References
- Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646–674.
- Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57–70.
- Liu X, Dai S, Zhu Y, . The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity 2003;19:341–352.
- Kelekar A, Thompson CB. Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol 1998;8:324–330.
- Bouillet P, Strasser A. BH3-only proteins—evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J Cell Sci 2002;115:1567–1574.
- Boyd JM, Gallo GJ, Elangovan B, . Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene 1995;11:1921–1928.
- Lomonosova E, Chinnadurai G. BH3-only proteins in apoptosis and beyond: an overview. Oncogene 2008;27(Suppl. 1):S2–S19.
- Germain M, Mathai JP, McBride HM, . Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. EMBO J 2005;24:1546–1556.
- Chinnadurai G, Vijayalingam S, Rashmi R. BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes. Oncogene 2008;27(Suppl. 1):S20–S29.
- Hur J, Chesnes J, Coser KR, . The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis. Proc Natl Acad Sci USA 2004;101:2351–2356.
- Reis PP, Rogatto SR, Kowalski LP, . Quantitative real-time PCR identifies a critical region of deletion on 22q13 related to prognosis in oral cancer. Oncogene 2002;21:6480–6487.
- Castells A, Ino Y, Louis DN, . Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer. Gastroenterology 1999;117:831–837.
- Kim TY, Zhong S, Fields CR, . Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res 2006;66:7490–7501.
- Dai Z, Liu S, Marcucci G, . 5-Aza-2′-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer). Biochem Biophys Res Commun 2006;351:455–461.
- Pompeia C, Hodge DR, Plass C, . Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line. Cancer Res 2004;64:3465–3473.
- Fennell DA, Chacko A, Mutti L. BCL-2 family regulation by the 20S proteasome inhibitor bortezomib. Oncogene 2008;27:1189–1197.
- Zhu H, Zhang L, Dong F, . Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors. Oncogene 2005;24:4993–4999.
- Richardson P, Mitsiades C, Schlossman R, . The treatment of relapsed and refractory multiple myeloma. Hematology Am Soc Hematol Educ Program 2007:317–323.
- Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000;132:365–386.
- Altschul SF, Madden TL, Schaffer AA, . Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997;25:3389–3402.
- Sturm I, Stephan C, Gillissen B, . Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma. Cell Death Differ 2006;13:619–627.
- Bouillet P, Metcalf D, Huang DC, . Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999;286: 1735–1738.
- Villunger A, Scott C, Bouillet P, . Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. Blood 2003;101:2393–2400.
- Kuribara R, Honda H, Matsui H, . Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors. Mol Cell Biol 2004;24:6172–6183.
- Kuroda J, Puthalakath H, Cragg MS, . Bim and Bad mediate imatinib-induced killing of Bcr/Abl + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci USA 2006;103:14907–14912.
- Zhao Y, Tan J, Zhuang L, . Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc Natl Acad Sci USA 2005;102:16090–16095.
- Amundson SA, Myers TG, Scudiero D, . An informatics approach identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 2000;60:6101–6110.