99
Views
2
CrossRef citations to date
0
Altmetric
Original Articles: Research

DNA repair initiation induces expression of ribonucleotide reductase in human chronic lymphocytic leukemia cells

, , , &
Pages 876-883 | Received 30 Jan 2013, Accepted 04 Jun 2013, Published online: 29 Jul 2013

References

  • Reichard P. Ribonucleotide reductase and deoxyribonucleotide pools. Basic Life Sci 1985;31:33–45.
  • Thelander L, Eriksson S, Akerman M. Ribonucleotide reductase from calf thymus. Separation of the enzyme into two nonidentical subunits, proteins M1 and M2. J Biol Chem 1980;255:7426–7432.
  • Rubin EH, Cory JG. Differential turnover of the subunits of ribonucleotide reductase in synchronized leukemia L1210 cells. Cancer Res 1986;46:6165–6168.
  • Nicander B, Reichard P. Relations between synthesis of deoxyribonucleotides and DNA replication in 3T6 fibroblasts. J Biol Chem 1985;260:5376–5381.
  • Kolodner RD, Marsischky GT. Eukaryotic DNA mismatch repair. Curr Opin Genet Dev 1999;9:89–96.
  • Naegeli H. Roadblocks and detours during DNA replication: mechanisms of mutagenesis in mammalian cells. Bioessays 1994; 16:557–564.
  • Sancar A. DNA repair in humans. Annu Rev Genet 1995;29:69–105.
  • Wood RD. DNA repair in eukaryotes. Annu Rev Biochem 1996; 65:135–167.
  • Iwasaki H, Huang P, Keating MJ, et al. Differential incorporation of ara-C, gemcitabine, and fludarabine into replicating and repairing DNA in proliferating human leukemia cells. Blood 1997;90:270–278.
  • Xu YZ, Huang P, Plunkett W. Functional compartmentation of dCTP pools. Preferential utilization of salvaged deoxycytidine for DNA repair in human lymphoblasts. J Biol Chem 1995;270:631–637.
  • Bianchi V, Pontis E, Reichard P. Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis. J Biol Chem 1986;261:16037–16042.
  • Elledge SJ, Davis RW. DNA damage induction of ribonucleotide reductase. Mol Cell Biol 1989;9:4932–4940.
  • Hurta RA, Wright JA. Alterations in the activity and regulation of mammalian ribonucleotide reductase by chlorambucil, a DNA damaging agent. J Biol Chem 1992;267:7066–7071.
  • Kuo ML, Kinsella TJ. Expression of ribonucleotide reductase after ionizing radiation in human cervical carcinoma cells. Cancer Res 1998;58:2245–2252.
  • Hunting DJ, Dresler SL. Dependence of u.v.-induced DNA excision repair on deoxyribonucleoside triphosphate concentrations in permeable human fibroblasts: a model for the inhibition of repair by hydroxyurea. Carcinogenesis 1985;6:1525–1528.
  • Day RS 3rd. Deoxyguanosine reverses inhibition by hydroxyurea of repair of UV-irradiated adenovirus 5. Mutat Res 1993;293:215–223.
  • Snyder RD. The role of deoxynucleoside triphosphate pools in the inhibition of DNA-excision repair and replication in human cells by hydroxyurea. Mutat Res 1984;131:163–172.
  • Jurlander J. The cellular biology of B-cell chronic lymphocytic leukemia. Crit Rev Oncol Hematol 1998;27:29–52.
  • Sandoval A, Consoli U, Plunkett W. Fludarabine-mediated inhibition of nucleotide excision repair induces apoptosis in quiescent human lymphocytes. Clin Cancer Res 1996;2:1731–1741.
  • Tew KD, Colvin OM, Chabner BA. Alkylating agents. In: Chabner BA, Longo DL, editors. Cancer chemotherapy & biotherapy. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001. pp. 373–414.
  • Evans RG, Norman A. Unscheduled incorporation of thymidine in ultraviolet-irradiated human lymphocytes. Radiat Res 1968;36: 287–298.
  • Evans RG, Norman A. Radiation stimulated incorporation of thymidine into the DNA of human lymphocytes. Nature 1968;217: 455–456.
  • Joiner MC, Lambin P, Marples B. Adaptive response and induced resistance. C R Acad Sci III 1999;322:167–175.
  • Tyrrell RM. UV activation of mammalian stress proteins. EXS 1996;77:255–271.
  • Blattner C, Sparks A, Lane D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol Cell Biol 1999;19:3704–3713.
  • Hofferer M, Wirbelauer C, Humar B, et al. Increased levels of E2F-1-dependent DNA binding activity after UV- or gamma-irradiation. Nucleic Acids Res 1999;27:491–495.
  • Hayes S, Shiyanov P, Chen X, et al. DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1. Mol Cell Biol 1998;18:240–249.
  • Scanlon KJ, Kashani-Sabet M, Miyachi H. Differential gene expression in human cancer cells resistant to cisplatin. Cancer Invest 1989;7:581–587.
  • Gandhi V, Plunkett W, Kantarjian H, et al. Cellular pharmacodynamics and plasma pharmacokinetics of parenterally infused hydroxyurea during a phase I clinical trial in chronic myelogenous leukemia. J Clin Oncol 1998;16:2321–2331.
  • Gao WY, Cara A, Gallo RC, et al. Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication. Proc Natl Acad Sci USA 1993;90:8925–8928.
  • Chaney SG, Sancar A. DNA repair: enzymatic mechanisms and relevance to drug response. J Natl Cancer Inst 1996;88:1346–1360.
  • Bramson J, McQuillan A, Aubin R, et al. Nitrogen mustard drug resistant B-cell chronic lymphocytic leukemia as an in vivo model for crosslinking agent resistance. Mutat Res 1995;336:269–278.
  • Bramson J, McQuillan A, Panasci LC. DNA repair enzyme expression in chronic lymphocytic leukemia vis-a-vis nitrogen mustard drug resistance. Cancer Lett 1995;90:139–148.
  • Thompson LH, Schild D. The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie 1999;81:87–105.
  • Lindahl T, Karran P, Wood RD. DNA excision repair pathways. Curr Opin Genet Dev 1997;7:158–169.
  • Yamauchi T, Keating MJ, Plunkett W. UCN-01 (7-hydroxy staurosporine) inhibits DNA repair and increases cytotoxicity in normal lymphocytes and chronic lymphocytic leukemia lymphocytes. Mol Cancer Ther 2002;1:287–294.
  • Elledge SJ, Zhou Z, Allen JB, et al. DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays 1993;15: 333–339.
  • Eriksson S, Graslund A, Skog S, et al. Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis. J Biol Chem 1984;259:11695–11700.
  • Mann GJ, Musgrove EA, Fox RM, et al. Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation. Cancer Res 1988;48:5151–5156.
  • Bjorklund S, Skog S, Tribukait B, et al. S-phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs. Biochemistry 1990;29:5452–5458.
  • Bjorklund S, Skogman E, Thelander L. An S-phase specific release from a transcriptional block regulates the expression of mouse ribonucleotide reductase R2 subunit. EMBO J 1992;11:4953–4959.
  • Elledge SJ, Davis RW. Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev 1990;4:740–751.
  • Yamauchi T, Nowak BJ, Keating MJ, et al. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clin Cancer Res 2001;7:3580–3589.
  • O’Brien SM, Kantarjian HM, Cortes J, et al. Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia. J Clin Oncol 2001;19:1414–1420.
  • Flinn IW, Neuberg DS, Grever MR, et al. Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J Clin Oncol 2007;25:793–798.
  • Eichhorst BF, Busch R, Obwandner T, et al. Health-related quality of life in younger patients with chronic lymphocytic leukemia treated with fludarabine plus cyclophosphamide or fludarabine alone for first-line therapy: a study by the German CLL Study Group. J Clin Oncol 2007;25:1722–1731.
  • Catovsky D, Richards S, Matutes E, et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 trial): a randomised controlled trial. Lancet 2007;370:230–239.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.