Clinical significance of productive immunoglobulin heavy chain gene rearrangements in childhood acute lymphoblastic leukemia

References

• Alt FW, Yancopoulos GD, Blackwell TK, et al. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J 1984;3:1209–1219.
   PubMed Web of Science ®Google Scholar
• Matsuda F, Ishii K, Bourvagnet P, et al. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med 1998;188:2151–2162.
   PubMed Web of Science ®Google Scholar
• Mortuza FY, Moreira IM, Papaioannou M, et al. Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of J(H)-proximal variable gene segments. Blood 2001;97:2716–2726.
   PubMed Web of Science ®Google Scholar
• Corbett SJ, Tomlinson IM, Sonnhammer EL, Buck D, Winter G. Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, ‘minor’ D segments or D-D recombination. J Mol Biol 1997;270:587–597.
   PubMed Web of Science ®Google Scholar
• Mattila PS, Schugk J, Wu H, Mäkelä O. Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus. Eur J Immunol 1995;25:2578–2582.
   PubMed Web of Science ®Google Scholar
• Kiyoi H, Naoe T, Horibe K, Ohno R. Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells. J Clin Invest 1992;89:739–746.
   PubMed Web of Science ®Google Scholar
• Wasserman R, Ito Y, Galili N, et al. The pattern of joining (JH) gene usage in the human IGH@ chain is established predominantly at the B precursor cell stage. J Immunol 1992;149:511–516.
   PubMed Web of Science ®Google Scholar
• Raaphorst FM, Raman CS, Tami J, Fischbach M, Sanz I. Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences. Int Immunol 1997;9:1503–1515.
   PubMed Web of Science ®Google Scholar
• Rao SP, Riggs JM, Friedman DF, Scully MS, LeBien TW, Silberstein LE. Biased VH gene usage in early lineage human B cells: evidence for preferential Ig gene rearrangement in the absence of selection. J Immunol 1999;163:2732–2740.
   PubMed Web of Science ®Google Scholar
• Kraj P, Rao SP, Glas AM, Hardy RR, Milner EC, Silberstein LE. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J Immunol 1997;158:5824–5832.
   PubMed Web of Science ®Google Scholar
• Marshall AJ, Paige CJ, Wu GE. V(H) repertoire maturation during B cell development in vitro: differential selection of Ig heavy chains by fetal and adult B cell progenitors. J Immunol 1997;158:4282–4291.
   PubMed Web of Science ®Google Scholar
• Bennett JM, Catovsky D, Daniel MT, et al. The morphological classification of acute lymphoblastic leukemia: concordance among observers and clinical correlations. Br J Haematol 1981;47:553–561.
   PubMed Web of Science ®Google Scholar
• Tzortzatou-Stathopoulou F, Moschovi MA, Papadopoulou AL, et al. Could intensified treatment in childhood acute lymphoblastic leukemia improve outcome independently of risk factors? Eur J Haematol 2005;75:361–369.
   PubMed Web of Science ®Google Scholar
• Pieters R, Schrappe M, De Lorenzo P, et al. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet 2007;370:240–250.
   PubMed Web of Science ®Google Scholar
• Pongers-Willemse MJ, Seriu T, Stolz F, et al. Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: report of the BIOMED-1 CONCERTED ACTION: investigation of minimal residual disease in acute leukemia. Leukemia 1999;13:110–118.
   PubMed Web of Science ®Google Scholar
• Katsibardi K, Moschovi MA, Braoudaki M, Papadhimitriou SI, Papathanasiou C, Tzortzatou-Stathopoulou F. Sequential monitoring of minimal residual disease in acute lymphoblastic leukemia: 7-year experience in a Pediatric Hematology-Oncology unit. Leuk Lymphoma 2010;51:846–852.
   PubMed Web of Science ®Google Scholar
• Lefranc MP, Giudicelli V, Ginestoux C, et al. IMGT, the international ImMunoGeneTics database. Nucleic Acids Res 1999;27:209–212.
   PubMed Web of Science ®Google Scholar
• Giudicelli V, Duroux P, Ginestoux C, et al. IMGT/LIGM-DB, the IMGT comprehensive database of immunoglobulin and T cell receptor nucleotide sequences. Nucleic Acids Res 2006;34(Database issue): D781–D784.
   Google Scholar
• Souto-Carneiro MM, Longo NS, Russ DE, Sun HW, Lipsky PE. Characterization of the human Ig heavy chain antigen binding complementarity determining region 3 using a newly developed software algorithm, JOINSOLVER. J Immunol 2004;172:6790–6792.
   PubMed Web of Science ®Google Scholar
• Lefranc MP. Nomenclature of the human immunoglobulin heavy (IGH@) genes. Exp Clin Immunogenet 2001;18:100–116.
   PubMedGoogle Scholar
• Riffenburgh R. Statistics in medicine. 2nd ed. Burlington, MA: Elsevier Academic Press; 2006.
   Google Scholar
• Li A, Rue M, Zhou J, et al.; Dana-Farber Cancer Institute ALL Consortium. Utilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: implications for the mechanisms of VDJ recombination and for pathogenesis. Blood 2004;103:4602–4609.
   PubMed Web of Science ®Google Scholar
• Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J Exp Med 1990;171:843–859.
   PubMed Web of Science ®Google Scholar
• Van Es JH, Raaphorst FM, van Tol MJ, Meyling FH, Logtenberg T. Expression pattern of the most JH-proximal human VH gene segment (VH6) in the B cell and antibody repertoire suggests a role of VH6-encoded IgM antibodies in early ontogeny. J Immunol 1993;150:161–168.
   PubMed Web of Science ®Google Scholar
• Yu CC, Larijani M, Miljanic IN, Wu GE. Differential usage of VH gene segments is mediated by cis elements. J Immunol 1998;161:3444–3454.
   PubMed Web of Science ®Google Scholar
• Pascual V, Verkruyse L, Casey ML, Capra JD. Analysis of Ig H chain gene segment utilization in human fetal liver. Revisiting the ‘proximal utilization hypothesis’. J Immunol 1993;151:4164–4172.
   PubMed Web of Science ®Google Scholar
• Cole-Sinclair M, Foroni L, Wright F, Mehta A, Prentice HG, Hoffbrand AV. Minimal residual disease in acute lymphoblastic leukemia--PCR analysis of immunoglobulin gene rearrangements. Leuk Lymphoma 1993;11:49–58.
   PubMed Web of Science ®Google Scholar
• Steenbergen EJ, Verhagen OJ, van Leeuwen EF, et al. B precursor acute lymphoblastic leukemia third complementarity-determining regions predominantly represent an unbiased recombination repertoire: leukemic transformation frequently occurs in fetal life. Eur J Immunol 1994;24:900–908.
   PubMed Web of Science ®Google Scholar
• Souto-Carneiro MM, Sims GP, Girschik H, Lee J, Lipsky PE. Developmental changes in the human heavy chain CDR3. J Immunol 2005;175:7425–7436.
   PubMed Web of Science ®Google Scholar
• Tuaillon N, Capra JD. Evidence that terminal deoxynucleotidyltransferase expression plays a role in Ig heavy chain gene segment utilization. J Immunol 2000;164:6387–6397.
   PubMed Web of Science ®Google Scholar
• Lo Nigro L, Cazzaniga G, Di Cataldo A, et al. Clonal stability in children with acute lymphoblastic leukemia (ALL) who relapsed five or more years after diagnosis. Leukemia 1999;13:190–195.
   PubMed Web of Science ®Google Scholar
• Li A, Zhou J, Zuckerman D, et al. Sequence analysis of clonal immunoglobulin and T-cell receptor gene rearrangements in children with acute lymphoblastic leukemia at diagnosis and at relapse: implications for pathogenesis and for the clinical utility of PCR-based methods of minimal residual disease detection. Blood 2003;102:4520–4526.
   PubMed Web of Science ®Google Scholar
• Foroni L, Hoffbrand AV. Molecular analysis of minimal residual disease in adult acute lymphoblastic leukaemia. Best Pract Res Clin Haematol 2002;15:71–90.
   PubMed Web of Science ®Google Scholar
• Meleshko AN, Lipay NV, Stasevich IV, Potapnev MP. Rearrangements of IGH@, TCRD and TCRG genes as clonality marker of childhood acute lymphoblastic leukemia. Exp Oncol 2005;27:319–324.
   PubMed Web of Science ®Google Scholar
• Szczepański T, Willemse MJ, van Wering ER, van Weerden JF, Kamps WA, van Dongen JJ. Precursor-B-ALL with D(H)-J(H) gene rearrangements have an immature immunogenotype with a highfrequency of oligoclonality and hyperdiploidy of chromosome 14. Leukemia 2001;15:1415–1423.
   PubMed Web of Science ®Google Scholar
• Moreira I, Papaioannou M, Mortuza FY, et al. Heterogeneity of VH-JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL. Leukemia 2001;15:1527–1536.
   PubMed Web of Science ®Google Scholar
• Csinady E, van der Velden VH, Joas R, et al. Chromosome 14 copy number-dependent IGH gene rearrangement patterns in high hyperdiploid childhood B-cell precursor ALL: implications for leukemia biology and minimal residual disease analysis. Leukemia 2009;23:870–876.
   PubMed Web of Science ®Google Scholar