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Commentary

MHC class II as a therapeutic target in B-cell lymphomas: the CIITA road to paradise?

Pages 1740-1741 | Published online: 28 Oct 2009

References

  • Rimsza LM, Roberts RA, Miller TP, et al Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Molecular Profiling Project. Blood 2004;103:4251–4258.
  • Roberts RA, Wright G, Rosenwald AR, et al Loss of major histocompatibility class II gene and protein expression in primary mediastinal large B-cell lymphoma is highly coordinated and related to poor patient survival. Blood 2006;108:311–318.
  • Diepstra A, van Imhoff GW, Karim-Kos HE, et al HLA class II expression by Hodgkin Reed–Sternberg cells is an independent prognostic factor in classical Hodgkin's lymphoma. J Clin Oncol 2007;25:3101–3108.
  • Wilkinson ST, Fernandez DR, Murphy SP, et al Decreased major histocompatibility complex class II expression in diffuse large B-cell lymphoma does not correlate with CpG methylation of class II transactivator promoters III and IV. Leuk Lymphoma 2009;50:1875–1878.
  • Cycon KA, Rimsza LM, Murphy SP. Alterations in CIITA constitute a common mechanism accounting for downregulation of MHC class II expression in diffuse large B-cell lymphoma (DLBCL). Exp Hematol 2009;37:184–194.
  • Rimsza LM, Roberts RA, Campo E, et al Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletions. Blood 2006;107:1101–1107.
  • Rimsza LM, Chan WC, Gascoyne RD, et al CIITA or RFX coding region loss of function mutations occur rarely in diffuse large B-cell lymphoma cases and cell lines with low levels of major histocompatibility complex class II expression. Haematologica 2009;94:596–598.
  • Jordanova ES, Riemersma SA, Philippo K, Giphart-Gassler M, Schuuring E, Kluin PM. Hemizygous deletions in the HLA region account for loss of heterozygosity in the majority of diffuse large B-cell lymphomas of the testis and the central nervous system. Genes Chromosomes Cancer 2002;35:38–48.

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