56
Views
10
CrossRef citations to date
0
Altmetric
Original Article

Mitoxantrone, Etoposide, Carboplatinum and Ara-C Combination Therapy (Meca) in Refractory and Relapsed Acute Leukemia

, , , , , , , , & show all
Pages 583-590 | Accepted 30 May 2000, Published online: 05 Aug 2009

References

  • Löwenberg B, Downing J R, Burnett A. Acute myeloid leukemia. N Eng J Med 1999; 341: 1051–1062
  • Pui C H, Evans W E. Acute lymphoblastic leukemia. N Ens J Mud 1998; 339: 605–615
  • Forman S J, Schmidt G M, Nademanee A P, Amylon M D, Chao N J, Fahey J L, Konrad P N, Margolin K A, Niland J C, O'Donnell M R, Parker P M, Smith E P, Snyder D S, Somlo G, Stein A S, Blume K G. Allogeneic bone marrow transplantation as therapy for primary induction failure for patients with acute leukemia. J Clin Oncol 1991; 9: 1570–1574
  • Biggs J C, Horowitz M M, Gale R P, Ash R C, Atkinson K, Helbig W, Jacobsen N, Phillips G L, Rimm A A, Ringdén O, Roman C, Sobocinski K A, Veum J A, Bortin M M. Bone marrow transplants may cure patients with acute leukemia never achieving remission with chemotherapy. Blood 1992; 80: 1090–1093
  • Hiddemann W, Kreutzmann H, Straif K, Ludwig W D, Mertelsmann R, Donhuijsenant R, Lengfelder E, Arlin Z, Büchner D. High-dose cytosine arabinoside and mitoxantrone: A highly effective regimen in refractory acute myeloid leukemia. Blood 1987; 69: 744–749
  • Walters R S, Kantarjian H M, Keating M J, Plunkett W K, Estey E H, Andersson B, Beran M, McCredie K B, Freireich E J. Mitoxantrone and high-dose cytosine arabinoside in refractory acute myelogenous leukemia. Cancer 1988; 62: 677–682
  • Archimbaud E, Leblond V, Michallet M, Cordonier C, Fenaux P, Travade P, Dreyfus F, Jaubert J, Devaux Y, Fiere D. Intensive sequential chemotherapy with mitoxantrone and continuous infusion etoposide and cytarabine for previously treated acute myelogenous leukemia. Blood 1991; 77: 1894–1990
  • Keskin A, Tombuloglu M, Atamer M A, Büyükkeçeci F. Mitoxantrone and standard dose cytosine arabinoside therapy in refractory or relapsed acute leukemia. Am Haematol 1994; 92: 14–17
  • Guthrie T H., Jr. High-dose, continuous-infusion cyclo-phosphamide, cytarabine, vincristine, and prednisone for remission inductio in refractory adult acute leukemia. Cancer 1987; 59: 1255–1257
  • Carella A M, Carlier P, Pungolino E, Resegotti Liso L. V, Stasi R, Montillo M, Iacopino P, Mirto S, Pagano L, Leoni F, Martelli F M, Di Raimondo F, Porcelli A, De Riu L, Nosari A M, Cimino R, Damasio E, Miraglia E, Fioritoni G, Ricciuti Carotenuto F. M, Longinotti M, Defazio D, Fazi P, Mandelli F., for the GIMEMA Cooperative Group. Idarubicin in combination with intermediate-dose cytarabine and VP-16 in the treatment of refractory or rapidly relapsed patients with acute myeloid leukemia. Leukemia 1993; 7: 196–199
  • Martino R, Brunet S, Sureda A, Guardia R, Aventin A, Soler J, Altés A, Domingo-Albós A. Hematopoietic Growth Factor (G-CSF or GM-CSF) after salvage chemotherapy in refractory or relapsed adult de novo acute leukemia. Leukemia and Lymphoma 1996; 20: 321–326
  • Kornblau S M, Kantarjian H, O'Brian S, Andreeff M, Koller C A, Beran M, Keating M, Estey E. CECA-cyclophos-phamide, etoposide, carboplatin and cytosine arabinoside. A new salvage regimen for relapsed or refractory acute myelogenous leukemia. Leukemia and Lymphoma 1998; 28: 371–375
  • Mayers F J, Welborn J, Lewis J P, Flynn N. Infusion carboplatin treatment of relapsed and refractory acute leukemia: Evidence of efficacy with minimal extramedullary toxicity at intermediate doses. J Clin Oncol 1989; 7: 173–178
  • Martínez J A, Martin G, Sanz G F, Sempere A, Jarque I, de la Rubia J, Sanz M A. A phase II clinical trial of carboplatin infusion in high-risk acute non-lymphoblastic leukemia. J Clin Oncol 1991; 9: 39–43
  • Vogler W R. High-dose carboplatin in the treatment of hematologic malignancies. Oncology 1993; 50(Supp1. 2)42–46
  • Santana V, Mirro J, Kearns C, Schell M J, Crom W, Blakley R L. 2-Chloroadeoxyadenosine produces a high rate of complete hematologic remission in relapsed acute myeloid leukemia. J Clin Oncol 1992; 10: 364–370
  • Parker J E, Pagliuca A, Cullis J O, Czepulkowski B, Rassam S M, Samaratunga I R, Grace R, Cover P A, Mufti G J. Fludarabine, cytarabine, G-CSF and idarubicin (FLAG-IDA) for the treatment of poor-risk myelodysplastic syndromes and acute myeloid leukaemia. Br J Haematol 1997; 99: 939–944
  • Bassan R, Lerede T, Buelli M, Boleri G, Bellavita P, Ram-Baldi A, Barbui T. A new combination of carboplatin, high-dose cytarabine and cross-over mitoxantrone or idarubicin for refractory and relapsed acute myeloid leukemia. Haematologica 1998; 83: 422–427
  • Kanarjian H M, Estey E H, Keating M A. New chemo-therapeutic agents in acute myeloid leukemia. Leukemia; Suppl 1996; 1: S4–S6
  • List A E, Spier C, Greer J, Wolff S, Hutter J, Dorr R, Salmon S, Futscher B, Baier M, Dalton W. A phase MI trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia. J Clin Oncol 1993; 11: 1652–1660
  • Bennet J M, Catovsky D, Daniel M T, Fladrin G, Galton D AG, Gralnick H R, Sultan C. Proposal for the classification of acute leukemia. Br J Haematol 1976; 33: 451–458
  • Miller A B, Hoogstraten B, Staquet M, Winkler A. Reporting results of cancer treatment. Cancer 1981; 47: 207–214
  • Vaughan W P, Karp J E, Burke P J. Long chemotherapy-free remissions after single-cycle timed sequential chemotherapy for acute myelocytic leukemia. Cancer 1980; 45: 850–865
  • Amadori S, Arcese W, Isacchi G, Meloni G, Petti M C, Monarca B, Testi A M, Mandelli F. Mitoxantrone, etoposide, and intermediate-dose cytarabine: An effective and tolerable regimen for the treatment of refractory acute myeloid leukemia. J Clin Oncol 1991; 9: 1210–1214
  • Kern W, Aul C, Maschmeyer G, Kuse R, Kerkhoff Grote-Metke A, Eimermacher H, Kubica U, Wörmann B, Büchner Hiddemann T, for the German AML Cooperative Group. Granulocyte colony-stimulating factor shortens duration of critical neutropenia and prolongs disease-free survival after sequential high-dose cytosine arabinoside and mitoxantrone (S-HAM) salvage therapy for refractory and relapsed acute myeloid leukemia. Ann Hematol 1998; 77: 115–121
  • Bassan R, Chiodini B, Zucchetti M, Lerede T, Cornelli P E, Cortelazzo S, Barbui T. Short course infusion idarubicin plus intermittent cytarabine and etoposide for refractory hematologic malignancies: clinical and preliminary pharmacological results. Haematologica 1998; 83: 27–33
  • Clavio M, Carrara P, Miglino M, Pierri I, Canepa L, Balleari E, Gratti A M, Cerri R, Celesti L, Vallebella E, Sessarego M, Patrone F, Ghio R, Damasio E, Gobbi M. High efficacy of fludarabine-containing therapy (LANG-RANG) in poor risk acute myeloid leukemia. Haematologica 1996; 81: 513–520
  • Kern W, Schleyer E, Underhalt M, Wörmann B, Büchner T, Hiddemann W. High antileukemic activity of sequential high dose cytosine arabinoside and mitoxantrone in patients with refractory acute leukemias. Cancer 1997; 79: 59–68

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.