High proportion of CD34+/CD38−cells is positively correlated with poor prognosis in newly diagnosed childhood acute lymphoblastic leukemia

References

• Almalte Z, Samarani S, Iannello A, et al. Novel associations between activating killer-cell immunoglobulin-like receptor genes and childhood leukemia. Blood 2011;118:1323–1328.
   PubMed Web of Science ®Google Scholar
• Jeha S, Razzouk B, Rytting M, et al. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia. J Clin Oncol 2009;27:4392–4397.
   PubMed Web of Science ®Google Scholar
• Parker C, Waters R, Leighton C, et al. Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial. Lancet 2010;376:2009–2017.
   PubMed Web of Science ®Google Scholar
• Zhou J, Goldwasser MA, Li A, et al. Quantitative analysis of minimal residual disease predicts relapse in children with B-lineage acute lymphoblastic leukemia in DFCI ALL Consortium Protocol 95-01. Blood 2007;110:1607–1611.
   PubMed Web of Science ®Google Scholar
• Diamanti P, Cox CV, Blair A. Comparison of childhood leukemia initiating cell populations in NOD/SCID and NSG mice. Leukemia 2012;26:376–380.
   PubMed Web of Science ®Google Scholar
• Vargaftig J, Taussig DC, Griessinger E, et al. Frequency of leukemic initiating cells does not depend on the xenotransplantation model used. Leukemia 2012;26:858–860.
   PubMed Web of Science ®Google Scholar
• Majeti R, Weissman IL. Human acute myelogenous leukemia stem cells revisited: there's more than meets the eye. Cancer Cell 2011; 19:9–10.
   Google Scholar
• Konopleva MY, Jordan CT. Leukemia stem cells and microenvironment: biology and therapeutic targeting. J Clin Oncol 2011;29:591–599.
   PubMed Web of Science ®Google Scholar
• van Rhenen A, Feller N, Kelder A, et al. High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival. Clin Cancer Res 2005;11:6520–6527.
   PubMed Web of Science ®Google Scholar
• Bennett JM, Catovsky D, Daniel M-T, et al. Proposals for the classification of the acute leukaemias French-American-British (FAB) Co-operative Group. Br J Haematol 1976;33:451–458.
   PubMed Web of Science ®Google Scholar
• Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009; 114:937–951.
   PubMed Web of Science ®Google Scholar
• Jiao Y, Cui L, Gao C, et al. CASP8AP2 is a promising prognostic indicator in pediatric acute lymphoblastic leukemia. Leuk Res 2012;36:67–71.
   PubMed Web of Science ®Google Scholar
• Chen I-M, Harvey RC, Mullighan CG, et al. Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group Study. Blood 2012;119:3512–3522.
   PubMed Web of Science ®Google Scholar
• Ninomiya M, Abe A, Katsumi A, et al. Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. Leukemia 2007;21:136–142.
   PubMed Web of Science ®Google Scholar
• Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105–111.
   PubMed Web of Science ®Google Scholar
• Zhang L, Yang S, He YJ, et al. Fluorouracil selectively enriches stem-like leukemic cells in a leukemic cell line. Int J Biol Sci 2010;6: 419–427.
   PubMed Web of Science ®Google Scholar
• Ebinger M, Witte KE, Ahlers J, et al. High frequency of immature cells at diagnosis predicts high minimal residual disease level in childhood acute lymphoblastic leukemia. Leuk Res 2010;34: 1139–1142.
   PubMed Web of Science ®Google Scholar
• Hong D, Gupta R, Ancliff P, et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 2008;319:336–339.
   PubMed Web of Science ®Google Scholar
• Zelent A, Greaves M, Enver T. Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia. Oncogene 2004;23:4275–4283.
   PubMed Web of Science ®Google Scholar
• Cazzaniga G, van Delft FW, Lo Nigro L, et al. Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia. Blood 2011;118:5559–5564.
   PubMed Web of Science ®Google Scholar
• le Viseur C, Hotfilder M, Bomken S, et al. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell 2008;14:47–58.
   PubMed Web of Science ®Google Scholar
• Kong Y, Yoshida S, Saito Y, et al. CD34 + CD38+ CD19 + as well as CD34 + CD38-CD19 + cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia 2008;22:1207–1213.
   PubMed Web of Science ®Google Scholar
• Basso G, Lanza F, Orfao A, et al. Clinical and biological significance of CD34 expression in acute leukemia. J Biol Regul Homeost Agents 2001;15:68–78.
   PubMed Web of Science ®Google Scholar
• Dakka N, Bellaoui H, Bouzid N, et al. CD10 AND CD34 expression in childhood acute lymphoblastic leukemia in Morocco: clinical relevance and outcome. Pediatr Hematol Oncol 2009;26:216–231.
   PubMed Web of Science ®Google Scholar
• Morisot S, Wayne AS, Bohana-Kashtan O, et al. High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias. Leukemia 2010;24:1859–1866.
   PubMed Web of Science ®Google Scholar
• Rickert RC, Rajewsky K, Roes J. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 1995;376:352–355.
   PubMed Web of Science ®Google Scholar
• Mori H, Colman SM, Xiao Z, et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci USA 2002;99:8242–8247.
   PubMed Web of Science ®Google Scholar
• Castor A, Nilsson L, Astrand-Grundstrom I, et al. Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med 2005;11:630–637.
   PubMed Web of Science ®Google Scholar
• Vrooman LM, Silverman LB. Childhood acute lymphoblastic leukemia: update on prognostic factors. Curr Opin Pediatr 2009; 21:1–8.
   PubMed Web of Science ®Google Scholar
• Faderl S, Garcia-Manero G, Thomas DA, et al. Philadelphia chromosome-positive acute lymphoblastic leukemia—current concepts and future perspectives. Rev Clin Exp Hematol 2002;6: 142–160; discussion 200–142.
   PubMedGoogle Scholar