636
Views
58
CrossRef citations to date
0
Altmetric
Research Article

Up-regulated autophagy by endogenous high mobility group box-1 promotes chemoresistance in leukemia cells

, , , , , , , , , & show all
Pages 315-322 | Received 19 Apr 2011, Accepted 18 Aug 2011, Published online: 15 Nov 2011

References

  • Livesey KM, Tang D, Zeh HJ, . Autophagy inhibition in combination cancer treatment. Curr Opin Investig Drugs 2009;10: 1269–1279.
  • White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009;15:5308–5316.
  • Goodwin GH, Johns EW. Isolation and characterization of two calf-thymus chromatin non-histone proteins with high contents of acidic and basic amino acids. Eur J Biochem 1973;40:215–219.
  • Lotze MT, Tracey KJ. High mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005;5: 331–342.
  • Muller S, Scaffidi P, Degryse B, . The double life of HMGB1 chromatin protein: architectural factor and extracellular signal. EMBO J 2001;20:4337–4340.
  • Einck L, Bustin M. The intracellular distribution and function of the high mobility group chromosomal protein. Exp Cell Res 1985;156: 295–310.
  • Thomas JO, Travers AA. HMG1 and 2, and related “architectural” DNA-binding protein. Trends Biochem Sci 2001;26:167–174.
  • Bustin M. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal protein. Mol Cell Biol 1999;19:5237–5246.
  • Tang D, Kang R, Cheh CW, . HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene 2010;29: 5299–5310.
  • Thorburn A. Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis 2008;13:1–9.
  • Xie M, Kang R, Yu Y, . Enhancive effect of HMGB1 gene silence on adriamycin- induced apoptosis in K562/A02 drug resistance leukemia cells. Zhonghua Xue Ye Xue Za Zhi 2008;29:549–552.
  • Yu Y, Xie M, He YL, . Role of high mobility group box 1 in adriamycin-induced apoptosis in leukemia K562 cells. Ai Zheng 2008; 27:929–933.
  • Liu L, Yang M, Kang R, . HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells. Leukemia 2011; 25:23–31.
  • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55–63.
  • Tang D, Kang R, Xiao W, . The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J Immunol 2007;179:1236–1244.
  • Kang R, Tang D, Yu Y, . WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells. Leukemia 2010;24:177–186.
  • Maclean KH, Dorsey FC, Cleveland JL, . Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 2008;118:79–88.
  • Bellodi C, Lidonnici MR, Hamilton A, . Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009;119:1109–1123.
  • Carew JS, Nawrocki ST, Kahue CN, . Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 2007; 110:313–322.
  • Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010;140:313–326.
  • Tang D, Kang R, Livesey KM, . Endogenous HMGB1 regulates autophagy. J Cell Biol 2010;190:881–892.
  • Kihara A, Kabeya Y, Ohsumi Y, . Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2001;2:330–335.
  • Donohue TM Jr. Autophagy and ethanol-induced liver injury. World J Gastroenterol 2009;15:1178–1185.
  • Pankiv S, Clausen TH, Lamark T, . p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007;282:24131–24145.
  • Mathew R, Karp CM, Bcaudoin B, . Autophagy suppresses tumorigenesis through climination of p62. Cell 2009;137:1062–1075.
  • Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007;3:542–545.
  • Blommaart EF, Krause U, Schellens JP, . The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 1997;243:240–246.
  • Petiot A, Ogier-Denis E, Blommaart EF, . Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000;275: 992–998.
  • Botti J, Djavaheri-Mergny M, Pilatte Y, . Autophagy signaling and the cogwheels of cancer. Autophagy 2006;2:67–73.
  • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471–484.
  • Maiuri MC, Tasdemir E, Criollo A, . Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ 2009;16: 87–93.
  • Cui Q, Tashiro S, Onodera S, . Augmentation of oridonin-induced apotosis observed with reduced autophagy. J Pharmacol Sci 2009;101:230–239.
  • Klionsky DJ, Meijer AJ, Codogno P. Autophagy and p70S6 kinase. Autophagy 2005;1:59–60.
  • Arico S, Petiot A, Bauvy C, . The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2001;276:35243–35246.
  • Degenhardt K, Mathew R, Beaudoin B, . Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006;10:51–64.
  • Bhaskar PT, Hay N. The two TORCs and Akt. Dev Cell 2007;12: 487–502.
  • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004;18:1926–1945.
  • Sarbassov DD, Guertin DA, Ali SM, . Phosphorylation and regulation of Akt/PKB by the Rictor–mTOR complex. Science 2005;307:1098–1101.
  • Hara K, Maruki Y, Long X, . Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002;110:177–189.
  • Klionsky DJ, Abeliovich H, Agostinis P, . Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008;4:151–175.
  • Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000;290:1717–1721.
  • Levin B. Cell biology: autophagy and cancer. Nature 2007;446: 745–747.
  • Ross DD. Novel mechanisms of drug resistance in leukemia. Leukemia 2000;14:467–473.
  • Gozuacik D, Kimchi A. Autophagy and cell death. Curr Top Dev Biol 2007;78:217–245.
  • Kang R, Livesey KM, Zeh HJ, . HMGB1: a novel Beclin 1-binding protein active in autophagy. Autophagy 2010;6:1209–1211.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.