BCR-ABL Fails to Inhibit Apoptosis in U937 Myelomonocytic Cells Expressing a Carboxyl-Terminal Truncated Stat5

References

• Bedi Zehnbauer A., Barber A. BJP., Sharkis S J, Jones R I. Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood 1994; 83: 2038–2044
   PubMed Web of Science ®Google Scholar
• Cortez Kadlec D. L, Pendergast A M. Structural and signaling requirements for BCR-ABL mediated transformation and inhibition of apoptosis. Mol Cell Biol 1995; 15: 5531–5541
   PubMed Web of Science ®Google Scholar
• Ahmed Dusanter M., FourtBernard I., Mayeux M., Hawley P., Bennardo G. R, Novault T., Bonnet S., Gisselbrecht L. M, Varet S. B, Turban A G. BCR-ABL and constitutively active erythropoietin receptor (cEpoR) activate distinct mechanisms for growth factor-independence and inhibition of apoptosis in Ba/F3 cell line. Oncogene 1998; 16: 489–496
   PubMed Web of Science ®Google Scholar
• Amos T, Lewis A., Grand L. J, Gooding H. FRP., Goldman J M, Gordon M Y. Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids. Br J Haematol 1995; 91: 387–393
   PubMed Web of Science ®Google Scholar
• Albrecht Schwab T., Henkes R., Peschel M., Huber C. C, Aulitzky W E. Primary proliferating immature myeloid cells from CML patients are not resistant to induction of apoptosis by DNA damage and growth factor withdrawal. Br J Haematol 1996; 95: 501–507
   PubMed Web of Science ®Google Scholar
• Gisslinger Kurzrock H., Wetzler R., Tucker M., Kantarjian S., Robertson H. B, Talpaz M. Apoptosis in chronic myelogenous leukemia: studies of stage-specific differences. Leuk Lymphoma 1997; 25: 121–133
   PubMed Web of Science ®Google Scholar
• Hariharan I K, Adams J M, Cory S. bcr-abl oncogenes renders myeloid cell line factor independent: potential autocrine mechanisms in chronic myeloid leukemia. Oncogene Res 1988; 3: 387–399
   PubMedGoogle Scholar
• Sirard Laneuville C. P, Dick J E. Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism. Blood 1994; 83: 1575–1585
   PubMed Web of Science ®Google Scholar
• Puil Liu L., Gish J., Mbamalu G., Bowtell G., Pelicci D., Arlinghaus G. PR, Pawson T. Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBOJ 1994; 13: 764–773
   PubMed Web of Science ®Google Scholar
• Salgia Pisick R., Saltier E., Li M., Uemura L. J, Wong N., Burky K. W, Hirai A. SH., Chen L B, Griffin J D. p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. J Biol Chem 1996; 271: 25198–25203
   PubMed Web of Science ®Google Scholar
• McGahon Bissonnette A., Schmitt R., Cotter M. KM, Green D R, Cotter T G. Regulation of the Fas apoptotic cell death pathway by Abl. Blood 1994; 83: 1179–1187
   PubMedGoogle Scholar
• Amarante-Mendes Gnaekyung Kim P., Liu C., Huang L., Perkins Y., Green L. CDR, Bhalla K. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3. Blood 1998; 91: 1700–1705
   PubMed Web of Science ®Google Scholar
• Hawley R, Lieu G. FH, Fong A Z, Hawley T S. Versatile retroviral vectors for potential use in gene therapy. Gene Ther 1994; 1: 136–138
   PubMed Web of Science ®Google Scholar
• Dubrez Eymin L., Sordet B., Drain O. N, Turhan A G, Solary E. BCR-ABL delays apoptosis upstream of procaspase-3 activation. Blood 1998; 91: 2415–2422
   PubMed Web of Science ®Google Scholar
• Pallard Gouilleux C., Charon F., Groner M., Gisselbrecht B. S, Dusanter-Fourt I. Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lyrophoid cells. J Biol Chem 1995; 270: 15942–15945
   PubMed Web of Science ®Google Scholar
• Carlesso N., Frank D A, Griffin J D. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med 1996; 183: 811–820
   PubMed Web of Science ®Google Scholar
• Shuai Halpern K., ten Hoeve J., Rao J., Sawyers C L. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 1996; 13: 247–54
   PubMed Web of Science ®Google Scholar
• Ilaria R L, Van Etten R A. J Biol Chem P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific. STAT family members. 1996; 271: 31704–31710
   Google Scholar
• Gouilleux Pallard F., Dusanter C., FourtWakao I., Haldosen H., Norstedt A. L, Levy G. D, Groner B. Prolactin, growth hormone, erythropoietin and granulocyte-macrophagecolony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J 1995; 14: 2005–2013
   PubMed Web of Science ®Google Scholar
• Sanchez-Garcia Grutz I. G. Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2. Proc Natl Acad Sci U S A 1995; 92: 5287–5291
   PubMed Web of Science ®Google Scholar
• Datta S, Dudek R., Tao H., Masters X., Fu S., Gotoh H. Y, Greenberg M E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231–241
   PubMed Web of Science ®Google Scholar
• Skorski Bellacosa T., Nieborowska A., SkorskaMajewski M., Martinez M., Choi R., Trotta K. J, Wlodarski R., Perrotti P., Chan D., Wasik O. TMA., Tsichlis P N, Calabretta B. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J 1997; 16: 6151–6161
   PubMed Web of Science ®Google Scholar
• Salomoni Wasik P., Riedel A. M, Reiss F. R, Choi K., Skorski K. JT, Calabretta B. Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. J Exp Med 1998; 87: 1995–2007
   Web of Science ®Google Scholar
• Cortez Stoica D. G, Pierce J H, Pendergast A M. The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. Oncogene 1996; 19: 2589–2594
   Google Scholar
• Reuther J, Reuther Y., Cortez W. G, Pendergast D., Baldwin M. AAS, Jr. A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. Genes Dev 1998; 12: 968–981
   PubMed Web of Science ®Google Scholar
• Rui Xu H., Mehta J., Fang S., Williams H., Dong J. F, Grimley P M. Activation of the Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid. J Biol Chem 1998; 273: 28–32
   PubMed Web of Science ®Google Scholar
• Takeda Kaisho K., Yoshida T., Takeda N., Kishimoto J. T, Akira S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol 1998; 161: 4652–4660
   PubMed Web of Science ®Google Scholar
• Schindler C. STATs as activators of apoptosis. Trends Cell Biol 1998; 8: 97–98
   PubMed Web of Science ®Google Scholar
• Frank D A, Varticovski L. BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia 1996; 10: 1724–1730
   PubMed Web of Science ®Google Scholar
• Chai S K, Nichols G L, Rothman P. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J Immunol 1997; 159: 4720–4728
   PubMed Web of Science ®Google Scholar
• Azam Lee M., Strehlow C. I, Schindler C. Functionally distinct isoforms of STAT5 are generated by protein processing. Immunity 1997; 6: 691–701
   PubMed Web of Science ®Google Scholar
• Meyer Jucker J., Ostertag M. W, Stocking C. Carboxyl-tnmcated STAT5beta is generated by a nucleus-associated serine protease in early hematopoietic progenitors. Blood 1998; 91: 1901–1908
   PubMed Web of Science ®Google Scholar
• Lokuta M, Mc A., Dowell M A, Paulnock D M. Identification of an additional isoform of STAT5 expressed in immature macrophages. J Immunol 1998; 161: 1594–1597
   PubMed Web of Science ®Google Scholar
• Nieborowska-Skorska Wasik M., Slupianek A. M, Salomoni A., Kitamura P., Calabretta T. B, Skorski T. Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J Exp Med 1999; 189: 1229–1242
   PubMed Web of Science ®Google Scholar
• Mui A, Wakao L., Kinoshita H., Kitamura T. T, Miyajima A. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J 1996; 15: 2425–2433
   PubMed Web of Science ®Google Scholar
• Zamorano Wang J., Wang Y. H, Shi R. Y, Longmore G D, Keegan A D. Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression. J Immunol 1998; 160: 3502–3512
   PubMed Web of Science ®Google Scholar
• Bauer J, Liu H., You D. KY., Lai S Y, Goldsmith M A. Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis. J Biol Chem 1998; 273: 9255–9260
   PubMed Web of Science ®Google Scholar
• Simon H, Yousefi U., Dibbert S., Levi B., Schaffer F, Blaser K. Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. Eur J Immunol 1997; 27: 3536–3539
   PubMed Web of Science ®Google Scholar
• Zushi Shinomura S., Kiyohara Y., Miyazaki T., Kondo Y., Sugimachi S., Higashimoto M., Kanayama Y. S, Matsuzawa Y. STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells. Int J Cancer 1998; 78: 326–330
   PubMed Web of Science ®Google Scholar
• Bovolenta Testolin C., Benussi L. L, Lievens P M, Liboi E. Positive selection of apoptosis-resistant cells correlates with activation of dominant-negative STAT5. I Biol Chem 1998; 273: 20779–20784
   Web of Science ®Google Scholar
• Welte Koch T., Schuler F., Lechner G., Doppler J. W, Heufler C. Granulocyte-macrophage colony-stimulating factor induces a unique set of STAT factors in murine dendritic cells. Eur J Immunol 1997; 27: 2737–2740
   PubMed Web of Science ®Google Scholar
• Pellegrini S, Dusanter-Fourt I. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs). Eur J Biochem 1997; 248: 615–633
   PubMedGoogle Scholar
• Franzoso Biswas G., Poll P., Carlson G., Brown M. L, Tomita D. K, Yamaguchi M., Fauci A S, Siebenlist U K. A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells. J Exp Med 1994; 180: 1445–1456
   PubMed Web of Science ®Google Scholar
• Biemaux Loos C., Sels M., Huez A. G, Stryckmans P. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood 1995; 86: 3118–3122
   PubMed Web of Science ®Google Scholar
• Bose Deininger S., Gora M., Tybor J., Goldman J M, Melo J V. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood 1998; 92: 3362–3367
   PubMed Web of Science ®Google Scholar