Hydroxyurea-associated Platelet Count Oscillations in Polycythemia Vera: A Report of Four New Cases and a Review

References

• Tefferi A., Solberg L. A., Silverstein M. N. A clinical update in polycythemia vera and essential thrombocythemia. American Journal of Medicine 2000; 109: 141–149
   PubMed Web of Science ®Google Scholar
• Tefferi A. Diagnosing polycythemia vera: a paradigm shift. Mayo Clinic Proceedings 1999; 74: 159–162
   PubMed Web of Science ®Google Scholar
• Fruchtman S. M., Mack K., Kaplan M. E., Peterson P., Berk P. D., Wasserman L. R. From efficacy to safety: a polycythemia vera study group report on hydroxyurea in patients with polycythemia vera. Seminars in Hematology 1997; 34: 17–23
   PubMed Web of Science ®Google Scholar
• Navarra P., Preziosi P. Hydroxyurea: new insights on an old drug. Critical Reviews in Oncology-Hematology 1999; 29: 249–255
   PubMed Web of Science ®Google Scholar
• Yarbro J. W. Mechanism of action of hydroxyurea. Seminars in Oncology 1992; 19: 1–10
   PubMed Web of Science ®Google Scholar
• Donovan P. B., Kaplan M. E., Goldberg J. D., Tatarsky I., Najean Y., Silberstein E. B., Knospe W. H., Laszlo J., Mack K., Berk P. D., et al. Treatment of polycythemia vera with hydroxyurea. American Journal of Hematology 1984; 17: 329–334
   PubMed Web of Science ®Google Scholar
• Lofvenberg E., Wahlin A. Management of polycythaemia vera, essential thrombocythaemia and myelofibrosis with hydroxyurea. European Journal of Haematology 1988; 41: 375–381
   PubMed Web of Science ®Google Scholar
• Saleh A. W., Hillen H. F., Duits A. J. Levels of endothelial, neutrophil and platelet-specific factors in sickle cell anemia patients during hydroxyurea therapy. Acta Haematologica 1999; 102: 31–37
   PubMed Web of Science ®Google Scholar
• Weinfeld A., Swolin B., Westin J. Acute leukaemia after hydroxyurea therapy in polycythaemia vera and allied disorders: prospective study of efficacy and leukaemogenicity with therapeutic implications. European Journal of Haematology 1994; 52: 134–139
   PubMed Web of Science ®Google Scholar
• Nand S., Stock W., Godwin J., Fisher S. G. Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. American Journal of Hematology 1996; 52: 42–46
   PubMed Web of Science ®Google Scholar
• Tefferi A. Is hydroxyurea leukemogenic in essential thrombocythemia?. Blood 1998; 92: 1459–1460
   PubMed Web of Science ®Google Scholar
• Nguyen T. V., Margolis D. J. Hydroxyurea and lower leg ulcers. Cutis 1993; 52: 217–219
   PubMed Web of Science ®Google Scholar
• Best P. J., Daoud M. S., Pittelkow M. R., Petitt R. M. Hydroxyurea-induced leg ulceration in 14 patients. Annals of Internal Medicine 1998; 128: 29–32
   PubMed Web of Science ®Google Scholar
• Kato N., Kimura K., Yasukawa K., Yoshida K. Hydroxyurea-related leg ulcers in a patient with chronic myelogenous leukemia: a case report and review of the literature. Journal of Dermatology 1999; 26: 56–62
   PubMedGoogle Scholar
• Tefferi A., Elliott M. A., Kao P. C., Yoon S., El-Hemaidi I., Pearson T. C. Hydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera. Blood 2000; 96: 1582–1584
   PubMed Web of Science ®Google Scholar
• Tefferi A., Yoon S. Y., Li C. Y. Immunohistochemical staining for megakaryocyte c-Mpl may complement morphologic distinction between polycythemia vera and secondary erythrocytosis. Blood 2000; 96: 771–772
   PubMed Web of Science ®Google Scholar
• Haurie C., Dale D. C., Mackey M. C. Cyclical neutropenia and other periodic hematological disorders: a review of mechanisms and mathematical models. Blood 1998; 92: 2629–2640
   PubMed Web of Science ®Google Scholar
• Von Schulthess G. K., Gessner U. Oscillating platelet counts in healthy individuals: experimental investigation and quantitative evaluation of thrombocytopoietic feedback control. Scandinavian Journal of Haematology 1986; 36: 473–479
   PubMedGoogle Scholar
• Chikkappa G., Borner G., Burlington H., Chanana A. D., Cronkite E. P., Ohl S., Pavelec M., Robertson J. S. Periodic oscillation of blood leukocytes, platelets, and reticulocytes in a patient with chronic myelocytic leukemia. Blood 1976; 47: 1023–1030
   PubMed Web of Science ®Google Scholar
• Abe Y., Hirase N., Muta K., Okada Y., Kimura T., Umemura T., Nishimura J., Nawata H. Adult onset cyclic hematopoiesis in a patient with myelodysplastic syndrome. International Journal of Hematology 2000; 71: 40–45
   PubMed Web of Science ®Google Scholar
• Morley A. Blood-cell cycles in polycythaemia vera. Australasian Annals of Medicine 1969; 18: 124–126
   PubMedGoogle Scholar
• Wright D. G., Dale D. C., Fauci A. S., Wolff S. M. Human cyclic neutropenia: clinical review and long-term follow-up of patients. Medicine (Baltimore) 1981; 60: 1–13
   PubMed Web of Science ®Google Scholar
• Lange R. D. Cyclic hematopoiesis: human cyclic neutropenia. Experimental Hematology 1983; 11: 435–451
   PubMed Web of Science ®Google Scholar
• Haurie C., Person R., Dale D. C., Mackey M. C. Hematopoietic dynamics in grey collies. Experimental Hematology 1999; 27: 1139–1148
   PubMed Web of Science ®Google Scholar
• Jones J. B., Lange R. D. Cyclic hematopoiesis: animal models. Experimental Hematology 1983; 11: 571–580
   PubMed Web of Science ®Google Scholar
• Dale D. C., Rodger E., Cebon J., Ramesh N., Hammond W. P., Zsebo K. M. Long-term treatment of canine cyclic hematopoiesis with recombinant canine stem cell factor. Blood 1995; 85: 74–79
   PubMed Web of Science ®Google Scholar
• Vodopick H., Rupp E. M., Edwards C. L., Goswitz F. A., Beauchamp J. J. Spontaneous cyclic leukocytosis and thrombocytosis in chronic granulocytic leukemia. New England Journal of Medicine 1972; 286: 284–290
   PubMed Web of Science ®Google Scholar
• Yamauchi K., Ide A. Spontaneous remission with cyclic leukocytosis in chronic myelogenous leukemia. Acta Haematologica 1992; 88: 136–138
   PubMed Web of Science ®Google Scholar
• Rodriguez A. R., Lutcher C. L. Marked cyclic leukocytosis-leukopenia in chronic myelogenous leukemia. American Journal of Medicine 1976; 60: 1041–1047
   PubMed Web of Science ®Google Scholar
• Kennedy B. J. Cyclic leukocyte oscillations in chronic myelogenous leukemia during hydroxyurea therapy. Blood 1970; 35: 751–760
   PubMed Web of Science ®Google Scholar
• Nagasawa T., Hasegawa Y., Kamoshita M., Ohtani K., Komeno T., Itoh T., Shinagawa A., Kojima H., Ninomiya H., Abe T. Megakaryopoiesis in patients with cyclic thrombocytopenia. British Journal of Haematology 1995; 91: 185–190
   PubMed Web of Science ®Google Scholar
• Zent C. S., Ratajczak J., Ratajczak M. Z., Anastasi J., Hoffman P. C., Gewirtz A. M. Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura. British Journal of Haematology 1999; 105: 452–458
   PubMed Web of Science ®Google Scholar
• Menitove J. E., Pereira J., Hoffman R., Anderson T., Fried W., Aster R. H. Cyclic thrombocytopenia of apparent autoimmune etiology. Blood 1989; 73: 1561–1569
   PubMed Web of Science ®Google Scholar
• Kuyama J., Take H., Matsumoto S., Nakajima T., Sugase T., Hata A., Hanada M., Nakagawa K. Synchronous fluctuation of interleukin-6 and platelet count in cyclic thrombocytopenia and thrombocytosis. Internal Medicine 1995; 34: 636–639
   PubMed Web of Science ®Google Scholar
• Balduini C. L., Stella C. C., Rosti V., Bertolino G., Noris P., Ascari E. Acquired cyclic thrombocytopenia-thrombocytosis with periodic defect of platelet function. British Journal of Haematology 1993; 85: 718–722
   PubMed Web of Science ®Google Scholar
• Ogawa M., Matsunaga T. Humoral regulation of hematopoietic stem cells. Annals of the New York Academy of Sciences 1999; 872: 17–23
   PubMed Web of Science ®Google Scholar
• Veiby O. P., Mikhail A. A., Snodgrass H. R. Growth factors and hematopoietic stem cells. Hematology Oncology Clinics of North America 1997; 11: 1173–1184
   PubMed Web of Science ®Google Scholar
• Erslev A. J. Erythropoietin. New England Journal of Medicine 1991; 324: 1339–1344
   PubMed Web of Science ®Google Scholar
• Hoffman R. Regulation of megakaryocytopoiesis. Blood 1989; 74: 1196–1212
   PubMed Web of Science ®Google Scholar
• Nichol J. L., Hokom M. M., Hornkohl A., Sheridan W. P., Ohashi H., Kato T., Li Y. S., Bartley T. D., Choi E., Bogenberger J., et al. Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. Journal of Clinical Investigation 1995; 95: 2973–2978
   PubMed Web of Science ®Google Scholar
• Wendling F., Maraskovsky E., Debili N., Florindo C., Teepe M., Titeux M., Methia N., Breton-Gorius J., Cosman D., Vainchenker W. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 1994; 369: 571–574
   PubMed Web of Science ®Google Scholar
• Harker L. A., Roskos L. K., Marzec U. M., Carter R. A., Cherry J. K., Sundell B., Cheung E. N., Terry D., Sheridan W. Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers. Blood 2000; 95: 2514–2522
   PubMed Web of Science ®Google Scholar
• Sungaran R., Chisholm O. T., Markovic B., Khachigian L. M., Tanaka Y., Chong B. H. The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells. Blood 2000; 95: 3094–3101
   PubMed Web of Science ®Google Scholar
• Kaushansky K. Thrombopoietin: platelets on demand?. Annals of Internal Medicine 1997; 126: 731–733
   PubMed Web of Science ®Google Scholar
• Schiffer C. A., Miller K., Larson R. A., Amrein P. C., Antin J. H., Zani V. J., Stone R. M. A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood 2000; 95: 2530–2535
   PubMed Web of Science ®Google Scholar
• Vadhan-Raj S., Verschraegen C. F., Bueso-Ramos C., Broxmeyer H. E., Kudelka A. P., Freedman R. S., Edwards C. L., Gershenson D., Jones D., Ashby M., Kavanagh J. J. Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Annals of Internal Medicine 2000; 132: 364–368
   PubMed Web of Science ®Google Scholar
• Vadhan-Raj S., Murray L. J., Bueso-Ramos C., Patel S., Reddy S. P., Hoots W. K., Johnston T., Papadopolous N. E., Hittelman W. N., Johnston D. A., Yang T. A., Paton V. E., Cohen R. L., Hellmann S. D., Benjamin R. S., Broxmeyer H. E. Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer. Annals of Internal Medicine 1997; 126: 673–681
   PubMed Web of Science ®Google Scholar
• Santillan M., Mahaffy J. M., Belair J., Mackey M. C. Regulation of platelet production: the normal response to perturbation and cyclical platelet disease. Journal of Theoretical Biology 2000; 206: 585–603
   PubMed Web of Science ®Google Scholar
• Dunn C. D. Cyclic hematopoiesis: the biomathematics. Experimental Hematology 1983; 11: 779–791
   PubMed Web of Science ®Google Scholar
• Roeder I., De Haan G., Engel C., Nijhof W., Dontje B., Loeffler M. Interactions of erythropoietin, granulocyte colony-stimulating factor, stem cell factor, and interleukin-11 on murine hematopoiesis during simultaneous administration. Blood 1998; 91: 3222–3229
   PubMed Web of Science ®Google Scholar
• Mackey M. C., Glass L. Oscillation and chaos in physiological control systems. Science 1977; 197: 287–289
   PubMed Web of Science ®Google Scholar
• Tennenbaum M., Pollard H. Ordinary Differential Equations: A Textbook for Students of Mathematics, Engineering, and the Sciences (Dover Publications. Mineola, NY 1985
   Google Scholar
• Molitemo A. R., Siebel K. E., Sun A. Y., Hankins W. D., Spivak J. L. A novel thrombopoietin signaling defect in polycythemia vera platelets. Stem Cells 1998; 16: 185–192
   Google Scholar
• Moliterno A. R., Hankins W. D., Spivak J. L. Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera. New England Journal of Medicine 1998; 338: 572–580
   PubMed Web of Science ®Google Scholar