Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma

References

• The Non-Hodgkin's Lymphoma Classification Project. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. Blood 1997;89:3909–3916.
   PubMed Web of Science ®Google Scholar
• Muris JJ, Cillessen SA, Vos W, et al Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood 2005;105:2916–2923.
   PubMed Web of Science ®Google Scholar
• Hartge P, Wang SS. Overview of the etiology and epidemiology of lymphoma. In: Mauch PM, Armitage JO, Coiffier B, Dalla-Favera R, Harris NL, editors. Non-Hodgkin's lymphomas. New York: Lippincott, Williams & Wilkins; 2004. pp 711–727.
   Google Scholar
• Zabeau L, Lavens D, Peelman F, Eyckerman S, Vandekerckhove J, Tavernier J. The ins and outs of leptin receptor activation. FEBS Lett 2003;546:45–50.
   PubMed Web of Science ®Google Scholar
• Hegyi K, Fulop K, Kovacs K, Toth S, Falus A. Leptin-induced signal transduction pathways. Cell Biol Int 2004;28:159–169.
   PubMed Web of Science ®Google Scholar
• Uotani S, Bjørbaek C, Tornøe J, Flier JS. Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 1999;48:279–286.
   PubMed Web of Science ®Google Scholar
• Fox SB, Gasparini G, Harris AL. Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs. Lancet Oncol 2001;2:278–289.
   PubMed Web of Science ®Google Scholar
• Uddin S, Hussain AR, Siraj AK, et al Role of phosphatidylinositol 3′-kinase/AKT pathway in diffuse large B-cell lymphoma survival. Blood 2006;108:4178–4186.
   PubMed Web of Science ®Google Scholar
• Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 2004;10:4325–4331.
   PubMed Web of Science ®Google Scholar
• Garofalo C, Koda M, Cascio S, et al Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 2006;12:1447–1453.
   PubMed Web of Science ®Google Scholar
• Hardwick JCH, van Den Brink GR, Offerhaus GJ, van Deventer SJH, Peppelenbosch MP. Leptin is a growth factor for colonic epithelial cells. Gastroenterology 2001;121:79–90.
   PubMed Web of Science ®Google Scholar
• Schneider R, Bornstein SR, Chrousos GP, Boxberger S, Ehninger G, Breidert M. Leptin mediates a proliferative response in human gastric mucosa cells with functional receptor. Horm Metab Res 2001;33:1–6.
   PubMed Web of Science ®Google Scholar
• Sierra-Honigmann MR, Nath AK, Murakami C, et al Biological action of leptin as an angiogenic factor. Science 1998;281:1683–1686.
   PubMed Web of Science ®Google Scholar
• Konopleva M, Mikhail A, Estrov Z, et al Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 1999;93:1668–1676.
   PubMed Web of Science ®Google Scholar
• Nakao T, Hino M, Yamane T, Nishizawa Y, Morii H, Tatsumi N. Expression of the leptin receptor in human leukaemic blast cells. Br J Haematol 1998;102:740–745.
   PubMed Web of Science ®Google Scholar
• Wex H, Ponelis E, Wex T, Dressendörfer R, Mittler U, Vorwerk P. Plasma leptin and leptin receptor expression in childhood acute lymphoblastic leukemia. Int J Hematol 2002;76:446–452.
   PubMed Web of Science ®Google Scholar
• Reseland JE, Reppe S, Olstad OK, et al Abnormal adipokine levels and leptin-induced changes in gene expression profiles in multiple myeloma. J Haematol 2009;83:460–470.
   PubMed Web of Science ®Google Scholar
• Mouzaki A, Panagoulias I, Dervilli Z, et al Expression patterns of leptin receptor (OB-R) isoforms and direct in vitro effects of recombinant leptin on OB-R, leptin expression and cytokine secretion by human hematopoietic malignant cells. Cytokine 2009;48:203–211.
   PubMed Web of Science ®Google Scholar
• Pamuk GE, Demir M, Harmandar F, Yesil Y, Turgut B, Vural O. Leptin and resistin levels in serum of patients with hematologic malignancies: correlation with clinical characteristics. Exp Oncol 2006;28:241–244.
   PubMedGoogle Scholar
• Koda M, Sulkowska M, Kanczuga-Koda L, Surmacz E, Sulkowski S. Overexpression of the obesity hormone leptin in human colorectal cancer. J Clin Pathol 2007;60:902–906.
   PubMed Web of Science ®Google Scholar
• Uddin S, Bavi PP, Hussain AR, et al Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication. Carcinogenesis 2009;30:1832–1840.
   PubMed Web of Science ®Google Scholar
• Hong SJ, Kwon KW, Kim SG, et al Variation in expression of gastric leptin according to differentiation and growth pattern in gastric adenocarcinoma. Cytokine 2006;33:66–71.
   PubMed Web of Science ®Google Scholar
• Uddin S, Bu R, Ahmed M, et al Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer. Mol Cancer 2009;8:74.
   PubMed Web of Science ®Google Scholar
• Uddin S, Bavi P, Siraj A, et al Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma. Endocr Relat Cancer 2010;17:191–202.
   PubMed Web of Science ®Google Scholar
• Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 2004;10:4325–4331.
   PubMed Web of Science ®Google Scholar
• Hussain AR, Al-Jomah NA, Siraj AK, et al Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells. Cancer Res 2007;67:3888–3897.
   PubMed Web of Science ®Google Scholar
• Hussain AR, Ahmed M, Al-Jomah NA, et al Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Mol Cancer Ther 2008;7:3318–3329.
   PubMed Web of Science ®Google Scholar
• Uddin S, Hussain AR, Ahmed M, et al High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target. Am J Gastroenterol 2009;104:1790–1801.
   PubMed Web of Science ®Google Scholar
• Uddin S, Ahmed M, Bavi P, et al Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer. Cancer Res 2008;68:3379–3388.
   PubMed Web of Science ®Google Scholar
• Garofalo C, Surmacz E. Leptin and cancer. J Cell Physiol 2006;207:12–22.
   PubMed Web of Science ®Google Scholar
• Hoda MR, Keely SJ, Bertelsen LS, Junger WG, Dharmasena D, Barrett KE. Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells. Br J Surg 2007;94:346–354.
   PubMed Web of Science ®Google Scholar
• Ogunwobi OO, Beales IL. The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. Int J Colorectal Dis 2007;22:401–409.
   PubMed Web of Science ®Google Scholar
• Saxena NK, Sharma D, Ding X, et al Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res 2007;67:2497–2507.
   PubMed Web of Science ®Google Scholar
• Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 2001;21:952–965.
   PubMed Web of Science ®Google Scholar
• Datta SR, Dudek H, Tao X, et al Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231–241.
   PubMed Web of Science ®Google Scholar