Splenic marginal-zone lymphoma: ontogeny and genetics

References

• Defrance T, Casamayor-Palleja M, Krammer PH. The life and death of a B cell. Adv Cancer Res 2002;86:195–225.
   PubMed Web of Science ®Google Scholar
• Yuan JS, Kousis PC, Suliman S, et al. Functions of notch signaling in the immune system: consensus and controversies. Annu Rev Immunol 2010;28:343–365.
   PubMed Web of Science ®Google Scholar
• Swerdlow S, Campo E, Harris NL, et al., editors. WHO classification of tumors of haemopoietic and lymphoid tissues. Lyon, France: IARC Press; 2008.
   Google Scholar
• Kalpadakis C, Pangalis GA, Vassilakopoulos TP, et al. Treatment of splenic marginal zone lymphoma: should splenectomy be abandoned? Leuk Lymphoma 2013 Nov 6. [Epub ahead of print]
   Web of Science ®Google Scholar
• Sutton LA, Agathangelidis A, Belessi C, et al. Antigen selection in B-cell lymphomas--tracing the evidence. Semin Cancer Biol 2013; 23:399–409.
   PubMed Web of Science ®Google Scholar
• Stevenson FK, Sahota SS, Ottensmeier CH, et al. The occurrence and significance of V gene mutations in B cell-derived human malignancy. Adv Cancer Res 2001;83:81–116.
   PubMed Web of Science ®Google Scholar
• Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251–262.
   PubMed Web of Science ®Google Scholar
• Algara P, Mateo MS, Sanchez-Beato M, et al. Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course. Blood 2002;99:1299–1304.
   PubMed Web of Science ®Google Scholar
• Bahler DW, Pindzola JA, Swerdlow SH. Splenic marginal zone lymphomas appear to originate from different B cell types. Am J Pathol 2002;161:81–88.
   PubMed Web of Science ®Google Scholar
• Tierens A, Delabie J, Malecka A, et al. Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations. Am J Pathol 2003;162:681–689.
   PubMed Web of Science ®Google Scholar
• Papadaki T, Stamatopoulos K, Belessi C, et al. Splenic marginal-zone lymphoma: one or more entities? A histologic, immunohistochemical, and molecular study of 42 cases. Am J Surg Pathol 2007;31:438–446.
   PubMed Web of Science ®Google Scholar
• Stamatopoulos K, Belessi C, Papadaki T, et al. Immunoglobulin heavy- and light-chain repertoire in splenic marginal zone lymphoma. Mol Med 2004;10:89–95.
   PubMed Web of Science ®Google Scholar
• Hockley SL, Else M, Morilla A, et al. The prognostic impact of clinical and molecular features in hairy cell leukaemia variant and splenic marginal zone lymphoma. Br J Haematol 2012;158: 347–354.
   PubMed Web of Science ®Google Scholar
• Hockley SL, Giannouli S, Morilla A, et al. Insight into the molecular pathogenesis of hairy cell leukaemia, hairy cell leukaemia variant and splenic marginal zone lymphoma, provided by the analysis of their IGH rearrangements and somatic hypermutation patterns. Br J Haematol 2010;148:666–669.
   PubMed Web of Science ®Google Scholar
• Traverse-Glehen A, Davi F, Ben Simon E, et al. Analysis of VH genes in marginal zone lymphoma reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection. Haematologica 2005;90:470–478.
   PubMed Web of Science ®Google Scholar
• Arcaini L, Zibellini S, Passamonti F, et al. Splenic marginal zone lymphoma: Clinical clustering of immunoglobulin heavy chain repertoires. Blood Cells Mol Dis 2009;42:286–291.
   PubMed Web of Science ®Google Scholar
• Rinaldi A, Forconi F, Arcaini L, et al. Immunogenetics features and genomic lesions in splenic marginal zone lymphoma. Br J Haematol 2010;151:435–439.
   PubMed Web of Science ®Google Scholar
• Zibellini S, Capello D, Forconi F, et al. Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma. Haematologica 2010;95:1792–1796.
   PubMed Web of Science ®Google Scholar
• Bikos V, Darzentas N, Hadzidimitriou A, et al. Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications. Leukemia 2012;26:1638–1646.
   PubMed Web of Science ®Google Scholar
• Pommie C, Levadoux S, Sabatier R, et al. IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties. J Mol Recognit 2004;17:17–32.
   PubMedGoogle Scholar
• Silverman GJ, Goodyear CS. Confounding B-cell defences: lessons from a staphylococcal superantigen. Nat Rev Immunol 2006;6: 465–475.
   PubMed Web of Science ®Google Scholar
• Traverse-Glehen A, Baseggio L, Callet-Bauchu E, et al. Hairy cell leukaemia-variant and splenic red pulp lymphoma: a single entity? Br J Haematol 2010;150:113–116.
   PubMed Web of Science ®Google Scholar
• Lamminmaki U, Kankare JA. Crystal structure of a recombinant anti-estradiol Fab fragment in complex with 17beta -estradiol. J Biol Chem 2001;276:36687–36694.
   PubMed Web of Science ®Google Scholar
• Suzuki N, Harada T, Mihara S, et al. Characterization of a germline Vk gene encoding cationic anti-DNA antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus. J Clin Invest 1996;98:1843–1850.
   PubMed Web of Science ®Google Scholar
• Lee J, Cho YJ, Lipsky PE. The V(lambda)-J(lambda) repertoire of patients with systemic lupus erythematosus manifests characteristics of the natural antibody repertoire. Arthritis Rheum 2004;50:2604–2614.
   PubMed Web of Science ®Google Scholar
• McIntosh RS, Asghar MS, Watson PF, et al. Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection. J Immunol 1996;157:927–935.
   PubMed Web of Science ®Google Scholar
• Hadzidimitriou A, Darzentas N, Murray F, et al. Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia. Blood 2009;113:403–411.
   PubMed Web of Science ®Google Scholar
• Nemazee D. Receptor editing in lymphocyte development and central tolerance. Nat Rev Immunol 2006;6:728–740.
   PubMed Web of Science ®Google Scholar
• Bikos V, Stalika E, Baliakas P, et al. Selection of antigen receptors in splenic marginal-zone lymphoma: further support from the analysis of the immunoglobulin light-chain gene repertoire. Leukemia 2012;26:2567–2569.
   PubMed Web of Science ®Google Scholar
• Hadzidimitriou A, Agathangelidis A, Darzentas N, et al. Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases. Blood 2011;118:3088–3095.
   PubMed Web of Science ®Google Scholar
• Agathangelidis A, Darzentas N, Hadzidimitriou A, et al. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood 2012;119:4467–4475.
   PubMed Web of Science ®Google Scholar
• Darzentas N, Hadzidimitriou A, Murray F, et al. A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia 2009;24:125–132.
   PubMed Web of Science ®Google Scholar
• Murray F, Darzentas N, Hadzidimitriou A, et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 2008;111:1524–1533.
   PubMed Web of Science ®Google Scholar
• Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007;109:259–270.
   PubMed Web of Science ®Google Scholar
• Arcaini L, Paulli M, Boveri E, et al. Splenic and nodal marginal zone lymphomas are indolent disorders at high hepatitis C virus seroprevalence with distinct presenting features but similar morphologic and phenotypic profiles. Cancer 2004;100:107–115.
   PubMed Web of Science ®Google Scholar
• Vallisa D, Bernuzzi P, Arcaini L, et al. Role of anti-hepatitis C virus (HCV) treatment in HCV-related, low-grade, B-cell, non-Hodgkin's lymphoma: a multicenter Italian experience. J Clin Oncol 2005;23:468–473.
   PubMed Web of Science ®Google Scholar
• Mele A, Pulsoni A, Bianco E, et al. Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study. Blood 2003;102:996–999.
   PubMed Web of Science ®Google Scholar
• Warsame AA, Aasheim HC, Nustad K, et al. Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity. Blood 2011;118:3331–3339.
   PubMed Web of Science ®Google Scholar
• Sutton LA, Kostareli E, Hadzidimitriou A, et al. Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen. Blood 2009;114:4460–4468.
   PubMedGoogle Scholar
• Kostareli E, Sutton LA, Hadzidimitriou A, et al. Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution. Leukemia 2010;24:1317–1324.
   PubMedGoogle Scholar
• Sutton LA, Kostareli E, Stalika E, et al. Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence. Mol Med 2013;19:230–236.
   PubMed Web of Science ®Google Scholar
• Bikos V, Stalika E, Karypidou M, et al. Clonal selection in the ontogeny and evolution of splenic marginal zone lymphoma confirming the existence of distinct molecular subtypes. Blood 2012;120(Suppl. 1): Abstract 1556.
   Google Scholar
• Karypidou M, Stalika E, Bikos V, et al. Ongoing antigen interactions in splenic marginal zone lymphoma: revelations from the analysis of intraclonal diversification in immunoglobulin light chain genes. Blood 2013;122(Suppl. 1): Abstract 2999.
   Google Scholar
• Salido M, Baro C, Oscier D, et al. Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group. Blood 2010;116:1479–1488.
   PubMed Web of Science ®Google Scholar
• Fresquet V, Robles EF, Parker A, et al. High-throughput sequencing analysis of the chromosome 7q32 deletion reveals IRF5 as a potential tumour suppressor in splenic marginal-zone lymphoma. Br J Haematol 2012;158:712–726.
   PubMed Web of Science ®Google Scholar
• Rossi D, Trifonov V, Fangazio M, et al. The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med 2012;209:1537–1551.
   PubMed Web of Science ®Google Scholar
• Novara F, Arcaini L, Merli M, et al. High-resolution genome-wide array comparative genomic hybridization in splenic marginal zone B-cell lymphoma. Hum Pathol 2009;40:1628–1637.
   PubMed Web of Science ®Google Scholar
• Watkins AJ, Huang Y, Ye H, et al. Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis. J Pathol 2010;220:461–474.
   PubMed Web of Science ®Google Scholar
• Rinaldi A, Mian M, Chigrinova E, et al. Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome. Blood 2011;117:1595–1604.
   PubMed Web of Science ®Google Scholar
• Watkins AJ, Hamoudi RA, Zeng N, et al. An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma. PLoS One 2012;7:e44997.
   PubMed Web of Science ®Google Scholar
• Corcoran MM, Mould SJ, Orchard JA, et al. Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations. Oncogene 1999; 18:6271–6277.
   PubMed Web of Science ®Google Scholar
• Robles EF, Aldaz B, Akasaka T, et al. Homeobox NKX2-3 is over-expressed in human B-cell lymphomas and drives marginal zone B-cell lymphomagenesis in mice. Blood 2001;118(Suppl. 1): Abstract 260.
   Google Scholar
• Gruszka-Westwood AM, Hamoudi RA, Matutes E, et al. p53 abnormalities in splenic lymphoma with villous lymphocytes. Blood 2001;97:3552–3558.
   PubMed Web of Science ®Google Scholar
• Rossi D, Deaglio S, Dominguez-Sola D, et al. Alteration of BIRC3 and multiple other NF-kappaB pathway genes in splenic marginal zone lymphoma. Blood 2011;118:4930–4934.
   PubMed Web of Science ®Google Scholar
• Yan Q, Huang Y, Watkins AJ, et al. BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas. Haematologica 2012;97:595–598.
   PubMed Web of Science ®Google Scholar
• Kiel MJ, Velusamy T, Betz BL, et al. Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma. J Exp Med 2012;209:1553–1565.
   PubMed Web of Science ®Google Scholar
• Martinez N, Almaraz C, Vaque JP, et al. Whole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation. Leukemia 2013 Dec 3. [Epub ahead of print]
   Web of Science ®Google Scholar
• Parry M, Rose-Zerilli MJ, Gibson J, et al. Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma. PLoS One 2013;8:e83244.
   PubMed Web of Science ®Google Scholar
• Waterfall JJ, Arons E, Walker RL, et al. High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nat Genet 2014;46:8–10.
   PubMed Web of Science ®Google Scholar
• Varettoni M, Arcaini L, Zibellini S, et al. Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms. Blood 2013; 121:2522–2528.
   PubMed Web of Science ®Google Scholar
• Arcaini L, Lazzarino M, Colombo N, et al. Splenic marginal zone lymphoma: a prognostic model for clinical use. Blood 2006; 107:4643–4649.
   PubMed Web of Science ®Google Scholar
• Montalban C, Abraira V, Arcaini L, et al. Risk stratification for splenic marginal zone lymphoma based on haemoglobin concentration, platelet count, high lactate dehydrogenase level and extrahilar lymphadenopathy: development and validation on 593 cases. Br J Haematol 2012;159:164–171.
   PubMed Web of Science ®Google Scholar
• Montalban C Abraira V, Arcaini L, et al. Simplification of risk stratification for splenic marginal zone lymphoma: a point-based score for practical use. Leuk Lymphoma 2014;55:929–931.
   PubMed Web of Science ®Google Scholar
• Algrin C, Brisou G, Beldjord K, et al. Prognostic impact of somatic NOTCH2 mutation in splenic marginal zone lymphoma. Blood 2013;122(Suppl. 1): Abstract 4247.
   Google Scholar
• Krzywinski M, Schein J, Birol I, et al. Circos: an information aesthetic for comparative genomics. Genome Res 2009;19:1639–1645.
   PubMed Web of Science ®Google Scholar
• Goujon M, McWilliam H, Li W, et al. A new bioinformatics analysis tools framework at EMBL-EBI. Nucleic Acids Res 2010; 38:W695–W699.
   PubMed Web of Science ®Google Scholar
• Larkin MA, Blackshields G, Brown NP, et al. Clustal W and Clustal X version 2.0. Bioinformatics (Oxford, England) 2007;23:2947–2948.
   PubMed Web of Science ®Google Scholar
• Crooks GE, Hon G, Chandonia JM, et al. WebLogo: a sequence logo generator. Genome Res 2004;14:1188–1190.
   PubMed Web of Science ®Google Scholar