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Letters to The Editor

Knockdown of LYL1 impaired proliferation of CD34(+) myeloid leukemia cells

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Pages 1896-1899 | Received 12 Jul 2009, Accepted 30 Jul 2009, Published online: 03 Nov 2009

References

  • Giroux S, Kaushik AL, Capron C, et al lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny. Gene Expr Patterns 2007. 7:215–226.
  • Capron C, Lecluse Y, Kaushik AL, et al The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation. Blood 2006;107:4678–4786.
  • Chan WY, Follows GA, Lacaud G, et al The paralogous haemopoietic regulators Lyl1 and SCL are co-regulated by Ets and GATA factors yet Lyl1 cannot rescue the early SCL−/− phenotype. Blood 2007;109:1908–1916.
  • Souroullas GP, Salmon JM, Sablitzky F, et al Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell 2009;4:180–186.
  • Mellentin JD, Smith SD, Cleary ML. lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell 1989;58:77–83.
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  • Meng Y, Liu W, Ma X, et al Decreased proliferation of myeloid leukemia cells through down-regulating LYL1 expression with small interference RNA. Blood 2007;110:4158a.

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