References
- Kaatsch P. Epidemiology of childhood cancer. Cancer Treat Rev 2010;36:277–285.
- Barry EV, Silverman LB. Acute lymphoblastic leukemia in adolescents and young adults. Curr Hematol Malig Rep 2008;3:161–166.
- Belson M, Kingsley B, Holmes A. Risk factors for acute leukemia in children: a review. Environ Health Perspect 2007;115:138–145.
- Yan J, Yin M, Dreyer ZE, et al. meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children. Pediatr Blood Cancer 2012;58:513–518.
- Goyette P, Sumner JS, Milos R, et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet 1994;7:195–200.
- Yamada K, Chen Z, Rozen R, et al. Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc Natl Acad Sci USA 2001;98:14853–14858.
- Alcasabas P, Ravindranath Y, Goyette G, et al. 5,10-Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children. Pediatr Blood Cancer 2008;51:178–182.
- Franco RF, Simoes BP, Tone LG, et al. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol 2001;115:616–618.
- Damnjanovic T, Milicevic R, Novkovic T, et al. Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children. J Pediatr Hematol Oncol 2010;32:e148–e150.
- Chan JY, Ugrasena DG, Lum DW, et al. Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children. Hematol Oncol 2011;29:116–123.
- Kamel AM, Moussa HS, Ebid GT, et al. Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia. J Egypt Natl Cancer Inst 2007;19:96–105.
- Koppen IJ, Hermans FJ, Kaspers GJ. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol 2009;148:3–14.
- Pereira TV, Rudnicki M, Pereira AC, et al. 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2006;15:1956–1963.
- Wang J, Zhan P, Chen B, et al. MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis. Leuk Res 2010;34:1596–1600.
- Zintzaras E, Koufakis T, Ziakas PD, et al. A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol 2006;21:501–510.
- Vahid P, Farnaz R, Zaker F, et al. Methylene tetrahydro folate reductase gene polymorphisms and risk of myeloid leukemia. Lab Med 2010;41:490–494.
- Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263–265.
- Amigo J, Salas A, Phillips C, et al. SPSmart: adapting population based SNP genotype databases for fast and comprehensive web access. BMC Bioinformatics 2008;9:428.
- Krajinovic M, Lamothe S, Labuda D, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004;103:252–257.
- Chiusolo P, Reddiconto G, Cimino G, et al. Methylenetetrahydofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population. Hematologica 2004;89: 139–144.
- Gemmati D, Ongaro A, Scapoli GL, et al. Common gene polymorphism in temetabolic folate and Methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkins lymphoma in adults. Cancer Epidemiol Biomarker Prev 2004;13:787–794.
- Schnakenberg E, Mehles A, Cario G, et al. Polymorphism of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population. BMC Med Genet 2005;6:23.
- Matsuo K, Suzuki R, Hamajima N, et al. Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood 2001;97: 3205–3209.
- Wiemels JL, Smith RN, Taylor GM, et al. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA 2001;98:4004–4009.
- Franco RF, Simões BP, Tone LG, et al. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol 2001;115: 616–618.
- Kim NK, Chong SY, Jang MJU, et al. Association of the Methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia. AntiCancer Res 2006;26:2879–2882.
- Li X, Liao Q, Zhang S, et al. Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population. Eur J Med Res 2014;19:5.
- Conter V, Bartram CR, Valsecchi MG, et al. Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. Blood 2010;115: 3206–3214.
- Nicoloso MS, Sun H, Spizzo R, et al. Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res 2010;70:2789–2798.
- Khorshied MM, Shaheen IA, Abu Khalil RE, et al. Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in chronic myeloid leukemia: an Egyptian study. Med Oncol 2014;31:794.
- Schwahn B, Rozen R. Polymorphisms in the methylenetetrahydrofolate reductase gene:clinical consequences. Am J Pharmacogenomics 2001;1:189–201.
- Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111–113.
- Murphy TM, Perry AS, Lawler M. The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer. Endocr Relat Cancer 2008;15:11–25.
- Oh D, Kim NK, Jang MJ, et al. Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia. Anticancer Res 2007;27:3419–3424.
- Guenther BD, Sheppard CA, Tran P, et al. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat Struct Biol 1999;6:359–365.
- Robien K, Ulrich CM. 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview. Am J Epidemiol 2003;157:571–582.
- Qin YT, Zhang Y, Wu F, et al. Association between MTHFR polymorphisms and acute myeloid leukemia risk: a meta-analysis. PLoS One 2014;9:e88823.
- Koppen IJ, Hermans FJ, Kaspers GJ. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol 2010;148:3–14.
- Wang H, Wang J, Zhao L, et al. Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-analysis including 35 studies. BMC Med Genet 2012;13:77.
- Zintzaras E, Doxani C, Rodopoulou P, et al. Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: a synthesis of genetic association studies. Cancer Epidemiol 2012;36:169–176.
- Lucotte G, Mercier G. Brief communication: Y-chromosome haplotypes in Egypt. Am J Phys Anthropol 2003;121: 63–66.
- Manni F, Leonardi P, Barakat A, et al. Y-chromosome analysis in Egypt suggests a genetic regional continuity in Northeastern Africa. Hum Biol 2002;74:645–658.
- Mosaad YM, Fathy H, Fawzy Z, et al. Tumor necrosis factor-α -308 G> A and interleukin-6 -174 G> C promoter polymorphisms and pemphigus. Hum Immunol 2012;73:560–565.