The SKM-1 Leukemic Cell Line Established from a Patient with Progression to Myelomonocytic Leukemia in Myelodysplastic Syndrome (MDS)-Contribution to Better Understanding of MDS

References

• Bennett J. M., Catovsky D., Flandrin G., Galton D. A. G., Gralnick H. R., Sultan C. Proposals for the classification of the myelodysplastic syndromes. Brit. J. Haematol. 1982; 51: 189–99
   PubMed Web of Science ®Google Scholar
• Koeffler H. P. Myelodysplastic syndromes. Seminars in Hematol. 1986; 23: 284–99
   PubMed Web of Science ®Google Scholar
• Fialkow P. J., Singer J. W., Raskind W., Adamson J. W., Jacobson R. J., Bernstein J. D., Dow L. W. D., Najfeld V., Veith R. Clonal development stem-cell differentiation and clinical remission in acute non-lymphocytic leukemia. N. Eng. J. Med. 1987; 317: 468–473
   PubMed Web of Science ®Google Scholar
• Ferraris A. M., Canepa L., Mareni C. Reexpression of normal stem eels in erythroleukemia during remission. Blood 1983; 62: 177–179
   PubMed Web of Science ®Google Scholar
• Bartram C. R., Ludwig W. D., Hiddemann W., Lyons J., Buschle M., Ritter J., Harbott J., Frohlich A., Janssen J. W. G. Acute Myeloid Leukemia Analysis of Ras Gene Mutations and Clonality Defined by Polymorphic X-Linked Loci. Leukemia 1989; 3: 247–256
   PubMed Web of Science ®Google Scholar
• Fialkow P. J., Janssen J. W. G., Bartram C. R. Clinical remission in acute nonlymphocytic leukemia: Evidence for a multi step pathogenesis of the malignancy. Blood. 1991; 77: 1415–1417
   PubMed Web of Science ®Google Scholar
• Prchal J. T., Throckmorton D. W., Carrol A. J., Fuson E. W., Gams R. A., Prchal J. F. A common progenitor for human myeloid and lymphoid cells. Nature 1978; 274: 590–591
   PubMed Web of Science ®Google Scholar
• Raskind W. H., Tirumali N., Jacobson R., Singer J., Fialkow P. J. Evidence for a multistep pathogenesis of myelodysplastic syndrome. Blood 1984; 63: 1318–1323
   PubMed Web of Science ®Google Scholar
• Janssen J. W. G., Buschle M., Layton M., Drexler H. G., Lyons J., Vanden B. H., Heimpel H., Kubanek B., Kleihauer E., Mufti G. H., Bartram C. R. Clonal analysis of myelodysplastic syndromes: evidence of multipotent stem cell origin. Blood 1989; 73: 248–254
   PubMed Web of Science ®Google Scholar
• Classification Pathogenesis and etiology of neoplastic diseases of the Hematopoietic system. Wintrobe's Clinical Hematology, ninth edition, K. S. Arthur, 1993; 1725–1791
   Google Scholar
• Jacob A. Oncogenes in the myelodysplastic syndrome. Blood 1989; 3: 105–109
   Web of Science ®Google Scholar
• Bos J. L., Verlaan-De V. M., Van D. E. A. J., Janssen J. W. G., Delwel R., Lowenberg B., Colly L. P. Mutayions in Nras predominate in acute myeloid leukemia. Blood 1987; 69: 1237–1241
   PubMed Web of Science ®Google Scholar
• Farr J. F., Saiki R. K., Erlich H. A., McComick F., Marshall C. J. Analysis of ras gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc. Natl. Acad. Sci. USA 1988; 85: 1629–1633
   PubMed Web of Science ®Google Scholar
• Janssen J. W. G., Steenvoorden A. C. M., Lyon J., Anger B., Bohlke J., Bos J. L., Seliger H., Bartram C. R. Ras gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplasric syndromes. Proc. Natl. Acad. Sci. USA 1987; 84: 9228–9232
   PubMed Web of Science ®Google Scholar
• Bos J. L., Verlaan-De V. M., Jansen A. M., Veeneman G. H., Vanboom J. H., Van-der Eb A. J. Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization. Nucleic Acids Res. 1984; 12: 9155–9163
   PubMed Web of Science ®Google Scholar
• Hirai H., Kobayashi Y., Mano H., Hagiwara K., Maru Y., Omine M., Mizoguchi H., Nishida J., Takaku F. A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome. Nature 1987; 327: 430–432
   PubMed Web of Science ®Google Scholar
• Liu E., Hjelle B., Morgan R., Hecht F., Bishop M. Mutations of the Kirsten-ras proto-oncogene in human preleukemia. Nature 1987; 330: 186–188
   PubMed Web of Science ®Google Scholar
• Lyons J., Janssen J. W. G., Bartram C., Layton M., Mufti G. J. Mutation of Ki-ras oncogenes in myelodysplastic syndromes. Blood 1988; 71: 1707–1712
   PubMed Web of Science ®Google Scholar
• Padua R. A., Carter G., Hughes D., Gow J., Farr C., Oscier D., McCormick F., Jacob A. Ras mutations in myelodysplasia detected by amplification, oligonucleotide hybridization and transformation. Leukemia 1988; 2: 503–510
   PubMed Web of Science ®Google Scholar
• Melani C., Canepa L., Sessarego M., Miglino M., Ferraris A. M., Gaetani G. F. Molecular analysis of the bcr rearrangement in a case of PH1-negative blastic crisis of PH1-positive chronic myelogenous leukemia. Eur. J. Hemat. 1989; 42: 32–47
   PubMed Web of Science ®Google Scholar
• Nakagawa T., Saitoh S., Imoto S., Itoh M., Tsutsumi M., Hikiji K., Nakamura H., Matozaki S., Ogawa R., Nakao Y., Fujita T. Multiple Point Mutation of N-ras and K-ras Oncogenes in Myelodysplastic, Syndrome and Acute Myelogenous Leukemia. Oncol 1992; 49: 114–122
   Google Scholar
• Nakagawa T., Matozaki S., Murayama T., Nishimura R., Tsutsumi M., Kawaguchi R., Yokoyama Y., Hikiji K., Isobe T., Chihara K. Establishment of aleukemic cell line from a patient with acquisition of chromosal abnormalities during disease progression in myelodysplastic syndrome. Brit. J. Hematol. 1993; 85: 469–476
   PubMed Web of Science ®Google Scholar
• Nakagawa T., Saitoh S., Imoto S., Itoh M., Tsutsumi M., Hikiji K., Nakao Y., Fujita T. Loss of multiple point mutations of ras genes associated with acquisition of chromosomal abnormalities during disease progression in myelodysplastic syndrome. Br. J. Hematol. 1991; 77: 250–252
   PubMed Web of Science ®Google Scholar
• Jowitt S. N., Liu Yin J. A., Saunders M. J. Relapsed myelodysplastic clone differs from acute onset clone as shown by X-linked DNA polymorphism patterns in a patient with acute myeloid leukemia. Blood 1993; 82: 613–618
   PubMed Web of Science ®Google Scholar
• Knudson A. G. A two mutation model for human cancer. Adv Viral Oncology 1987; 7
   Google Scholar
• Busque L., Gilliland D. G. Clonal Evolution in Acute Myeloid Leukemia. Blood 1993; 82: 337–342
   PubMed Web of Science ®Google Scholar
• Slingerland J. M., Minden M. D., Benchimol S. Mutation of p53Gene in human acute myelogenous leukemia. Blood 1991; 77: 1500–1507
   PubMed Web of Science ®Google Scholar
• Matozaki S., Nakagawa T., Kawaguchi R., Aozaki R., Tsutsumi M., Murayama T., Nishimura R., Isobe T., Chihara K., Establishment of a myeloid leukemic cell line from the patient with t(8;21) who acquired 17 monosomy during disease progression (submitted)
   Google Scholar
• Miyoshi H., Kozu T., Shimizu K., Enomoto K., Maseki N., Kaneko Y., Kamada N., Ohki M. The t(8;21) translocation in acute myeloid leukemia results in production of an AMLI-MTG8 fusion transcript. The EMBO J. 1993; 12: 2715–2721
   PubMed Web of Science ®Google Scholar
• Eliyahu D., Michalovitz D., Eliyahu S., Pinhasi-Kimhi O., Oren M. Wild-type p53 can inhibit oncogene-mediated focus formation. Proc. Natl. Acad. Sci. USA 1989; 86: 8763–8767
   PubMed Web of Science ®Google Scholar
• Lane D. P., Benchimol S. p53 Oncogene or anti-oncogene?. Gene and Development 1990; 4: 1–8
   PubMed Web of Science ®Google Scholar
• Vogelstein B., Kinzler K. W. p53 function and dysfunction. Cell 1992; 70: 523–526
   PubMed Web of Science ®Google Scholar
• Levine A. J., Momand J., Finlay C. A. The p53 tumor suppressor gene. Nature 1991; 351: 453–456
   PubMed Web of Science ®Google Scholar
• Curtis C. H., Monica H. P. Clinical implications of the p53 tumor-suppressor gene. N. Eng. J. Med. 1993; 329: 1318–1327
   PubMed Web of Science ®Google Scholar
• Livingstone L. R., White A., Sprouse J., Livanos E., Jacks T., Tlsty T. D. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 1992; 70: 923–925
   PubMed Web of Science ®Google Scholar
• Yin Y., Tainsky M. A., Bischoff F. Z., Strong L. C., Wahi G. M. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell. 1992; 70: 937–948
   PubMed Web of Science ®Google Scholar
• Crine M. J. The molecular basis of leukemia. N. Eng. J. Med. 1994; 328–336
   PubMed Web of Science ®Google Scholar
• Weinberg R. A. Tumor Suppressor Genes. Sci. 1991; 254: 1138–1146
   PubMed Web of Science ®Google Scholar
• Yonish R. E., Resnitzky D., Lotem J., Sachs L., Kimchi A., Oren M. Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhabited by interleukin-6. Nature 1991; 352: 345–347
   PubMed Web of Science ®Google Scholar
• Hollstein M., Sidransky D., Vogelstein B., Harris C. C. p53 mutations in human cancers. Sci. 1991; 253: 49–53
   PubMed Web of Science ®Google Scholar
• Sugimoto K., Toyoshima H., Sakai R., Miyagawa K., Hagiwara K., Hirai H., Ishikawa F., Takaku F. Mutations of the p53 gene in lymphoid leukemia. Blood 1991; 77: 1153–1156
   PubMed Web of Science ®Google Scholar
• Sakashita A., Hattori T., Miller C. W., Suzushima H., Asou N., Takatsuki K., Koeffer H. P. Mutation of the p53 gene in adult T-cell leukemia. Blood 1992; 79: 477–480
   PubMed Web of Science ®Google Scholar
• Prokocimer M., Shaklai M., Ben B. H. Expression of p53 in human leukemia and lymphoma. Blood 1986; 68: 113–118
   PubMed Web of Science ®Google Scholar
• Sugimoto K., Toyoshima H., Sakai R., Miyagawa K., Hagiwara K., Ishikawa F., Takaku F., Yazaki Y., Hirai H. Frequent mutations in the p53 gene in human myeloid leukemia cell line. Blood 1992; 79: 2378–2383
   PubMed Web of Science ®Google Scholar
• Fenaux P., Jonveaux P., Quiquandon I. p53 gene mutations in acute myeloid leukemia with 17p monosomy. Blood 1991; 78: 1652–1657
   PubMed Web of Science ®Google Scholar
• Fenaux P., Preudhomme C., Quiquandon I. Mutation pf the p53 gene in acute myeloid leukemia. Br. J. Hemat. 1992; 80: 178–183
   PubMed Web of Science ®Google Scholar
• Joyce M. S., Mark D. M., Benchimol Samuel. Mutation of the p53 gene in human acute myelogenous leukemia. Blood 1991; 77: 1500–1507
   PubMed Web of Science ®Google Scholar
• Baker S. J., Fearon E. R., Nigro J. M., Hamilton S. R., Presinger A. C., Jessup J. M., van Tuinen P., Ledbetter D. H., Baker D. F., Nakamura Y., White R., Vogelstein B. Chromosome 17 deletions and p53 gene mutations in coloretal carcinomas. Sci. 1989; 244: 217–221
   PubMed Web of Science ®Google Scholar
• Feinstein E., Cimino G., Gale P., Alimena G., Berthier R., Kishi K., Goldman J., Zaccaria A., Berrebi A., Canaani E. p53 in chronic myelogenous leukemia in acute phase. Proc. Natl. Acad. Sci. USA 1991; 88: 6293–6297
   PubMed Web of Science ®Google Scholar
• Mashal R., Shtalrid M., Talpaz M., Kantarjian H., Smith L., Beran M., Cork A., Trujillo J., Gutterman J., Deisseroth A. Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukemia. Blood 1990; 78: 180–189
   Google Scholar
• Ahuja H., Bar-Eli M., Advani S. H., Benchmol S., Cline M. J. Alteration in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia. Proc. Natl. Acad. Sci. USA 1989; 86: 6783–6787
   PubMed Web of Science ®Google Scholar
• Ahuja H., Bar-Eli M., Arlin Z. The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia. J Clin Invest 1991; 87: 2042–2047
   PubMed Web of Science ®Google Scholar
• Nakai H., Misawa S., Toguchida J., Yandell D. W., Ishizaki K. Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia especially in myeloid crisis harboring loss of a chromosome 17p. Cancer Res. 1992; 52: 6588–6593
   PubMed Web of Science ®Google Scholar
• Kawaguchi R., Hosokawa Y., Komine A., Tsutsumi M., Hikiji K., Ishida A., Suzuki K., Nakagawa T., Yamaguchi K. The Monocytic Cell Line SKM-1 Strongly Expresses the Myeloperoxidase Gene. Leukemia. 1992; 6: 1296–1301
   PubMed Web of Science ®Google Scholar
• Kawaguchi R., Yoshioka J., Hikiji K., Nakagawa T., Matozaki S., Hosokawa Y., Totani T. Expression of myeloperoxidase mRNA in newly established monocytic and myelocytic human cell lines. Cancer Genetics and Cytogenetics, (in press)
   Web of Science ®Google Scholar
• McCarty Z. T. M., Rajaraman S., Elder F. F. B., Gadson P., Thompson B. Establishment and Characterization of a Human Myeloid Cell Line from Philadelphia Chromosome-Negative Myeloblastic Leukemia Arising in a Patient with Myelogyplastic Syndrome. Blood 1987; 70: 1655–1672
   Google Scholar
• Papadopoulos N., Nicolaides N. C., Wei Y. F., Ruben S. M., Carter K. C., Rosen C. A., Haseltine W. A., Fleschmann R. D., Fraser C. M., Adams M. D., Venter J. C., Hamilton S. R., Petersen G. M., Watson P., Lynch H. T., Peltomaki P., Mecklin J. P., Chapelle A., Kinzler K. W., Vogelstein B. Mutation of a mutL Homolog in Hereditary Colon Cancer. Sci. 1994; 263: 1625–1629
   PubMed Web of Science ®Google Scholar
• Fishel R., Lescoe M. K., Rao M. R. S., Copeland N. G., Jenkins N. A., Garber J., Kane M., Kolodner R. The Human Mutator Gene Homolog MSH2 and Its Association with Hereditary Nonpolyposis Colon Cancer. Cell 1993; 75: 1027–1038
   PubMed Web of Science ®Google Scholar
• Parsons R., Li G. M., Longley M. J., Fang W., Papadopoulos N., Jen J., Chapelle A., Kinzler K. W., Vogelstein B., Modrich P. Hypermutability and Mismatch Repair Deficiency in RER Tumor Cells. Cell 1993; 75: 1227–1236
   PubMed Web of Science ®Google Scholar
• Rydberg B. Bromuracil mutagenesis and mismatch repair in mutator strains of Escherichia coli. Mutat. Res. 1978; 52: 11–24
   PubMed Web of Science ®Google Scholar
• Sung P., Bailly V., Weber C., Thompson L. H., Prakash L., Prakash S. Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature 1993; 365: 852–855
   PubMed Web of Science ®Google Scholar
• Strand M., Prolla T. A., Liskay R. M., Petes T. D. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 1993; 365: 274–276
   PubMed Web of Science ®Google Scholar