47
Views
17
CrossRef citations to date
0
Altmetric
Original Article

The Diagnostic and Prognostic Value of Bone Marrow Immunostaining in Myelodysplastic Syndromes

, , &
Pages 231-239 | Received 27 Mar 1997, Published online: 01 Jul 2009

References

  • Kitagawa M., Kamiyama R., Takemura T., Kasuga T. Bone marrow analysis of the myelodysplasia syndromes: histological and immunohistochemical features related to the evolution of overt leukemia. Virchows Arch. B: Cell. Pathol 1989; 57: 47–53
  • Sultan C., Sigaux F., Imbert M., Reyes F. Acute myelodysplasia with myelofibrosis: a report of eight cases. Br. J. Haematol. 1981; 49: 11–16
  • Pagliuca A., Layton D. M., Manoharan A., Gordon S., Green P. J., Mufti Gℑ. Myelofibrosis in primary myelodysplastic syndromes: a clinico-morphological study of ten cases. Br. J. Haematol. 1989; 71: 499–504
  • Lambertenghi Deliliers G., Orazi A., Luksch R., Annaloro C., Soligo D. Myelodysplastic syndrome with increased marrow fibrosis: a distinct clinico-pathological entity. Br. J. Haemarol. 1991; 78: 161–166
  • Tricot G., De Wolf-Peters C., Vlientinck R., Verwilghen R. L. Bone marrow histology in myelodysplastic syndromes. II. Prognostic value of abnormal localization of immature precursors in MDS. Br. J. Haemarol. 1984; 58: 217–225
  • Lambertenghi-Deliliers G., Annaloro C., Oriani A., Soligo D., Pozzoli E., Polli E. E. Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes. Annals of Hemarol. 1993; 66: 85–91
  • Kitagawa M., Kamiyama R., Kasuga T. Expression of the proliferating cell nuclear antigen in bone marrow cells from patients with myelodysplastic syndromes and aplastic anemia. Hum. Parhol. 1993; 24: 359–363
  • Verhoef G. E. G., De Wolf-Peeters C., Ferrant A., Deprez S., Meeus P., Stul M., Zachee P., Cassiman J. J., Van den Berghe H., Boogaerts M. A. Myelodysplastic syndromes with bone marrow fibrosis: a myelodysplastic disorder with proliferative features. Ann. Hematol. 1991; 63: 235–241
  • Cordell J. L., Falini B., Erber W. N., Ghoshak A. K., Zainalabidden A., MacDonald S., Pulford K. A. F., Stein H., Mason D. Y. lmmunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J. Hisrochem. Cvrochem. 1984; 32: 219–229
  • Mangi M. H., Mufti G. J. Primary myelodysplastic syndromes: diagnostic and prognostic significance of immunohistochemical assessment of bone marrow biopsies. Blood 1992; 79: 198–205
  • Elghetany M. T., Sullivan A. K., Kurec A. S., MacCallum J. M., Bloomfield C. D., Sobol R. E., Davey F. R. The use of monoclonal antibodies against primary myeloid granules in normal and leukemic cells. Am. J. Clin. Pathol. 1992; 98: 430–436
  • Orazi A., Cattoretti G., Soligo D., Luksch R., Lambertenghi Deliliers G. Therapy-related myelodysplastic syndromes: FAB classification, bone marrow histology, and immunohistology in the prognostic assessment. Leukemia 1993; 7: 838–847
  • Delia D., Aiello A., Soligo D., Fontanella E., Melani C., Pezzella F., Pierotti M. A., Delia Porta G. bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells. Blood 1992; 79: 1291–1298
  • Titius B. R., Thiele J., Schaefer H., Kreipe H., Fischer R. Ki-S1 and proliferating cell nuclear antigen expression of bone marrow macrophages. Immunohistochemical and morphometric study including reactive (inflammatory) myelitis, secondary aplastic anemia, Aids, myelodysplastic syndromes and primary (idiopathic) osteomyelofibrosis. Ada Haematol 1994; 91: 144–149
  • Werner M., Kaloutsi V., Walter K., Buhr T., Bemhards J., Georgii A. Immunohistochemical examination of routinely processed bone marrow biopsies. Pathol Res. Pract. 1992; 188: 707–713
  • Weber-Matthiesen K., Deerberg J., Poetsch M., Grote W., Schlegelberger B. Numerical chromosome aberrations are present within the CD30+ Hodgkin and Reed-Sternberg cells in 100% of analyzed cases of Hodgkin's disease. Blood 1995; 86: 1464–1468
  • Guyotat D., Campos L., Thomas X., Vila L., Shi Z., Charrin C., Gentilhomme O., Fiere D. Myelodysplastic syndromes: a study of surface markers and in vitro growth patterns. Am. J. Hematoi 1990; 34: 26–31
  • Seo I. S., Li C. Y., Yam L. T. Myelodysplastic syndrome: diagnostic implications of cytochemical and immunocytochemical studies. Mayo Clin. Proc 1993; 68: 47–53
  • Felzmann T., Gisslinger H., Ludwig H. Immunologic findings in patients with myelodysplastic syndrome. Leukemia and Lymphoma 1994; 15: 201–208
  • Keim D. R., Hanash S. M. Proliferating cell nuclear antigen; a new marker of proliferation in cancer. Leukemia and Lymphoma 1992; 6: 459–468
  • Thiele J., Quitmann H., Wagner S., Fischer R. Dysmegakaryopoiesis in myelodysplastic syndromes (MDS): an immunomorphometric study of bone marrow trephine biopsy specimens. J. Clin. Pathol. 1991; 44: 300–305
  • Thiele J., Titius B. R., Kopsidis C., Fischer R. Atypical micromegakaryocytes, promegakaryoblasts and megakaryoblasts: a critical evaluation by immunohistochem-istry, cytochemistry and morphometry of bone marrow trephines in chronic myeloid leukemia and myelodysplastic syndromes. Virchows Arch. B: Cell. Pathol. Incl. Mol. Pathol 1992; 62: 275–282
  • Thiele J., Titius B. R., Quitmann H., Fischer R., Salzberger B., Dienemann D., Stein H. Megakaryocytopoiesis in bone marrow biopsies of patients with acquired immunodeficiency syndrome (Aids). An immunohistochemical and morphometric evaluation with special emphasis on myelodysplastic features and precursor cells. Pathol. Res. Pract. 1992; 188: 722–728
  • Thiele J., Hoffmann I., Bertsch H. P., Fischer R. Myelodysplastic syndromes: immunohistochemical and morphometric evaluation of proliferative activity in erythropoiesis and endoreduplicative capacity of megakaryocytes. Virchows Arch. A: Pathol. Anat. Histopathol 1993; 423: 33–38
  • Maschek H., Georgii A., Kaloutsi V., Werner M., Bandecar K., Kressel M. G., Choritz H., Freund M., Hufhagl D. Myelofibrosis in primary myelodysplastic syndromes: a retrospective study of 352 patients. Eur. J. Haematol 1992; 48: 208–214
  • Hockenbery D. M., Zutter M., Hickey W., Nahm M., Korsmeyer S. J. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. U.S.A. 1991; 88: 6961–6965
  • Eastman A. Activation of programmed cell death by anticancer agents: cisplatin as a model system. Cancer Cells 1990; 2: 275–280
  • Lepelley P., Preudhomme C., Vanrumbeke M., Quesnel B., Cosson A., Fenaux P. Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis. Leukemia 1994; 8: 1342–1349
  • Kitagawa M., Yoshida S., Kuwata T., Tanizawa T., Kamiyama R. p53 expression in myeloid cells of myelodysplastic syndromes. Association with evolution of overt leukemia. Am. J. Pathol 1994; 145: 338–344
  • Orazi A., Cattoretti G., Heerema N. A., Sozzi G., John K., Neiman R. S. Frequent p53 overexpression in therapy related myelodysplastic syndromes and acute myeloid leukemias: an immunohistochemical study of bone marrow biopsies. Mod. Pathol 1993; 6: 521–525
  • Zhou D., Marie J. P., Suberville A. M., Zittoun R. Relevance of mdrl gene expression in acute myeloid leukemia and comparison of different diagnostic methods. Leukemia 1992; 6: 879–885
  • Campos L., Guyotat D., Archimbaud E., Calmard-Oriol P., Tsuruo T., Troncy J., Treille D., Fiere D. Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood 1992; 79: 473–476
  • te Boekhorst P. A., de Leeuw K., Schoester M., Wittebol S., Nooter K., Hagemeijer A., Lowenberg B., Sonneveld P. Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells. Blood 1993; 82: 3157–3162
  • Lepelley P., Soenen V., Preudhomme C., Lai J. L., Cosson A., Fenaux P. Expression of the multidrug resistance P-glycoprotein and its relationship to hematological characteristics and response to treatment in myelodysplastic syndromes. Leukemia 1994; 8: 998–1004
  • McCormick D., Hall P. The complexities of proliferating cell nuclear antigen. Histopathology 1992; 21: 591–594
  • Soligo D., Delia D., Oriani A., Cattoretti G., Orazi A., Bertolli V., Quirici N., Lambertenghi Deliliers G. Identification of CD34+ in normal and pathological bone marrow biopsies by Qbend10 monoclonal antibody. Leukemia 1991; 5: 1026–1030
  • Borowitz M. J., Gockerman J. P., Moore J. O., Civin C., Page S. O., Robertson J., Bigner S. H. Clinicopathologic and cytogenetic features of CD34 (My 10)-positive acute nonlymphocytic leukemia. Am. J. Clin. Pathol 1989; 91: 265–270
  • Geller R. B., Zahurak M., Hurwitz C. A., Burke P. J., Karp J. E., Piantadosi S., Civin C. I. Prognostic importance of immunophenotyping in adults with acute myelocytic leukaemia: the significance of stem-cell glycoprotein CD34 (MY 10). Br. J. Haematol 1990; 76: 340–347
  • Campos L., Guyotat D., Archimbaud E., Devaux Y., Treille D., Larese A., Maupas J., Gentilhomme O., Ehrsam A., Fiere D. Surface marker expression in adult acute myeloid leukaemia: correlations with initial characteristics, morphology and response to therapy. Br. J. Haematol 1989; 72: 161–166
  • Sperling C., Büchner T., Creutzig U., Ritter J., Harbott J., Fonatsch C., Sauerland C., Mielcarek M., Maschmeyer G., Löffler H., Wolf-Dieter L. Clinical, morphologic, cytogenetic and prognostic implications of CD34 expression in childhood and adult de novo AML. Leukemia and Lymphoma 1995; 17: 417–426
  • Sullivan S. A., Marsden K. A., Lowenthal R. M., Jupe D. M., Jones M. E. Circulating CD34+ cells: an adverse prognostic factor in the myelodysplastic syndromes. Am. J. Hematoi. 1992; 39: 96–101
  • Oertel J., Oertel B., Beyer J., Huhn D. CD34 immunotyping of blasts in myelodysplasia. Ann. Hematoi 1994; 68: 77–80
  • Sawada K. I. Impaired Proliferation and differentiation of myelodysplastic CD34+ cells. Leukemia and Lymphoma 1994; 14: 37–47
  • Sawada K., Sato N., Notoya A., Tarumi T., Hirayama S., Takano H., Koizumi K., Yasukouchi T., Yamaguchi M., Koike T. Proliferation and differentiation of myelodysplastic CD34+ cells: phenotypic subpopulations of marrow CD34+ cells. Blood 1995; 85: 194–202
  • Soligo D. A., Oriani A., Annaloro C., Cortelezzi A., Calori R., Pozzoli E., Nosella D., Orazi A., Lambertenghi Deliliers G. CD34 immunohistochemistry of bone marrow biopsies: prognostic significance in primary myelodysplastic syndromes. Am. J. Hematol. 1994; 46: 9–17
  • Oriani A., Annaloro C., Soligo D., Pozzoli E., Cortelezzi A., Lambertenghi Deliliers G. Bone marrow histology and CD34 immunostaining in the prognostic evaluation of primary myelodysplastic syndromes. Br. J. Haematol. 1996; 92: 360–364

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.