web of Science ®Google Scholar
• Hagen W., Schwarzmeier J., Walchshofer S., Zojer N., Chott A., Sillaber C., Ackermann J., Simonitsch I., Bühring H. J., Drach J., Lechner K., Horny H. ‐P., Valent P. A case of bone marrow mastocytosis associated with multiple myeloma. Annals of Hematology 1998; 76: 167–174
   PubMed Web of Science ®Google Scholar
• Meggs W. J., Frieri M., Costello R., Metcalfe D. D., Papadopoulos N. M. Oligoclonal immunoglobulins in mastocytosis. Annals of Internal Medicine. 1985; 103: 894–895
   PubMed Web of Science ®Google Scholar
• Kröber S. M., Horny H. ‐P., Ruck P., Kammerer U., Geiselhart A., Handgretinger R., Griesser H., Menke D. M., Kaiserling E. Mastocytosis: reactive or neoplastic?. Journal of Clinical Pathology 1997; 50: 525–527
   PubMed Web of Science ®Google Scholar
• Cervero C., Escribano L., San Miguel J. F., Dim Agustin B., Bravo P., Villarmbia J., Garcia Sanz R., Velasco J. L., Herrera P., Vargas M., Gonzalez M., Navarro J. L., Orfao A. Expression of Bcl 2 by human bone marrow mast cells and its overexpression in mast ceIl leukemia. American Journal of Hematology 1999; 60: 191–195
   PubMed Web of Science ®Google Scholar
• Sotlar K., Marafioti T., Griesser H., Theil J., Aepinus C., Jaussi R., Menke D. M., Stein H., Valent P., Horny H. ‐P. Detection of c‐kit point mutation Asp816 Val in microdissected bone marrow infiltrates in a case of systemic mastocytosis associated with CMML, submitted
   Google Scholar
• Akin C., Kirshenbaum A., Scott L. M., Semere T., Metcalfe D. D. Demonstration of an activating c‐kit mutation in myeloid and lymphoid cells in peripheral blood and bone marrow in mastocytosis. Blood (suppl) 1998; 92: 210a
   Web of Science ®Google Scholar
• Afonja O., Amorosi E., Ashman L., Takeshita K. Multilineage involvement and erythropoietin “independent” erythroid progenitor cells in a patient with systemic mastocytosis. Annals of Hematology 1998; 77: 183–186
   PubMed Web of Science ®Google Scholar
• Metcalfe D. D. The treatment of mastocytosis. Journal of Investigative Dermatology 1991; 96: 55S–56S
   Web of Science ®Google Scholar
• Parker R. I. Hematologic aspects of mastocytosis. II. management of hematologic disorders in association with systemic mast cell disease. Journal of Investigative Dermatology 1991; 96: 52S–53S
   Web of Science ®Google Scholar
• Kluin‐Nelemans H. C., Jansen J. H., Breukelman H., Wolthers B. G., Kluin P. M., Kroon H. M., Willemze R. Response to interferon alpha‐2b in a patient with systemic mastocytosis. New England Journal of Medicine 1992; 326: 619–623
   PubMed Web of Science ®Google Scholar
• Worobec A. S., Kirshenbaum A. S., Schwartz L. B., Metcalfe D. D. Treatment of three patients with systemic mastocytosis with interferon alpha‐2b. Leukemia and Lymphoma 1996; 22: 501–508
   PubMed Web of Science ®Google Scholar
• Przepiorka D., Giralt S., Khouri I., Champlin R., Bueso Ramos C. Allogeneic marrow transplantation for myeloproliferative disorders other than chronic myelogenous leukemia: review of forty cases. American Journal of Hematology 1998; 57: 24–28
   PubMed Web of Science ®Google Scholar
• Butterfield J. H. Response of severe systemic mastocytosis to interferon alpha. British Journal of Dermatology 1998; 138: 489–495
   PubMed Web of Science ®Google Scholar