Advanced search
Publication Cover
Leukemia & Lymphoma Volume 17, 1995 - Issue 3-4
Submit an article Journal homepage
40
Views
22
CrossRef citations to date
0
Altmetric
Original Article

Clonal CD3+CD8+ Large Granular Lymphocyte (LGL)/NK-Associated (NKa) Expansions: Primary Malignancies or Secondary Reactive Phenomena?

Stephen J. Richards Haematological Malignancy Diagnostic Service, Institute of Pathology, Leeds General Infirmary, Leeds, England, UK
,
Michael Short Haematological Malignancy Diagnostic Service, Institute of Pathology, Leeds General Infirmary, Leeds, England, UK
&
Colin Stephen Scott Haematological Malignancy Diagnostic Service, Institute of Pathology, Leeds General Infirmary, Leeds, England, UK
Pages 303-311 | Received 10 Jul 1994, Published online: 01 Jul 2009

References

  • Scott C. S., Richards S. J. Classification of large granular lymphocyte (LGL) and NK-associated (NKa) disorders. Blood Reviews 1992; 6: 220–233
  • Scott C. S., Richards S. J., Sivakumaran M., Short M., Child J. A., Hunt K. M., McEvoy M. W., Steed A. J., Balfour I. C., Parapia L. A., McVerry B. A., Bynoe A. G., Galvin M. C., Norfolk D. R., Roberts B. E. Transient and persistent expansions of large granular lymphocytes (LGL) and NK-associated (NKa) cells: The Yorkshire Leukaemia Group study. Br. J. Haematol. 1993; 83: 504–515
  • Sivakumaran M., Richards S. J., Hunt K. M., Steed A. J., Bynoe A. G., Morgan M. M., Pyrah R., Roberts B. E., Scott C. S. Patterns of CD 16 and CD56 expression in persistent expansions of CD3+NKa+ lymphocytes are predictive for clonal T-cell receptor gene rearrangements. Br. J. Haematol. 1991; 78: 368–377
  • Scott C. S., Richards S. J., Sivakumaran M., Steed A. J., Norfolk D. R., Milligan D. W., Short M. Persistent clonal expansions of lymphocytes associated with neutropenia. Leukemia and Lymphoma 1994, (in press)
  • Wagner L., Base W., Wiesholzer M., Sexl V., Bognar H., Worman C. P. Detection of BLT substrate-specific proteases in individual human peripheral blood leucocytes and bone marrow cells: Application to the classification of leukaemia. Journal of Immunological Methods 1991; 142: 147–155
  • Richards S. J., Scott C. S. Immunophenotypic dissection of normal peripheral blood NK associated (NKa) subpopulations by flow cytometry: Morphological features and relationships between membrane NKa (CD11b, CD16, CD56 and CD57) and T-cell (CD2, CD3, TCR, CD5, CD7, CD8 and CD38) associated determinant expression. Leukemia and Lymphoma 1990; 2: 111–126
  • Richards S. J., Scott C. S. Human NK cells in health and disease: Clinical, functional, phenotypic and DNA genotypic characteristics. Leukemia and Lymphoma. 1992; 7: 377–399
  • Waldmann T. A. The arrangement of immunoglobulin and T cell receptor genes in human lymphoproliferative disorders. Advances in Immunol. 1987; 40: 247–321
  • Wang E. C. Y., Taylor-Wiedman J., Perera P., Fisher J., Borysiewicz L. K. Subsets of CD8+ CD57+ cells in normal. healthy individuals: correlations with human cytomegalovirus (HCMV) carrier status, phenotypic and functional analyses. Clin. Exp. Immunol. 1993; 94: 297–305
  • Braakman E., Sturm E., Vijverberg K., van Krimpen B. A., Gratama J. W., Bolhuis R. L. H. Expression of CD45 isoforms by fresh and activated human γ T lymphocytes and natural killers cells. Internatl. Immunol. 1991; 3: 691–697
  • Richards S. J., Jones R. A., Roberts B. E., Scott C. S. Relationships between 2H4 (CD45RA) and UCHL1 (CD45RO) expression by normal blood CD4+CD8-, CD4-CD8+, CD4-CD8dim+, CD3+CD4-CD8- and CD3-CD4-CD8 lymphocytes. Clin. Exp. Immunol. 1990; 81: 149–155
  • Richards S. J., Jones R. A., Roberts B. E., Scott C. S. T-cell membrane CD45RA (2H4) and CD45RO (UCHLI) determinants: Diverse patterns of expression in mature (post-thymic) T-cell proliferations. Leukemia and Lymphoma 1991; 4: 27–37
  • Loughran T. P. Clonal diseases of large granular lymphocytes. Blood 1993; 82: 1–14

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.