Role of the Cyclin-Dependent Kinase 4 and 6 Inhibitor Gene Family p15, p16, p18 and p19 in Leukemia and Lymphoma

References

• Cordon-Cardo C. Mutation of cell cycle regulators. Am. J. Pathol. 1995; 147: 545–560
   PubMed Web of Science ®Google Scholar
• Roberts J. M., Koff A., Polyak K., Firpo R., Collins S., Ohtsubo M., Massague J. Cyclins, CDKs, and cyclin kinase inhibitors. Cold Spring Harbour Symposia on Quantitative Biology 1994; 59: 31–38
   PubMedGoogle Scholar
• Biggs J. R., Kraft A. S. Inhibitors of cyclin-dependent kinase and cancer. J. Mol. Med. 1995; 73: 509–514
   PubMed Web of Science ®Google Scholar
• Nurse P. Ordering S phase and M phase in the cell cycle. Cell 1994; 79: 547–550
   PubMed Web of Science ®Google Scholar
• Grana X., Reddy E. P. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 1995; 11: 211–219
   PubMed Web of Science ®Google Scholar
• Xiong Y., Zhang H., Beach D. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 1992; 71: 505–514
   PubMed Web of Science ®Google Scholar
• Dulic V., Lees E., Reed S. I. Association of human cyclin E with a periodic Gl-S-phase protein kinase. Science 1992; 257: 1958–1961
   PubMed Web of Science ®Google Scholar
• Ohtsubo M., Roberts J. M. Cyclin-dependent regulation of Gl in mammalian fibroblasts. Science 1993; 259: 1908–1912
   PubMed Web of Science ®Google Scholar
• Resnitzky D., Gossen M., Bujard H., Reed S. I. Acceleration of Gl/S phase transition by expression of cyclins Dl and E with an inducible system. Mol. Cell Biol. 1994; 14: 1669–1679
   PubMed Web of Science ®Google Scholar
• Weinberg R. A. The retinoblastoma protein and cell cycle control. Cell 1995; 81: 323–330
   PubMed Web of Science ®Google Scholar
• Rosenblatt J., Gu Y., Morgan D. O. Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc. Natl. Acad. Sci. USA 1992; 89: 2824–2828
   PubMed Web of Science ®Google Scholar
• Lewin B. Driving the cell cycle: M phase kinase, its partners, and substrates. Cell 1990; 61: 743–752
   PubMed Web of Science ®Google Scholar
• Parker L. L., Piwnica-Worms H. Inactivation of the p34cdc2-Cyclin B complex by the human WEE1 tyrosine kinase. Science 1992; 257: 1955–1957
   PubMed Web of Science ®Google Scholar
• Lee M. S., Enoch T., Piwnica-Worms H. mikl+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15. J. Biol. Chem. 1994; 269: 30530–30537
   PubMed Web of Science ®Google Scholar
• Hartwell L. H., Kastan M. B. Cell cycle control and cancer. Science 1994; 266: 1821–1828
   PubMed Web of Science ®Google Scholar
• Hirama T., Koeffler H. P. Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood 1995; 86: 841–854
   PubMed Web of Science ®Google Scholar
• Hatakeyama M., Herrera R. A., Makela T., Dowdy S. F., Jacks T., Weinberg R. A. The cancer cell and the cell cycle clock. Cold Spring Harbour symposia on quantitative biology 1994; 59: 1–10
   PubMedGoogle Scholar
• Motokura T., Arnold A. Cyclins and oncogenesis. Bioch. Bioph. Acta 1993; 1155: 63–78
   PubMed Web of Science ®Google Scholar
• Delmer A., Ajchenbaum-Cymbalista F., Tang R., Ramond S., Faussat A., Marie J., Zittoun R. Over-expression of cyclin D1 in chronic B-cell malignancies with abnormality of chromosome 11q13. Br. J. Haem. 1995; 89: 798–804
   PubMed Web of Science ®Google Scholar
• Serrano M., Hannon G. J., Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclinD/CDK4. Nature 1993; 366: 704–707
   PubMed Web of Science ®Google Scholar
• Kamb A., Gruis N. A., Weaver-Feldhaus J., Liu Q., Harshman K., Tavtigian S. V., Stockert E., Day R. S., III, Johnson B. E., Skolnick M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994; 264: 436–440
   PubMed Web of Science ®Google Scholar
• Guidal-Giroux C., Gerard B., Cave H., Duval M., Rohrlich P., Elion J., Vilmer E., Grandchamp B. Deletion mapping indicates that MTS1 is the target of frequent deletions at chromosome 9p21 in paediatric acute lymphoblastic lekaemias. Br. J. Haem. 1996; 92: 410–419
   PubMed Web of Science ®Google Scholar
• Xiong Y., Zhang H., Beach D. Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev. 1993; 7: 1572–1583
   PubMed Web of Science ®Google Scholar
• Yang R., Gombart A. F., Serrano M., Koeffler H. P. Mutational effects on the p16INK4a tumor suppressor protein. Cancer Res. 1995; 55: 2503–2506
   PubMed Web of Science ®Google Scholar
• Tam S. W., Shy J. W., Pagano M. Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16INK4. Cancer Res. 1994; 54: 5816–5820
   PubMed Web of Science ®Google Scholar
• Yeager T., Stadler W., Belair C., Puthenveettil J., Olopade O., Reznikoff C. Increase of p16 levels correlate with pRB alterations in human urothelial cells. Cancer Res. 1995; 55: 493–497
   PubMed Web of Science ®Google Scholar
• Shapiro G. I., Edwards C. D., Kobzik L., Godleski J., Richards W., Sugarbaker D. J., Rollins B. J. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res. 1995; 55: 505–509
   PubMed Web of Science ®Google Scholar
• Hannon G. J., Beach D. p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 1994; 371: 257–261
   PubMed Web of Science ®Google Scholar
• Guan K. L., Jenkins C. W., Li Y., Nichols M. A., Wu X., O'Keefe C. L., Matera A. G., Xiong Y. Growth suppression by p18, a p16INK4/MS2-and p14INK4/MTS2-related CDK6 inhibitor correlates with wild-type pRB function. Genes Dev. 1994; 8: 2939–2952
   PubMed Web of Science ®Google Scholar
• Chan F. K. M., Zhang J., Cheng L., Shapiro D. N., Winoto A. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16INK4. Mol. Cell. Biol. 1995; 15: 2682–2688
   PubMed Web of Science ®Google Scholar
• Nobori T., Miura K., Wu D. J., Lois A., Takabayashi K., Carson D. A. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994; 368: 753–756
   PubMed Web of Science ®Google Scholar
• Aagaard L., Lukas J., Bartkova J., Kjerluff A., Strauss M., Bartek J. Aberrations of the p16ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines. Int. J. Cancer 1995; 61: 115–120
   PubMed Web of Science ®Google Scholar
• Gombart A. F., Morosetti R., Miller C. W., Said J. W., Koeffler H. P. Deletions of the cyclin-dependent kinase inhibitor genes p16INK4A and p15INK4B in Non-Hodgkin's Lymphomas. Blood 1995; 86: 1534–1539
   PubMed Web of Science ®Google Scholar
• Liu Q., Neuhausen S., McClure M., Frye C., Weaver-Feldhaus J., Gruis N. A., Eddington K., Allalunis-Turner M. J., Skolnick M. H., Fujimura F. K., Kamb A. CDKN2 (MTS1) tumor suppressor gene mutations in human tumor cell lines. Oncogene 1995; 10: 1061–1067
   PubMed Web of Science ®Google Scholar
• Nakamaki T., Kawamata N., Schwaller J., Tobler A., Fey M., Pakkala S., Lee Y. Y., Kim B. K., Fukuchi K., Tsuruoka N., Kahan J., Miller C. W., Koeffler H. P. Structural integrity of the cyclin-dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukaemias. Br. J. Haem. 1995; 91: 139–149
   PubMed Web of Science ®Google Scholar
• Ogawa S., Hirano N., Sato N., Takahashi T., Hangaishi A., Tanaka K., Kurokawa M., Tanaka T., Mitani K., Yazaki Y., Hirai H. Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias. Blood 1994; 84: 2431–2435
   PubMed Web of Science ®Google Scholar
• Okamoto A., Demetrick D. J., Spillare E. A., Hagiwara K., Hussain S. P., Bennett W. P., Forrester K., Gerwin B., Serrano M., Beach D. H., Harris C. C. Mutations and altered expression of p16INK4 in human cancer. Proc. Natl. Acad. Sci. USA 1994; 91: 11045–11049
   PubMed Web of Science ®Google Scholar
• Ohnishi H., Kawamura M., Ida K., Sheng X. M., Hanada R., Nobori T., Yamamori S., Hayashi Y. Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia. Blood 1995; 86: 1269–1275
   PubMed Web of Science ®Google Scholar
• Otsuki T., Clark H. M., Wellmann A., Jaffe E. S., Raffeld M. Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4A/MTS2 in human leukemias and lymphomas. Cancer Res. 1995; 55: 1436–1440
   PubMed Web of Science ®Google Scholar
• Stranks G., Height S. E., Mitchell P., Jadayel D., Yuille M. A. R., Delord C., Clutterbuck R. D., Treleaven J. G., Powles R. L., Nacheva E., Oscier D. G., Karpas A., Lenoir G. M., Smith S. D., Millar J. L., Catovsky D., Dyer M. J. S. Deletions and rearrangements of CDKN2 in lymphoid malignancy. Blood 1995; 85: 893–901
   PubMed Web of Science ®Google Scholar
• Zhou M., Gu L., James C. D., He J., Yeager A. M., Smith S. D., Findley H. W. Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia. Leukemia 1995; 9: 1159–1161
   PubMed Web of Science ®Google Scholar
• Siebert R., Willers C. P., Schramm A., FossÅ A., Gana Dresen I. M., Uppenkamp M., Nowrousian M. R., Seeber S., Opalka B. Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines. Br. J. Haem. 1995; 91: 350–354
   PubMed Web of Science ®Google Scholar
• Siebert R., Willers C. P., FossÅ A., Kloke O., Nowrousian M. R., Seeber S., Opalka B. Analysis of the novel cyclin-dependent kinase 4 and 6 inhibitor gene p18 in lymphoma and leukemia cell lines. Leuk. Res. 1996; 20: 197–200
   PubMed Web of Science ®Google Scholar
• SchrÖDer M., Mathieu U., Dreyling M., Bohlander S. K., Hagemeijer A., Beverloo B. H., Olopade O. I., Stilgenbauer S., Fischer K., Bentz M., Lichter P., DÖHner H. CDKN2 gene deletion is not found in chronic lymphoid leukaemias of B-and T-cell origin but is frequent in acute lymphoblastic leukaemia. Br. J. Haem. 1995; 91: 865–870
   PubMed Web of Science ®Google Scholar
• Diaz M. O., Ziemin S., Le Beau M. M., Pitha P., Smith S. D., Chilcote R. R., Rowley J. D. Homozygous deletion of the alpha- and beta-1-interferon genes in human leukemia and derived cell lines. Proc. Natl. Acad. Sci. USA 1988; 85: 5259–5263
   PubMed Web of Science ®Google Scholar
• Diaz M. O., Rubin C. M., Harden A., Ziemin S., Larson R. A., Le Beau M. M., Rowley J. D. Deletions of interferon genes in acute lymphoblastic leukemia. N. Engl. J. Med. 1990; 322: 77–82
   PubMed Web of Science ®Google Scholar
• Raimondi S. C. Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood 1993; 81: 2237–2251
   PubMed Web of Science ®Google Scholar
• Heim S., Mitelman F. Cytogenetic analysis in the diagnosis of acute leukemia. Cancer 1992; 70: 1701–1709
   PubMed Web of Science ®Google Scholar
• Rabbits T. H. Chromosomal translocations in human cancer. Nature 1994; 372: 143–149
   PubMed Web of Science ®Google Scholar
• Iolascon A., Faienza M. F., Coppola B., Ragione F. D., Santoro N., Schettini F. High frequency of homozygous deletions of CDK4I gene in childhood acute lymphoblastic leukaemia. Br. J. Haem. 1995; 91: 647–651
   PubMed Web of Science ®Google Scholar
• Cayuela J. M., Hebert J., Sigaux F. Homozygous MTS1 (p16INK4A) deletion in primary tumor cells of 163 leukemic patients. Blood 1995; 85: 854
   PubMed Web of Science ®Google Scholar
• Hebert J., Cayuela J. M., Berkeley J., Sigaux F. Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood 1994; 84: 4038–4044
   PubMed Web of Science ®Google Scholar
• Delmer A., Tang R., Senamaud-Beaufort Paterlini P., Brechot C., Zittoun R. Alterations of cyclin-dependent kinase 4 inhibitor (p16INK4A/MTS1) gene structure and expression in acute lymphoblastic leukemias. Leukemia 1995; 9: 1240–1245
   PubMed Web of Science ®Google Scholar
• Duro D., Flexor M., Bernard O., D'Agay M., Berger R., Larsen C. Alterations of the putative tumor suppressor gene p16/MTS1 in human hematologic malignancies. C. R. Acad. Sci. Paris III 1994; 317: 913–919
   PubMed Web of Science ®Google Scholar
• Fizzotti M., Cimino G., Pisegna S., Alimena G., Quartarone C., Mandelli F., Pelicci P. G., Lo Coco F. Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic factors. Blood 1995; 85: 2685–2690
   PubMed Web of Science ®Google Scholar
• Ogawa S., Hangaishi A., Miyawaki S., Hirosawa Miura. Y., Takeyama K., Kamada N., Ohtake S., Uike N., Shimazaki C., Toyama K., Hirano M., Mizoguchi H., Kobayashi Y., Furusawa S., Saito M., Emi N., Yazaki Y., Ueda R., Hirai H. Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies. Blood 1995; 86: 1548–1556
   PubMed Web of Science ®Google Scholar
• Quesnel B., Preudhomme C., Philippe N., Vanrumbeke M., Dervite I., Lai J. L., Bauters F., Wattel E., Fenaux P. p16 gene homozygous deletions in acute lymphoblastic leukemia. Blood 1995; 85: 657–663
   PubMed Web of Science ®Google Scholar
• Rasool O., Heyman M., Brandter L. B., Liu Y., Grander Y. L., SÖDerhÄLl S., Einhom S. p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia. Blood 1995; 85: 3431–3436
   PubMed Web of Science ®Google Scholar
• Stock W., Sher D. A., Dodge R. K., Westbrook C. A., Larson R. A., Arthur D., Frankel S. R., Soble R. E., Davey F. R., Schneider D., Diaz M., Bloomfield C. D. High incidence of p16 deletion in adult acute lymphoblastic leukemia (ALL) correlation with clinical features and response to treatment. Blood 1995; 86 (Suppl. 1): 268a
   Google Scholar
• Takeuchi S., Bartram C. R., Seriu T., Miller C. W., Tobler A., Janssen J. W. G., Reiter A., Ludwig W. D., Zimmermann M., Schwaller J., Lee E., Miyoshi I., Koeffler H. P. Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood. Blood 1995; 86: 755–760
   PubMed Web of Science ®Google Scholar
• Okuda T., Shurtleff S. A., Valentine M. B., Raimondi S. C., Head D. R., Behm F., Curcio-Brint A. M., Liu Q., Pui C. H., Sherr C. J., Beach D., Look A. T., Downing J. R. Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS12 in pediatric acute lymphoblastic leukemia. Blood 1995; 85: 2321–2330
   PubMed Web of Science ®Google Scholar
• Guidal C., Gerard B., Cave H., Elion J., Vilmer E., Grandchamp B. Absence of mutation of the p16INK4 gene in childhood acute lymphoblastic leukemia even when blasts display loss of heterozygosity in the 9p21 chromosomic region. Blood 1994; 84 (Suppl. 1): 297a
   Web of Science ®Google Scholar
• Yang C. H., Perentesis J. P. Novel CDKN2 (p16-INK4A) mutations in hematologic malignancies: potential insight into the structural basis of cell cycle regulation. Blood 1995; 86 (Suppl. 1): 748a
   Google Scholar
• Iolascon A., Giudice E. M. D., Perrotta S., Russo Oliva A., Mercurio C., Ragione F. D. p16INK4A gene deletions in childhood acute lymphoblastic leukemias. Leuk. Res. 1995; 19: 883–885
   PubMed Web of Science ®Google Scholar
• Sill H., Goldman J. M., Cross N. C. P. Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood 1995; 85: 2013–2016
   PubMed Web of Science ®Google Scholar
• Iolascon A., Faienza M. F., Coppola B., Ragione F. D., Schettini F., Biondi A. CDKI genes in T-cell ALL. Blood 1995; 86 (Suppl. 1): 328a
   Google Scholar
• Yu A. L., Diccianni M. B., Batova A., Vu T., Pullen J., Amylon M., Pollock B., Yu J. High frequency alterations of the p16 and p15, but not p18, CDK inhibitors in T cell acute lymphoblastic leukemia. Blood 1995; 86 (Suppl. 1): 268a
   Google Scholar
• Berger R. Chromosomal abnormalities in T-cell malignant lymphoma. Bull. Cancer 1991; 78: 283–290
   PubMed Web of Science ®Google Scholar
• Kamada N., Sakurai M., Miyamoto K., Sanada I., Sadamori N., Fukuhara S., Abe S., Shiraishi Y., Abe T., Kaneko Y., Shimoyama M. Chromosome abnormalities in adult T-cell leukemia/lymphoma: a karyotype review committee report. Cancer Res. 1992; 52: 1481–1493
   PubMed Web of Science ®Google Scholar
• Fujiwara H., Arima N., Hidaka S., Ohtsubo H., Matsushita K., Kukita T., Arimura K., Tanaka H, Shima T. Alteration of the CDKN2 (p16/INK4A/MTS1) gene in adult T-cell leukemia/lymphoma (ATLL). Blood 1995; 86 (Suppl. 1): 563a
   Google Scholar
• Hatta Y., Hirama T., Miller C. W., Yamada Y., Tomonaga M., Koeffler H. P. Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. Blood 1995; 85: 2699–2704
   PubMed Web of Science ®Google Scholar
• Hatta Y., Morosetti R., Hirama T., Kawamata N., Yamada Y., Tomonaga M., Miller C. W., Koeffler H. P. Mutational analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, p18. p19 and p27/Kipl genes and the Rb gene in adult T-cell leukemia. Blood 1995; 86 (Suppl. 1): 563a
   Google Scholar
• Huret J. L., Brizard A., Babin P., Schoenwald M., Briault S., Guilhot F., Tanzer J. Translocation (8;9)(q12;p21) a new non-random rearrangement in lymphoid malignancies. Cancer Genet. Cytogenet. 1990; 45: 125–129
   PubMed Web of Science ®Google Scholar
• Offit K., Parsa N. Z., Jhanwar S. C., Filippa D., Wachtel M., Chaganti R. S. K. Clusters of chromosome 9 aberrations are associated with clinico-pathologic subsets of non-Hodgkin's lymphoma. Genes Chrom. Cancer 1993; 7: 1–7
   PubMed Web of Science ®Google Scholar
• Chaganti S. R., Gaidano G., Louie D. C., Dalla-Favera R., Chaganti R. S. K. Diffuse large cell lymphomas exhibit frequent deletions in 9p21-22 and 9q31-34 regions. Genes Chrom. Cancer 1995; 12: 32–36
   PubMed Web of Science ®Google Scholar
• Offit K. Chromosome analysis in the management of patients with Non-Hodgkin's lymphoma. Leuk. Lymph. 1992; 7: 275–282
   PubMed Web of Science ®Google Scholar
• Offit K., Wong G., Filippa D. A., Tao Y., Chaganti R. S. K. Cytogenetic analysis of 434 consecutively ascertained specimens of Non-Hodgkin's Lymphoma: Clinical Correlations. Blood 1991; 77: 1508–1515
   PubMed Web of Science ®Google Scholar
• The Non-Hodgkin's Lymphoma Pathologic Classification Project. National Cancer Institute sponsored study of classification of non-Hodgkin's lymphomas. Summary and description of a working formulation for clinical usage. Cancer 1982; 49: 2112–2135
   PubMed Web of Science ®Google Scholar
• Dreyling M. H., Bohlander S. K., Vardiman J. R., Olopade O. I. CDKN2 deletion is a frequent event in the histologic transformation to diffuse large cell lymphoma. Blood 1995; 86 (Suppl. 1): 329a
   Google Scholar
• Newcomb E. W., Rao L. S., Giknavorian S. S., Lee S. Y. Alterations of multiple tumor suppressor genes (p53 (17p13), p16INK4 (9p21), and DBM (13q14)) in B-cell chronic lymphocytic leukemia. Mol. Carcinogenesis 1995; 14: 141–146
   PubMed Web of Science ®Google Scholar
• Koduru P. R. K., Zariwala M., Soni M., Gong J. Z., Xiong Y., Broome J. D. Deletion of the cyclin-dependent kinase 4 inhibitor genes p15 and p16 in Non-Hodgkin's Lymphoma. Blood 1995; 86: 2900–2905
   PubMed Web of Science ®Google Scholar
• Uchida T., Watanabe T., Kinoshita T., Murate T., Saito H., Hotta T. Mutational analysis of the CDKN2 (MTS1/p16ink4A) gene in primary B-cell lymphomas. Blood 1995; 86: 2724–2731
   PubMed Web of Science ®Google Scholar
• Williams M. E., Woytowitz D., Finkelstein S. D., Swerdlow S. H. MTS1/MTS2 (p15/p16) deletions and p53 mutations in mantle cell (centrocytic) lymphoma. Blood 1995; 86 (Suppl. 1): 747a
   Google Scholar
• SchrÖDer M., Mathieu U., Dreyling M. H., Bohlander S. K., Hagemeijer A., Olopade O. I., Stilgenbauer S., MÖLler P., Fischer K., Bentz M., Lichter P., DÖHner H. Detection of CDKN2 gene deletions in lymphoid malignancies by fluorescence in situ hybridization (FISH). Med. Genetik 1995; 2: 41
   Google Scholar
• Shiohara M., Gombart A. F., Morosetti R., Said J. W., Spirin K., Koeffler H. P. Mutational analysis of CDKIs in a large series of Non-Hodgkin's lymphomas. Blood 1995; 86 (Suppl. 1): 823a
   Google Scholar
• Schlegelberger B., Weber-Matthiesen K., Himmler A., Bartels H., Sonnen R., Kuse R., Feller A. C., Grote W. Cytogenetic findings and results of combined immunophenotyping and karyotyping in Hodgkin's disease. Leukemia 1994; 8: 72–80
   PubMed Web of Science ®Google Scholar
• Weber-Matthiesen K., Deerberg J., Poetsch M., Grote W., Schlegelberger B. Numerical chromosome aberrations are present within the CD30+ Hodgkin and Reed-Sternberg cells in 100% of analyzed cases of Hodgkin's disease. Blood 1995; 86: 1464–1468
   PubMed Web of Science ®Google Scholar
• Sawyer J. R., Waldron J. A., Jagannath S., Barlogie B. Cytogenetic findings in 200 patients with multiple myeloma. Cancer Genet. Cytogenet. 1995; 82: 41–49
   PubMed Web of Science ®Google Scholar
• Tasaka T., Berenson J., Hirama T., Koeffler H. P. Analysis of the INK4 family of genes in multiple myeloma. Blood 1995; 86 (Suppl. 1): 63a
   Google Scholar
• Bloomfield C. D., De La Chapelle A. Chromosome abnormalities in acute nonlymphocytic leukemia: clinical and biological significance. Sem. Oncol. 1987; 14: 372–383
   PubMed Web of Science ®Google Scholar
• Hirsch-Ginsberg C., Huh Y. O., Kagan J., Liang J. C., Stass S. A. Advances in the diagnosis of acute leukemia. Haem. Oncol. Clinics North America 1993; 7: 1–46
   PubMed Web of Science ®Google Scholar
• Bennett J. M., Catovsky D., Daniel M., Flandrin G., Galton D. A. G., Gralinck H. R., Sultan C. Proposals for the classification of the acute leukemias. Br. J. Haem. 1976; 33: 451–458
   PubMed Web of Science ®Google Scholar
• Heim S. Cytogenetic findings in primary and secondary MDS. Leuk. Res. 1992; 16: 43–46
   PubMed Web of Science ®Google Scholar
• Mitelman F. The cytogenetic scenario of chronic myeloid leukemia. Leuk. Lymph. 1993; 11 (Suppl. 1): 11–15
   PubMed Web of Science ®Google Scholar
• Serra A., Gottardi E., Ragione F. D., Saglio G., Iolascon A. Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukaemia. Br. J. Haem. 1995; 91: 625–629
   PubMed Web of Science ®Google Scholar
• Garicochea B., Bendit I., Giorgi R., Manzella L., Dorlhiac-Llacer P. E., Chamone D. A. F., Bydlowski S. P. NF1, p15 and p16 tumor suppressor genes in chronic myelogenous leukemia in chronic phase and blast crisis. A mutational analysis. Blood 1995; 86 (Suppl. 1): 794a
   Google Scholar
• Hodgson S. V., Maher E. R. A practical guide to human cancer genetics. Cambridge University Press, CambridgeUK 1993
   Google Scholar
• Heyman M., Rasool O., Brandter L. B., Liu Y., Grander D., SÖDerhÄLl S., Gustavsson G., Einhorn S. Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia. Blood 1995; 86 (Suppl. 1): 175a
   Google Scholar
• Pollock P. M., Pearson J. V., Hayward N. K. Compilation of somatic mutations of the CDKN2 gene in human cancers: Non-random distribution of base substitutions. Genes Chrom. Cancer 1996; 15: 77–88
   PubMed Web of Science ®Google Scholar
• Gonzalez-Zulueta M., Bender C. M., Yang A. S., Nguyen T., Beart R. W., Tornout M. V., Jones P. A. Methylation of the 5'CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissue correlates with gene silencing. Cancer Res. 1995; 55: 4531–4535
   PubMed Web of Science ®Google Scholar
• Herman J. G., Merlo A., Mao L., Lapidus R. G., Issa J. J., Davidson N. E., Sidransky D., Baylin S. B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res. 1995; 55: 4525–4530
   PubMed Web of Science ®Google Scholar
• Duro D., Bernard O., Valle V. D., Berger R., Larsen C. A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies. Oncogene 1995; 11: 21–29
   PubMed Web of Science ®Google Scholar
• Mao L., Merlo A., Bedi G., Shapiro G. I., Edwards C. D., Rollins B. J., Sidransky D. A novel p16INK4A transcript. Cancer Res. 1995; 55: 2995–2997
   PubMed Web of Science ®Google Scholar
• Lois A. F., Cooper L. T., Geng Y., Nobori T., Carson D. Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation. Cancer Res. 1995; 55: 4010–4013
   PubMed Web of Science ®Google Scholar
• Gombart A. F., Campbell M. J., Yang R., Cho S. K., Tun R. Y. M., Koeffler H. P. Retroviral transfer and expression of the human p16INK4A gene inhibits the proliferation of human leukemias. Blood 1995; 86 (Suppl. 1): 432a
   Google Scholar
• Quesnel B., Preudhomme C., Lepelley P., Hetuin D., Vanrumbeke M., Bauters F., Velu T., Fenaux P. Transfer of p16 gene in leukemic cell lines with p16 homozygous deletion inhibits cell proliferation. Blood 1995; 86 (Suppl. 1): 432a
   Google Scholar
• Zhang X., Jin X., Consoli U., Zhao S., Jiang S., Roth J., Andreeff M. Adenovirus delivered p16/CDKN2 gene decreases cell proliferation and induces erythroid differentiation in K562 cells. Blood 1995; 86 (Suppl. 1): 148a
   Google Scholar