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Commentary

Missing the notch in NOTCH1

, , &
Pages 1579-1580 | Published online: 16 Feb 2013

References

  • Andersson ER, Sandberg R, Lendahl U. Notch signaling: simplicity in design, versatility in function. Development 2011;138:3593–3612.
  • Burger JA, Ghia P, Rosenwald A, et al. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 2009;114:3367–3375.
  • Rosati E, Sabatini R, Rampino G, et al. Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells. Blood 2009;113:856–865.
  • Sportoletti P, Baldoni S, Del Papa B, et al. A novel NOTCH1 proline, glutamic acid, serine and threonine domain mutation in a case of chronic lymphocytic leukemia. Leuk Lymphoma 2013;54:1780–1782.
  • Gianfelici V. Activation of the NOTCH1 pathway in chronic lymphocytic leukemia. Haematologica 2012;97:328–330.
  • Chiang MY, Xu ML, Histen G, et al. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol 2006;26:6261–6271.

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