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Letters

Rapid detection of FLT3 exon 20 tyrosine kinase domain mutations in patients with acute myeloid leukemia by high-resolution melting analysis

, , , , , , , & show all
Pages 1225-1229 | Received 19 Sep 2011, Accepted 25 Nov 2011, Published online: 13 Jan 2012

References

  • Nakao M, Yokota S, Iwai T, . Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 1996;10: 1911–1918.
  • Rombouts WJ, Blokland I, Lowenberg B, . Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene. Leukemia 2000;14: 675–683.
  • Thiede C, Steudel C, Mohr B, . Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002;99:4326–4335.
  • Yamamoto Y, Kiyoi H, Nakano Y, . Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood 2001;97:2434–2439.
  • Bacher U, Haferlach C, Kern W, . Prognostic relevance of FLT3-TKD mutations in AML: the combination matters—an analysis of 3082 patients. Blood 2008;111:2527–2537.
  • Chen W, Jones D, Medeiros LJ, . Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type. Br J Haematol 2005;130:726–728.
  • Clark JJ, Cools J, Curley DP, . Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. Blood 2004;104:2867–2872.
  • Mead AJ, Gale RE, Hills RK, . Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease. Blood 2008;112:444–445; author reply 445.
  • Pratz K, Levis M. Incorporating FLT3 inhibitors into acute myeloid leukemia treatment regimens. Leuk Lymphoma 2008;49:852–863.
  • Bianchini M, Ottaviani E, Grafone T, . Rapid detection of Flt3 mutations in acute myeloid leukemia patients by denaturing HPLC. Clin Chem 2003;49:1642–1650.
  • Murphy KM, Levis M, Hafez MJ, . Detection of FLT3 internal tandem duplication and D835 mutations by a multiplex polymerase chain reaction and capillary electrophoresis assay. J Mol Diagn 2003;5:96–102.
  • Gari M, Abuzenadah A, Chaudhary A, . Detection of FLT3 oncogene mutations in acute myeloid leukemia using conformation sensitive gel electrophoresis. Int J Mol Sci 2008;9:2194–2204.
  • Krypuy M, Ahmed AA, Etemadmoghadam D, . High resolution melting for mutation scanning of TP53 exons 5–8. BMC Cancer 2007;7:168.
  • Do H, Dobrovic A. Limited copy number-high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies. Mol Cancer 2009;8:82.
  • Tan AY, Westerman DA, Carney DA, . Detection of NPM1 exon 12 mutations and FLT3-internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia. J Hematol Oncol 2008;1:10.
  • Spiekermann K, Bagrintseva K, Schoch C, . A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia. Blood 2002;100:3423–3425.

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