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Original Article

A Comparative Analysis of the Sensitivity of Multidrug Resistant (MDR) and Non-MDR Cells to Different Anthracycline Derivatives

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Pages 255-264 | Received 20 Jun 1992, Published online: 01 Jul 2009

References

  • Moscow J. A., Cowan K. H. Multidrug resistance. J. Natl. Cancer Inst. 1988; 80: 14–20
  • Kaye S. B. The multidrug resistance phenotype. J. Cancer 1988; 58: 691–694
  • Nooter K., Herweijer H. Multidrug resistance (mdr) genes in human cancer. Br. J. Cancer 1991; 63: 663–669
  • Pastan I., Gottesman M. Multiple drug resistance in human cancer. N. Eng. J. Med. 1987; 316: 1388–1393
  • Luk C. K., Tannock I. F. Flow cytometric analysis of doxorubicin accumulation in cells from human and rodent cell lines. J. Natl. Cancer Inst. 1989; 81: 55–59
  • Inaba M., Kobayashi H., Sakurai Y., Johnson R. K. Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia. Cancer Res. 1979; 39: 2200–2203
  • Weistein R. S., Kuszak J. R., Kluskens L. F., Coon J. S. P-glycoproteins in pathology: the multidrug resistance gene family in humans. Human Pathol. 1990; 21: 34–48
  • Hitchins R. N., Harman D. H., Davey R. A., Bell D. R. Identification of a multidrug resistance associated antigen (P-glycoprotein) in normal human tissues. Eur. J. Cancer Clin. Oncol. 1988; 24: 449–454
  • Sugawara I., Kataoka I., Morishita Y., Hamada H., Tsuruo T., Itoyama S., Mori S. Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK-16. Cancer Res. 1988; 48: 1926–1929
  • Cordon-Cardo C., O'Brien J. P., Casals D., Rittmann-Grauer L., Biedler J. L., Melamed M. T., Bertino J. R. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA 1989; 86: 695–698
  • Damiani D., Michieli M., Michelutti A., Geromin A., Raspadori D., Fanin R., Savignano C., Giacca M., Pileri S., Mallardi F., Baccarani M. Expression of multidrug resistance gene (mdr-1) in normal human leukocytes. 1992, Submitted to Haematologica
  • Pileri S. A., Sabattini E., Falini B., Tazzari P. L., Gherlinzoni F., Michieli M. G., Damiani D., Zucchini L., Gobbi M., Tsuruo T., Baccarani M. Immuno-histochemical detection of the multidrug transport protein P170 in human normal tissues and malignant lymphomas. Histopathol. 1991; 19: 131–140
  • Campos L., Guyotat D., Archimbaud E., Calmard-Oriol P., Tsuruo T., Troncy J., Treille D., Fiere D. Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood 1992; 79: 473–476
  • Michieli M., Damiani D., Geromin A., Michelutti A., Fanin R., Raspadori D., Russo D., Visani G., Dinota A., Pileri S., Tsuruo T., Grandi M., Baccarani M., Tura S. Overexpression of multidrug resistance-associated P170-glycoprotein in acute non-lymphocytic leukemia. Eur. J. Haematol. 1992; 48: 87–92
  • Michieli M., Raspadori D., Damiani D., Geromin A., Gallizia C., Michelutti A., Fanin R., Fasola G., Russo D., Tazzari P., Pileri S., Mallardi F., Baccarani M. The expression of the multidrug resistance-associated glycoprotein in B-cell chronic lymphocytic leukaemia. Brit. J. Haematol. 1991; 77: 460–465
  • Sato H., Preisler H., Day R., Raza A., Larson R., Browman G., Goldberg J., Vogler R., Grunwald H., Gottlieib A., Bennet J., Gottesman M., Pastan I. MDR1 transcript levels as an indication of resistant disease in acute myelogenous leukaemia. Brit. J. Haematol. 1990; 75: 340–345
  • Dalton W. S., Grogan T. M., Rybski J. A., Scheper R. J., Richter L., Kailey J., Broxterman H. J., Pinedo H. M., Salmon S. E. Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation. Blood 1989; 73: 747–752
  • Speth P. A. J., Minderman H., Haanen C. Idarubicin v Daunorubicin: preclinical and clinical pharmaco-kinetic studies. Semin. Oncol. 1989; 16: 2–9
  • Schott B., Vrignaud P., Ries C., Robert J., Londos-Gagliardi D. Cellular pharmacology of 4'-iodo-4'-deoxydoxorubicin. Br. J. Cancer 1990; 61: 543–547
  • Barbieri B., Giuliani F. C., Bordoni T., Casazza A. M., Geroni C., Bellini O., Suarato A., Gioia B., Penco S., Arcamone F. Chemical and biological characterization of 4'-iodo-4'-deoxydoxorubicin. Cancer Res. 1987; 47: 4001–4006
  • Young R. C., Ozols R. F., Myers C. E. The anthracycline antineoplastic drugs. N. Eng. J. Med. 1981; 305: 139–153
  • Drewinko B., Romsdahl M. M., Yang L. Y., Ahearn M. J., Trujillo J. M. Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line. Cancer Res. 1976; 36: 467–475
  • Grandi M., Geroni C., Giuliani F. C. Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin. Br. J. Cancer 1986; 54: 515–518
  • Foley G. E., Lazarus H., Farber S., Uzman B. G., Boone B. A., McCarthy R. E. Continuous culture of human lymphoblasts from peripheral blood of child with acute leukemia. Cancer 1965; 18: 522–529
  • Beck W. T., Mueller T. J., Tanzer L. R. Altered surface membrane glycoproteins in vinca alkaloid-resistant human leukemic lymphoblasts. Cancer Res. 1979; 39: 2070–2076
  • Ballinari D., Radice P., Grandi M., Sozzi G., Pezzoni G., Mondini P., Pierotti M. A., Giuliani F. C. MDR amplification and karyotypic analysis of anthracycline-resistant human tumor cell lines. Cancer Communic. 1988; 3: 69–74
  • Shen D. W., Fojo A., Chin L. E., Roninson I. B., Richert N., Pastan I., Gottesman M. M. Human multidrug-resistant cell lines: increased mdr-1 expression can precede gene amplification. Science 1986; 232: 643–645
  • Lozzio C. B., Lozzio B. B. Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood 1975; 45: 321–334
  • Lasky S. R., Bell W., Huhn R. D., Posner M. R., Wiemann M., Calabresi P., Eil C. Effects of lα, 25-Dihydroxyvitamin D3 on the human chronic myelogenous leukemia cell line RWLeu-4. Cancer Res. 1990; 50: 3087–3094
  • Pulfertaft R. J. Cytology of Burkitt's tumor (african lymphoma). Lancet 1964; 1: 238–242
  • Collins S. J., Gallo R. C., Gallagher R. E. Continuous growth and differentiation of human myeloid leukemic cells in suspension culture. Nature 1977; 270: 347–349
  • Brahic M., Haase A. T. Detection of viral sequences of low reiteration frequency by in situ hybridization. Proc. Natl. Acad. Sci. USA 1978; 75: 6125–6129
  • Chen C., Clark D., Ueda K., Pastan I., Gottesman M., Roninson I. B. Genomic organization of the human multidrug resistance (mdr-1) gene and origin of P-glycopro-teins. J. Biol. Chem. 1990; 265: 506–514
  • Samoszuk M., Nansen L. Detection of interleukin-5 messenger RNA in Reed-Sternberg cells of Hodgkin's disease with eosinophilia. Blood 1990; 75: 13–16
  • Hamada H., Tsuruo T. Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 1986; 83: 7785–7789
  • Schmid I., Schmid P., Giorgi J. V. Conversion of logarithmic channel numbers into relative linear fluorescence intensity. Cytometry 1988; 9: 533–538
  • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983; 65: 55–63
  • Finlay G. J., Wilson W. R., Bagulei B. C. Comparison of in vitro activity of cytotoxic drugs towards human carcinoma and leukemia cell lines. Int. J. Cancer Clin. Oncol. 1986; 22: 655–662
  • Salmon S. E., Liu R. M., Casazza A. M. Evaluation of new anthracycline analogs with the human tumor stem cell assay. Cancer Chemother. Pharmacol. 1981; 6: 103–110
  • Twentyman P. R., Fox N. E., Wright K. A., Workman P., Broadhurst M. J., Martin J. A., Bleehen N. M. The in vitro effects and cross-resistance patterns of some novel anthracyclines. Br. J. Cancer 1986; 53: 585–594
  • Kaye S., Merry S. Tumor cell resistance to anthracyclines-A review. Cancer Chemother. Pharmacol. 1985; 14: 96–103
  • Hill B. T., Dennis L. Y., Li X. T., Whelan R. D. H. Identification of anthracycline analogues with enhanced cytotoxicity and lack of cross-resistance to adriamycin using a series of mammalian cell lines in vitro. Cancer Chemother. Pharmacol. 1985; 14: 194–201
  • Berman E., McBride M., Clarkson B. Clinical implications of idarubicin pharmacology. Haematologica 1991; 76(suppl. 4)8
  • Speth P. A. J. Cellular pharmacokinetics and pharmacodynamics of anthracyclines in man. SSN, Nijmegen, Druk 1986
  • Luk C. K., Tannock I. F. Flow cytometric analysis of doxorubicin accumulation in cells from human and rodent cell lines. J. Natl. Cancer Inst. 1989; 81: 55–59
  • Gerlach J. H., Endicott J. A., Juranka P. F., Henderson G., Sarangi F., Deuchars K. L., Ling V. Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance. Nature 1986; 324: 485–489
  • Cornwell M. M., Safa A. R., Felstead R. L., Gottesman M., Pastan I. Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labelling. Proc. Natl. Acad. Sci. USA 1986; 83: 3847–3850
  • Cornwell M. M., Pastan I., Gottesman M. M. Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J. Biol. Chem. 1987; 262: 2166–2170
  • Inaba M., Kobayashi H., Sakurai Y., Johnson R. K. Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia. Cancer Res. 1979; 39: 2200–2203
  • Krishan A., Ganapathi R. Laser flow cytometry studies on the intracellular fluorescence of anthracyclines. Cancer Res. 1980; 40: 3895–3900
  • Tsuruo T., Iida H., Tsukagoslin S., Sakwai Y. Overcoming of vincristine resistance in P388 leukemia through enhanced cytotoxicity by verapamil. Cancer Res. 1981; 41: 1967–1972
  • Yusa K., Tsuruo T. Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites, and transport of verapamil outward across the plasma membrane of K562/ADM cells. Cancer Res. 1989; 49: 5002–5006
  • Twentyman P. R., Fox N. E., White D. J. G. Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multidrug resistant human lung cancer cell line. Brit. J. Cancer 1987; 56: 55–57
  • Gosland M. P., Lum B. L., Sikie B. I. Reversal by cefoperazone of resistance to etoposide, doxorubicin and vinblastine in multi-drug resistant human sarcoma cells. Cancer Res. 1989; 49: 6901–6905
  • De Gregorio M. W., Ford J. M., Benz C. C., Wiebe V. J. Toremifene: pharmacologic and pharmacokinetics basis of reversing multidrug resistance. J. Clin. Oncol. 1989; 7: 1359–1364
  • Boesch D., Gaveriaux C., Jachez B., Pourtier-Manzanedo A., Bollinger P., Loor F. In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res. 1991; 51: 4226–4233
  • Berman E., Adams M., Duigou-Osterndorf R., Godfrey L., Clarkson B., Andreeff M. Effect of tamoxifen on cell lines displaying the multidrug-resistant phenotype. Blood 1991; 77: 818–825
  • Krishan A., Sridhar K. S., Davila E., Vogel C., Sternheim W. Patterns of anthracycline retention modulation in human tumor cells. Cytometry 1987; 8: 306–314
  • Holmes J. A. Multidrug resistance in leukaemia. Leuk. and Lymph. 1990; 1: 163–168
  • Michieli M., Giacca M., Fanin R., Damiani D., Geromin A., Baccarani M. mdr-1 gene amplification in acute lymphoblastic leukaemia prior to antileukaemic treatment. Brit. J. Haematol. 1991; 78: 290–291
  • Verrelle P., Meissonnier F., Fonck Y., Feillel V., Dionet C., Kwiatkowski F., Plagne R., Chassagne J. Clinical relevance of immunohistochemical detection of multidrug resistance P-glycoprotein in breast carcinoma. J. Natl. Cancer Inst. 1991; 83: 111–116
  • Sonneveld P., Nooter K., Burghouts J., Th M., Herweijer H., Adriaansen H. J., van Dongen J. J. M. High expression of the mdr-3 multidrug-resistance gene in advanced-stage chronic lymphocytic leukemia. Blood 1992; 79: 1496–1500
  • Herweijer H., Sonneveld P., Baas F., Nooter K. Expression of mdr-1 and mdr-3 mutlidrug-resisitance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. J. Natl. Cancer Inst. 1990; 82: 1133–1140
  • Marie J. P., Zittoun R., Sikic B. I. Multidrug resistance (mdr-1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity. Blood 1991; 78: 586–592
  • Pirker R., Wallner J., Geissler K., Linkesch W., Haas O. A., Bettelheim P., Hopfner M., Scherrer R., Valent P., Havelec L., Ludwig H., Lechner K. MDR1 gene expression and treatment outcome in acute myeloid leukemia. J Natl. Cancer Inst. 1991; 83: 708–712
  • Wiernik P. H., Banks P. H. L., Case D. C., Arlin Z. A., Periman P. O., Todd M. B., Ritch P. S., Enck R. E., Weitberg A. B. Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia. Blood 1992; 79: 313–319
  • Berman E., Heller G., Santorsa J., McKenzie S., Gee T., Kempin S., Gulati S., Andreeff M., Kolitz J., Gabrilove J., Reich L., Mayer K., Keefe D., Trainor K., Schluger A., Penenberg D., Raymond V., O'Reilly R., Jhanwar S., Young C., Clarkson B. Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. Blood 1991; 77: 1666–1674
  • Mandelli F., Petti M. C., Ardia A., Di Pietro N., Di Raimondo F., Ganzina F., Falconi E., Geraci E., Ladogana S., Latagliata R., Malleo C., Nobile F., Petti N., Rotoli B., Specchia G., Tabilio A., Resegotti L. A randomized clinical trial comparing idarubicin and cytarbine to daunorubicin and cytarabine in the treatment of acute nonlymphoid leukemia. Eur. J. Cancer 1991; 27: 750–756
  • Vogler W. R., Velez-Garcia E., Omura G., Raney M. A phase-three trial comparing daunorubicin or idarubicin combined with cytosine arabinoside in acute myelogenous leukemia. Semin. Oncol. 1989; 16: 21–24

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