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Leukemia & Lymphoma Volume 41, 2001 - Issue 1-2
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Original Article

Reversal of Fludarabine Induced Testicular Damage in a Patient with Chronic Lymphocytic Leukaemia (CLL), by Suppression of Pituitary-Testicular Axis Using Gonadotrophin Releasing Hormone (GnRH)

Ratna Chatterjee Reproductive Medicine Unit, Department Of Obstetrics and Gynaecology
,
Panagiotis D. Kottaridis Department of Haematology, University College London Hospitals, Huntley street., London, WCIE, 6AU, UK
,
Hugh McGarrigle Reproductive Medicine Unit, Department Of Obstetrics and Gynaecology
&
Anthony H. Goldstone Department of Haematology, University College London Hospitals, Huntley street., London, WCIE, 6AU, UK
Pages 213-215 | Received 20 Jun 2000, Published online: 01 Jul 2009

References

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  • Clark S. T., Radford J. A., Crowther D., Swindell R., Shalet S. M. Gonadal function following chemotherapy for Hodgkin's disease: a comparative study of MVPP and a seven drug hybrid regimen. J Clin Oncol 1995; 13: 134–9
  • Chatterjee R., Mills W., Katz M., McGarrigle H. H., Goldstone A. H. Germ cell failure and Leydig cell insufficiency in post-pubertal males after autologous bone marrow transplantation with BEAM for lymphoma. Bone Marrow Transplant 1994; 13: 519–22
  • Haines G. A., Marples B. M., Daniel P., Morris I. D. Measurment of radiation induced damage in mammalian spermatozoa using the Comet assay. Adv Exp Biol Med 1998; 444: 79–93
  • Chatterjee R., Haines G. A., Perera D. M., Goldstone A., Morris I. D. Testicular and sperm DNA damage after treatment with fludarabine for chronic lymphocytic leukaemia. Hum Reprod 2000; 15: 762–766
  • Heikens J., Behrendt H., Adriaanse R., Berghout A. Irreversible gonadal damage in male survivors of pediatric Hodgkin's disease. Cancer 1996; 78: 2020–4
  • Chatterjee R., Goldstone A. H. Gonadal damage and effects on fertility in adult patients with haematological malignancy undergoing stem cell transplantation. Bone Marrow Transplant 1996; 17: 3–11
  • Glode L. M., Robinson J., Gould S. F. Protection from cyclophosphamide induced testicular damage with an analogue of gonadotrophin releasing hormone. Lancet 1981; i: 1132–1134
  • Morris I. D. Protection against cytotoxic induced testis damage-experimental approaches. Eur Urol 1993; 23: 143–7
  • Meistrich M. L. Hormonal stimulation of the recovery of spermatogenesis following chemo-or radiotherapy. Review article. APMIS 1998; 106: 37–45, discussion 45–6

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