201
Views
7
CrossRef citations to date
0
Altmetric
Letters to the Editor

A novel NOTCH1 PEST domain mutation in a case of chronic lymphocytic leukemia

, , , , , , , , & show all
Pages 1780-1782 | Received 06 Sep 2012, Accepted 08 Nov 2012, Published online: 10 Dec 2012

References

  • Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006;107:2223–2233.
  • Di Ianni M, Baldoni S, Rosati E, et al. A new genetic lesion in B-CLL: a NOTCH1 PEST domain mutation. Br J Haematol 2009;146:689–691.
  • Sportoletti P, Baldoni S, Cavalli L, et al. NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL. Br J Haematol 2010; 151:404–406.
  • Puente XS, Pinyol M, Quesada V, et al. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 2011;475:101–105.
  • Fabbri G, Rasi S, Rossi D, et al. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med 2011;208:1389–1401.
  • Rosati E, Sabatini R, Rampino G, et al. Constitutively activated Notch signaling is involved in survival and apoiptosis resistance of B-CLL cells. Blood 2009;113:856–865.
  • Gianfelici V. Activation of the NOTCH1 pathway in chronic lymphocytic leukemia. Haematologica 2012;97:328–330.
  • South AP, Cho RJ, Aster JC. The double-edged sword of Notch signaling in cancer. Semin Cell Dev Biol 2012;23:458–464.
  • La Starza R, Barba G, Matteucci C, et al. Chronic lymphocytic leukaemia. Is terminal del(14)(q24) a new marker for prognostic stratification?Leuk Res 2006;30:1569–1572.
  • Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306:269–271.
  • Armstrong F, Brunet de la Grange P, Gerby B, et al. NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity. Blood 2009;113:1730–1740.
  • Rossi D, Rasi S, Fabbri G, et al. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 2012;119:521–529.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.