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Original Article

Bone Marrow Purging in Acute Leukemia with Alkyl-Lysophospholipids: A New Family of Anticancer Drugs

Pages 53-60 | Received 26 Jun 1993, Published online: 01 Jul 2009

References

  • Lee T.-C., Snyder F. Function, metabolism, and regulation of platelet activating factor and related ether lipids. Phospholipids and Cellular Regulation, J.F. Kuo. CRC Press, Boca Raton, FL 1985; vol. 2: 2–39
  • Pirotzky E., Hosford D., Mencia-Huerta J.-M., Bra-Quet P. Role of platelet-activating factor in immune process. Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury, K.V. Honn, L.J. Marnett, S. Nigam, T.L. Waldon, Jr. Kluwer Academic Publishers, Norwell, MA 1991; 427–437
  • Andreesen R., Modolell M., Weltzien H.U., Eibl H., Common H.H., Lohr G.W., Munder P.G. Selective destruction of human leukemic cells by alkyl-lyso-phospholipids. Cancer Res. 1978; 38: 3894–3899
  • Modolell M., Andreesen R., Pahlke W., Brugger U., Munder P.G. Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids. Cancer Res. 1979; 39: 4681–4686
  • Vogler W.R., Whigham E.A., Somberg L.B., Long R.C., Jr., Winton E.F. The effect of alkyl-lyso phospholipids on tritiated thymidine incorporation and clon-ogenicity in vitro of normal and leukemic human cells. Exp. Hematol. 1984; 12: 569–574
  • Hoffman D.R., Hajdu J., Snyder F. Cytotox-icity of platelet activating factor and related alkyl-phospho-lipid analogs in human leukemia cells, polymorphonuclear neutrophils, and skin fibroblasts. Blood 1984; 63: 545–552
  • Schick H.D., Berdel W.E., Fromm M., Fink U., Jehn U., Ulm K., Reichert A., Eibl H., Unger C., Rastetter J. Cytotoxic effects of ether lipids and derivatives in human non-neoplastic bone marrow cells and leukemic cells in vitro. Lipids 1987; 22: 904–910
  • Verdonck L.F., Witteveen E.O., van Heugten H.G., Rozemuller E., Rijksen G. Selective killing of malignant cells from leukemic patients by alkyl-lysophospho-lipid. Cancer Res. 1990; 50: 4020–4025
  • Helfman D.M., Barnes K.C., Kinkade J.M., Jr., Vogler W.R., Shoji M., Kuo J.F. Phospholipid-sen-sitive Ca2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in hu man leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid. Cancer Res. 1983; 43: 2955–2961
  • Van Blitterswijk W.J., van der Bend R.L., Kramer I.M., Verhoeven A.J., Hilkmann H., de Widt J. A metabolite of an antineoplastic ether phospholipid may inhibit transmembrane signalling via protein kinase C. Lipids 1987; 22: 842–846
  • Powis G., Seewald M.J., Gratas C., Melder D., Riebow J., Modest E.J. Selective inhibition of phospha-tidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 1992; 52: 2835–2840
  • Lohmeyer M., Workman P. Antitumor ether lip ids and platelet-activating factor analogues have different cytotoxic profiles and calcium mobilizing effects—A structure-activity study. Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury, S. Nigam, K.V. Honn, L.J. Marnett, T.L. Walden, Jr. Kluwer Academic Publishers, Norwell, MA 1993; 699–702
  • Seewald M.J., Olsen R.A., Sehgal I., Melder D.C., Modest E.J., Powis G. Inhibition of growth factor-dependent inositol phosphate Ca2+ signaling by antitumor ether lipid analogues. Cancer Res. 1990; 50: 4458–4463
  • Zheng B., Oishi K., Shoji M., Eibl H., Berdel W.E., Hajdu J., Vogler W.R., Kuo J.F. Inhibition of protein kinase C, (sodium plus potassium)-activated adeno-sine triphosphatase, and sodium pump by synthetic phospho lipid analogues. Cancer Res. 1990; 50: 3025–3031
  • Kiss Z., Deli E., Vogler W.R., Kuo J.F. An-tileukemic agent alkyl-lysophospholipid regulates phosphor ylation of distinct proteins in HL60 and K562 cells and dif ferentiation of HL60 cells promoted by phorbol ester. Biochem. Biophys. Res. Comm. 1987; 142: 661–666
  • Shoji M., Raynor R.L., Berdel W.E., Vogler W.R., Kuo J.F. Effects of thioether phospholipid BM 41.440 on protein kinase C and phorbol ester-induced differentiation of human leukemia HL60 and KG-1 cells. Cancer Res. 1988; 48: 6669–6673
  • Honma Y., Kasukabe T., Hozumi T., Tsushima S., Nomura H. Induction of differentiation of cultured human and mouse myeloid leukemia cells by alkyl-lysophos pholipids. Cancer Res. 1981; 41: 3211–3216
  • Vogler W.R., Whigham E., Bennett W.D., Olson A.C. The effect of alkyl-lysophospholipids on phos-phatidylcholine biosynthesis in leukemic cell lines. Exp. He matol. 1985; 13: 629–633
  • Lands W. E. M., Hart P. Metabolism of glycer-olipids. VI. Specificities of acyl coenzyme A: Phospholipid acyltransferases. J. Biol. Chem. 1965; 240: 1905–1911
  • Vogler W.R., Olson A.C. The effect of alkyl-lysophospholipids on phosphatidylcholine biosynthesis. The Cell Membrane as a Target for Tumor Therapy. Aktuelle On-kologie, C. Unger, H. Eibl, G.A. Nagel. W. Zuckschwerdt Verlag, MunichGermany 1987; Vol. 34: 80–92
  • Kennedy E.P., Weiss S.B. The function of cy-tidine coenzymes in the biosynthesis of phospholipids. J. Biol. Chem. 1956; 222: 193–214
  • Vogler W.R., Goodwyn D., Sergenton S. The effect of edelfosine on de novo phospholipid biosynthesis in leukemic cell lines. Proceedings of American Association for Cancer Research. 1993; vol. 34: 353
  • Tidwell T., Guzman G., Vogler W.R. The effects of alkyl-lysophospholipids on leukemic cell lines. I. Dif ferential action on two human leukemic cell lines HL60 and K562. Blood 1981; 57: 794–797
  • Long R.C., Jr., Small W.C., Brynes R.K., Tidwell T., Goldstein J.H., Vogler W.R. Effects of alkyl-lysophospholipids on human leukemic cell lines measured by nuclear magnetic resonance. Cancer Res. 1983; 43: 770–775
  • Vogler W.R., Olson A.C., Shoji M., Li H., Kiss Z., Kuo J.F. Effect of alkyl-lysophospholipids in phosphatidylcholine biosynthesis in leukemic cell lines. The Pharmacological Effects of Lipids II, J.J. Kabara. Lauricidin, Inc., Galena, IL 1989; 314–329
  • Hoffman D.R., Hoffman L.H., Snyder F. Cy-totoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells. Cancer Res. 1986; 46: 5803–5809
  • Van Blitterswijk W.J., Hilkmann H., Storme G.A. Accumulation of an alkyl-lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 1987; 22: 820–823
  • Bazill G.W., Dexter T.M. Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells. Cancer Res. 1990; 50: 7505–7512
  • Kelley E.E., Modest E.J., Burns C.P. Uni directional membrane uptake on the ether lipid antineoplastic agent edelfosine by L1210 cells. Biochem. Pharmacol. 1993, In press
  • Fromm M., Berdel W.E., Schick H.D., Fink U., Pahlke W., Bicker U., Reichert A., Rastetter J. Anti-neoplastic activity of the thioether lysophospholipid derivative BM 41.440 in vitro. Lipids 1987; 22: 916–918
  • Vogler W.R., Olson A.C., Okamoto S., Somberg L.B., Glasser L. Experimental studies on the role of alkyl-lysophospholipids in autologous bone marrow trans plantation. Lipids 1987; 22: 919–923
  • Glasser L., Somberg L.B., Vogler W.R. Purg ing murine leukemic marrow with alkyl-lysophospholipids. Blood 1984; 64: 1288–1291
  • Vogler W.R., Somberg L.B., Glasser L. Effect of cryopreservation on purging of leukemic marrow with al kyl-lysophospholipids. Exp. Hematol. 1987; 15: 360–364
  • Okamoto S., Olson A.C., Vogler W.R., Winton E.F. Purging leukemic cells from simulated human re mission marrow with alkyl-lysophospholipid. Blood 1987; 69: 1381–1387
  • Berdel W.E., Schlehe H., Fink U., Emmerich B., Mau-Back P.A., Emslander H.P., Daum S., Rastetter J. Early tumor and leukemia response to alkyl-lysophos pholipids in a phase I study. Cancer 1982; 50: 2011–2015
  • Vogler W.R., Berdel W.E., Olson A.C., Winton E.F., Heffner L.T., Gordon D.G. Autologous bone marrow transplantation in acute leukemia with marrow purged with alkyl-lysophospholipid. Blood 1992; 80: 1423–1429
  • Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 1958; 53: 457–481
  • Yeager A.M., Kaizer H., Santos G.W., Saral R., Col-Vin O.M., Stuart R.K., Braine H.G., Burke P.J., Am-Binder R.F., Bums W.H., Fuller D.J., Davis J.M., Karp J.E., May S., Rowley S.D., Sensenbrenner L.L., Vogelsang G.B., Wingard J.R. Autologous bone marrow transplantation in patients with acute nonlymphocytic leukemia, using ex vivo treatment with 4-hydroperoxycyclo-phosphamide. N. Engl. J. Med. 1986; 315: 141–147
  • Gorin N.C., Aegerter P., Auvert B., Meloni B., Gold-Stone A.H., Burnett A., Carella A., Körbling M., Herve P., Maraninchi D., Löwenberg R., Verdonck L.F., de Planque M., Hermans J., Helbig W., Porcellini A., Riz-Zoli V., Alesandrino E.P., Franklin I.M., Reiffers J., Colleselli P., Goldman J.M. Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: A European survey of the role of marrow purging. Blood 1990; 75: 1606–1614
  • Chopra R., Goldstone A.H., McMillan A.K., Powles R., Smith A.G., Prentice H.G., Reid C., Marcus R., Bell A., Milligan D., McCarthy D., Morgenstern G., Bar nard D. Successful treatment of acute myeloid leukemia beyond first remission with autologous bone marrow transplantation using busulfan/cyclophosphamide and un-purged marrow: The British Autograft Group Experience. J. Clin. Oncol. 1991; 9: 1840–1847
  • McMillan A.K., Goldstone A.H., Linch D.C., Gribben J.G., Patterson K.G., Richards J. D. M., Franklin I., Boughton B.J., Milligan D.W., Leyland M., Hutchison R.M., Newland A.C. High-dose chemotherapy and autologous bone marrow transplantation in acute myeloid leukemia. Blood 1990; 76: 480–488
  • Körbling M., Hunstein W., Fliedner T.M., Cayeux S., Dorken B., Fehrentz D., Haas R., Ho A.D., Keilholz U., Knauf W., Konig A., Mende U., Pezzutto A., von Reumont J., Wolf G.K., Wannenmacher M., zum Winkel K., Rother K. Disease-free survival after autologous bone marrow transplantation in patients with acute my-elogenous leukemia. Blood 1989; 74: 1898–1904
  • Büchner T., Hiddemann W., Loffler G., Gassmann W., Maschmeyer G., Heit W., Hossfeld D., Weh H., Ludwig W.-D., Thiel E., Nowrousian M., Aul C., Lengfelder E., Lathan B., Mainzer K., Urbanitz D., Emmerich B., Mid-Delhoff G., Donhuijsen-Ant H.R., Hellriegel H.-P., Heinecke A. Improved cure rate by very early intensification combined with prolonged maintenance chemother apy in patients with acute myeloid leukemia: data from the AML Cooperative Group. Semin. Hematol. 1991; 28: 76–79
  • Schiller G., Gajewski J., Territo M., Nimer S., Lee M., Belin T., Champlin R. Long-term outcome of high-dose cytarabine-based consolidation chemotherapy for adults with acute myelogenous leukemia. Blood 1992; 80: 2977–2982
  • Omura G., Raney M. Long-term survival in adult acute lymphoblastic leukemia: follow-up of a Southeastern Cancer Study Group trial. J. Clin. Oncol. 1985; 3: 1053–1058
  • Hoelzer D., Thiel E., Loffler H., Büchner T., Ganser A., Heil G., Koch P., Freund M., Diedrich H., Ruhl H., Maschmeyer G., Lipp T., Nowrousian M.R., Burkert M., Gereck D., Pralle H., Muller U., Lunscken C., Fulle H., Ho A.D., Kuchler R., Busch F.W., Schneider W., Gorg C., Emmerich B., Braumann D., Vaupel H.A., von Pa-Leske A., Bartels H., Neiss A., Messerer D. Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults. Blood 1988; 71: 123–131
  • Gaynor J., Chapman D., Little C., McKenzie S., Miller W., Andreeff M., Arlin Z., Berman E., Kempin S., Gee T., Clarkson B. A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lym phoblastic leukemia: The Memorial Hospital experience since 1969. J. Clin. Oncol. 1988; 6: 1014–1030
  • Hussein K.K., Dahlberg S., Head D., Waddell C.C., Dabich L., Weick J.K., Momson F., Saiki J.H., Metz E., Rivkin S.E., Grever M.R., Boldt D., for the Southwestern Oncology Group. Treatment of acute lymphoblastic leukemia in adults with intensive induction, consolidation, and maintenance chemotherapy. Blood 1989; 73: 57–63
  • Ramsay N., LeBien T., Nesbit M., McGlave P., Weis-Dorf D., Kenyon P., Hurd D., Goldman A., Kim T., Kersey J. Autologous bone marrow transplantation for patients with acute lymphoblastic leukemia in second or sub sequent remission: Results of bone marrow treated with monoclonal antibodies BA-1, BA-2, and BA-3 plus complement. Blood 1985; 66: 508–513
  • Simonsson B., Burnett A.K., Prentice H.G., Hann I.H., Brenner M.K., Gibson B., Grob J.P., Lönnerholm G., Morrison A., Smedmyr B., Todd A., Öberg G., Gilmore M., Campana D., Tötterman T. Autologous bone marrow transplantation with monoclonal antibody purged marrow for high risk acute lymphoblastic leukemia. Leukemia 1989; 3: 631–636
  • Arnold R., Schmeiser T., Heit W., Frickhofen N., Pabst G., Heimpel H., Kubanek B. Hemopoietic re-constitution after bone marrow transplantation. Exp. Hematol. 1986; 14: 271–277
  • Rowley S.D., Jones R.J., Piantadosi S., Braine H.G., Colvin O.M., Davis J., Saral R., Sharkis S., Wingard J., Yeager A.M., Santos G.W. Efficacy of ex vivo purging for autologous bone marrow transplantation in the treatment of acute nonlymphoblastic leukemia. Blood 1989; 74: 501–506
  • Fenaux P., Castaigne S., Dombret H., Archimbaud E., Duarte M., Morel P., Lamy T., Tilly H., Guerci A., Ma-Loisel F., Bordessoule D., Sadoun A., Tiberghien P., Fe-Gueux N., Daniel M.T., Chomienne C., Degos L. A controlled trial of recombinant human granulocyte-macrophage colony-stimulating factor after total body irradiation, high-dose chemotherapy, and autologous bone marrow transplantation for acute lymphoblastic leukemia or malignant lymphoma. Blood 1992; 80: 2188–2195

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