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Original Article

A Polymorphism in the BCL-6 Gene is Associated with Follicle Center Lymphoma

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Pages 1343-1350 | Published online: 01 Jul 2009

References

  • Cattoretti G., Chang C. C., Cechova K., Zhang J., Ye B. H., Falini B., Louie D. C., Offit K., Chaganti R. S., Dalla-Favera R. BCL-6 protein is expressed in germinal-center B cells. Blood 1995; 86: 45–53
  • Chang C. C., Ye B. H., Chaganti R. S., Dalla-Favera R. BCL-6 a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc. Natl. Acad. Sci. USA 1996; 93: 6947–6952
  • Seyfert V. L., Allman D., He Y., Staudt L. M. Transcriptional repression by the proto-oncogene BCL-6. Oncogene 1996; 12: 2331–2342
  • Kerckaert J. P., Deweindt C., Tilly H., Quief S., Lecocq G., Bastard C. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nat. Genet. 1993; 5: 66–70
  • Dent A. L., Hu-Li J., Paul W. E., Staudt L. M. T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6. Proc. Natl. Acad. Sci. USA 1998; 95: 13823–13828
  • Ye B. H., Cattoretti G., Shen Q., Zhang J., Hawe N., De Waard R., Leung C., Nouri-Shirazi M., Orazi A., Chaganti R. S., Rothman P., Stall A. M., Pandolfi P. P., Dalla-Favera R. The BCL-6 proto-oncogene controls germinal centre formation and Th2-type inflammation. Nat. Genet. 1997; 16: 161–170
  • Liu Y. J., Zhang J., Lane P. J., Chan E. Y., MacLennan I. C. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 1991; 21: 2951–2962
  • Kroese F. G., Wubbena A. S., Seijen H. G., Nieuwenhuis P. Germinal centers develop oligoclonally. Eur. J. Immunol. 1987; 17: 1069–1072
  • MacLennan I.C. Germinal centers. Annu. Rev. Immunol. 1994; 12: 117–139
  • Ye B. H., Lista F., Lo Coco F., Knowles D. M., Offit K., Chaganti R. S., Dalla-Favera R. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 1993; 262: 747–750
  • Chaganti S. R., Chen W., Parsa N., Offit K., Louie D. C., Dalla-Favera R., Chaganti R. S. Involvement of BCL6 in chromosomal aberrations affecting band 3q27 in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer 1998; 23: 323–327
  • Pasqualucci L., Migliazza A., Fracchiolla N., William C., Neri A., Baldini L., Chaganti R. S., Klein U., Kuppers R., Rajewsky K., Dalia-Favera R. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. USA 1998; 95: 11816–11821
  • Migliazza A., Martinotti S., Chen W., Fusco C., Ye B. H., Knowles D. M., Offit K., Chaganti R. S., Dalla-Favera R. Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. Proc. Natl. Acad. Sci. USA 1995; 92: 12520–12524
  • Lossos I. S., Levy R. Mutation analysis of the 5′ noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity. Blood 2000; 95: 1400–1405
  • Pasqualucci L., Migliazza A., Ye B., Cattoretti G., Chaganti R., Dalla-Favera R. Transcriptional deregulation of mutated BCL-6 alleles in diffuse large cell lymphomas. Blood 1999; 94: 58a
  • Harris N. L., Jaffe E. S., Stein H., Banks P. M., Chan J. K., Cleary M. L., Delsol G., De Wolf-Peeters C., Falini B., Gatter K. C. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994; 84: 1361–1392
  • Collins F. S., Brooks L. D., Chakravarti A. A DNA polymorphism discovery resource for research on human genetic variation. Genome Res. 1999; 8: 1229–1231
  • Heid C. A., Stevens J., Livak K. J., Williams P. M. Real time quantitative PCR. Genome Res. 1996; 6: 986–994
  • Weir B. Genetic data analysis. Methods for Discrete Population Genetic Data. Sinauer Associated, Sunderland, MA 1990
  • Xie D., Shu X. O., Deng Z., Wen W. Q., Creek K. E., Dai Q., Gao Y. T., Jin F., Zheng W. Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk. J. Natl. Cancer Inst. 2000; 92: 412–417
  • Lemos M. C., Cabrita F. J., Silva H. A., Vivan M., Placido F., Regateiro F. J. Genetic polymorphism of CYP2D6, GSTMI and NAT2 and susceptibility to haemato-logical neoplasias. Carcinogenesis 1999; 20: 1225–1229
  • Skibola C. F., Smith M. T., Kane E., Roman E., Rollinson S., Cartwright R. A., Morgan G. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc. Natl. Acad. Sci. USA 1999; 96: 12810–12815
  • El-Omar E. M., Carrington M., Chow W. H., McColl K. E., Bream J. H., Young H. A., Herrera J., Lissowska J., Yua C. C., Rothman N., Lanyon G., Martin M., Fraumeni J.F., Jr., Rabkin C.S., Jr. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404: 398–402
  • Warzocha K., Ribeiro P., Bienvenu J., Roy P., Chariot C., Rigal D., Cofffier B., Salles G. Genetic polymorphisms in the tumor necrosis factor locus influence non-Hodgkin's lymphoma outcome. Blood 1998; 91: 3574–3581
  • Lo Coco F., Ye B. H., Lista F., Corradini P., Offit K., Knowles D. M., Chaganti R. S., Dalla-Favera R. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 1994; 83: 1757–1759
  • Bastard C., Deweindt C., Kerckaert J. P., Lenormand B., Rossi A., Pezzella F., Fruchart C., Duval C., Monconduit M., Tilly H. LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immuno-phenotype, karyotype, clinical outcome in 217 patients. Blood 1994; 83: 2423–2427
  • Chen W., Iida S., Louie D. C., Dalia-Favera R., Chaganti R. S. Heterologous promoters fused to BCL6 by chromosomal translocations, affecting band 3q27 cause its deregulated expression during B-cell differentiation. Blood 1998; 91: 603–607
  • Bernardin F., Collyn-d'Hooghe M., Quief S., Bastard C., Leprince D., Kerckaert J. P. Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation. Oncogene 1997; 14: 849–855
  • Nakamura Y., Saito K., Furusawa S. Analysis of internal deletions within the BCL6 gene in B-cell non-Hodgkin's lymphoma. Br. J. Haematol. 1999; 105: 274–277
  • Peng H. Z., Du M. Q., Koulis A., Aiello A., Dogan A., Pan L. X., Isaacson P. G. Nonimmunoglobulin gene hypermutation in germinal center B cells. Blood 1999; 93: 2167–2172
  • Alizadeh A. A., Eisen M. B., Davis R. E., Ma C., Lossos I. S., Rosenwald A., Boldrick J. C., Sabet H., Tran T., Yu X., Powell J. I., Yang L., Marti G. E., Moore T., Hudson J, Jr., Lu L, Jr., Lewis D.B., Jr., Tibshirani R, Jr., Sherlock C, Jr., Chan W.C., Jr., Greiner T.C., Jr., Weisenburger D.D., Jr., Armitage J.O., Jr., Warnke R, Jr., Staudt L.M., Jr., et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503–511
  • Skinnider B. F., Horsman D. E., Dupuis B., Gascoyne R. D. Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: correlation with 3q27 and 18q21 chromosomal abnormalities. Hum. Pathol. 1999; 30: 803–808

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