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Leukemia & Lymphoma Volume 54, 2013 - Issue 10
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Research Article

Modeling progression risk for smoldering multiple myeloma: results from a prospective clinical study

Benjamin M. CherryMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Neha KordeMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Mary KwokMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;Walter Reed National Military Medical Center, Bethesda, MD, USA
,
Elisabet E. ManasanchMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Manisha BhutaniMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Marcia MulquinMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Diamond ZuchlinskiMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Mary Ann YanceyMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Irina MaricHematology Service, Department of Laboratory Medicine, NIH, Bethesda, MD, USA
,
Katherine R. CalvoHematology Service, Department of Laboratory Medicine, NIH, Bethesda, MD, USA
,
Raul BraylanHematology Service, Department of Laboratory Medicine, NIH, Bethesda, MD, USA
,
Maryalice Stetler-StevensonLaboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
,
Constance YuanLaboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
,
Prashant TembhareLaboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
,
Adriana ZingoneMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Rene CostelloMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
,
Mark J. RoschewskiMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
&
Ola LandgrenMultiple Myeloma Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USACorrespondence[email protected].
 show all
Pages 2215-2218 | Received 05 Sep 2012, Accepted 03 Jan 2013, Published online: 29 Jul 2013

References

  • Landgren O, Waxman AJ. Multiple myeloma precursor disease. JAMA 2010;304:2397–2404.
  • Kyle RA, Remstein ED, Therneau TM, et al. Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma. N Engl J Med 2007;356:2582–2590.
  • Rajkumar SV, Kyle RA, Therneau TM, et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood 2005;106:812–817.
  • Kyle RA, Durie BG, Rajkumar SV, et al. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia 2010;24:1121–1127.
  • Korde N, Kristinsson SY, Landgren O. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM): novel biological insights and development of early treatment strategies. Blood 2011;117:5573–5581.
  • Dispenzieri A, Kyle RA, Katzmann JA, et al. Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma. Blood 2008;111: 785–789.
  • Perez-Persona E, Vidriales MB, Mateo G, et al. New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells. Blood 2007;110:2586–2592.
  • McShane LM, Altman DG, Sauerbrei W, et al. Reporting recommendations for tumor marker prognostic studies. J Clin Oncol 2005;23:9067–9072.
  • Landgren O, Kyle RA, Rajkumar SV. From myeloma precursor disease to multiple myeloma: new diagnostic concepts and opportunities for early intervention. Clin Cancer Res 2011;17:1243–1252.
  • Landgren O, Rajkumar SV. Development of early treatment strategies for high-risk myeloma precursor disease in the future. Semin Hematol 2011;48:66–72.
  • Landgren O, Korde N. Treating myeloma: the future is already here!. Blood 2012;120:1754–1756.

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