Mantle cell lymphoma cell lines show no evident immunoglobulin heavy chain stereotypy but frequent light chain stereotypy

References

• Achille A, Scarpa A, Montresor M, et al. Routine application of polymerase chain reaction in the diagnosis of monoclonality of B-cell lymphoid proliferations. Diagn Mol Pathol 1995;4:14–24.
   PubMed Web of Science ®Google Scholar
• van Dongen JJM, Langerak AW, Brggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003;17:2257–2317.
   PubMed Web of Science ®Google Scholar
• Kuppers R, Zhao M, Rajewsky K and Hansmann MLDetection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction. Am J Pathol 1993;143:230–239.
   PubMed Web of Science ®Google Scholar
• Garcia-Munoz R, Galiacho VR and Llorente L Immunological aspects in chronic lymphocytic leukemia (CLL) development. Ann Hematol 2012;91:981–996.
   PubMed Web of Science ®Google Scholar
• Gobessi S, Laurenti L, Longo PG, et al. Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells. Leukemia 2009;23:686–697.
   PubMed Web of Science ®Google Scholar
• Chen L, Monti S, Juszczynski P, et al. SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood 2008;111:2230–2237.
   PubMed Web of Science ®Google Scholar
• Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010;463:88–92.
   PubMed Web of Science ®Google Scholar
• Swerdlow SH, Campo E, Seto M and Muller-Hermelink HK. Mantle cell lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri S, Stein H, Thiele J and Vardiman J WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Lyon: IARC Press; 2008. pp. 229–232.
   Google Scholar
• Burger JA and Ford RJ. The microenvironment in mantle cell lymphoma: cellular and molecular pathways and emerging targeted therapies. Semin Cancer Biol 2011;21:308–312.
   PubMed Web of Science ®Google Scholar
• Pighi C, Gu TL, Dalai I, et al. Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling. Cell Oncol (Dordr) 2011.
   Google Scholar
• Rinaldi A, Kwee I, Taborelli M, et al. Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma. Br J Haematol 2006;132:303–316.
   PubMed Web of Science ®Google Scholar
• Camacho FI, Algara P, Rodriguez A, et al. Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations. Blood 2003;101:4042–4046.
   PubMed Web of Science ®Google Scholar
• Kienle D, Krober A, Katzenberger T, et al. VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome. Blood 2003;102:3003–3009.
   PubMed Web of Science ®Google Scholar
• Orchard J, Garand R, Davis Z, et al. A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease. Blood 2003;101:4975–4981.
   PubMed Web of Science ®Google Scholar
• Schraders M, Oeschger S, Kluin PM, et al. Hypermutation in mantle cell lymphoma does not indicate a clinical or biological subentity. Mod Pathol 2009;22:416–425.
   PubMed Web of Science ®Google Scholar
• Thorselius M, Walsh S, Eriksson I, et al. Somatic hypermutation and V(H) gene usage in mantle cell lymphoma. Eur J Haematol 2002;68:217–224.
   PubMed Web of Science ®Google Scholar
• Walsh SH, Thorselius M, Johnson A, et al. Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma. Blood 2003;101:4047–4054.
   PubMed Web of Science ®Google Scholar
• Hadzidimitriou A, Agathangelidis A, Darzentas N, et al. Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases. Blood 2011;118:3088–3095.
   PubMed Web of Science ®Google Scholar
• Bea S, Salaverria I, Armengol L, et al. Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling. Blood 2009;113:3059–3069.
   PubMed Web of Science ®Google Scholar
• Cecconi D, Zamo A, Bianchi E, et al. Signal transduction pathways of mantle cell lymphoma: a phosphoproteome-based study. Proteomics 2008;8:4495–4506.
   PubMed Web of Science ®Google Scholar
• Vater I, Wagner F, Kreuz M, et al. GeneChip analyses point to novel pathogenetic mechanisms in mantle cell lymphoma. Br J Haematol 2009;144:317–331.
   PubMed Web of Science ®Google Scholar
• Drexler HG and MacLeod RA. Malignant hematopoietic cell lines: in vitro models for the study of mantle cell lymphoma. Leuk Res 2002;26:781–787.
   PubMed Web of Science ®Google Scholar
• Amin HM, McDonnell TJ, Medeiros LJ, et al. Characterization of 4 mantle cell lymphoma cell lines. Arch Pathol Lab Med 2003;127: 424–431.
   PubMed Web of Science ®Google Scholar
• Ek S, Ortega E and Borrebaeck CA. Transcriptional profiling. and assessment of cell lines as in vitro models for mantle cell lymphoma. Leuk Res 2005;29:205–213.
   PubMed Web of Science ®Google Scholar
• Zamo A, Ott G, Katzenberger T, et al. Establishment of the MAVER-1 cell line, a model for leukemic and aggressive mantle cell lymphoma. Haematologica 2006;91:40–47.
   PubMed Web of Science ®Google Scholar
• M’Kacher R, Bennaceur A, Farace F, et al. Multiple molecular mechanisms contribute to radiation sensitivity in mantle cell lymphoma. Oncogene 2003;22:7905–7912.
   PubMed Web of Science ®Google Scholar
• Kuppers R, Zhao M, Hansmann ML and Rajewsky K. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. Embo J 1993;12: 4955–4967.
   PubMed Web of Science ®Google Scholar
• Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998;102:1515–1525.
   PubMed Web of Science ®Google Scholar
• Lefranc MP, Giudicelli V, Ginestoux C, et al. IMGT, the international ImMunoGeneTics database. Nucleic Acids Res 1999;27:209–212.
   PubMed Web of Science ®Google Scholar
• Giudicelli V, Brochet X and Lefranc MP. IMGT/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences. Cold Spring Harb Protoc 2011;2011: 695–715.
   PubMedGoogle Scholar
• Kuppers R, Willenbrock K, Rajewsky K, Hansmann ML. Detection of clonal lambda light chain gene rearrangements in frozen and paraffin-embedded tissues by polymerase chain reaction. Am J Pathol 1995;147:806–814.
   PubMed Web of Science ®Google Scholar
• van der Burg M, Tumkaya T, Boerma M, et al. Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at the IGL locus. Blood 2001;97:1001–1008.
   PubMed Web of Science ®Google Scholar
• Chen Z, Collins AM, Wang Y and Gaeta BA. Clustering-based identification of clonally-related immunoglobulin gene sequence sets. Immunome Res 6 Suppl 1:S4.
   Google Scholar
• Darzentas N, Hadzidimitriou A, Murray F, et al. A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia 2010;24:125–132.
   PubMed Web of Science ®Google Scholar
• Navarro A, Clot G, Royo C, et al. Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biological and clinical features. Cancer Res 2012;72:5307–16.
   PubMed Web of Science ®Google Scholar
• Bertoni F, Zucca E, Genini D, et al. Immunoglobulin light chain kappa deletion rearrangement as a marker of clonality in mantle cell lymphoma. Leuk Lymphoma 1999;36:147–150.
   PubMed Web of Science ®Google Scholar
• Binder M, Lechenne B, Ummanni R, et al. Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells. PLoS One 2010;5:e15992.
   PubMed Web of Science ®Google Scholar
• Thelander EF, Walsh SH, Thorselius M, et al. Mantle cell lymphomas with clonal immunoglobulin V(H)3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V(H) genes. Mod Pathol 2005;18:331–339.
   PubMed Web of Science ®Google Scholar
• Thorselius M, Krober A, Murray F, et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status. Blood 2006;107:2889–2894.
   PubMed Web of Science ®Google Scholar
• Tobin G, Thunberg U, Johnson A, et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood 2003;101:4952–4957.
   PubMed Web of Science ®Google Scholar
• Tobin G, Thunberg U, Johnson A, et al. Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002;99:2262–2264.
   PubMed Web of Science ®Google Scholar
• Bhat NM, Lee LM, van Vollenhoven RF, Teng NN and Bieber MM VH4-34 encoded antibody in systemic lupus erythematosus: effect of isotype. J Rheumatol 2002;29:2114–2121.
   PubMed Web of Science ®Google Scholar
• Pascual V, Victor K, Spellerberg M, et al. VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities. J Immunol 1992;149:2337–2344.
   PubMed Web of Science ®Google Scholar
• Riboldi P, Gaidano G, Schettino EW, et al. Two acquired immunodeficiency syndrome-associated Burkitt’s lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments. Blood 1994;83:2952–2961.
   PubMed Web of Science ®Google Scholar
• Silberstein LE, Jefferies LC, Goldman J, et al. Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens. Blood 1991;78:2372–2386.
   PubMed Web of Science ®Google Scholar
• Kostareli E, Hadzidimitriou A, Stavroyianni N, et al. Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Leukemia 2009;23:919–924.
   PubMed Web of Science ®Google Scholar
• Arons E, Suntum T, Stetler-Stevenson M and Kreitman RJ VH4-34 + hairy cell leukemia, a new variant with poor prognosis despite standard therapy. Blood 2009;114:4687–4695.
   PubMed Web of Science ®Google Scholar
• Lai R, Lefresne SV, Franko B, et al. Immunoglobulin VH somatic hypermutation in mantle cell lymphoma: mutated genotype correlates with better clinical outcome. Mod Pathol 2006;19:1498–1505.
   PubMed Web of Science ®Google Scholar
• Papadaki T, Stamatopoulos K, Belessi C, et al. Splenic marginal-zone lymphoma: one or more entities? A histologic, immunohistochemical, and molecular study of 42 cases. Am J Surg Pathol 2007;31:438–446.
   PubMed Web of Science ®Google Scholar
• Arcaini L, Zibellini S, Passamonti F, et al. Splenic marginal zone lymphoma: Clinical clustering of immunoglobulin heavy chain repertoires. Blood Cells Mol Dis 2009;42:286–291.
   PubMed Web of Science ®Google Scholar
• Bikos V, Darzentas N, Hadzidimitriou A, et al. Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications. Leukemia 2012;26:1638–1646.
   PubMed Web of Science ®Google Scholar
• Bahler DW, Szankasi P, Kulkarni S, et al. Use of similar immunoglobulin VH gene segments by MALT lymphomas of the ocular adnexa. Mod Pathol 2009;22:833–838.
   PubMed Web of Science ®Google Scholar
• Bomben R, Dal Bo M, Capello D, et al. Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study. Br J Haematol 2009;144:492–506.
   PubMed Web of Science ®Google Scholar
• Rettig MB, Vescio RA, Cao J, et al. VH gene usage is multiple myeloma: complete absence of the VH4.21 (VH4-34) gene. Blood 1996;87:2846–2852.
   PubMed Web of Science ®Google Scholar
• Gonzalez D, van der Burg M, Garcia-Sanz R, et al. Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma. Blood 2007;110:3112–3121.
   PubMed Web of Science ®Google Scholar
• Wang J, Bu D and Zhu X. Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in association with paraneoplastic autoimmune multiorgan syndrome.Int J Dermatol 2007;46:1146–1154.
   PubMed Web of Science ®Google Scholar
• Lecerf JM, Chen Y, Richalet-Secordel P, Wang X and Stollar BD. Autoreactivity of human VH domains from cDNA libraries: analysis with a bacterial expression system. J Immunol 1998;161:1274–1283.
   PubMed Web of Science ®Google Scholar
• Stamatopoulos K, Belessi C, Hadzidimitriou A, et al. Immunoglobulin light chain repertoire in chronic lymphocytic leukemia. Blood 2005;106:3575–3583.
   PubMed Web of Science ®Google Scholar
• Ghiotto F, Fais F, Albesiano E, et al. Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia. Mol Med 2006;12:300–308.
   PubMed Web of Science ®Google Scholar
• Hadzidimitriou A, Darzentas N, Murray F, et al. Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia. Blood 2009;113: 403–11.
   PubMed Web of Science ®Google Scholar
• Kostareli E, Gounari M, Agathangelidis A, Stamatopoulos K. Immunoglobulin gene repertoire in chronic lymphocytic leukemia: insight into antigen selection and microenvironmental interactions. Mediterr J Hematol Infect Dis 2012;4:e2012052.
   PubMedGoogle Scholar
• Smilevska T, Tsakou E, Hadzidimitriou A, et al. Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma. Blood Cells Mol Dis 2008;41:215–8.
   PubMed Web of Science ®Google Scholar
• Bikos V, Stalika E, Baliakas P, et al. Selection of antigen receptors in splenic marginal-zone lymphoma: further support from the analysis of the immunoglobulin light-chain gene repertoire. Leukemia 2012:2567–2569.
   PubMed Web of Science ®Google Scholar
• Combriato G and Klobeck HG. V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb. and rearrange by a deletion mechanism. Eur J Immunol 1991;21:1513–1522.
   PubMed Web of Science ®Google Scholar
• Maura F, Cutrona G, Fabris S, et al. Relevance of stereotyped B-cell receptors in the context of the molecular, cytogenetic and clinical features of chronic lymphocytic leukemia. PLoS One 2011;6:e24313.
   PubMed Web of Science ®Google Scholar