Advanced search
Publication Cover
Leukemia & Lymphoma Volume 57, 2016 - Issue 3
Submit an article Journal homepage
959
Views
10
CrossRef citations to date
0
Altmetric
Letters to the Editor

Diffuse large B-cell lymphoma cell-of-origin classification using the Lymph2Cx assay in the context of BCL2 and MYC expression status

Samantha KendrickDepartment of Pathology, University of Arizona, Tucson, AZ, USA,
,
Katalin TusDepartment of Pathology, University of Arizona, Tucson, AZ, USA,
,
George WrightNational Cancer Institute, Bethesda, MD, USA,
,
Elaine S. JaffeLaboratory of Pathology, National Cancer Institute, Bethesda, MD, USA,
,
Andreas RosenwaldInstitute of Pathology, University of Wuerzburg, and Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany,
,
Elías CampoDepartment of Pathology, Hospital Clínic, Barcelona, Spain,
,
Wing Chung ChanDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USA,
,
Joseph M. ConnorsCentre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada,
,
Rita M. BrazielDepartment of Clinical Pathology, Oregon Health & Science University, Portland, OR, USA,
,
German OttDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany,
,
Jan DelabieDepartment of Pathology, Oslo University Hospital, Radiumhospitalet, Oslo, Norway,
,
James R. CookDepartment of Molecular Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA,
,
Dennis D. WeisenburgerDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USA,
,
Timothy C. GreinerDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA,
,
Kai FuDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA,
,
Louis M. StaudtMetabolism Branch, Center for Cancer Research, National Cancer Institute, National Health Institutes, Bethesda, MD, USA, and
,
Randy D. GascoyneCentre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada, ;Department of Pathology, British Columbia Cancer Agency, Vancouver, BC, Canada
,
David W. ScottCentre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada,
&
Lisa M. RimszaDepartment of Pathology, University of Arizona, Tucson, AZ, USA, Correspondence[email protected]
 show all
Pages 717-720 | Received 13 Apr 2015, Accepted 10 Jul 2015, Published online: 05 Oct 2015

References

  • Alizadeh AA, Eisen MB, Davis E, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503–511.
  • Scott DW, Wright GW, Williams PM, et al. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed parraffin-embedded tissue. Blood 2014; 123: 1214–1217.
  • Johnson NA, Slack GW, Savage KJ, et al. Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol 2012; 30: 3452–3459.
  • Perry AM, Alvarado-Bernal Y, Laurini JA, et al. MYC and BCL2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with rituximab. Br J Haematol 2014; 165: 382–391.
  • Green TM, Young KH, Visco C, et al. Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol 2012; 30: 3460–3467.
  • Horn H, Ziepert M, Becher C, et al. MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood 2013; 121: 2253–2263.
  • Hu S, Xu-Monette ZY, Tzankov A, et al. MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from the International DLBCL Rituximab-CHOP Consortium Program. Blood 2013; 121: 4021–4031.
  • Wilson WH, Gerecitano JF, Goy A, et al. The Bruton’s Tyrosine Kinase (BTK) inhibitor, Ibrutinib (PCI-32765) has preferential activity in the ABC subtype of relapsed/refractory de novo diffuse large B-cell Lymphoma (DLBCL): interim results of a multicenter, open-label, phase II study. Blood 2012; 120: 686.
  • Zaman S, Wang R, Gandhi V. Targeting the apoptosis pathway in hematologic malignancies. Leuk Lymphoma 2014; 55: 1980–1992.
  • Delmore JE, Issa GC, Lemieux, ME. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011; 146: 904–917.
  • Brown RV, Gokhale V, Hurley LH, Brooks TA. Demonstration that drug-targeted downregulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J Biol Chem 2011; 286: 41018–41027.
  • Lenz G, Wright G, Dave SS, et al. Stromal gene signatures in large-B-cell lymphomas. New Eng J Med 2008; 359: 2313–2323.
  • Kendrick SL, Redd L, Muranyi A, et al. BCL2 antibodies targeted at different epitopes detect varying levels of protein expression and correlate with frequent gene amplification in diffuse large B-cell lymphoma. Human Pathol 2014; 45: 2144–2153.
  • Cheson BD, Pfistner B, Juweid ME, et al. Revised response criteria for malignant lymphoma. J Clin Oncol 2007; 25: 579–586.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.