Advanced search
Publication Cover
Leukemia & Lymphoma Volume 52, 2011 - Issue 10
Submit an article Journal homepage
277
Views
12
CrossRef citations to date
0
Altmetric
Original Article: Clinical

Importance of immunoglobulin heavy chain variable region mutational status in del(13q) chronic lymphocytic leukemia

Douglas E. GladstoneThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USACorrespondence[email protected]
,
Lode SwinnenThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
,
Yvette KasamonThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
,
Amanda BlackfordThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
,
Christopher D. GockeThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
,
Constance A. GriffinThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
,
Javier Bolanos MeadeThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
&
Richard J. JonesThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
 show all
Pages 1873-1881 | Received 04 Feb 2011, Accepted 01 May 2011, Published online: 18 Aug 2011

References

  • Dighiero G. Unsolved issues in CLL biology and management. Leukemia 2003;17:2385–2391.
  • Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS. Clinical staging of chronic lymphocytic leukemia. Blood 1975;46:219–234.
  • Montserrat E, Sanchez-Bisono J, Vinolas N, Rozman C. Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance. Br J Haematol 1986;62:567–575.
  • Codony C, Crespo M, Abrisqueta P, Montserrat E, Bosch F. Gene expression profiling in chronic lymphocytic leukaemia. Best Pract Res Clin Haematol 2009;22:211–222.
  • Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000;343:1910–1916.
  • Dewald GW, Brockman SR, Paternoster SF, et al. Chromosome anomalies detected by interphase fluorescence in situ hybridization: correlation with significant biological features of B-cell chronic lymphocytic leukaemia. Br J Haematol 2003;121:287–295.
  • Shanafelt TD, Witzig TE, Fink SR, et al. Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia. J Clin Oncol 2006;24:4634–4641.
  • Shanafelt TD, Jenkins G, Call TG, et al. Validation of a new prognostic index for patients with chronic lymphocytic leukemia. Cancer 2009;115:363–372.
  • Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003;348:1764–1775.
  • Marjanovic G, Stanojevic I, Jankovic-Velickovic L, Hubl W, Marjanovic V. Detection of ZAP-70 in patients with chronic lymphocytic leukemia. J BUON 2008;13:543–546.
  • Erikci AA, Karagoz B, Ozyurt M, Ozturk A, Kilic S, Bilgi O. HLA-G expression in B chronic lymphocytic leukemia: a new prognostic marker? Hematology 2009;14:101–105.
  • Gattei V, Bulian P, DelPrincipe MI, et al. Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia. Blood 2008;111:865–873.
  • Carlucci F, Marinello E, Tommassini V, Pisano B, Rosi F, Tabucchi A. A 57-gene expression signature in B-cell chronic lymphocytic leukemia. Biomed Pharmacother 2009;63:663–671.
  • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999;94:1848–1854.
  • Hamblin TJ, Orchard JA, Ibbotson RE, et al. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 2002;99:1023–1029.
  • Nelson BP, Gupta R, Dewald GW, Paternoster SF, Rosen ST, Peterson LC. Chronic lymphocytic leukemia FISH panel: impact on diagnosis. Am J Clin Pathol 2007;128:323–332.
  • Krober A, Seiler T, Benner A, et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002;100:1410–1416.
  • Van Dyke DL, Shanafelt TD, Call TG, et al. A comprehensive evaluation of the prognostic significance of 13q deletions in patients with B-chronic lymphocytic leukaemia. Br J Haematol 2010;148:544–550.
  • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999;94:1840–1847.
  • Kharfan-Dabaja MA, Chavez JC, Khorfan KA, Pinilla-Ibarz J. Clinical and therapeutic implications of the mutational status of IgVH in patients with chronic lymphocytic leukemia. Cancer 2008;113:897–906.
  • Trojani A, Montillo M, Nichelatti M, et al. ZAP-70, IgVh, and cytogenetics for assessing prognosis in chronic lymphocytic leukemia. Cancer Biomark 2010;6:1–9.
  • Hamblin TJ, Davis ZA, Oscier DG. Determination of how many immunoglobulin variable region heavy chain mutations are allowable in unmutated chronic lymphocytic leukaemia - long-term follow up of patients with different percentages of mutations. Br J Haematol 2008;140:320–323.
  • Lin K, Sherrington PD, Dennis M, Matrai Z, Cawley JC, Pettitt AR. Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia. Blood 2002;100:1404–1409.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.