Advanced search
Publication Cover
Leukemia & Lymphoma Volume 55, 2014 - Issue 3
Submit an article Journal homepage
277
Views
4
CrossRef citations to date
0
Altmetric
Letter

DNMT3A mutations at R882 hotspot are only found in major clones of acute myeloid leukemia

Kathrin E. BislingBrighton and Sussex Medical School, University of Sussex, Brighton, UK;Faculty of Medicine, Ludwig Maximilian University, Munich, Germany
,
John N. BrewinBrighton and Sussex Medical School, University of Sussex, Brighton, UK
,
Andrew P. McGovernBrighton and Sussex Medical School, University of Sussex, Brighton, UK
,
Gillian A. HorneBrighton and Sussex Medical School, University of Sussex, Brighton, UK
,
Tom RiderBrighton and Sussex Medical School, University of Sussex, Brighton, UK
,
Helen J. StewartBrighton and Sussex Medical School, University of Sussex, Brighton, UK
,
Bernard H. RamsahoyeInstitute of Genetics and Molecular Medicine, University of Edinburgh, UK
&
Timothy J. ChevassutBrighton and Sussex Medical School, University of Sussex, Brighton, UK;Department of Haematology, Royal Sussex County Hospital, Brighton, UKCorrespondence[email protected]
 show all
Pages 711-714 | Received 12 Mar 2013, Accepted 31 May 2013, Published online: 25 Jul 2013

References

  • Greaves M, Maley CC. Clonal evolution in cancer. Nature 2012;481:306–313.
  • Ding L, Ley TJ, Larson DE, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 2012;481:506–510.
  • Walter MJ, Shen D, Ding L, et al. Clonal architecture of secondary acute myeloid leukemia. N Engl J Med 2012;366:1090–1098.
  • Welch JS, Ley TJ, Link DC, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 2012;150:264–278.
  • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010;363:2424–2433.
  • Yan XJ, Xu J, Gu ZH, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011;43:309–315.
  • Ostronoff F, Othus M, Ho PA, et al. Mutations in the DNMT3A exon 23 independently predict poor outcome in older patients with acute myeloid leukemia: a SWOG report. Leukemia 2013;27:238–241.
  • Shen Y, Zhu YM, Fan X, et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood 2011;118:5593–5603.
  • Patel JP, Gönen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012;366:1079–1089.
  • Ribeiro AF, Pratcorona M, Erpelinck-Verschueren C, et al. Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood 2012;119:5824–5831.
  • Horne G, Brewin J, Chevassut T. Genetic profiling in acute myeloid leukemia. N Engl J Med 2012;366:2321.
  • Brewin JN, Horne GA, Bisling KE, et al. Rapid detection of DNMT3A R882 codon mutations allows early identification of poor risk patients with acute myeloid leukemia. Leuk Lymphoma 2013;54:1336–1339.
  • Singh RR, Bains A, Patel KP, et al. Detection of high-frequency and novel DNMT3A mutations in acute myeloid leukemia by high-resolution melting curve analysis. J Mol Diagn 2012;14:336–345.
  • Hou HA, Kuo YY, Liu CY, et al. DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications. Blood 2012;119:559–568.
  • Wakita S, Yamaguchi H, Omori I, et al. Mutations of the epigenetics modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia. Leukemia 2013;27:1044–1052.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.