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Original Article

2-Chlorodeoxyadenosine: A New Nucleoside Agent Effective in the Treatment of Lymphoid Malignancies

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Pages 43-49 | Published online: 01 Jul 2009

References

  • Giblett E. R., Anderson J. E., Cohen F., Pollara B., Meuwissen H. J. Adenosine deaminase deficiency in two patients with severely impaired cellular immunity. Lancet 1972; 2: 1067–1069
  • Carson D. A., Kaye J., Wasson D. B., et al. Deoxycytidine kinase mediated toxicity of deoxyadenosine analogs towards malignant human lymphoblasts in vivo. Proceedings of the National Academy of Sciences of the United States of America 1980; 77: 6865–6869
  • Carson D. A., Wasson D. B., Taetle R., Yu A. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. Blood 1983; 62(4)737–743
  • Seto S., Carrera C. J., Kubota M., Wasson D. B., Carson D. A. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. Journal of Clinical Investigation 1985; 75: 377–383
  • Seto S., Carrera C. J., Wasson D. B., Carson D. A. Inhibition of DNA repair by deoxyadenosine in resting human lymphocytes. Journal of Immunology 1986; 136: 2839–2843
  • Carrera C. J., Terai C., Piro L., Saven A., Beutler E., Carson D. 2-CdA phemotherapy triggers programmed cell death in normal and malignant lymphocytes. J. Purine Pyrimidine Res. 1991; 2(Suppl 1)38
  • Juliusson G., Liliemark J. 2-Chlorodeoxyaden-osine (2-CdA) in lymphoproliferative diseases. Clinicial and pharmacokinetic studies. Blood 1990; 76: 354A, (Abstract)
  • Carson D. A., Wasson D. B., Beutler E. Anti-leukemic and immunosuppressive activity of 2-chloro-2′deoxyadenosine. Proceedings of The National Academy of Sciences of the United States of America 1984; 81: 2232–2236
  • Saven A., Waltz T., Carrera C. J., Kawasaki H., Carson D. A., Beutler E., Piro L. D. Phase I study of 2-chlorodeoxyadenosine (2-CdA) in non-hemato-logic malignancies. Proceedings of the American Society of Clinical Oncology 1992; 119: 299
  • Piro L. D., Carrera C. J., Carson D. A., Beutler E. Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. New England Journal of Medicine 1990; 322: 1117–1121
  • Piro L. D., Saven A., Ellison D., Thurston D., Carson D. A., Beutler E. Prolonged complete remissions following 2-chloredeoxyadenosine (2-CdA) in hairy cell leukemia (HCL). Proceedings of the American Society of Clinical Oncology 1992; 11: 846
  • Carrera C. J., Piro L. D., Saven A., Cox K., Beutler E., Carson D. A., Kipps T. J. Restoration of lymphocyte subsets following 2-chlorodeoxyadenosine remission induction in hairy cell leukemia. Blood 1990; 76(Suppl. 1)260a, (Abstract)
  • Piro L. D., Carrera C. J., Beutler E., Carson D. A. 2-chlorodeoxyadenosine: An effectrive new agent for the treatment of chronic lymphocytic leukemia. Blood 1988; 72(3)1069–1073
  • Saven A., Carrera C. J., Carson D. A., Beutler E., Piro L. D. 2-Chlorodeoxyadenosine treatment of refractory chronic lymphocytic leukemia. Leukemia Lym-phoma 1991; 5(Suppl)133–138
  • Cheson B. D., Bennett J. M., Rai K. R., Grever M. R., Kay N. E., Schiffer C. A., Oken M. M., Keating M. J., Boldt D. H., Kempin S. J., Foon K. A. Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the National Cancer Institute-sponsored Working Group. Journal of Hematology 1988; 29: 152–163
  • Kay A. C., Carrera C. J., Carson D. A., Beutler E., Piro L. D. Phase II trial of 2-chlorodeoxyadenosine in low grade lymphoma. Blood 1989; 74: 121a, (Abstract)
  • Kay A. C., Saven A., Carrera C. J., Carson D. A., Beutler E., Piro L. D. 2-chlorodeoxyadenosine treatment of low-grade lymphomas. Journal of Clinical Oncology 1992; 10: 371–377
  • Saven A., Carrera C. J., Carson D. A., Beutler E., Piro L. D. 2-Chlorodeoxyadenosine: An active agent in the treatment of cutaneous T-cell lymphoma. Blood 1992; 809: 587–592
  • Kuzel T., Samuelson E., Roenigk H., Trop E., Rosen S. Phase II trial of 2-chlorodeoxyadenosine (2-CdA) for the treatment of mycosis fungoides or the Se-zary Syndrome (MF-SS). Proceedings of the American Society of Clinical Oncology 1992; 11: 1089, (Abstract)
  • Petzer A. L., Bilgen R., Zilian U., et al. Inhibitory effect of 2-chlorodeoxyadenosine on granulocytic, erythroid and T-lymphocytic colony growth. Blood, 78: 2583–2587
  • Saven A., Figueroa M. L., Piro L. D., Beutler E. Complete hematological remissions in chronic myelogenous leukemia (CML) following 2-chlorodeoxyadenosine (2-CdA). Proceedings of the American Society of Clinical Oncology 1992; 11: 855
  • Santana V. M., Mirro J. L., Jr., Kearns C., Schell M. J., Crom W., Blakley R. L. 2-Chlorodeoxy-adenosine produces a high rate of complete hematologic remissions in relapsed myeloid leukemia. Journal of Clinical Oncology 1992; 10: 364–370
  • Carson D. A., Wasson D. B., Esparza L. M., Carrera C. J., Kipps T. J., Cottam H. B. Oral anti-lymphocytic activity and induction of apoptosis by 2′-chloro-2′-ARA-2′-deoxyadenosine (CAFdA). Proceedings of the National Academy of Sciences of the United States of America 1992; 89: 2970–2974
  • Estey E. M., Kurzrock R., Kantarjian H. M., O'Brien S., McCredie K., Beran M., Koller C., Keating M., Hirsch-Ginsberg C., Huy Y. O., Stass S., Freireich E. Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA). Blood 1992; 79: 882–887
  • Juliusson G., Liliemark J. Rapid recovery from cytopenia in hairy cell leukemia after treatment with 2-chloro-2′deoxyadenosine (CdA): Relation to opportunistic infections. Blood 1992; 79: 888–894
  • Hoffman M., Rai K., Sawitsky A., Janson D. 2-chlorodeoxyadenosine (2-CdA) in hairy cell leukemia. Blood 1991; 78(Suppl 1)454a, (Abstract)
  • Tallman M., Hakimian D., Variakojis D., Kaul K., Koslow D. 2-Chlorodeoxyadenosine (2-CdA) in the treatment of hairy cell leukemia (HCL). Blood 1991; 78(Suppl 1)34a, (Abstract)
  • Lauria F., Benfenati D., Zinzani P. L., Raspadori D., Rondelli D., Tura S. 2-Chlorodeoxyadenosine in the treatment of hairy cell leukemia patients relapsed after α-interferon. Blood 1991; 78(Suppl 1)34a, (Abstract)
  • Santana V. M., Mirro J., Jr., Harwood F. C., Cherrie J., Schell M., Kalwinsky D., Blakley R. L. A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia. Journal of Clinical Oncology 1991; 9: 416–422

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