Alterations of the Retinoblastoma a Susceptibility Gene in Chronic Lymphocytic Leukemia

References

• Bishop J.M. Cellular oncogenes and retroviruses. Ann. Rev. Biochem. 1983; 52: 301–354
   PubMed Web of Science ®Google Scholar
• Shih C., Weinberg R.A. Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell 1982; 29: 161–169
   PubMed Web of Science ®Google Scholar
• Weinberg R. Tumor suppressor genes. Science 1991; 254: 1138–1146
   PubMed Web of Science ®Google Scholar
• Weismani B., Stanbridge E.J. Complementation of the tumorigenic phenotype in human cellhybrids. J. Natl. Cancer Inst. 1983; 70: 667–672
   PubMed Web of Science ®Google Scholar
• Schechter A.L., Hung M.C., Vaidyanathan L., Weinberg Yang- R.A., Feng T.L., Francke U., Ullrich A., Coussens L. The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. Science 1985; 229: 976–978
   PubMed Web of Science ®Google Scholar
• O'Bryan J.P., Frye R A., Cogswell P.C., Neubauer A., Kitch B., Prokop C., Espinoza R., Beau Le, Earp M. M.H. S., Liu E.T. axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol. Cell Biol. 1991; 11: 5016–5031
   PubMed Web of Science ®Google Scholar
• Janssen J.W.G., Schulz A.S., Steenvoorden A.C.M., Schmidberger M., Strehl S., Ambros P.F., Bartram C.R. A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene 1991; 6: 2113–2120
   PubMed Web of Science ®Google Scholar
• De The HI, Lavau C., Marchio A., Chomienne C., Degos L., Dejean A. The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 1991; 66: 675–684
   PubMed Web of Science ®Google Scholar
• Kakizukii A., Miller W.H., Umesono K., Warell R.P., Frankel S.R., Murty V.V., Dmitrovsky E., Evans R.M. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor. Cell 1991; 66: 663–674
   PubMed Web of Science ®Google Scholar
• Korsmeyer S.J. BCL-2 initiates a new cytegory of oncogenes: regulators of cell deaths. Blood 1992; 80: 879–886
   PubMed Web of Science ®Google Scholar
• Lee W.H., Shew J.Y., Hong F.D., Sery T.W., Donoso L.A., Young I.J., Bookstein R., Lee E. Y. H. P. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature 1987; 329: 642–645
   PubMed Web of Science ®Google Scholar
• Harris C.C., Hollstein IM. Clinical implications of the p53 tumor-suppressor gene. New Engl. J. Med. 1993; 329: 1318–1327
   PubMed Web of Science ®Google Scholar
• Fitchett M., Griffiths M.I., Oscier D.G., Johnson S., Seabright M. Chromosome abnormalities involving band 13q 14 in hematologic malignancies. Cancer Genet Cytogenet 1987; 24: 143–150
   PubMed Web of Science ®Google Scholar
• Juliusson G., Oscier D.G., Fitchett M., Ross F.M., Stockdill G., Mackie Parker M.J., Castoldi A. C. G. L., Cuneg A., Knuutila S., Elonen E., Gahrton G. Prognostic subgroups in B cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. New Engl. J. Med. 1990; 323: 720–724
   PubMed Web of Science ®Google Scholar
• Kornblau S.M., Chen dcl N., Giglio A., O'Brien S., Deisseroth A.B. Retinoblastoma protein expression is frequently altered in chronic lymphocytic leukemia. Cancer Res. 1994; 54: 242–246
   PubMed Web of Science ®Google Scholar
• Stilgenbauer S., Dohner H., Bulgay-Morschel M., Weitz S., Bentz M., Lichter P. High frequency of monoallelic retinoblastoma gene deletion in B-cell chronic lymphoid leukemia shown by interphase cytogenetics. Blood 1993; 81: 2118–2124
   PubMed Web of Science ®Google Scholar
• Goddard A.D., Balakier H., Canton M., Dunn M., Squire J., Reyes E., Becker A., Philips R.A., Gallie B.L. Infrequent genomic rearrangement and normal expression of the putative RB1 gene in retinoblastoma tumors. Mol. Cell Biol. 1988; 8: 2082–2088
   PubMed Web of Science ®Google Scholar
• Horowitz J.M., Yandell D.W., Park S.H., Canning S., Whyte R., Buchkovich K., Harlow E., Weinberg R., Dryja T.D. Point mutational incativation of the retinoblastoma antioncogene. Science 1989; 243: 937–940
   PubMed Web of Science ®Google Scholar
• Raghoebier S., Krieken J. H. J. M., Kluin-Nelemans J.C., Gillis A., van Ommen G.J.B., Ginsberg A.M., Raffeld M., Kluin P.M. Oncogene rearrangements in chronic B-cell leukemia. Blood 1991; 17: 1560–1564
   Google Scholar
• Ginsberg A.M., Raffeld M., Cossman J. Inactivation of the retinoblastoma gene in human lymphoid malignancies. Blood 1991; 77: 833–840
   PubMed Web of Science ®Google Scholar
• Kruger A., Sadullah S., Chapman R., Hodges E., Mould S., Hamblin T.J., Oscier D.G. Use of a retinoblastoma gene probe to investigate clonality in Richter' s syndrome. Leukemia 1993; 7: 1891–1895
   PubMed Web of Science ®Google Scholar
• Ahuja H.G., Jat P.S., Bar-Eli M. Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia. Blood 1991; 78: 3259–3268
   PubMed Web of Science ®Google Scholar
• Liu Y., Szekely L., Grander D., Söderhall S., Juliusson G., Gahrton G., Linder S., Einhorn S. Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus. Proc. Natl. Acad. Sci. USA 1993; 90: 8697–8701
   PubMed Web of Science ®Google Scholar
• Chapman R.M., Corcoran M.M., Gardiner A., Hawthorn L.A., Cogwell J.K., Oscier D.G. Frequent homozygous deletions of the D13S25 locus in chromosome region 13q 14 defines the location of a gene critical in leukemogenesis in chronic B-cell lymphocytic leukemia. Oncogene 1994; 9: 1289–1293
   PubMed Web of Science ®Google Scholar
• Hawthorn L.A., Chapman R., Oscier D., Cowell J.K. The consistent 13q14 translocation breakpoints seen in B-cell leukemia (B-CLL) involves deletion of the D13S25 locus which lies distal to the retinoblastoma predisposition gene. Oncogene 1993; 8: 1415–1419
   PubMed Web of Science ®Google Scholar
• Kay N.E., Suen R., Ranheim E., Peterson L.C. Confirmation of Rb gene defects in B-CLL clones and evidence for variable predominance of the Rb defective cells within the CLL clone. Br. J. Haematol. 1993; 84: 257–264
   PubMed Web of Science ®Google Scholar
• Knudson A.G. Mutation and cancer: Statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 1971; 68: 820–823
   PubMed Web of Science ®Google Scholar
• Yandell D.W., Campell T.A., Dayton S.H., Petersen R., Walton D., Little J.B., McConkie-Rosell A., Buckley E.G., Dryja T.P. Oncogenic point mutations in the human retinoblastoma gene: Their application to genetic counseling. New Engl. J. Med. 1989; 321: 1689–1695
   PubMed Web of Science ®Google Scholar
• Hamel P.A., Phillips R.A., Muncaster M., Gallie B.L. Speculations on the roles of RB1 in tissue-specific differentiation, tumor initiation, and tumor progression. FASEB J. 1993; 7: 846–854
   PubMed Web of Science ®Google Scholar
• Cance W.G., Brennan M.F., Dudas M.E., Huang C.M., Cordon-Cardo C. Altered expression of the retinoblastoma gene product in human sarcomas. New Engl. J. Med. 1990; 323: 1457–1462
   PubMed Web of Science ®Google Scholar
• Neubauer A., De Kant E., Rochlitz C.R., Laser J., Zanetta A.M., Gallardo Oert J., El Herrmann L.R., Huhn D. Altered expression of the retinoblastoma susceptibility and gene in chronic. lymphocytic leukemia. Br. J. Haematol. 1993; 85: 498–503
   PubMed Web of Science ®Google Scholar
• Ludlow J.W., Shon J., Pipas J.M., Livingston D.M., De Capricio J.A. The retinoblastoma susceptibility gene product undergoes cell-cycle dependent dephosphorylation and binding to and release from SV40 large T. Cell 1990; 60: 387–396
   PubMed Web of Science ®Google Scholar
• Chellappan S.P., Hiebert S., Mudryj M., Horowith J.M., Nevins J.R. The E2F transcription factor is a cellular target for the RB protein. Cell 1991; 65: 1053–1061
   PubMed Web of Science ®Google Scholar
• Shirodkar S., Ewen M., De Caprio J.A., Morgan J., Livingston D.M., Chittenden T. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 1992; 66: 157–166
   Web of Science ®Google Scholar
• Weintraub S.J., Prater C., Dean D.C. Retinoblastoma protein switches the E2F site from positive to negative element. Nature 1992; 358: 259–261
   PubMed Web of Science ®Google Scholar
• Rustgi A.K., Dyson N., Bernards R. Amino-terminal domains of c-myc and N-myc proteins mediated binding to the retinoblastoma gene product. Nature 1991; 352: 541–544
   PubMed Web of Science ®Google Scholar
• Cziepluch C., Wenzel A., Schurmann J., Schwab M. Activation of gene transcription by the amino terminus of the N-Myc protein does not require association with the protein encoded by the retinoblastoma suppressor gene RBI. Oncogene 1993; 8: 2833–2838
   PubMed Web of Science ®Google Scholar
• Gallie B.L. Retinoblastoma gene mutations in human cancer. New Engl. J. Med. 1994; 330: 786–787
   PubMed Web of Science ®Google Scholar
• Muller H., Lukas J., Schneider A., Warthoe P., Bartek J., Eilers M., Strauss M. Cyclin D1 expression is regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. USA 1994; 91: 2945–2949
   PubMed Web of Science ®Google Scholar
• Fung Y.K.T., T'Ang A., Murphee L., Zhang F.H., Qiu W.R., Wang S.W., Shi X.H., Lee L., Driscoll B., Wu K.J. The Rb gene suppresses the growth of normal cells. Oncogene 1993; 8: 2659–2672
   PubMed Web of Science ®Google Scholar
• Kivinen L., Pitkanen K., Laiho M. Human retinoblastoma gene product prevents c-Ha-ras oncogene mediated cellular transformation of mouse fibroblasts. Oncogene 1993; 8: 2703–2711
   PubMed Web of Science ®Google Scholar
• Wiman K.G. The retinoblastoma gene: role in cell cycle control and cell differentiation. FASEB J. 1993; 7: 841–845
   PubMed Web of Science ®Google Scholar
• Harlow E. For our eyes only. Nature 1992; 359: 270–271
   PubMed Web of Science ®Google Scholar
• Furukawa Y., De Caprio J.A., Belvin M., Griffin J.D. Heterogeneous expression of the product of the retinoblastoma susceptibility gene in primary human leukemia cells. Oncogene 1991; 6: 1343–1346
   PubMed Web of Science ®Google Scholar