566
Views
67
CrossRef citations to date
0
Altmetric
Original Articles: Clinical

Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia

, , , , , , , , , & show all
Pages 211-217 | Received 14 Jun 2011, Accepted 21 Jun 2011, Published online: 19 Sep 2011

References

  • Jemal A, Siegel R, Xu J, . Cancer statistics, 2010. CA Cancer J Clin 2010;60:277–300.
  • Zent CS, Kay NE. Management of chronic lymphocytic leukemia patients with a high risk of adverse outcome: the Mayo Clinic approach. Leuk Lymphoma 2011;52:1425–1434.
  • Sorror ML, Storer BE, Sandmaier BM, . Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol 2008;26:4912–4920.
  • Dreger P, Dohner H, Ritgen M, . Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood 2010;116:2438–2447.
  • Spaner DE, Masellis A. Toll-like receptor agonists in the treatment of chronic lymphocytic leukemia. Leukemia 2007;21:53–60.
  • Zent CS. Cell-mediated immunity in chronic lymphocytic leukemia. Leuk Lymphoma 2010;51:1775–1776.
  • Krieg AM. Development of TLR9 agonists for cancer therapy. J Clin Invest 2007;117:1184–1194.
  • Jahrsdorfer B, Muhlenhoff L, Blackwell SE, . B-cell lymphomas differ in their responsiveness to CpG oligodeoxynucleotides. Clin Cancer Res 2005;11:1490–1499.
  • Decker T, Schneller F, Sparwasser T, . Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 2000;95:999–1006.
  • Kim YH, Girardi M, Duvic M, . Phase I trial of a Toll-like receptor 9 agonist, PF-3512676 (CPG 7909), in patients with treatment-refractory, cutaneous T-cell lymphoma. J Am Acad Dermatol 2010;63: 975–983.
  • Jahrsdorfer B, Wooldridge JE, Blackwell SE, . Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells. J Leukoc Biol 2005;77:378–387.
  • Liang X, Moseman EA, Farrar MA, . Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood 2010;115:5041–5052.
  • Krieg AM, Efler SM, Wittpoth M, . Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist. J Immunother 2004;27: 460–471.
  • Yamada K, Nakao M, Fukuyama C, . Phase I study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer. Cancer Sci 2010;101:188–195.
  • Manegold C, Gravenor D, Woytowitz D, . Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26: 3979–3986.
  • Link BK, Ballas ZK, Weisdorf D, . Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma. J Immunother 2006;29:558–568.
  • Leonard JP, Link BK, Emmanouilides C, . Phase I trial of toll-like receptor 9 agonist PF-3512676 with and following rituximab in patients with recurrent indolent and aggressive non Hodgkin's lymphoma. Clin Cancer Res 2007;13:6168–6174.
  • Cheson BD, Bennett JM, Grever M, . National Cancer Institute-Sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996;87:4990–4997.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.