5
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Empiric Treatment of Localized Infections in the Febrile Neutropenic Patient with Monotherapy

, , &
Pages 193-203 | Received 02 Jun 1992, Published online: 01 Jul 2009

References

  • Raber-Durlacher J. E., Abraham-Inpijn L., Van Leeuwen E. F., Lustig K. H. M.E., Van Winkelhof A. J. The prevention of oral complications in bone marrow transplantations by means of oral hygeine and dental intervention. Neth. J. Med. 1989; 34: 98–108
  • Raemaekers J., De Witte T., Schattenberg A., Van Der Lely N. Prevention of leukemic relapse after transplantation with lymphocyte-depleted marrow by intensification of the conditioning regimen with a 6-day continuous infusion of anthracyclines. Bone Marrow Trans. 1989; 4: 167–171
  • Scarffe J. H. Emerging Clinical Uses for GM-CSF. Eur. J. Cancer 1991; 27(11)1493–1504
  • Bone R. C., Fisher C. J., Clemmer T. P., Slotman G. J., Metz C. A., Balk R. A., The Methylprednisolone Sever Sepsis Study Group. Sepsis syndrome: a valid clinical entity. Critical Care Med. 1989; 17: 389–393
  • Ligtenberg P. C., Hoepelman I. M., Oude Sogtoen G. A. C., Dekker A. W., van der Twee L. I., Rozenberg-Arska M., Verhoef J. C-reactive protein in the diagnosis and management of infections in granulocytopenic and non-granulocytopenic patients. Eur. J. Clin. Microbiol. and Infect. Dis. 1991; 10(1)25–31
  • De Bel C., Gerritsen E., De Maaker G., Moolenaar A., Vossen J. C- reactive protein in the management of children with fever after allogeneic bone marrow transplantation. Infection 1991; 19(2)92–96
  • Donowitz G. R., Harman C., Pope T., Stewart M. The role of the chest roentgenogram in febrile neutropenic patients. Arch. Int. Med. 1991; 151: 701–704
  • Brown D. F. J., Warren R. E. Effect of sample volume on yield of positive blood cultures from adult patients with haematological malignancy. J. Clin. Pathol. 1990; 43: 777–779
  • Kiehn T. E., Armstrong D. Changes in the spectrum of organisms causing bacteraemia and fungaemia in immun-compromised patients due to venous access devices. Eur. J. Clin. Microbiol. and Infect. Dis. 1990; 9(12)869–872
  • Kurrle E., Bhaduri S., Kreiger D., Gaus W., Heimpel H., Pflieger H., Arnold R., Vanek E. Risk factors for infections of the oropharynx and the respiratory tract in patients with acute leukemia. J. Infect. Dis. 1981; 144: 128–136
  • Schimpff S. C. An overview of empiric antibiotic therapy for the febrile neutropenic patient. Rev. Infect. Dis. 1985; 7(suppl 4)S734–740
  • Hughes W. T., Armstrong D., Bodey G. P., Feld R., Mandell G. L., Meyers J. D., Pizzo P. A., Schimpff S. C., Shenep J. L., Wade J. C., Younc L. S., Yow M. D. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. J. Infect. Dis. 1990; 161: 381–396
  • EORTC International Antimicrobial Therapy Cooperative Group. Ceftazidime combined with a short or long course of amikacin for empirical therapy of Gram-negative bacteraemia in cancer patients with granulocytopenia. N. Eng. J. Med. 1987; 317: 1692–1698
  • Anaissie E. J., Fanstein V., Bodey G. P., Rolston K., Elting L., Kantarjian H., Cabanillas F., McCredie K. B. Randomized trials of β-lactams regimens in febrile neutropenic cancer patients. Am. J. Med. 1988; 84: 581–589
  • Bodey G. P., Fainstein V., Elting L. S., Anaissie E., Rolston K., Khardori N., Kantarjian H., Plager C., Murphy W. K., Holmes F., Cabanillas F. β-lactams rgimens for the febrile neutropenic patient. Cancer 1990; 65: 9–16
  • De Pauw B. E., Kauw F., Muytjens H., Williams K. J., Bothof T. Randmized study of ceftazidime versus gentamicin plus cefotaxime for infections in severe granulocytopenic patients. J. Antimicrob. Chemother. 1983; 12(Suppl A)93–99
  • De Pauw B. E., Williams K. J., De Neeff J., Bothoff T., De Witte T., Holdrinet R., Haanen C. A randomized prospective study of ceftazidime versus ceftazidime plus flucloxacinillin in the empiric treatment of febrile episodes in severely neutropenic patients. Antimicrob. Ag. Chemother 1985; 28: 824–828
  • Donnelly J. P., Worsley A. M., Marcus R. E., Goldman J. M., Cohen J., Worsley A. M., Catovsky D., Darrell J. H., Want S. V., Galton D. A. G. Ceftazidime as first-line therapy for the treatment of fever in acute leukemia. J. Infect. 1985; 11: 205–215
  • Nováková I. R. O., Donnelly J. P., De Pauw B. E. Ceftazidime as monotherapy or combined with teicoplanin for initial empiric treatment of presumed bacteraemia in febrile granulocytopenic patients. Antimicrob. Ag. Chemother. 1991; 35: 672–678
  • Nováková I. R. O., Donnelly J. P., De Pauw B. E. Ceftazidime with or without amikacin for the empiric treatment of localized infections in febrile granulocytopenic patients. Ann. Hematol. 1991; 63: 195–200
  • Nováková I. R. O., Donnelly J. P., De Pauw B. E. Amikacin plus piperacillin versus ceftazidime as initial therapy in granulocytopenic patients with presumed bacteraemia. Scan. J. Infect. Dis. 1990; 22: 705–711
  • Pizzo P. A., Hathorn J. W., Hiemenz J., Browne M., Commers J., Cotton D., Gress J., Longo D. A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. N. Eng. J. Med. 1986; 315: 552–558
  • Verhagen C. S., De Pauw B. E., De Witte T., Janssen J., Williams K. J., De Mulder P., Bothof T. Randomized prospective study of ceftazidime versus ceftazi-dime plus cephalothin in empiric treatment of febrile episodes in severely neutropenic patients. Antimicrob. Ag. Chemother. 1987; 31: 191–196
  • Sanders J. W., Powe N. R., Moore R. D. Ceftazidime monotherapy for empiric treatment of febrile neutropenic patients-A metaanalysis. J. Infect. Dis. 1991; 164(5)907–916
  • Liang R., Yung R., Chau C. E. P., Chan T., Lam W., Todd D. Ceftazidime versus imipenem-cilastatin as initial monotherapy for febrile neutropenic patients. Antimicrob. Ag. Chemother. 1990; 34: 1336–1341
  • Winston D. J., Ho W. G., Bruckner D. A., Champlin R. E. Beta-lactam antibiotic therapy in febrile granulocyto-penic patients-A randomized trial comparing cefoperazone plus piperacillin, ceftazidime plus piperacillin and imipenem alone. Ann. Int. Med. 1991; 115(11)849–859
  • Rolston K. V. I., Berkey P., Bodey G. P., Anaissie E. J., Khardori N., Joshi J. H., Keating M. J., Holmes F. A., Cabanillas F. F., Elting L. A comparison of imipenem to ceftazidime with and without amikacin as empiric therapy in febrile neutropenic patients. Arch. Int. Med. 1992; 152: 283–291
  • Bayston K. F., Want S., Cohen J. A prospective, randomized comparison of ceftazidime and ciprofloxacin as initial empiric therapy in neutropenic patients with fever. Am. J. Med. 1989; 87(suppl 5A)269S–273S
  • Johnson P. R. E., Liu Yin J. A., Tooth J. A. High dose intravenous ciprofloxacin in febrile neutropenic patients. J. Antimicrob. Chemother. 1990; 26(suppl F)101–107
  • Meunier F., Zinner S. H., Gaya H., Calandra T., Viscoli C., Klatersky J., Glauser M. Prospective randomized evaluation of ciprofloxacin versus piperacillin plus amikacin for empiric antibiotic therapy of febrile granulocytopenic cancer patients with Lymphomas and Solid Tumors. Antimicrob. Ag. Chemother. 1991; 35(5)873–878
  • Malik I. A., Abbas Z., Karim M. Randomized comparison of oral ofloxacin alone with combination of parenteral antibiotics in neutropenic febrile patients. Lancet 1992; 339: 1092–1096
  • Verhagen C., De Pauw B. E., Donnelly J. P., Williams K. J., De Witte T., Janssen J. T. P. Ceftazidime alone for treating Pseudomonas aeruginosa septicaemia in neutropenic patients. J. Infect. 1986; 13: 125–131
  • Burden A. D., Oppenheim B. A., Crowther D., Howell A., Morgenstern G. R., Scarffe J. H., Thatcher N. Viridans Streptococcal bacteraemia in patients with haematolo-gical and solid malignancies. Eur. J. Cancer 1991; 27(4)409–411
  • Van der Lelie H., Van Ketel R. J., Von dem Borne A. E. G. K., Van Oers R. H. J., Thomas B. L. M., Goudsmit R. Incidence and clinical epidemiology of streptococcal septicemia during treatment of acute myeloid leukemia. Scan. J. Infect. Dis. 1991; 23(2)163–168
  • Elliot C. R., Pater J. L. The effect of different measures of outcome on the results of studies of empiric antibiotic therapy in febrile neutropenic patients. Clin. Invest. Med. 1988; 11: 327–330
  • Donnelly J. P. Assessment and reporting of clinical trials of empirical therapy in neutropenic patients. J. Antimicrob. Chemother. 1991; 27: 377–387
  • Rubin M., Hathorn J. W., Marshall D., Gress J., Steinberg S. M., Pizzo P. A. Gram-positive infections and the use of vancomycin in 550 episodes of fever and neutropenia. Ann. Int. Med. 1988; 108: 30–35
  • Awidi A. S. Infections in adults with cancer in a developing country: a three year prospective study. Eur. J. Cancer 1991; 27(4)423–426
  • Pizzo P. A. After empiric therapy: what to do until the granulocyte comes back. Rev. Infect. Dis. 1987; 9: 214–219
  • Calandra T. Vancomycin added to empirical combination antibiotic therapy for fever in granulocytopenic cancer patients-From the EORTC and National Cancer Institute of Canada. J. Infect. Dis. 1991; 163(5)951–958
  • De Pauw B. E., Donnelly J. P., Elves A., Verhagen C., Nováková I. R. O., Van Der Meer J. W. M. Towards individually tailored empiric antibiotic therapy in febrile granulocytopenic patients. Neth. J. Med. 1990; 37: 111–119
  • Walsh T. J., Pizzo P. A. Nosocomial fungal infections: a classification for hospital-acquired fungal infections and mycoses arising from endogenous flora or reactivation. Ann. Rev. Microbiol. 1988; 42: 517–545
  • Ognibene F. P., Martin S. E., Parker M. M., Schlessinger T., Roach P., Burch C., Shelhamer J. H., Parrillo J. E. Adult respiratory distress syndrome in patients with severe neutropenia. N. Eng. J. Med. 1986; 315: 547–551
  • Kern W., Kurrle E., Vanek E. High risk of streptococcal septicemia after high dose cytosine arabinoside treatment for acute myelogenous leukemia. Klin. Wochenschr. 1987; 65: 773–780
  • Arning M., Gehrt A., Aul C., Runde V., Hadding U., Schneider W. Septicemia due to Streptococcus mitis in neutropenic patients with acute leukemia. Blut 1990; 61: 364–368
  • Meyer R. D. Role of the quinolones in the treatment of legionellosis. J. Antimicrob. Chemother. 1991; 28: 623–625
  • Meunier F., Aoun M., Gerard M. Therapy for oropharyngeal candidiasis in the immunocompromised host: a randomized double-blind study of fluconazole vs ketocona-zole. Rev. Infect. Dis. 1990; 12(suppl 3)S364–S368
  • Bergman O. J., Mogensen S. C., Ellegaard J. Herpes simplex virus and intraoral ulcers in immunocompromised patients with haematologic malignancies. Eur. J. Clin. Microbiol. and Infect. Dis. 1990; 9: 184–190
  • Ringdén O., Heimdahl A., Lönnequist B., Malmborg A. S., Wilczek H. Decreased incidence of viridens streptococcal septicaemia in allogeneic bone marrow transplant recipients after the introduction of acyclovir. Lancet 1984; i: 744
  • Talbot G. H., Huang A., Provencher M. Invasive aspergillus rhinosinusitis in patients with acute leukemia. Rev. Infect. Dis. 1991; 13: 219–232
  • Denning D. W., Stevens D. A. Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. Rev. Infect. Dis. 1990; 12: 1147–1201
  • Weightman N. C., Simpson E. M., Speller D. C. E., Mott M. G., Oakhill A. Bacteraemia related to indwelling central venous catheters: prevention, diagnosis and treatment. Eur. J. Clin. Microbioi. and Infect. Dis. 1988; 7: 125–129
  • Hedin G., Hambraeus A. Multiple antibiotic-resistant Staphylococcus epidermidis in patients, staff and environment-a one-week survey in a bone marrow transplant unit. J. Hosp. Infect. 1991; 17: 95–106
  • De Pauw B. E., Nováková I. R. O., Donnelly J. P. Options and limitations of teicoplanin in febrile granulocytopenic patients. Brit. J. Haematol. 1990; 76(suppl 2)1–5
  • Nováková I. R. O., Donnelly J. P., De Pauw B. E., Verhagen C. Teicoplanin for modification of empirical treatment in neutropenic patients. J. Antimicrob. Chemother. 1990; 25: 985–993
  • Grant A. C., Lacey R., Brownjohn A. M., Turney J. H. Teicoplanin-resistant coagulase-negative staphylococcus. Lancet 1986; ii(letter)1166–1167
  • Schwalbe R. S., Stapleton J. T., Gilligan P. H. Emergence of vancomycin resistance in coagulase negative staphylococci. N. Eng. J. Med. 1987; 316: 927–931
  • Wilson A. P. R., O'Hare M. D., Felmington D., Gruneberg R. N. Teicoplanin-resistant coagulase-negative staphylococcus. Lancet 1986; ii(letter)973
  • Brumfitt W., Hamilton-Miller J. M. T., Neville L. O. Teicoplanin-resistant coagulase-negative staphylococci. Lancet 1987; ii(letter)328
  • Arioli V., Pallanza R. Teicoplanin-resistant coagulase-negative staphylococci. Lancet 1987; i(letter)39
  • Shenep J., Hughes W. T., Roberson P. K., Blankenship K., Baker D., Meyer W. H., Gigliotti F., Sixbey J. W., Santana V. M., Feldman S., Lott L. Vancomycin, ticarcillin and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile neutropenic children with cancer. N. Eng. J. Med. 1988; 319: 1053–1058
  • Anaissie E., Bodey G. P., Kantarjian H., David C., Barnett K., Bow E., Defelice R., Downs N., File T., Karam G., Potts D., Shelton M., Sugar A. Fluconazole therapy for chronic disseminated candidiasis in patients with leukemia and prior amphotericin-B therapy. Am. J. Med. 1991; 91(2)142–150
  • Thaler M., Pastakia B., Shawker T. H., O'Leary T., Pizzo P. A. Hepatic candidiasis in cancer patients. The evolving picture of the syndrome. Ann. Int. Med. 1988; 108: 88–100
  • Kauffman C. A., Bradley S. F., Ross S. C., Weber D. R. Hepatosplenic candidiasis-successful treatment with fluconazole. Am. J. Med. 1991; 91(2)137–141
  • Propst T., Vogel W., Propst A., Dietze O., Braunsteiner H. Successful treatment of recurrent hepatic candida infection with fluconazole after chemotherapy for acute leukemia-A case report. Clin. Invest. 1992; 70(1)55–58
  • Warren R. E., Wimperis J. Z., Baglin T. P., Constantine C. E., Marcus R. Prevention of infection by ciprofloxacin in neutropenia. J. Antimicrob. Chemother. 1990; 26(suppl F)109–123
  • Whimbey E., Kiehn T. E., Brannon P., Blevins A., Armstrong D. Bacteraemia and fungemia in patients with neoplastic disease. Am. J. Med. 1987; 82: 723–730
  • O'Hanley P., Easaw J., Rugo H., Easaw S. Infectious disease management of adult leukemic patients undergoing chemotherapy: 1982 to 1986 experience at Stanford University Hospital. Am. J. Med. 1989; 87: 605–613

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.