Advanced search
Publication Cover
Leukemia & Lymphoma Volume 56, 2015 - Issue 9
Submit an article Journal homepage
226
Views
14
CrossRef citations to date
0
Altmetric
Original Articles: Clinical

Prognostic value of inhibitor of apoptosis protein family expression in patients with acute myeloid leukemia

Agnieszka PlutaDepartment of Hematology, Medical University of Lodz, Lodz, Poland
,
Agnieszka WierzbowskaDepartment of Hematology, Medical University of Lodz, Lodz, Poland
,
Barbara Cebula-ObrzutDepartment of Experimental Hematology, Medical University of Lodz, Lodz, Poland
,
Piotr PlutaDepartment of Surgical Oncology, Medical University of Lodz, Lodz, Poland
,
Konrad StępkaDepartment of Hematology, Medical University of Lodz, Lodz, Poland
,
Anna Szmigielska-KapłonDepartment of Hematology, Medical University of Lodz, Lodz, Poland
,
Olga Grzybowska-IzydorczykDepartment of Experimental Hematology, Medical University of Lodz, Lodz, Poland
,
Magdalena CzemerskaDepartment of Hematology, Medical University of Lodz, Lodz, Poland
,
Piotr SmolewskiDepartment of Experimental Hematology, Medical University of Lodz, Lodz, Poland
,
Agata Wrzesien-KusDepartment of Hematology, Medical University of Lodz, Lodz, Poland
&
Tadeusz RobakDepartment of Hematology, Medical University of Lodz, Lodz, PolandCorrespondence[email protected]
 show all
Pages 2529-2535 | Received 12 Jul 2014, Accepted 22 Dec 2014, Published online: 20 Feb 2015

References

  • Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9–29.
  • Robak T, Wierzbowska A. Current and emerging therapies for acute myeloid leukemia. Clin Ther 2009;31:2349–2370.
  • Haferlach T. Molecular genetics pathways as therapeutic targets in acute myeloid leukemia. Hematology Am Soc Hematol Educ Program 2008:400–411.
  • Zhivotovsky B, Orrenius S. Carcinogenesis and apoptosis: paradigms and paradoxes. Carcinogenesis 2006;27:1939–1945.
  • Zhivotovsky B, Orrenius S. Cell death mechanisms: cross-talk and role in disease. Exp Cell Res 2010;316:1374–1383.
  • Wrzesień-Kuś A, Smolewski P, Sobczak-Pluta A, et al. The inhibitor of apoptosis protein family and its antagonists in acute leukemias. Apoptosis 2004;9:705–715.
  • Smolewski P, Robak T. Inhibitors of apoptosis proteins (IAPs) as potential molecular targets for therapy of hematological malignancies. Curr Mol Med 2011;11:633–649.
  • Fulda S. Inhibitor of apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities. Leukemia 2014;28:1414–1422.
  • Tamm I, Kornblau SM, Segall H, et al. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res 2000;6:1796–1803.
  • Tamm I, Richter S, Oltersdorf D, et al. High expression levels of X-linked inhibitor of apoptosisprotein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. Clin Cancer Res 2004;10:3737–3744.
  • Tamm I, Richter S, Scholz F, et al. XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis. Hematol J 2004;5:489–495.
  • Carter BZ, Kornblau SM, Tsao T, et al. Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or survivin does not affect cell survival or prognosis. Blood 2003;102:4179–4186.
  • Carter BZ, Milella M, Altieri DC, et al. Cytokine-regulated expression of survivin in myeloid leukemia. Blood 2001;97:2784–2790.
  • Guenova ML, Balatzenko GN, Nikolova VR, et al. An anti-apoptotic pattern correlates with multidrug resistance in acute myeloid leukemia patients: a comparative study of active caspase-3, cleaved PARPs, Bcl-2, survivin and MDR1 gene. Hematology 2010; 15:135–143.
  • Pluta A, Wrzesien-Kus A, Cebula-Obrzut B, et al. Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients. Leuk Res 2010;34:1308–1313.
  • Weinberg OK, Seetharam M, Ren L, et al. Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system. Blood 2009; 113:1906–1908.
  • Holowiecki J, Grosicki S, Giebel S, et al. Cladribine, but not fludarabine, added to daunorubicin and cytarabine during induction prolongs survival of patients with acute myeloid leukemia: a multicenter, randomized phase III study. J Clin Oncol 2012:30:2441–2448.
  • Grzybowska-Izydorczyk O, Cebula B, Robak T, et al. Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia. Eur J Cancer 2010;46:800–810.
  • Sung KW, Choi J, Hwang YK, et al. Overexpression of X-linked inhibitor of apoptosis protein (XIAP) is an independent unfavorable prognostic factor in childhood de novo acute myeloid leukemia. J Korean Med Sci 2009;24:605–613.
  • Yamamoto H, Ngan Ch, Monden M, et al. Cancer cells survive with survivin. Cancer Science 2008;99:1709–1714.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.