Role of leptin and leptin receptors in hematological malignancies

References

• Friedman JM. Leptin and the regulation of body weigh. Keio J Med 2011;60:1–9.
   PubMedGoogle Scholar
• Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 2006;3937–20.
   Google Scholar
• Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–32.
   PubMed Web of Science ®Google Scholar
• Uddin S, Bavi P, Siraj AK, et al. Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma. Endocr Relat Cance. 2010;17:191–202.
   PubMed Web of Science ®Google Scholar
• Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000;62:413–37.
   PubMed Web of Science ®Google Scholar
• Skoczen S, Tomasik PJ, Bik-Multanowski M, et al. Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia. J Exp Clin Cancer Res 2011;30:64.
   PubMed Web of Science ®Google Scholar
• Tsiotra PC, Pappa V, Koukourava A, et al. Expression of leptin receptors in mononuclear cells from myelodysplastic syndromes and acute myeloid leukemias. Acta Haematol 2005;114:71–7.
   PubMed Web of Science ®Google Scholar
• Uddin S, Hussain AR, Siraj AK, et al. Role of leptin and its receptors in the pathogenesis of thyroid cancer. Int J Clin Exp Pathol 2011;4: 637–43.
   PubMed Web of Science ®Google Scholar
• Liu L, Zhong R, Wei S, et al. The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer. PLoS One 2013;8:e60777.
   PubMed Web of Science ®Google Scholar
• Chen C, Chang YC, Lan MS, et al. Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways. Int J Oncol 2013;42:1113–9.
   PubMed Web of Science ®Google Scholar
• Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263–71.
   PubMed Web of Science ®Google Scholar
• Ceddia RB, Koistinen HA, Zierath JR, et al. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J 2002;16:1163–76.
   PubMed Web of Science ®Google Scholar
• Chua SC, Jr., White DW, Wu-Peng XS, et al. Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 1996;45:1141–3.
   PubMed Web of Science ®Google Scholar
• Lin J, Barb CR, Matteri RL, et al. Long form leptin receptor mRNA expression in the brain, pituitary, and other tissues in the pig. Domest Anim Endocrinol 2000;19:53–61.
   PubMed Web of Science ®Google Scholar
• Caprio M, Fabbrini E, Isidori AM, et al. Leptin in reproduction. Trends Endocrinol Metab 2001;12:65–72.
   PubMed Web of Science ®Google Scholar
• Tartaglia LA. The leptin receptor. J Biol Chem 1997;272:6093–6.
   PubMed Web of Science ®Google Scholar
• Myers MG, Jr. Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res 2004;59:287–304.
   PubMedGoogle Scholar
• Kloek C, Haq AK, Dunn SL, et al. Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem 2002;277: 41547–55.
   PubMed Web of Science ®Google Scholar
• Devos R, Guisez Y, Van der Heyden J, et al. Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J Biol Che. 1997;272:18304–10.
   Google Scholar
• Ghilardi N, Ziegler S, Wiestner A, et al. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A 1996;93:6231–5.
   PubMed Web of Science ®Google Scholar
• Eisenberg A, Biener E, Charlier M, et al. Transactivation of erbB2 by short and long isoforms of leptin receptors. FEBS Lett 2004;565: 139–42.
   PubMed Web of Science ®Google Scholar
• Bjorbaek C, Uotani S, da Silva B, et al. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997;272:32686–95.
   PubMed Web of Science ®Google Scholar
• Bahrenberg G, Behrmann I, Barthel A, et al. Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Mol Endocrinol 2002;16:859–72.
   PubMed Web of Science ®Google Scholar
• Uddin S, Hussain AR, Khan OS, et al. Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis. Tumour Biol 2014;35:871–9.
   PubMed Web of Science ®Google Scholar
• Truksa J, Lee P, Beutler E. The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters. Blood Cells Mol Dis 2007;39:255–62.
   PubMed Web of Science ®Google Scholar
• Hebenstreit D, Horejs-Hoeck J, Duschl A. JAK/STAT- dependent gene regulation by cytokines. Drug News Perspect 2005; 18:243–9.
   PubMed Web of Science ®Google Scholar
• Zhang J, Scarpace PJ. The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo. Br J Pharmacol 2009;158:475–82.
   PubMed Web of Science ®Google Scholar
• Gao J, Tian J, Lv Y, Shi F, et al. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. Cancer Sci 2009;100: 389–95.
   PubMed Web of Science ®Google Scholar
• Ling Y, Maile LA, Badley-Clarke J, et al. DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. J Biol Chem 2005;280:3151–8.
   PubMed Web of Science ®Google Scholar
• Knobelspies H, Zeidler J, Hekerman P, et al. Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochem 2010;11:2.
   PubMed Web of Science ®Google Scholar
• Dunn SL, Bjornholm M, Bates SH, et al. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol 2005;19:925–38.
   PubMed Web of Science ®Google Scholar
• Jiang L, Li Z, Rui L. Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways. J Biol Chem 2008;283: 28066–73.
   PubMed Web of Science ®Google Scholar
• Banks AS, Davis SM, Bates SH, et al. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000;275:14563–72.
   PubMed Web of Science ®Google Scholar
• Bates SH, Stearns WH, Dundon TA, et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003;421:856–9.
   PubMed Web of Science ®Google Scholar
• da Silva BA, Bjorbaek C, Uotani S, et al. Functional properties of leptin receptor isoforms containing the gln--> pro extracellular domain mutation of the fatty rat. Endocrinology 1998;139:3681–90.
   PubMed Web of Science ®Google Scholar
• Uddin S, Bu R, Ahmed M, et al. Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer. Mol Cancer 2009;8:74.
   PubMed Web of Science ®Google Scholar
• Lin S, YuJun L, XiaoMing X, et al. Expression and significance of leptin receptor, p-STAT3 and p-AKT in diffuse large B-cell lymphoma. Acta Histochem 2014;116:126–30.
   PubMed Web of Science ®Google Scholar
• Li Z, Shen J, Wu WK, et al. Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways. PLoS One 2012;7:e53176.
   PubMed Web of Science ®Google Scholar
• Tong KM, Shieh DC, Chen CP, et al. Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts. Cell Signal 2008;20:1478–88.
   PubMed Web of Science ®Google Scholar
• Carpenter CL, Duckworth BC, Auger KR, et al. Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem 1990;265:19704–11.
   PubMed Web of Science ®Google Scholar
• Chen HC, Guan JL. Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 1994;91:10148–52.
   PubMed Web of Science ®Google Scholar
• Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655–7.
   PubMed Web of Science ®Google Scholar
• Jiang BH, Aoki M, Zheng JZ, et al. Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B. Proc Natl Acad Sci U S A 1999;96:2077–81.
   PubMed Web of Science ®Google Scholar
• Franke TF, Hornik CP, Segev L, et al. PI3K/Akt and apoptosis: size matters. Oncogene 2003;22:8983–98.
   PubMed Web of Science ®Google Scholar
• Matsuzawa A, Ichijo H. Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid Redox Signal 2005;7:472–81.
   PubMed Web of Science ®Google Scholar
• Anderson KE, Jackson SP. Class I phosphoinositide 3-kinases. Int J Biochem Cell Biol 2003;35:1028–33.
   PubMed Web of Science ®Google Scholar
• Wang D, Chen J, Chen H, et al. Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway. J Biosci 2012;37:91–101.
   PubMed Web of Science ®Google Scholar
• Beauchamp EM, Platanias LC. The evolution of the TOR pathway and its role in cancer. Oncogene 2013;32:3923–32.
   PubMed Web of Science ®Google Scholar
• Nam HY, Han MW, Chang HW, et al. Radioresistant cancer cells can be conditioned to enter senescence by mTOR inhibition. Cancer Res 2013;73:4267–77.
   PubMed Web of Science ®Google Scholar
• Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013;493:338–45.
   PubMed Web of Science ®Google Scholar
• Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011;12:21–35.
   PubMed Web of Science ®Google Scholar
• Zhang H, Berel D, Wang Y, et al. A comparison of Ku0063794, a dual mTORC1 and mTORC2 inhibitor, and temsirolimus in preclinical renal cell carcinoma models. PLoS One 2013;8:e54918.
   PubMed Web of Science ®Google Scholar
• Wolin EM. PI3K/Akt/mTOR pathway inhibitors in the therapy of pancreatic neuroendocrine tumors. Cancer Lett 2013;335:1–8.
   PubMed Web of Science ®Google Scholar
• Uddin S, Hussain AR, Siraj AK, et al. Role of phosphatidylinositol 3’-kinase/AKT pathway in diffuse large B-cell lymphoma survival. Blood 2006;108:4178–86.
   PubMed Web of Science ®Google Scholar
• Hussain AR, Ahmed SO, Ahmed M, et al. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS One 2012;7:e39945.
   PubMed Web of Science ®Google Scholar
• Uddin S, Ahmed M, Hussain A, et al. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. Int J Cancer 2010;126:382–94.
   PubMed Web of Science ®Google Scholar
• Cota D, Proulx K, Smith KA, et al. Hypothalamic mTOR signaling regulates food intake. Science. 2006;312:927–30.
   PubMed Web of Science ®Google Scholar
• Woods SC, Seeley RJ, Cota D. Regulation of food intake through hypothalamic signaling networks involving mTOR. Annu Rev Nutr 2008;28:295–311.
   PubMed Web of Science ®Google Scholar
• Kim JY, Park HK, Yoon JS, et al. Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin. Oncol Rep 2010;23:1369–74.
   PubMed Web of Science ®Google Scholar
• Gorska E, Popko K, Wasik M. Leptin receptor in childhood acute leukemias. Adv Exp Med Biol 2013;756:155–61.
   PubMed Web of Science ®Google Scholar
• Konopleva M, Mikhail A, Estrov Z, et al. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 1999;93:1668–76.
   PubMed Web of Science ®Google Scholar
• Mouzaki A, Panagoulias I, Dervilli Z, et al. Expression patterns of leptin receptor (OB-R) isoforms and direct in vitro effects of recombinant leptin on OB-R, leptin expression and cytokine secretion by human hematopoietic malignant cells. Cytokine 2009;48:203–11.
   PubMed Web of Science ®Google Scholar
• Bansal P, Ghalaut VS, Sharma TK, et al. Status of leptin in MBCR-ABL p210 positive chronic myeloid leukemia patients before and after imatinib therapy: a conflicting scenario. Clin Lab 2014;60:1845–52.
   PubMed Web of Science ®Google Scholar
• Ozturk K, Avcu F, Ural AU. Aberrant expressions of leptin and adiponectin receptor isoforms in chronic myeloid leukemia patients. Cytokine 2012;57:61–7.
   PubMed Web of Science ®Google Scholar
• Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006;354:166–78.
   PubMed Web of Science ®Google Scholar
• Aref S, Ibrahim L, Azmy E, et al. Impact of serum adiponectin and leptin levels in acute leukemia. Hematology 2013;18:198–203.
   PubMed Web of Science ®Google Scholar
• Pamuk GE, Demir M, Harmandar F, et al. Leptin and resistin levels in serum of patients with hematologic malignancies: correlation with clinical characteristics. Exp Oncol 2006;28:241–4.
   PubMedGoogle Scholar
• Dalamaga M, Crotty BH, Fargnoli J, et al. B-cell chronic lymphocytic leukemia risk in association with serum leptin and adiponectin: a case-control study in Greece. Cancer Causes Control 2010;21:1451–9.
   PubMed Web of Science ®Google Scholar
• Saxena NK, Sharma D, Ding X, et al. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res 2007;67:2497–507.
   PubMed Web of Science ®Google Scholar
• Hoda MR, Keely SJ, Bertelsen LS, et al. Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells. Br J Surg 2007;94:346–54.
   PubMed Web of Science ®Google Scholar
• Chen C, Chang YC, Liu CL, et al. Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1. Breast Cancer Res Treat 2006;98:121–32.
   PubMed Web of Science ®Google Scholar
• Ogunwobi O, Mutungi G, Beales IL. Leptin stimulates proliferation and inhibits apoptosis in Barrett’s esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activation. Endocrinology 2006;147:4505–16.
   PubMed Web of Science ®Google Scholar
• Sharma D, Saxena NK, Vertino PM, et al. Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways. Endocr Relat Cancer 2006;13:629–40.
   PubMed Web of Science ®Google Scholar
• Uddin S, Bu R, Ahmed M, et al. Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma. Leuk Lymphoma 2010;51:1305–14.
   PubMed Web of Science ®Google Scholar
• Hallek M, Bergsagel PL, Anderson KC. Multiple myeloma: increasing evidence for a multistep transformation process. Blood 1998;91:3–21.
   PubMed Web of Science ®Google Scholar
• Hofmann JN, Liao LM, Pollak MN, et al. A prospective study of circulating adipokine levels and risk of multiple myeloma. Blood 2012;120:4418–20.
   PubMed Web of Science ®Google Scholar
• Reseland JE, Reppe S, Olstad OK, et al. Abnormal adipokine levels and leptin-induced changes in gene expression profiles in multiple myeloma. Eur J Haematol 2009;83:460–70.
   PubMed Web of Science ®Google Scholar
• Holly EA, Lele C, Bracci PM, et al. Case-control study of non-Hodgkin’s lymphoma among women and heterosexual men in the San Francisco Bay Area, California. Am J Epidemiol 1999;150: 375–89.
   PubMed Web of Science ®Google Scholar
• Calle EE, Rodriguez C, Walker-Thurmond K, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625–38.
   PubMed Web of Science ®Google Scholar
• Bahl S, Cotterchio M, Kreiger N, et al. Antidepressant medication use and non-Hodgkin’s lymphoma risk: no association. Am J Epidemiol 2004;160:566–75.
   PubMed Web of Science ®Google Scholar
• Pan SY, Johnson KC, Ugnat AM, et al; Canadian Cancer Registries Epidemiology Research G. Association of obesity and cancer risk in Canada. Am J Epidemiol 2004;159:259–68.
   PubMed Web of Science ®Google Scholar
• Lichtman MA. Obesity and the risk for a hematological malignancy: leukemia, lymphoma, or myeloma. Oncologist 2010; 15:1083–101.
   PubMed Web of Science ®Google Scholar
• Soderberg KC, Kaprio J, Verkasalo PK, et al. Overweight, obesity and risk of haematological malignancies: a cohort study of Swedish and Finnish twins. Eur J Cancer 2009;45:1232–8.
   PubMed Web of Science ®Google Scholar
• Engeland A, Tretli S, Hansen S, et al. Height and body mass index and risk of lymphohematopoietic malignancies in two million Norwegian men and women. Am J Epidemiol 2007;165:44–52.
   PubMed Web of Science ®Google Scholar
• MacInnis RJ, English DR, Hopper JL, et al. Body size and composition and the risk of lymphohematopoietic malignancies. J Natl Cancer Inst 2005;97:1154–7.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Wolk A. Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies. Int J Cancer 2008; 122:1418–21.
   PubMed Web of Science ®Google Scholar
• Kasim K, Levallois P, Abdous B, et al. Lifestyle factors and the risk of adult leukemia in Canada. Cancer Causes Control 2005;16: 489–500.
   PubMed Web of Science ®Google Scholar
• Strom SS, Yamamura Y, Kantarijian HM, et al. Obesity, weight gain, and risk of chronic myeloid leukemia. Cancer Epidemiol Biomarkers Prev 2009;18:1501–6.
   PubMed Web of Science ®Google Scholar
• Tritos NA, Mantzoros CS. Leptin: its role in obesity and beyond. Diabetologia. 1997;40:1371–9.
   PubMed Web of Science ®Google Scholar
• Mattevi VS, Zembrzuski VM, Hutz MH. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord 2002;26:1179–85.
   PubMed Web of Science ®Google Scholar
• Mammes O, Betoulle D, Aubert R, et al. Association of the G-2548A polymorphism in the 5’ region of the LEP gene with overweight. Ann Hum Genet 2000;64:391–4.
   PubMed Web of Science ®Google Scholar
• Hager J, Clement K, Francke S, et al. A polymorphism in the 5’ untranslated region of the human ob gene is associated with low leptin levels. Int J Obes Relat Metab Disord 1998;22:200–5.
   PubMed Web of Science ®Google Scholar
• Lamas O, Marti A, Martinez JA. Obesity and immunocompetence. Eur J Clin Nutr 2002;56(Suppl. 3):S42–5.
   PubMedGoogle Scholar
• Gotoda T, Manning BS, Goldstone AP, et al. Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum Mol Genet 1997;6:869–76.
   PubMed Web of Science ®Google Scholar
• Skibola CF, Holly EA, Forrest MS, et al. Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 2004;13:779–86.
   PubMed Web of Science ®Google Scholar
• Willett EV, Skibola CF, Adamson P, et al. Non-Hodgkin’s lymphoma, obesity and energy homeostasis polymorphisms. Br J Cancer 2005;93:811–6.
   PubMed Web of Science ®Google Scholar
• Vasku V, Vasku A, Vasku JB. Pharmacogenetic contribution of leptin gene polymorphism in cutaneous T-cell lymphoma. Int J Clin Exp Pathol 2009;2:163–8.
   PubMed Web of Science ®Google Scholar