Inactivation of the Cdkn2a locus cooperates with HMGA1 to drive T-cell leukemogenesis

References

• Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008;371:1030–1043.
   PubMed Web of Science ®Google Scholar
• Ferrando AA, Look AT. Gene expression profiling in T-cell acute lymphoblastic leukemia. Semin Hematol 2003;40:274–280.
   PubMed Web of Science ®Google Scholar
• Grabher C, von Boehmer H, Look AT. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 2006;6:347–359.
   PubMed Web of Science ®Google Scholar
• Winter SS, Jiang Z, Khawaja HM, et al.Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the children's oncology group. Blood 2007;110:1429–1438.
   PubMed Web of Science ®Google Scholar
• Andersson A, Ritz C, Lindgren D, et al.Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status. Leukemia 2007;21:1198–1203.
   PubMed Web of Science ®Google Scholar
• Homminga I, Pieters R, Langerak AW, et al.Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. Cancer Cell 2011;19:484–497.
   PubMed Web of Science ®Google Scholar
• Zhang J, Ding L, Holmfeldt L, et al.The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012;481: 157–163.
   PubMed Web of Science ®Google Scholar
• Meijerink JP. Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia. Best Pract Res Clin Haematol 2010;23:307–318.
   PubMed Web of Science ®Google Scholar
• Krug U, Ganser A, Koeffler HP. Tumor suppressor genes in normal and malignant hematopoiesis. Oncogene 2002;21:3475–3495.
   PubMed Web of Science ®Google Scholar
• Lowe SW, Sherr CJ. Tumor suppression by Ink4a-arf: progress and puzzles. Curr Opin Genet Dev 2003;13:77–83.
   PubMed Web of Science ®Google Scholar
• Cleveland JL, Sherr CJ. Antagonism of myc functions by arf. Cancer Cell 2004;6:309–311.
   PubMed Web of Science ®Google Scholar
• Kees UR, Burton PR, Lu C, et al.Homozygous deletion of the p16/MTS1 gene in pediatric acute lymphoblastic leukemia is associated with unfavorable clinical outcome. Blood 1997;89: 4161–4166.
   PubMed Web of Science ®Google Scholar
• Zhou M, Gu L, Yeager AM, et al.Incidence and clinical significance of CDKN2/MTS1/P16ink4A and MTS2/P15ink4B gene deletions in childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol 1997;14:141–150.
   PubMed Web of Science ®Google Scholar
• Reeves R. Molecular biology of HMGA proteins: hubs of nuclear function. Gene 2001;277:63–81.
   PubMed Web of Science ®Google Scholar
• Fusco A, Fedele M. Roles of HMGA proteins in cancer. Nat Rev Cancer 2007;7:899–910.
   PubMed Web of Science ®Google Scholar
• Resar LM. The high mobility group A1 gene: transforming inflammatory signals into cancer?Cancer Res 2010;70:436–439.
   PubMed Web of Science ®Google Scholar
• Shah SN, Resar LM. High mobility group A1 and cancer: potential biomarker and therapeutic target. Histol Histopathol 2012;27: 567–579.
   PubMed Web of Science ®Google Scholar
• Ben-Porath I, Thomson MW, Carey VJ, et al.An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008;40:499–507.
   PubMed Web of Science ®Google Scholar
• Chou BK, Mali P, Huang X, et al.Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res 2011;21:518–529.
   PubMed Web of Science ®Google Scholar
• Zhou G, Chen J, Lee S, et al.The pattern of gene expression in human CD34(+) stem/progenitor cells. Proc Natl Acad Sci USA 2001;98:13966–13971.
   PubMed Web of Science ®Google Scholar
• Karp JE, Smith BD, Resar LS, et al.Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias. Blood 2011;117:3302–3310.
   PubMed Web of Science ®Google Scholar
• Nelson DM, Joseph B, Hillion J, et al.Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia. Leuk Lymphoma 2011;52:1999–2006.
   PubMed Web of Science ®Google Scholar
• Somervaille TC, Matheny CJ, Spencer GJ, et al.Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 2009;4:129–140.
   PubMed Web of Science ®Google Scholar
• Wood LJ, Mukherjee M, Dolde CE, et al.HMG-I/Y, a new c-myc target gene and potential oncogene. Mol Cell Biol 2000;20:5490–5502.
   PubMed Web of Science ®Google Scholar
• Wood LJ, Maher JF, Bunton TE, et al.The oncogenic properties of the HMG-I gene family. Cancer Res 2000;60:4256–4261.
   PubMed Web of Science ®Google Scholar
• Dolde CE, Mukherjee M, Cho C, et al.HMG-I/Y in human breast cancer cell lines. Breast Cancer Res Treat 2002;71:181–191.
   PubMed Web of Science ®Google Scholar
• Xu Y, Sumter TF, Bhattacharya R, et al.The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia. Cancer Res 2004;64:3371–3375.
   PubMed Web of Science ®Google Scholar
• Tesfaye A, Di Cello F, Hillion J, et al.The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. Cancer Res 2007;67:3998–4004.
   PubMed Web of Science ®Google Scholar
• Di Cello F, Hillion J, Hristov A, et al.HMGA2 participates in transformation in human lung cancer. Mol Cancer Res 2008;6: 743–750.
   PubMed Web of Science ®Google Scholar
• Di Cello F, Hillion J, Kowalski J, et al.Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts. Mol Cancer Ther 2008;7:2090–2095.
   PubMed Web of Science ®Google Scholar
• Hillion J, Dhara S, Sumter TF, et al.The high-mobility group A1a/signal transducer and activator of transcription-3 axis: An achilles heel for hematopoietic malignancies?Cancer Res 2008;68:10121–10127.
   PubMed Web of Science ®Google Scholar
• Hillion J, Wood LJ, Mukherjee M, et al.Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer. Mol Cancer Res 2009;7:1803–1812.
   PubMed Web of Science ®Google Scholar
• Hristov AC, Cope L, Reyes MD, et al.HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. Mod Pathol 2009;22:43–49.
   PubMed Web of Science ®Google Scholar
• Hristov AC, Cope L, Di Cello F, et al.HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma. Mod Pathol 2010;23:98–104.
   PubMed Web of Science ®Google Scholar
• Schuldenfrei A, Belton A, Kowalski J, et al.HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis. BMC Genomics 2011;12:549.
   PubMed Web of Science ®Google Scholar
• Belton A, Gabrovsky A, Bae YK, et al.HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells. PLoS One 2012;7:e30034.
   PubMed Web of Science ®Google Scholar
• Pomeroy SL, Tamayo P, Gaasenbeek M, et al.Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 2002;415:436–442.
   PubMed Web of Science ®Google Scholar
• Fedele M, Pentimalli F, Baldassarre G, et al.Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene 2005;24:3427–3435.
   PubMed Web of Science ®Google Scholar
• Battista S, Pentimalli F, Baldassarre G, et al.Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation. FASEB J 2003;17:1496–1498.
   PubMed Web of Science ®Google Scholar
• Fedele M, Fidanza V, Battista S, et al.Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res 2006;66:2536–2543.
   PubMed Web of Science ®Google Scholar
• Ikeda K, Mason PJ, Bessler M. 3’UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice. Blood 2011;117:5860–5869.
   PubMed Web of Science ®Google Scholar
• Resar LM, Brodsky RA. “Let”-ing go with clonal expansion? Blood 2011;117:5788–5790.
   Google Scholar
• Serrano M, Lee H, Chin L, et al.Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996;85:27–37.
   PubMed Web of Science ®Google Scholar
• Morse HC 3rd, Anver MR, Fredrickson TN, et al.Bethesda proposals for classification of lymphoid neoplasms in mice. Blood 2002;100:246–258.
   PubMed Web of Science ®Google Scholar
• Herman JG, Civin CI, Issa JP, et al.Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res 1997;57:837–841.
   PubMed Web of Science ®Google Scholar
• Cashen AF, Schiller GJ, O’Donnell MR, et al.Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J Clin Oncol 2010;28:556–561.
   PubMed Web of Science ®Google Scholar
• Serrano M, Lin AW, McCurrach ME, et al.Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593–602.
   PubMed Web of Science ®Google Scholar
• Secchiero P, Bosco R, Celeghini C, et al.Recent advances in the therapeutic perspectives of nutlin-3. Curr Pharm Des 2011;17:569–577.
   PubMed Web of Science ®Google Scholar
• Della Gatta G, Palomero T, Perez-Garcia A, et al.Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. Nat Med 2012;18:436–440.
   PubMed Web of Science ®Google Scholar
• Shah SN, Kerr C, Cope L, et al.HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks. PLoS One 2012;7:e48533.
   PubMed Web of Science ®Google Scholar
• Hillion J, Smail SS, Di Cello F, et al.The HMGA1-COX-2 axis: a key molecular pathway and potential target in pancreatic adenocarcinoma. Pancreatology 2012;12:372–379.
   PubMed Web of Science ®Google Scholar
• Beckerbauer L, Tepe JJ, Cullison J, et al.FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo. Chem Biol 2000;7:805–812.
   PubMed Web of Science ®Google Scholar