28
Views
4
CrossRef citations to date
0
Altmetric
Original Article

Telomerase Activity and Clinical Progression in Chronic Lymphoproliferative Disorders of B-Cell Lineage

, , &
Pages 35-45 | Received 07 Jul 2000, Published online: 01 Jul 2009

References

  • Moyzis R. K., Buckingham J. M., Cram L. S., Dani M., Deaven L. L., Jones M. D., Meyne J., Ratliff R. L., Wu J. R. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proceeding of the National Academy of Sciences of the United States of America 1988; 85: 6622–6626
  • Griffith J. D., Comeau L., Rosenfield S., Stansel R. M., Bianchi A., Moss H., de Lange T. Mammalian telomeres end in a large duplex loop. Cell 1999; 97: 503–514
  • van Steensel B., de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature 1997; 385: 740–743
  • van Steensel B., Smogorzewska A., de Lange T. TRF2 protects human telomeres from end-to-end fusion. Cell 1998; 92: 401–413
  • Blackburn E. H. Structure and function of telomeres. Nature 1991; 350: 569–573
  • Watson J. D. Origin of concatemeric T7 DNA. Nature New Biology 1972; 239: 197–201
  • Olovnikov A. M. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. Journal of Theoretical Biology 1973; 41: 181–190
  • Harley C. B., Futcher A. B., Greider C. W. Telomeres shorthen during ageing of human fibroblasts. Nature 1990; 345: 458–460
  • Allsopp R. C., Vaziri H., Patterson C., Goldstein S., Younglai E. V., Futcher A. B., Greider C. W., Harley C. B. Telomere length predicts replicative capacity of human fibroblasts. Proceeding of the National Academy of Sciences of the United States of America 1992; 89: 10114–10118
  • Feng J., Funk W. D., Wang S. S., Weinrich S. L., Avilion A. A., Chiu C. P., Adams R. R., Chang E., Allsopp R. C., Yu J., Le S., West M. D., Harley C. B., Andrews W. H., Greider C. W., Villeponteau B. The RNA component of human telomerase. Science 1995; 269: 1236–1241
  • Chen J. L., Blasco M. A., Greider C. W. Secondary structure of vertebrate telomerase RNA. Cell 2000; 100: 503–514
  • Nakamura T. M., Morin G. B., Chapman K. B., Weinrich S. L., Andrews W. H., Lingner J., Harley C. B., Cech T. R. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277: 955–959
  • Bodnar A. G., Ouellette M., Frolkis M., Holt S. E., Chiu C. P., Morin G. B., Harley C. B., Shay J. W., Lichtsteiner S., Wright W. E. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349–352
  • Kim N. W., Piatyszek M. A., Prowse K. R., Harley C. B., West M. D., Ho P. L., Coviello G. M., Wright W. E., Weinrich S. L., Shay J. W. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011–2015
  • Shay J. W., Bacchetti S. A survey of telomerase activity in human cancer. European Journal of Cancer 1997; 33: 787–791
  • Hahn W. C., Stewart S. A., Brooks M. W., York S. G., Eaton E., Kurachi A., Beijersbergen R. L., Knoll J. H., Meyerson M., Weinberg R. A. Inhibition of telomerase limits the growth of human cancer cells. Nature Medicine 1999; 5: 1164–1170
  • Weng N. P., Palmer L. D., Levine B. L., Lane H. C., June C. H., Hodes R. J. Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunological Reviews 1997; 160: 43–54
  • Weng N. P., Hathcock K. S., Hodes R. J. Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential. Immunity 1998; 9: 151–157
  • Wright W. E., Shay J. W., Piatyszek M. A. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Research 1995; 23: 3794–3795
  • Chiu C. P., Drogowska W., Kim N. W., Vaziri H., Yui J., Thomas T. E., Harley C. B., Lansdorp P. M. Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells 1996; 14: 239–248
  • Counter C. M., Gupta J., Harley C. B., Leber B., Bacchetti S. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 1995; 85: 2315–2320
  • Broccoli D., Young J. W., de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proceeding of the National Academy of Sciences of the United States of America 1995; 92: 9082–9086
  • Norrback K. F., Dahlenborg K., Carlsson R., Roos G. Telomerase activity in normal B lymphocytes and non-Hodgkin's lymphoma. Blood 1996; 88: 222–229
  • Igarashi H., Sakaguchi N. Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to antigen receptor. Blood 1997; 89: 1299–1307
  • Weng N. P., Levine B. L., June C. H., Hodes R. J. Regulated expression of telomerase activity in human T lymphocyte development and activation. The Journal of Experimental Medicine 1996; 183: 2471–2479
  • Weng N. P., Granger L., Hodes R. J. Telomere lengthening and telomerase activation during human B cell differentiation. Proceeding of the National Academy of Sciences of the United States of America 1997; 94: 10827–10832
  • Kelsoe G. Life and death in germinal centers (redux). Immunity 1996; 4: 107–111
  • Liu Y. J., de Bouteiller O., Arpin C., Briere F., Galibert L., Ho S., Martinez-Valdez H., Banchereau J., Lebecque S. Normal human IgD+IgM-germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts. Immunity 1996; 4: 603–613
  • Pascual V., Liu Y. J., Magalski A., de Bouteiller O., Banchereau J., Capra J. D. Analysis of somatic mutation in five B cell subsets of human tonsil. The Journal of Experimental Medicine 1994; 180: 329–339
  • Kelsoe G. V(D)J hypermutation and receptor revision: coloring outside the lines. Current Opinion in Immunology 1999; 11: 70–75
  • Klein U., Goossens T., Fischer M., Kanzler H., Braeuninger A., Rajewsky K., Kuppers R. Somatic hypermutation in normal and transformed human B cells. Immunological Reviews 1998; 162: 261–280
  • Hoang A. T., Lutterbach B., Lewis B. C., Yano T., Chou T. Y., Barrett J. F., Raffeld M., Hann S. R., Dang C. V. A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain. Molecular and Cellular Biology 1995; 15: 4031–4042
  • Pasqualucci L., Migliazza A., Fracchiolla N., William C., Neri A., Baldini L., Chaganti R. S., Klein U., Kuppers R., Rajewsky K., Dalla-Favera R. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proceeding of the National Academy of Sciences of the United States of America 1998; 95: 11816–11821
  • Cattoretti G., Chang C. C., Cechova K., Zhang J., Ye B. H., Falini B., Louie D. C., Offit K., Chaganti R. S., Dalla Favera R. BCL-6 protein is expressed in germinal-center B cells. Blood 1995; 86: 45–53
  • Dent A. L., Shaffer A. L., Yu X., Allman D., Staudt L. M. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997; 276: 589–592
  • Ye B. H., Cattoretti G., Shen Q., Zhang J., Hawe N., de Waard R., Leung C., Nouri-Shirazi M., Orazi A., Chaganti R. S., Rothman P., Stall A. M., Pandolfi P. P., Dalla Favera R. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nature Genetics 1997; 16: 161–170
  • Jacob J., Kelsoe G., Rajewsky K., Weiss U. Intraclonal generation of antibody mutants in germinal centres. Nature 1991; 354: 389–392
  • Berek C., Berger A., Apel M. Maturation of the immune response in germinal centers. Cell 1991; 67: 1121–1129
  • Kuppers R., Zhao M., Hansmann M. L., Rajewsky K. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. The EMBO Journal 1993; 12: 4955–4967
  • Kelsoe G. In situ studies of germinal center reaction. Advances in Immunology 1995; 60: 267–288
  • Migliazza A., Martinotti S., Chen W., Fusco C., Ye B. H., Knowles D. M., Offit K., Chaganti R. S., Dalla-Favera R. Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. Proceeding of the National Academy of Sciences of the United States of America 1995; 92: 12520–12524
  • Shen H. M., Peters A., Baron B., Zhu X., Storb U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 1998; 280: 1750–1752
  • Stevenson F., Sahota S., Zhu D., Ottensmeier C., Chapman C., Oscier D., Hamblin T. Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes. Immunological Reviews 1998; 162: 247–259
  • Kuppers R., Klein U., Hansmann M. L., Rajewsky K. Cellular origin of human B-cell lymphomas. The New England Journal of Medicine 1999; 341: 1520–1529
  • Capello D., Vitolo U., Pasqualucci L., Quattrone S., Migliaretti G., Fassone L., Ariatti C., Vivenza D., Gloghini A., Pastore C., Lanza C., Nomdedeu J., Botto B., Freilone R., Buonaiuto D., Zagonel V., Gallo E., Palestro G., Saglio G., Dalla-Favera R., Carbone A., Gaidano G. Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia. Blood 2000; 95: 651–659
  • Mandal M., Kumar R. BCL-2 modulates telomerase activity. The Journal of Biological Chemistry 1997; 272: 14183–14187
  • Herrera E., Martinez A. C., Blasco M. A. Impaired germinal center reaction in mice with short telomeres. The EMBO Journal 2000; 19: 472–481
  • Harris N. L., Jaffe E. S., Stein H., Banks P. M., Chan J. K., Cleary M. L., Delsol G., De Wolf-Peeters C., Falini B., Gatter K. C. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994; 84: 1361–1392
  • Rosolen A., Nakanishi M., Poplack D. G., Cole D., Quinones R., Reaman G., Trepel J. B., Cotelingam J. D., Sausville E. A., Marti G. E. Expression of interleukin-2 receptor beta subunit in hematopoietic malignancies. Blood 1989; 73: 1968–1972
  • Trentin L., Zambello R., Agostini C., Siviero F., Adami F., Marcolongo R., Raimondi R., Chisesi T., Pizzolo G., Semenzato G. Expression and functional role of tumor necrosis factor receptors on leukemic cells from patients with type B chronic lymphoproliferative disorders. Blood 1993; 81: 752–758
  • Rubaltelli A., Sitia R., Zicca A., Grossi C. E., Ferrarini M. Differentiation of chronic lymphocytic leukemia cells: correlation between the synthesis and secretion of immunoglobulins and the ultrastructure of the malignant cells. Blood 1983; 62: 495–504
  • Rassenti L. Z., Kipps T. J. Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia. The Journal of Experimental Medicine 1993; 177: 1039–1046
  • Kipps T. J., Duffy S. F. Relationship of the CD5 B cell to human tonsillar B lymphocytes that express autoantibody-associated cross-reactive idiotypes. The Journal of Clinical Investigation 1991; 87: 2087–2096
  • Caligaris-Cappio F., Gobbi M., Bofill M., Janossy G. Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia. The Journal of Experimental Medicine 1982; 155: 623–628
  • Malisan F., Fluckiger A. C., Ho S., Guret C., Banchereau J., Martinez-Valdez H. B-chronic lymphocytic leukemias can undergo isotype switching in vivo and can be induced to differentiate and switch in vitro. Blood 1996; 87: 717–724
  • Maloum K., Davi F., Magnac C., Pritsch O., McIntyre E., Valensi F., Binet J. L., Merle-Beral H., Dighiero G. Analysis of VH gene expression in CD5+ and CD5-B-cell chronic lymphocytic leukemia. Blood 1995; 86: 3883–3890
  • Juliusson G., Oscier D. G., Fitchett M., Ross F. M., Stockdill G., Mackie M. J., Parker A. C., Castoldi G. L., Guneo A., Knuutila S. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. The New England Journal of Medicine 1990; 323: 720–724
  • Matutes E., Oscier D., Garcia-Marco J., Ellis J., Copplestone A., Gillingham R., Hamblin T., Lens D., Swansbury G. J., Catovsky D. Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical, and laboratory features in 544 patients. British Journal of Haematology 1966; 92: 382–388
  • Fegan C., Robinson H., Thompson P., Whittaker J. A., White D. Karyotypic evolution in CLL: identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease. Leukemia 1995; 9: 2003–2008
  • Gaidano G., Ballerini P., Gong J. Z., Inghirami G., Neri A., Newcomb E. W., Magrath I. T., Knowles D. M., Dalla-Favera R. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proceeding of the National Academy of Sciences of the United States of America 1991; 88: 5413–5417
  • Aoki H., Takishita M., Kosaka M., Saito S. Frequent somatic mutations in D and/or JH segments of Ig gene in Waldenstrom's macroglobulinemia and chronic lymphocytic leukemia (CLL) with Richter's syndrome but not in common CLL. Blood 1995; 85: 1913–1919
  • Abe M., Tominaga K., Wakasa H. Phenotypic characterization of human B-lymphocytic subpopulations, particularly human CD5+ B-lymphocyte subpopulation within the mantle zones of secondary follicles. Leukemia 1994; 8: 1039–1044
  • Hummel M., Tamaru J., Kalvelage B., Stein H. Mantle cell (previously centrocytic) lymphoma express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood 1994; 84: 403–407
  • Peng H. Z., Du M. Q., Koulis A., Aiello A., Dogan A., Pan L. X., Isaacson P. G. Non immunoglobulin gene hypermutation in germinal center B cells. Blood 1999; 93: 2167–2172
  • Laszlo T., Nagy M., Kelenyi G., Matolcsy A. Immunoglobulin V(H) gene mutational analysis suggests that blastic variant of mantle cell lymphoma derives from different stages of B-cell maturation. Leukemia Research 2000; 24: 27–31
  • Pittaluga S., Tierens A., Pinyol M., Campo E., Delabie J., De Wolf-Peeters C. Blastic variant of MCL shows a heterogeneous pattern of somatic mutations of the rearranged immunoglobulin heavy chain variable genes. British Journal of Haematology 1998; 102: 1301–1306
  • Lukas J., Jadayel D., Bartkova J., Nacheva E., Dyer M. J., Strauss M., Bartek J. BCL-1/Cyclin Dl oncoprotein oscillates and subverts the Gl phase control in B-cell neoplasms carrying the t(11;14) translocation. Oncogens 1994; 9: 2159–2167
  • Lovec H., Grzeschiczek A., Kowalski M. B., Moroy T. Cyclin D1/Bcl-1 cooperates with myc genes in generation of B-cell lymphoma in transgenic mice. The EMBO Journal 1994; 13: 3487–3495
  • Weisenburger D. D., Armitage J. O. Mantle cell lymphoma-an entity comes of age. Blood 1996; 87: 4483–4494
  • Maloum K., Magnac C., Azgui Z., Cau C., Charlotte F., Binet J. L., Merle-Beral H., Dighiero G. VH gene expression in hairy cell leukemia. British Journal of Haematology 1998; 101: 171–178
  • Miranda R. N., Cousar J. B., Hammer R. D., Collins R. D., Vnencak-Jones C. L. Somatic mutation analysis of IgH variable regions reveals that tumor cells of most parafollicular (monocytoid) B-cell lymphoma, splenic marginal zone B-cell lymphoma, and some hairy cell leukemia are composed of memory B lymphocytes. Human Pathology 1999; 30: 306–312
  • Schmid M., Porzsolt F. Autocrine and paracrine regulation of neoplastic cell growth in hairy cell leukemia. Leukemia and Lymphoma 1995; 17: 401–410
  • Bechter O. E., Eisterer W., Pall G., Hilbe W., Ruhr T., Thaler J. Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia. Cancer Research 1998; 58: 4918–4922
  • Engelhardt M., Mackenzie K., Drullinsky P., Silver R. T., Moore M. A. Telomerase activity and telomere length in acute and chronic leukemia, pre-and post-ex vivo culture. Cancer Research 2000; 60: 610–617
  • Zhang W., Piatyszek M. A., Kobayashi T., Estey E., Andreeff M., Deisseroth A. B., Wright W. E., Shay J. W. Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents. Clinical Cancer Research 1996; 2: 799–803
  • Zhu X., Kumar R., Mandal M., Sharma N., Sharma H. W., Dhingra U., Sokoloski J. A., Hsiao R., Narayanan R. Cell cycle-dependent modulation of telomerase activity in tumor cells. Proceeding of the National Academy of Sciences of the United States of America 1996; 93: 6091–6095
  • Holt S. E., Wright W. E., Shay J. W. Regulation of telomerase activity in immortal cell lines. Molecular and Cellular Biology 1996; 16: 2932–2939
  • Trentin L., Ballon G., Ometto L., Perin A., Basso U., Chieco-Bianchi L., Semenzato G., De Rossi A. Telomerase activity in chronic lymphoproliferative disorders of B-cell lineage. British Journal of Haematology 1999; 106: 662–668
  • Soder A. I., Hoare S. F., Muir S., Going J. J., Parkinson E. K., Keith W. N. Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene 1997; 14: 1013–1021
  • Wu K. J., Grandori C., Amacker M., Simon-Vermot N., Polack A., Lingner J., Dalla Favera R. Direct activation of TERT transcription by c-MYC. Nature Genetics 1999; 21: 220–224
  • Oh S., Song Y. H., Yim J., Kim T. K. Identification of MAD as a represser of the human telomerase (hTERT) gene. Oncogene 2000; 19: 1485–1490
  • Schroeder H. W., Jr., Dighiero G. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunology Today 1994; 15: 288–294
  • Kurec A. S., Threatte G. A., Gottlieb A. J., Smith J. R., Anderson J., Davey F. R. Immunophenotypic subclassification of chronic lymphocytic leukemia (CLL). British Journal of Haematology 1994; 83: 2602–2610
  • Oscier D. G., Thompsett A., Zhu D., Stevenson F. K. Differential rates of somatic hypermutation in V (H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. Blood 1997; 89: 4153–4160
  • Brousset P., Saati T., Chaouche N., Zenou R. C., Schlaifer D., Chittal S., Delsol G. Telomerase activity in reactive and neoplastic lymphoid tissues: infrequent detection of activity in Hodgkin's disease. Blood 1997; 89: 26–31
  • Kondo Y., Kondo S., Tanaka Y., Haqqi T., Barna B. P., Cowell J. K. Inhibition of telomerase increases susceptibility to human malignant glioblastoma cells to cisplatin-induced apoptosis. Oncogene 1998; 16: 2243–2248
  • Bisoffi M., Chakerian A. E., Fore M. L., Bryant J. E., Hernandez J. P., Moyzis R. K., Griffith J. K. Inhibition of human telomerase by a retrovirus expressing telomeric antisense RNA. European Journal of Cancer 1998; 34: 1242–1249
  • Pitts A. E., Corey D. R. Inhibition of human telomerase by 2′-O-methyl-RNA. Proceeding of the National Academy of Sciences of the United States of America 1998; 95: 11549–11554
  • Shammas M. A., Simmons C. G., Corey D. R., Reis R. J. S. Telomerase inhibition by peptide nucleic acids reverses “immortality” of transformed human cells. Oncogene 1999; 18: 6191–6200
  • Vonderheide R. H., Hahn W. C., Schultze J. L., Nadler L. M. Telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity 1999; 10: 673–679
  • Minev B., Hipp J., Firat H., Schmidt J. D., Langlade-Demoyen P., Zanetti M. Cytotoxic T cell immunity against telomerase reverse transcriptase in humans. Proceeding of the National Academy of Sciences of the United States of America 2000; 97: 4796–4801
  • Alizadeh A. A., Eisen M. B., Davis R. E., Ma C., Lossos I. S., Rosenwald A., Boldrick J. C., Sabet H., Tran T., Yu X., Powell J. I., Yang L., Marti G. E., Moore T., Hudson J., Jr, Lu L., Lewis D. B., Tibshirani R., Sherlock G., Chan W. C., Greiner T. C., Weisenburger D. D., Armitage J. O., Warnke R., Levy R., Wilson W., Grever M. R., Byrd J. C., Botstein D., Brown P. O., Staudt L. M. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503–511
  • Hiyama E., Hiyama K., Yokoyama T., Matsuura Y., Piatyszek M. A., Shay J. W. Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Medicine 1995; 1: 249–255
  • Hiyama E., Yokoyama T., Tatsumoto N., Hiyama K., Imamura Y., Murakami Y., Kodama T., Piatyszek M. A., Shay J. W., Matsuura Y. Telomerase activity in gastric cancer. Cancer Research 1995; 55: 3258–3262
  • Falchetti M. L., Pallini R., Larocca L. M., Verna R., D'Ambrosio E. Telomerase expression in intracranial tumors: prognostic potential for malignant gliomas and meningiomas. Journal of Clinical Pathology 1999; 52: 234–236
  • Clark G. M., Osborne C. K., Levitt D., Wu F., Kim N. W. Telomerase activity and survival of patients with node-positive breast cancer. Journal of National Cancer Institute 1997; 89: 1874–1881
  • Marchetti A., Betacca G., Buttitta F., Chella A., Quattrocolo G., Angeletti C. A., Bevilacqua G. Telomerase activity as a prognostic indicator in stage I non-small cell lung cancer. Clinical Cancer Research 1999; 5: 2077–2081
  • Ohyashiki K., Ohyashiki J. H., Iwama H., Hayashi S., Shay J. W., Toyama K. Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression. Leukemia 1997; 11: 190–194

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.