261
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Familial CD3+ T large granular lymphocyte leukemia: evidence that genetic predisposition and antigen selection promote clonal cytotoxic T-cell responses

, , , , , , , , , , & show all
Pages 1781-1787 | Received 16 May 2013, Accepted 24 Oct 2013, Published online: 17 Feb 2014

References

  • Sokol L, Loughran TP Jr. Large granular lymphocyte leukemia. Oncologist 2006;11:263–273.
  • Zhang R, Shah MV, Loughran TP Jr. The root of many evils: indolent large granular lymphocyte leukaemia and associated disorders. Hematol Oncol 2010;28:105–117.
  • Posnett DN, Sinha R, Kabak S, et al. Clonal populations of T cells in normal elderly humans: the T cell equivalent to “benign monoclonal gammapathy”. J Exp Med 1994;179:609–618.
  • Wack A, Cossarizza A, Heltai S, et al. Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol 1998;10:1281–1288.
  • Ghia P, Prato G, Stella S, et al. Age-dependent accumulation of monoclonal CD4+ CD8+ double positive T lymphocytes in the peripheral blood of the elderly. Br J Haematol 2007;139:780–790.
  • Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95:1534–1541.
  • Mohan SR, Maciejewski JP. Diagnosis and therapy of neutropenia in large granular lymphocyte leukemia. Curr Opin Hematol 2009; 16:27–34.
  • Prochorec-Sobieszek M, Rymkiewicz G, Makuch-Lasica H, et al. Characteristics of T-cell large granular lymphocyte proliferations associated with neutropenia and inflammatory arthropathy. Arthritis Res Ther 2008;10:R55.
  • Wlodarski MW, O’Keefe C, Howe EC, et al. Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia. Blood 2005;106:2769–2780.
  • Starkebaum G, Loughran TP Jr, Gaur LK, et al. Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis. Arthritis Rheum 1997;40:624–626.
  • Bux J, Behrens G, Jaeger G, et al. Diagnosis and clinical course of autoimmune neutropenia in infancy: analysis of 240 cases. Blood 1998;91:181–186.
  • Stamatopoulos K, Papadaki T, Pontikoglou C, et al. Lymphocyte subpopulation imbalances, bone marrow hematopoiesis and histopathology in rituximab-treated lymphoma patients with late-onset neutropenia. Leukemia 2008;22:1446–1449.
  • van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003;17:2257–2317.
  • Koskela HL, Eldfors S, Ellonen P, et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med 2012; 366:1905–1913.
  • Stalika E, Spanoudaki M, Darzentas N, et al. Skewing of the T cell receptor gene repertoire and public clonotypes in cytotoxic T cells of patients with chronic idiopathic neutropenia: a role for antigen selection in disease development. Blood 2012;120(Suppl. 1): Abstract 831.
  • Jerez A, Clemente MJ, Makishima H, et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood 2012;120: 3048–3057.
  • Yang J, Epling-Burnette PK, Painter JS, et al. Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia. Blood 2008;111:1610–1616.
  • Clemente MJ, Wlodarski MW, Makishima H, et al. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. Blood 2011;118:4384–4393.
  • Nann-Rutti S, Tzankov A, Cantoni N, et al. Large granular lymphocyte expansion after allogeneic hematopoietic stem cell transplant is associated with a cytomegalovirus reactivation and shows an indolent outcome. Biol Blood Marrow Transplant 2012; 18:1765–1770.
  • Papalexandri A, Stalika E, Iskas M, et al. Molecular evidence for repertoire skewing of T large granular lymphocyte proliferations after allogeneic hematopoietic stem cell transplantation: report of two cases. Bone Marrow Transplant 2013;48:1260–1261.
  • Raddassi K, Kent SC, Yang J, et al. Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J Immunol 2011;187:1039–1046.
  • Stalika E, Papalexandri A, Kannelis G, et al. Transient monoclonal CD3+ T large granular lymphocyte proliferation in a case of mantle cell lymphoma with rituximab-associated late onset neutropenia. Hematol Oncol 2011;29:144–146.
  • Stamatopoulos K, Economidou D, Papadaki T, et al. Large granular lymphocyte leukemia after renal transplantation: an immunologic, immunohistochemical, and genotypic study. Transplantation 2007; 83:102–103.
  • Lanasa MC, Allgood SD, Weinberg JB. Monoclonal B cell lymphocytosis. Leuk Lymphoma 2010;51:1386–1388.
  • Bashford-Rogers R, Palser A, Huntly B, et al. Network properties derived from deep sequencing of the human B-cell receptor repertoires delineates B-cell populations. Genome Res 2013;23:1874–1884.
  • Plevova K, Skuhrova Francova H, Burckova K, et al. Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones. Haematologica 2013;99:329–338.
  • Lefranc MP, Lefranc G. The T cell receptor factsbook. San Diego, CA: Academic Press; 2001.
  • Wlodarski MW, Nearman Z, Jankowska A, et al. Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia. J Leukoc Biol 2008;83:589–601.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.