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Original Article

T Cells in Multiple Myeloma: Is This a Reliable Population to Count on as Antitumor Effector Cells?

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Pages 63-70 | Received 16 May 1994, Published online: 01 Jul 2009

References

  • Boccadoro M., Pileri A. Standard chemotherapy for myelomatosis: an area of great controversy. Hematol. Oncol. Clin. N. Am. 1992; 6: 371–382
  • Alexanian R., Haut A., Khan A.U., Lane M., McKelvey E.M., Migliore P.J., Stuckey W.J., Wilson E.M. Treatment of multiple myeloma: combination chemotherapy with different melphalan dose regimens. JAMA 1969; 208: 1680–1685
  • Mandelli F., Avvisati G., Amadori S., Boccadoro M., Gernone A., Lauta V.M., Marmont F., Petrucci M.T., Tribalto M., Vegna M.L., Dammacco F., Pileri A. Maintenance treatment with alpha-2b recombinant interferon significantly improves response and survival duration in multiple myeloma patients responding to conventional induction chemotherapy. N. Engl. J. Med. 1990; 322: 1430–1434
  • Hoover R.G., Kornbluth J. Immunoregulation of murine and human myeloma. Hematol. Oncol. Clin. N. Am. 1992; 6: 407–424
  • Kyle R.A. Long-term survival in multiple myeloma. N. Engl. J. Med. 1983; 308: 314–316
  • Alexanian R., Gehan E., Haut A., Saiki J., Weick J. Unmaintained remissions in multiple myeloma. Blood 1978; 51: 1005–1011
  • Joshua D.E., Wearne A., Kronenberg H. Immunoregulation and prognosis in myeloma. Lancet 1987; ii: 251–253
  • Lea T., Forre O.T., Michaelsen T.E., Natvig J.B. Shared idiotypes on human peripheral blood B and T lymphocytes. J. Immunol. 1979; 122: 2413–2417
  • Preud'homme J.L., Klein M., LaBaume S., Seligman M. Idiotype-bearing and antigen-binding receptors produced by blood T lymphocytes in a case of human myeloma. Eur. J. Immunol. 1977; 7: 840–844
  • Moller G. Idiotypes on T and B cells. Immunol. Rev. 1977; 34: 1–164
  • Hoover R.C., Hickman S., Gebel H.M., Rebbe N., Lynch R.G. Expansion of Fc Receptor-bearing T lymphocytes in patients with immunoglobulin G and immunoglobulin A myeloma. J. Clin, invest. 1981; 67: 308–311
  • Berenson J., Lichtenstein A. Clonal rearrangement of the beta-T cell receptor gene in multiple myeloma. Leukemia 1989; 3: 133–136
  • Dianzani U., Pileri A., Boccadoro M., Palumbo A., Pioppo P., Bianchi A., Camponi A., Battaglio S., Massaia M. Activated idiotype-reactive cells in suppressor/cytotoxic subpopulations of monoclonal gammopathies: correlation with diagnosis and disease status. Blood 1988; 72: 1064–1068
  • Wen T., Mellstedt H., Jondal M. Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma. J. Exp. Med. 1990; 171: 659–666
  • Janson C.H., Grunewald J., Osterborg A., Der Simonian H., Brenner M.B., Mellstedt H., Wigzell H. Predominant T cell receptor V gene usage in patients with abnormal clones of B cells. Blood 1991; 77: 1776–1780
  • Holm G., Bergenbrant S., Lefvert A.K., Yi Q., Osterborg A., Mellstedt H. Anti-idiotypic immunity as a potential regulator in myeloma and related diseases. Ann. NY Acad. Sci. 1992; 636: 178–183
  • Osterborg A., Masucci M., Bergenbrant S., Holm G., Lefvert A.K., Mellstedt H. Generation of T cell clones binding F(ab')2 fragments of the idiotypic immunoglobulin in patients with monclonal gammopathy. Cancer Immunol. Immunother. 1991; 34: 157–162
  • Massaia M., Dianzani U., Bianchi A., Camponi A., Boccadoro M., Pileri A. Defective generation of alloreactive cytotoxic T lymphocytes (CTL) in human monoclonal gammopathies. Clin. Exp. Immunol. 1988; 73: 214–218
  • Massaia M., Bianchi A., Dianzani U., Camponi A., Attisano C., Boccadoro M., Pileri A. Defective interleukin-2 induction of lymphokine-activated killer (LAK) activity in peripheral blood T lymphocytes of patients with monoclonal gammopathies. Clin. Exp. Immunol. 1989; 79: 100–104
  • Boccadoro M., Omede P., Massaia M., Dianzani U., Pioppo P., Battaglio S., Meregalli M., Pileri A. Human myeloma: several subsets of circulating lymphocytes express plasma cell-associated antigens. Eur. J. Haematol. 1988; 40: 299–304
  • Omede P., Boccadoro M., Gallone G., Frieri R., Battaglio S., Redoglia V., Pileri A. Multiple myeloma: increased circulating lymphocytes carrying plasma cell-associated antigens as an indicator of poor survival. Blood 1990; 76: 1375–1379
  • Massaia M., Dianzani U., Bianchi A., Camponi A., Boccadoro M., Pileri A. Immune dysregulation in monoclonal gammopathies. Bone Marrow Transplant 1989; 4(suppl 1)165–167
  • Massaia M., Ma D. D. F., Boccadoro M., Golzio F., Gavarotti P., Dianzani U., Pileri A. Decreased ecto-5′nucleoti-dase activity of peripheral blood lymphocytes in human monoclonal gammopathies: correlation with tumor cell kinetics. Blood 1985; 65: 530–534
  • San Miguel J.F., Gonzalez M., Gascon A., Moro M.J., Hernandez J.M., Ortega F., Jimenez R., Guerras L., Romero M., Casanova F. Lymphoid subsets and prognostic factors in multiple myeloma. Cooperative Group for the Study of Monoclonal Gammopathies. Br. J. Haematol. 1992; 80: 305–309
  • Vacca A., Di Stefano R., Frassanito A., Lodice G., Dammacco F. A disturbance of the IL-2/IL-2 receptor system parallels the activity of multiple myeloma. Clin. Exp. Immunol. 1991; 84: 429–434
  • Cimino G., Avvisati G., Amadori S., Cava M.C., Giannarelli D., Di Nucci G.D., Magliocca V., Petrucci M.T., Poti G., Sgadari C. High serum IL-2 levels are predictive of prolonged survival in multiple myeloma. Br. J. Haematol. 1990; 75: 373–377
  • Bretscher P. The two-signal model of lymphocyte activation twenty-one years later. Immunol. Today 1992; 13: 74–76
  • Raff M.C. Social controls on cell survival and cell death. Nature 1992; 356: 397–400
  • Uehara T., Miyawaki T., Ohta K., Tamaru Y., Yokoi T., Nakamura S., Taniguchi N. Apoptotic cell death of primed CD45R0+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis. Blood 1992; 80: 452–458
  • Meyaard L., Otto S.A., Jonker R.R., Mijnster M.J., Keet R. P. M., Miedema F. Programmed death of T cells in HIV-1 infection. Science 1992; 257: 217–219
  • Truneh A., Albert F., Goldstein P., Schmitt-Verhulst A.M. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature 1985; 313: 318–320
  • Massaia M., Bianchi A., Attisano C., Peola S., Redoglia V., Dianzani U., Pileri A. Detection of hyperreactive T cells in multiple myeloma by multivalent cross-linking of the CD3/TCR complex. Blood 1991; 78: 1770–1780
  • June C.H., Fletcher M.C., Ledbetter J.A., Samelson L.E. Increases in tyrosine phopshorylation are detectable before phospholipase C activation after T cell receptor stimulation. J. Immunol. 1990; 144: 1591–1599
  • Massaia M., Perrin L., Bianchi A., Ruedi J., Attisano C., Altieri A., Rijkers G.T., Thompson L.F. Human T cell activation: synergy between CD73 (ecto-5′nucleotidase) and signals delivered through CD3 and CD2 molecules. J. Immunol. 1990; 145: 1664–1674
  • Yun Y.S., Hargrove M.E., Ting C.C. In vivo antitumor activity of anti-CD3-induced activated killer cells. Cancer Res. 1989; 49: 4770–4774
  • Anderson P.M., Blazar B.R., Bach F.H., Ochoa A.C. Anti-CD3 + IL-2-stimulated murine killer cells. In vitro generation and in vivo antitumor activity. J. Immunol. 1989; 142: 1383–1394
  • Gallinger S., Hoskin D.W., Mullen J. B. M., Wong A. H. C., Roder J.C. Comparison of cellular immunotherapies and anti-CD3 in the treatment of MCA 38-LD experimental hepatic metastases in C57BL/6 mice. Cancer Res. 1990; 50: 2476–2480
  • Yang S.C., Owen-Schaub L.B., Roth J.A., Grimm E.A. Characterization of OKT3-initiated lymphokine-activated effectors expanded with interleukin-2 and tumor necrosis factor-α. Cancer Res. 1990; 50: 3526–3532
  • Ellenhom J.D., Hirsch R., Schreiber H., Bluestone J.A. In vivo administration of anti-CD3 prevents malignant progressor tumor growth. Science 1988; 242: 569–571
  • Yoshizawa H., Chang A.E., Shu S. Specific adoptive immunotherapy mediated by tumor-draining lymph node cells sequentially activated with anti-CD3 and IL-2. J. Immunol. 1991; 147: 729–737
  • Schoof D.D., Selleck C.M., Massaro A.F., Jung S.E., Eberlein T.J. Activation of human tumor-infiltrating lymphocytes by monoclonal antibodies directed to the CD3 complex. Cancer Res. 1990; 50: 1138–1143
  • Crossland K.D., Lee V.K., Chen W., Riddell S.R., Greenberg P.D., Cheever M.A. T cells from tumor-immune mice nonspecifically expanded in vitro with anti-CD3 plus IL-2 retain specific function in vitro and eradicate disseminated leukemia in vivo. J. Immunol. 1991; 146: 4414–4420
  • Massaro A.F., Schoof D.D., Rubinstein A., Zuber M., Leonard-Vidal F.J., Eberlein T.J. Solid-phase anti-CD3 antibody activation of murine tumor-infiltrating lymphocytes. Cancer Res. 1990; 50: 2587–2592
  • Yoshizawa H., Sakai K., Chang A.E., Shu S. Activation by anti-CD3 of tumor-draining lymph node cells for specific adoptive immunotherapy. Cell. Immunol. 1991; 134: 473–479
  • Urba W.J., Ewel C., Kopp W., Smith J.W., Steis R.G., Ashwell J.D., Creekmore S.P., Rossio J., Sznol M., Sharfman W., Fenton R., Janik J., Watson T., Beveridge J., Longo D.L. Anti-CD3 monoclonal antibody treatment of patients with CD3-negative tumors: a phase IA/B study. Cancer Res. 1992; 52: 2394–2401
  • Massaia M., Bianchi A., Peola S., Borrione P., Attisano C., Pileri A. Sequential administration of OKT3 (anti-CD3) and interleukin-2 in two patients with chemoresistant hematological disease. Eur. J. Haematol. 1992; 49: 150–152
  • Curti B.D., Longo D.L., Ochoa A.C., Conlon K.C., Smith J.W., Alvord G., Creekmore S.P., Fenton R.G., Gause B.L., Holmlund J., Janik J.E., Ochoa J., Rice P.A., Sharfman W.H., Sznol M., Urba W.J. Treatment of cancer patients with ex vivo anti-CD3-activated killer cells and interleukin-2. J. Clin. Oncol. 1993; 11: 652–660
  • Crabtree G.R. Contingent genetic regulatory events in T lymphocyte activation. Science 1989; 243: 355–361
  • Anderson K.C., Jones R.M., Morimoto C., Leavitt P., Barm B.A. Response patterns of purified myeloma cells to hematopoietic growth factors. Blood 1989; 73: 1915–1924
  • Zhang X.G., Klein B., Bataille R. Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma. Blood 1989; 74: 11–13
  • Zhang X.G., Bataille R., Jourdan M., Saeland S., Banchereau J., Mannoni P., Klein B. Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells. Blood 1990; 76: 2599–2605
  • Caligaris-Cappio F., Bergui L., Gregoretti M.G., Gaidano G.L., Gaboli M., Schena M., Zambonin Zallone A., Marchisio P.C. Role of bone marrow stromal cells in the growth of human multiple myeloma. Blood 1991; 77: 2688–2693
  • Vernino L., McAnally L.M., Ramberg J., Lipsky P.E. Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated with anti-CD3 activated T cells. J. Immunol. 1992; 148: 404–410
  • Massaia M., Attisano C., Peola S., Montacchini L., Omede P., Corradini P., Ferrero D., Boccadoro M., Bianchi A., Pileri A. Rapid generation of anti-plasma cell activity in the bone marrow of myeloma patients by CD3 cross-linking. Blood 1993; 82: 1787–1797
  • Charak B.S., Malloy B., Agah R., Mazumder A. A novel approach to purging of leukemia by activation of bone marrow with interleukin-2. Bone Marrow Transplant 1990; 6: 193–198
  • Van den Brink M. R. M., Voogt P.J., Marjit W. A. F., van Luxemburg-Heys S. A. P., van Rood J.J., Brand A. Lymphokine activated killer cells selectively kill tumor cells in bone marrow without compromising stem cell function in vitro. Blood 1989; 74: 254–360
  • Weiden P.L., Sullivan K. ML, Flournoy N., Storb R., Thomas E.D. Antileukemic effect of chronic graft-versus-host disease. N. Engl. J. Med. 1981; 304: 1529–1531
  • Maraninchi D., Blaise D., Rio B., Leblond V., Dreyfus F., Gluckman E., Guyotat D., Pico J.L., Michallet M., Ifrah N., Bordigoni A. Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukemias. Lancet 1987; II: 175–178
  • Charak B.S., Brynes R.K., Groshen S., Chen S.C., Mazumder A. Bone marrow transplantation with interleukin-2-activated bone marrow followed by interleukin-2-therapy for acute myeloid leukemia in mice. Blood 1990; 76: 2187–2191
  • Gibson F.M., Malkovska V., Myint A.A., Meager A., Gordon-Smith E.C. Mechanism of suppression of normal hemopoietic activity by lymphokine-activated killer cells and their products. Exp. Hematol. 1991; 19: 659–663
  • Takahashi M., Oshimi K., Mizoguchi H. Inhibition of human granulocite-macrofage colony formation by interleukin-2-treated lymphocytes is mediated by interferon-γ and tumor necrosis factor-α. Exp. Hematol. 1990; 18: 395–399
  • Monaco A.P. Renal prophylaxis with Orthoclone OKT3 in the United States. Transplant. Proc 1989; 21(Suppl. 2)7–13
  • Busuttil R.W. Use of Orthoclone OKT3 for prophylaxis in liver transplantation and its re-use in liver allograft rejection. Transplant. Proc 1989; 21(Suppl. 2)19–23
  • Goldstein J.P., Primo G. Prophylaxis with OKT3 in high-risk heart transplant patients. Transplant. Proc 1989; 21(Suppl. 2)35–36
  • Burke G.W., III, Vercellotti G.M., Simmons R.L., Howe R.B., Canafax D.M., Najarian J.S. Reversible pancytopenia following OKT3. Use in the contest of multidrug suppression for kidney allografting. Transplantation 1989; 48: 403–408
  • Notter M., Maurer J., Krackhardt A., Henkel B., Henze K., Bochert G., Ludwig W.D., Berdel W.E., Thiel E. Ex vivo elimination of chronic myeloid leukemia (CML) cells following activation and targeting of host T cells by combination of cytokines and CD3 monoclonal antibodies. Blood 1993; 82(suppl 1)975
  • Abramowicz A., Schandene L., Goldman M., Crusiaux A., Vereerstraeten P., De Pauw L., Wybran J., Kinnaert P., Dupont E., Toussaint C. Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients. Transplantation 1989; 47: 606–608
  • Ferran C., Sheehan K., Dy M., Schreiber R., Merite S., Landais P., Noel L.H., Grau G., Bluestone J., Bach J.F., Chatenoud L. Cytokine-related syndrome following injection of anti-CD3 monoclonal antibody: further evidence for transient in vivo T cell activation. Eur. J. Immunol. 1990; 20: 509–515
  • Ellenhorn J.D., Woodle E.S., Ghobreal I., Thistlewaite J.R., Bluestone J.A. Activation of human T cells in vivo following treatment of transplant recipients with OKT3. Transplantation 1990; 50: 608–612
  • Nishimura T., Nakamura Y., Takeuchi Y., Tokuda Y., Iwasawa M., Kawasaki A., Okumura K., Habu S. Generation, propagation, and targeting of human CD4+ helper/killer T cell induced by anti-CD3 monoclonal antibody plus recombinant IL-2. J. Immunol. 1992; 148: 285–291
  • Yannelli J.R., Crumpacker D.B., Good R.W., Friddell C.D., Poston R., Horton S., Maleckar J.R., Oldham R.K. Use of anti-CD3 monoclonal antibody in the generation of effector cells from human solid tumors for use in cancer biotherapy. J. Immunol. Methods 1990; 1: 91–94
  • Attisano C., Bianchi A., Montacchini L., Carlesso N., Peola S., Bruno B., Roux V., Ferrero D., Gallo E., Boccadoro M., Pileri A., Massaia M. Generation of anti-tumour activity by OKT3-stimulation in multiple myeloma: in vitro inhibition of autologous haemopoiesis. Brit. J. Haematol. 1994; 87, in press

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