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Original Article

Ras Protooncogene Activation in Acute Myeloid Leukemia and Related Disorders

Pages 85-91 | Received 03 Nov 1990, Accepted 11 Mar 1991, Published online: 01 Jul 2009

References

  • Barbacid M. ras genes. Ann Rev Bioch 1987; 56: 779–827
  • Bos J. L. The ras gene family in human carcinogenesis. Mutat Res 1988; 195: 255–271
  • Needleman S. W. Retroviral and cellular oncogenes, Ch. 8 in Comprehensive Textbook of Oncology, A. R. Moosa, S. C. Schimpff. Williams and Wilkins, Baltimore 1989
  • Yuasa Y., Eva A., Kraus M. H., Srivastava S., Needleman S. W., Pierce J. H., Rhim J. S., Reddy E. P., Tronick S. R., Aaronson S. A. Ras-related oncogenes of human tumors. Cancer Cell: Oncogenes and Viral Genes, G. Vandewoude. Cold Spring Harbor Monographs, New York 1984; 439, 433
  • Weinberg R. A. Ras oncogenes and the molecular mechanisms of carcinogenesis. Blood. 1984; 1143–1145
  • Der C. J., Krontiris T. G., Cooper G. M. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci USA 1982; 79: 3637
  • Parada L. F., Tabin C. J., Shih C., Weinberg R. A. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 1982; 297: 474–478
  • Reddy E. P., Reynolds R. K., Santos E., Barbacid M. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature 1982; 300: 149–153
  • Tabin C. J., Bradley S. M., Bargmann C. I., Weinberg R. A., Papageorge A. G., Scolnick E. M., Dhar R., Lowy D. R., Chang E. H. Mechanisms of activation of a human oncogene. Nature 1982; 300: 143–147; 2
  • Taparowsky E., Suard Y., Fasano O., Shimizu K., Goldfarb M., Wigler M. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature 1983; 300: 762–766
  • Chang E. H., Furth M. E., Scolnick E. M., Lony D. R. Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey Murine sarcoma virus. Nature 1982; 297: 479–483
  • Wigler M. The role of ras in oncogenesis. Adv. Onc 1986; 2: 1–7
  • Shimizu K., Goldfarb M., Perucho M., Wigler M. Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci USA 1986; 80: 383–387
  • Shimizu K., Birnbaum D., Ruley M. A., Fasano O., Suard Y., Edlund L., Taparowsky E., Goldfarb M., Wigler M. Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature 1983; 304: 450–497
  • Konkel D. A. What do ras oncogenes do?. Mol Endoc 1988; 2: 883–885
  • Gilman A. G. G proteins and dual control of adenylate. Cell 1984; 36: 577–579
  • Wakelam M. J. O., Davies S. A., Houslay M. D., McKay I., Marshall C. J., Hall A. Normal p21N-res couples bombesin and other growth factor receptors to inositol phosphate production. Nature 1986; 323: 173–176
  • Wolfman A., Macara I. G. Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts. Nature 1987; 325: 359–361
  • Wakelam M. J. O. Inhibition of amplified bombesin-stimulated inositol phosphate response in N-ras transformed cells by high density culturing. Feb 1988; 228: 182–186
  • McGrath J. P., Capon D. J., Goeddel D. V., Levinson A. D. Comparative biochemical properties of normal and activated human ras p21 protein. Nature 1984; 310: 643–649
  • Sweet R. W., Yokoyama S., Kamata T., Feramisco J. R., Rosenberg M., Gross M. Nature 1984; 311: 273–275
  • Gibbs J. B., Schaber M. D., Allard W. J., Sigal I. S., Scolnick E. M. Purification of ras GTPase activating protein from bovine brain. Proc Natl Acad Sci 1988; 85: 5026–5030
  • Vogel U. S., Dixon R. A. F., Schaber M. D., Diehl R. E., Marshall M. S., Scolnick E. M., Sigal I. S., Gibbs J. B. Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature 1988; 335: 90–93
  • McCormick F. ras GTPase activating protein: signal transmitter and signal terminator. Cell 1989; 56: 5–8
  • Pulciani S., Santos E., Lauver A. V., Long L. K., Aaronson S. A., Barbacid M. Oncogenes in solid human tumors. Nature 1982; 300: 539–542
  • Fujita J., Yoshida O., Yuasa Y., Rhim J. S., Hatanaka M., Aaronson S. A. Ha-ras oncogenes are activated by somatic alterations in human urinary tract tumors. Nature 1984; 309: 464–468
  • Needleman S. W., Kraus M. H., Srivastava S. K., Levine P. H., Aaronson S. A. High frequency of N-ras activation in acute myelogenous leukemia. Blood 1986; 67: 753–757
  • Bos J. L., Toksoz D., Marshall C. J., Verlaan-deVries M., Veeneman G. H., der Eb A., van Boom J. H., Janssen J. W. G., Steenvoorden A. C. M. Amino acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukemia. Nature 1985; 5: 315, 726–730
  • Eva A., Tronick S. R., Gol R. A., Pierce J. H., Aaronson S. A. Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype. Proc Natl Acad Sci USA 1983; 80: 4926–4930, 1983.
  • Murray M. J., Cunningham J. M., Parada L. F., Dantry F., Lebowitz P., Weinberg R. A. The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cells 1983; 33: 749–753
  • Bos J. L., Verlaan-deVries M., van der Eb A. J., Janssen J. W. G., Derwel R., Lowenberg B., Colly L. P. Mutations in N-ras predominant in acute myeloid leukemia. Blood 1987; 69: 1237–1241
  • Hirai H., Tanaka S., Azuma M., Anraku Y., Urabe A., Takaku F. Transforming genes in human leukemia cells. Blood 1985; 56: 1371–1378, 1985.
  • Farr C. J., Saiki R. K., Erlich H. A., McCormick F., Marshall C. J. Analysis of ras gene mutation in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc Natl Acad Sci, USA 1988; 85: 1629–1633
  • Senn H. P., Tran-Thang C., Wodnar-Filipowicz A., Jioricny J., Fopp M., Gratwohl A., Singer E., Weber W., Moroni C. Mutations analysis of the N-ras protooncogene in active and remission phase of human acute leukemias. Int J Cancer 1988; 41: 59–64
  • Bartram C. R. Mutations in ras genes in myelocytic leukemias and myelodysplastic syndromes. Blood Cells 1988; 14: 533–538
  • Janssen J. W. G., Steenvoorden A. C. M., Lyone J., Anger B., Bos J. L., Bartram C. R. Ras gene mutations in acute and chronic myelogenous leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes. Proc Natl. Acad, Sci, USA 1987; 7: 84, 9228–9232
  • Hirai H., Nishida J., Takaku F. Highly frequent detection of transforming genes in acute leukemias by transfection using in vivo selection assays. Biochem Biophys Res Comm 1987; 147: 108–114
  • Mane S. M., Meltzer S. J., Kapil V., Gutheil J. C., Lee E. J., Schiffer C. A., Needleman S. W. Ras gene mutations in acute myeloid leukemia: analysis by in vitro amplification and base sequence determination. Blood, submitted
  • Bos J. L. Ras oncogenes in human cancer: a review. Can Res 1989; 49: 4682–4689
  • Gonzalez N. F., Zhou D., Battifor H., Bareli M., Cline M. J. Direct sequencing analysis of exon-1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas. Oncogene 1989; 4: 1137–1140
  • Mallet M., Mane S. M., Meltzer S., Needleman S. W. C-myc amplification coexisting with N-ras point mutation in the biphenotypic cell line RED-3. Leukemia 1989; 3: 511–515
  • Murray M. J., Cunningham J. M., Parada L. F., Dantry F., Lebowitz P., Weinberg R. A. The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cells 1983; 33: 749–754
  • Zarbl H., Sukumar S., Arthur A. V., Martin-Zanca D., Barbacid M. Direct mutagenesis of the Ha-ras-I oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 1985; 315: 382–385
  • Needleman S. W., Gutheil J. C., Kapil V., Mane S. M. Infrequent activation in chronic myelogenous leukemia; activating second ras exon mutation in the CML-derived cell line, IM-9. Leukemia 1989; 3: 827–928
  • Land H., Parada L. F., Weinberg R. A. Cellular oncogenes and multistep carcinogenesis. Science 1983; 222: 773–778
  • Liu E., Hyelle B., Morgan R., Hicht F., Bishop J. M. Mutations of the Kirsten-ras protooncogene in human preleukemia. Nature 1987; 330: 186–188
  • Bar-Eli M., Cadavid N. G., Foti A., Cline M. J. Analysis of N-ras exon-1 mutations in myelodysplastic syndromes by polymerase chain reaction and direct sequencing. Blood 1989; 73: 281–283
  • Lyons J., Janssen J. W. G., Bartram C., Layton M., Mufti G. J. Mutations of ki-ras and N-ras oncogenes in myelodysplastic syndromes. Blood 1988; 71: 1707–1712
  • Hirai H., Kobayashi Y., Mano H. A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome. Nature 1987; 327: 430–432
  • Padua R. A., Carter G., Hughes D. Ras mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation. Leukemia 1988; 2: 503–510
  • Neri A., Knowles D. M., Greco A., McCormick F., Dalla-Favbara R. Analysis of ras oncogene mutations in human lymphoid malignancies. Proc Nat'l Acad Sci 1988; 85: 9268–9272
  • Rodenhuis S., Bos J. L., Slater R. M., Behrendt H., van't Verr M., Smets L. A. Absence of oncogene amplifications and occasional activation of N-ras in lymphoblastic leukemia of childhood. Blood 1986; 67: 1698–1704
  • Unpublished observations
  • Sukumar S., Notario V., Zanca D., Barbacid M. Induction of mammary carcinomas in rats by NMU involves malignant activation of H-ras-1 locus by single point mutations. Nature 1983; 306: 658–661
  • Pedersen-Bjergaard J., Janssen J. W. G., Lyons J., Philip P., Bartram C. R. Point mutation of the ras protooncogenes and chromosome aberrations in acute nonlymphocytic leukemia and preleukemia related to therapy with alkylating agents. Cancer Research 1988; 48: 1812–1817
  • Hand P. H., Thor A., Wunderlich D. Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas. Proc Natl Acad Sci USA 1984; 81: 5227–5231
  • Lundy J., Grimson R., Mishriki Y. Elevated ras oncogene expression correlates with lymph node metastasis in breast cancer patients. J Clin Onc 1986; 4: 1321–1325
  • Viola M. V., Fromowitz F., Oravez S. Expression of ras oncogene p21 in prostate cancer. NEJM 1986; 314: 133–137
  • Robinson A., Williams A. R. W., Piris J. Evaluation of a monoclonal antibody to ras peptide, RAP-5, claimed to bind preferentially to cells of infiltrating carcinomas. Br. J. Cancer 1988; 54: 877–881
  • Samowitz W. S., Paul G., Hamilton S. R. Reported binding of monoclonal antibody RAP-5 to formalin-fixed tissue sections is not indicative of ras p21 expression. Hum Pathol 1988; 19: 127
  • Gutheil J. C., Mane S. M., Kapil V., Needleman S. W. Immunoprecipitation of cell lysates with RAP-5 does not specifically detect ras oncogene product, p21. Human Pathology 1989; 20: 1176–1180
  • Gutheil J. C., Mane S. M., Bass K. N., Lee E. J., Needleman S. W. Ras gene product level determination in leukemic blast cells. Biotech, submitted
  • Schwartz R. C., Stanton L. W., Riley S. C., Marcu K. B., Witte O. N. Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells. Mol Cell Biol 1986; 16: 3221–3231
  • Mavilio F., Sposi N. M., Petrini M., Bottero L., Marinucci M., DeRossi G., Amadori S., Mandelli F., Deschle C. Expression of cellular oncogenes in primary cells from human acute leukemia. Proc Nat'l Acad Sci, USA 1986; 83: 4394–4398
  • Slamon D. J., DeKernion J. B., Verma I. M., Cline M. J. Expression of cellular oncogenes in human malignancies. Science 1984; 224: 256–262
  • Weinberg R. A. Oncogenes, antioncogenes and the molecular bases of multistep carcinogenesis. Can Res 1989; 49: 3713–3721, 1989.
  • Huber B. E., Dearfield K. L., Williams J. R., Heilman C. A., Thorgeirsson S. S. Tumorigenicity and transcriptional modulation of c-myc and n-ras oncogenes in a human hepatoma cell line. Can Res 1985; 45: 4322–4329
  • Ernst T. J., Gazdar A., Ritz J., Shipp M. A. Identification of a second transforming gene, rasH in a human multiple myeloma line with a rearranged c-myc allele. Blood 1983; 72: 1163–1167
  • Carloni G., Champ B., Vilarem M. J., Lavialle C., Cassingena R. Activation of c-Ki-ras coexists with c-myc amplification in cells from a nude mouse tumor induced by the human breast carcinoma cell line SW613-S. FEB 1988; 233: 268–272

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