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Leukemia & Lymphoma Volume 54, 2013 - Issue 7
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Research Articles

Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes

Yasunori UedaDepartment of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Okayama, JapanCorrespondence[email protected]
,
Chisato MizutaniDepartment of Hematology/Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Okayama, Japan
,
Yasuhito NannyaDepartment of Hematology and Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Mineo KurokawaDepartment of Hematology and Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Sumiko KobayashiDepartment of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
,
Jin TakeuchiDepartment of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan
,
Hideto TamuraDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
,
Kiyoyuki OgataDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
,
Kazuo DanDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
,
Hirohiko ShibayamaDepartment of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Yuzuru KanakuraDepartment of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
,
Keiko NiimiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
Ko SasakiDepartment of Hematology and Oncology, Dokkyo Medical University Hospital, Tochigi, Japan
,
Masato WatanabeDepartment of Hematology, Fujita Health University School of Medicine, Aichi, Japan
,
Nobuhiko EmiDepartment of Hematology, Fujita Health University School of Medicine, Aichi, Japan
,
Masanao TeramuraDepartment of Hematology, Tokyo Women's Medical University, Tokyo, Japan
,
Toshiko MotojiDepartment of Hematology, Tokyo Women's Medical University, Tokyo, Japan
,
Michiko KidaDivision of Hematology, NTT Kanto Medical Center, Tokyo, Japan
,
Kensuke UsukiDivision of Hematology, NTT Kanto Medical Center, Tokyo, Japan
,
Satoru TakadaDepartment of Hematology, Saiseikai Maebashi Hospital, Gunma, Japan
,
Toru SakuraDepartment of Hematology, Saiseikai Maebashi Hospital, Gunma, Japan
,
Yoshikazu ItoDivision of Hematology, Tokyo Medical University Hospital, Tokyo, Japan
,
Kazuma OhyashikiDivision of Hematology, Tokyo Medical University Hospital, Tokyo, Japan
,
Hiroyasu OgawaDivision of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
,
Takahiro SuzukiDivision of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan
,
Keiya OzawaDivision of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan
,
Kiyotoshi ImaiDepartment of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
,
Masaharu KasaiDepartment of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
,
Tomoko HataDepartment of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
,
Yasushi MiyazakiDepartment of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
,
Yasuyoshi MoritaDivision of Hematology, Kinki University School of Medicine, Osaka, Japan
,
Akihisa KanamaruDivision of Hematology, Kinki University School of Medicine, Osaka, Japan
,
Akira MatsudaDepartment of Hemato-Oncology, Saitama International Medical Center, Saitama Medical University, Saitama, Japan
,
Kaoru TohyamaDepartment of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan
,
Daisuke KogaDiagnostic Division, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan
,
Hiroya TamakiDivision of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
,
Kinuko MitaniDepartment of Hematology and Oncology, Dokkyo Medical University Hospital, Tochigi, Japan
,
Tomoki NaoeDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
,
Haruo SugiyamaDepartment of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan
&
Fumimaro TakakuJichi Medical University, Tochigi, Japan
 show all
Pages 1450-1458 | Received 19 Aug 2012, Accepted 24 Oct 2012, Published online: 26 Nov 2012

References

  • Locatelli F, Zecca M, Pession A, et al. Myelodysplastic syndromes: the pediatric point of view. Haematologica 1995;80:268–279.
  • Inoue K, Sugiyama H, Ogawa H, et al. WT1 as a new prognostic factor and new marker for the detection of minimal residual disease in acute leukemia. Blood 1994;84:3071–3079.
  • Miyawaki S, Hatsumi N, Tamaki T, et al. Prognostic potential of detection of WT1 mRNA level in peripheral blood in adult acute myeloid leukemia. Leuk Lymphoma 2010;51:1855–1861.
  • Tamaki H, Ogawa H, Ohyashiki K, et al. The Wilms’ tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes. Leukemia 1999;13:393–399.
  • Patmasiriwat P, Fraizer G, Kantarjian H, et al. WT1 and GATA1 expression in myelodysplastic syndrome and acute leukemia. Leukemia 1999;13:891–900.
  • Cilloni D, Gottardi E, Messa F, et al. Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System score in patients with myelodysplastic syndromes. J Clin Oncol 2003;21:1988–1995.
  • Bader P, Niemeyer C, Weber G, et al. WT1 gene expression: useful marker for minimal residual diseases in childhood myelodysplastic syndromes and juvenile myelo-monocytic leukemia. Eur J Haematol 2004;73:25–28.
  • Tamura K, Kanazawa T, Suzuki M, et al. Successful rapid discontinuation of immunosuppressive therapy at molecular relapse after allogeneic bone marrow transplantation in a pediatric patient with myelodysplastic syndrome. Am J Hematol 2006;81:139–141.
  • Iwasaki T, Sugisaki C, Nagata K, et al. Wilms’ tumor 1 message and protein expression in bone marrow failure syndrome and acute leukemia. Pathol Int 2007;57:645–651.
  • Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997;89:2079–2088.
  • Malcovati L, Germing U, Kuendgen A, et al. Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. J Clin Oncol 2007;25:3503–3510.
  • Heim S, Mitelman F. Chromosome abnormalities in the myelodysplastic syndromes. Clin Haematol 1986;15:1003–1021.
  • Yunis JJ, Lobell M, Arnesen MA, et al. Refined chromosome study helps define prognostic subtypes in most patients with primary myelodysplastic syndromes and acute myelogenous leukemia. Br J Haematol 1988;68:189–194.
  • Nowell PC. Chromosome abnormalities in myelodysplastic syndromes. Semin Oncol 1992;19:25–33.
  • Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982;51:189–199.
  • Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 2002;100:2292–2302.
  • Brunning RD, Porwit A, Orazi A, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press; 2008. pp 88–93.
  • Perkins NJ, Schisterman EF. The inconsistency of “optimal” cutpoints obtained using two criteria based on the receiver operating characteristic curve. Am J Epidemiol 2006;163:670–675.
  • Tamura H, Dan K, Yokose N, et al. Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes. Leuk Res 2010;34: 986–990.
  • Appelbaum FR, Barrall J, Storb R, et al. Bone marrow transplantation for patients with myelodysplasia. Pretreatment variables and outcome. Ann Intern Med 1990;112:590–597.
  • Nakai K, Kanda Y, Fukuhara S, et al. Value of chemotherapy before allogeneic hematopoietic stem cell transplantation from an HLA-identical sibling donor for myelodysplastic syndrome. Leukemia 2005;19:396–401.
  • Cutler CS, Lee SJ, Greenberg P, et al. A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome. Blood 2004;104:579–585.
  • Nakao S, Deeg HJ, Ishikawa T, et al. Myelodysplastic syndrome. Int J Hematol 2005;82:412–416.
  • Van Dijk JP, Knops GH, Van De Locht LT, et al. Abnormal WT1 expression in the CD34-negative compartment in myelodysplastic bone marrow. Br J Haematol 2002;118:1027–1033.

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