Chromosomal Rearrangement of the PAX-5 Locus in Lymphoplasmacytic Lymphoma with t(9; 14) (p13; q32)

References

• Rabbitts T. H. Chromosomal translocations in human cancer. Nature 1994; 372: 143–149
   PubMed Web of Science ®Google Scholar
• Gaidano G., Dalla-Favera R. Molecular biology of lymphomas. Principles and Practice of Oncology, Fifth Ed, V T DeVita, S Hellman, SA Rosenberg. JB Lippencott Co. 1997; 2131–2144
   Google Scholar
• Dalla-Favera R., Bregni M., Erickson D., Patterson D., Gallo R. C., Croce C. M. Human c-myc oncogene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA 1982; 79: 7824–7827
   PubMed Web of Science ®Google Scholar
• Bakhshi A., Jensen J. P., Goldman P., Wright J. J., McBride O. W., Epstein A. L., Korsmeyer S. J. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 1985; 41: 889–906
   Web of Science ®Google Scholar
• Cleary M. L., Sklar J. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad. Sci USA 1985; 82: 7439–7443
   PubMed Web of Science ®Google Scholar
• Tsujimoto Y., Yunis J., Onorato-Showe L., Erikson J., Nowell P. C., Croce C. M. Molecular cloning of chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science 1984; 224: 1403–1406
   PubMed Web of Science ®Google Scholar
• Motokura T., Bloom T., Kim H. G., Juppner H., Ruderman J. V., Kronenberg H. M., Arnold A. A novel cyclin encoded by a bcl-1 linked candidate oncogene. Nature 1991; 350: 512–515
   PubMed Web of Science ®Google Scholar
• Ye B. H., Lista E, Lo Coco E, Knowles D. M., Offit K, Chaganti R. S. K., Dalla-Favera R. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 1993; 262: 747–750
   PubMed Web of Science ®Google Scholar
• Gaidano G., Ballerini P., Gong J. Z., Inghirami G., Neri A., Newcomb E. W., Magrath I. T., Knowles D. M., Dalla-Favera R. p53 mutations in human lymphoid malignancies: Association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci USA 1991; 88: 5413–5417
   PubMed Web of Science ®Google Scholar
• Lo Coco E, Gaidano G., Louie D. C., Offit K., Chaganti RS., Dalla-Favera R. p53 mutations are associated with histologic transformation of follicular lymphoma. Blood 1993; 82: 2289–2295
   PubMed Web of Science ®Google Scholar
• Gaidano G., Hauptschein R. S., Parsa N. Z., Offit K., Rao PH., Lenoir G., Knowles D. M., Chaganti R. S.K., Dalla-Favera R. Deletions involving two distinct regions of 6q in B-cell non-Hodgikin's lymphoma. Blood 1992; 80: 1781–1787
   PubMed Web of Science ®Google Scholar
• Iida S., Rao P. H., Nallasivam P., Hibshoosh H., Butler M, Louie D. C., Dyomin V., Ohno H., Chaganti R. S. K., Dalla-Favera R. The t(9;14)(p25;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene. Blood 1996; 88: 4110–4117
   PubMed Web of Science ®Google Scholar
• Harris N. L., Jaff E. S., Stein H., Banks P. M., Chan J. K. C., Cleary M. L., Delsol G., Wolf-Peeters C. D., Falini B., Gatter K. C., Grogan T. M., Isaacson P. G., Knowles D. M., Mason D. Y., Muller-Hermelink H-K., Pileri S. A., Piris M. A., Ralfkiger E., Warnke R. A. A revised European-American classification of lymphoid neoplasms: A proposal from the international lymphoma study group. Blood 1993; 84: 1361–1392
   Web of Science ®Google Scholar
• Offit K., Parsa N. Z., Filippa D., Jhanwar S. C., Chaganti R. S. K. t(9;14)(p13;q32) denotes a subset of low-grade non-Hodgkin's lymphoma with plasmacytoid differentiation. Blood 1992; 80: 2594–2599
   PubMed Web of Science ®Google Scholar
• Offit K, Parsa N. Z., Jhanwar S. C., Filippa D., Wachell M., Chaganti R. S. K. Clusters of chromosome 9 aberrations are associated with clinico-pathologic subsets of non-Hodgkin's lymphoma. Genes Chromsom Cancer 1993; 7: 1–7
   PubMed Web of Science ®Google Scholar
• Ohno H., Furukawa T., Fukuhara S., Zong S. Q., Kamesaki H., Shows T. B., Le Beau M. M., McKeithan T. W., Kawakami T., Honjo T. Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen. Proc Natl Acad Sci USA 1990; 87: 628–632
   PubMed Web of Science ®Google Scholar
• Busslinger M., Klix N., Pfeffer P., Graninger P. G., Kozmik Z. Deregulation of PAX-5 by translocation of the Eμ enhancer of the IgH locus adjacent to two alternative PAX 5 promoters in a diffuse large-cell lymphoma. Proc Natl Acad Sci USA 1996; 93: 6129–6134
   PubMed Web of Science ®Google Scholar
• Pellet P., Berger R., Bernheim A., Brouet J. C., Tsapis A. Molecular analysis of a t(9;14)(p11;q32) translocation occurring in a case of human alpha heavy chain disease. Oncogene 1989; 4: 653–657
   PubMed Web of Science ®Google Scholar
• Withers D. A., Harvey R. C., Faust J. B., Melnyk O., Carey K., Meeker T. C. Characterization of a candidate bcl-1 gene. Mol Cell Biol 1991; 11: 4846–4853
   PubMed Web of Science ®Google Scholar
• Seto M., Jaeger U., Hockett R. D., Graninger W., Bennett S., Goldman P., Korsmeyer S. J. Alternative promotors and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBOJ 1988; 7: 123–131
   PubMed Web of Science ®Google Scholar
• Pelicci P-G., Knowles D. M., Magrath I., Dalla-Favera R. Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma. Proc Natl Acad Sci USA 1986; 83: 2984–2988
   PubMed Web of Science ®Google Scholar
• Madisen L., Groudine M. Identification of a locus control region in the immunoglobulin heavy-chain locus that regulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev 1994; 8: 2212–2226
   PubMed Web of Science ®Google Scholar
• Adams B., Dorfer P., Aguzzi A., Kozmik Z., Urabanek P., Maurer-Fogy I., Busslinger M. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev 1992; 6: 1589–1607
   PubMed Web of Science ®Google Scholar
• Urbanek P., Wang Z-Q., Fetka I., Wagner E. F., Busslinger M. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 1994; 79: 901–912
   PubMed Web of Science ®Google Scholar
• Stuart E. T., Grass P. PAX genes: what's new in developmental biology and cancer. Hum Mol Genet 1995; 4: 1717–1720
   PubMed Web of Science ®Google Scholar
• Baker S. J., Reddy E. P. B cell differentiation: role of E2A and Pax5/BSAP transcription factors. Oncogene 1995; 11: 413–426
   PubMed Web of Science ®Google Scholar
• Bain G., Robanus Maandag E. C., Izon D. J., Amsen D., Kruisbeek A. M., Weintraub B. C., Krop I., Schlissel M. S., Feeney A. J., Van Roon M., Van der Valk M., Te Riele H. P. J., Berns A., Murre C. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 1994; 79: 885–892
   PubMed Web of Science ®Google Scholar
• Czerny T., Schaffner G., Busslinger M. DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev 1993; 7: 2048–2061
   PubMed Web of Science ®Google Scholar
• Dorfler P., Busslinger M. C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8. EMBO J 1996; 15: 1971–1982
   PubMed Web of Science ®Google Scholar
• Michaelson J. S., Singh M., Birshtein B. K. B cell lineagespecific activator protein (BSAP): A player at multiple stages of B cell development. J Immunol 1996; 156: 2349–2351
   PubMed Web of Science ®Google Scholar
• Desiderio S. Transcription factors controlling B-cell development. Curr Biol 1995; 5: 605–608
   PubMed Web of Science ®Google Scholar
• Kozmik Z., Wang S., Dorfler P., Adams B., Busslinger M. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol Cel Biol 1992; 12: 2662–2672
   PubMed Web of Science ®Google Scholar
• Neurath M. R, Stuber E. R., Strober W. BSAP: a key regulator of B-cell development and differentiation. Immunol Today 1995; 16: 564–569
   PubMedGoogle Scholar
• Zwollo P., Desiderio S. Specific recognition of the blkpromoter by the B-lymphoid transcription factor B-cell-specific activator protein. J Biol Chem 1994; 269: 15310–15317
   PubMed Web of Science ®Google Scholar
• Liao R, Birshtein Busslinger B. K. M., Rothman P. The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line epsilon transcription. J Immunol 1994; 148: 2904–2911
   Google Scholar
• Neurath M. F., Max E. E., Strober W. Pax5 (BSAP) regulates the murine immunoglobulin 3′ α enhancer by suppressing binding of NF-αP, a protein that controls heavy chain transcription. Proc Natl Acad Sci USA 1995; 92: 5336–5340
   PubMed Web of Science ®Google Scholar
• Singh M, Birshtein B. K. NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3′ α enhancer at early stages of B-cell differentiation. Mol Cell Biol 1993; 13: 3611–3622
   PubMed Web of Science ®Google Scholar
• Rinkenberger J. L., Wallin J. J., Johnson K. W., Koshland M. E. An interleukin-2 signal relieves BSAP(Pax-5)-mediated repression of the immunoglobulin J chain gene. Immunity 1996; 5: 377–386
   PubMed Web of Science ®Google Scholar
• Tian J., Okabe T., Miyazaki T., Takeshita S., Kudo A. Pax-5 is identical to EBB/KLP and binds to the Vpreß and lambda 5 promoters as well as the KI and KII sites upstream of the J kappa genes. Em J Immunol 1997; 27(3)750–755
   PubMed Web of Science ®Google Scholar
• Maulbecker C. C., Grass P. The oncogenic potential of Pax genes. EMBO J 1993; 12: 2361–2367
   PubMed Web of Science ®Google Scholar
• Read A. P. Pax-genes-Paired feet in three camps. Nat Genet 1996; 9: 333–334
   Web of Science ®Google Scholar
• Galili N., Davis R. J., Fredericks W. J., Mukhopadhyay S., Rauscher I II F. J., Emanuel B. S., Rovera G., Barr F. G. Fusion of a fork head domain gene to PAX-3 in the solid tumor alveolar rhabdomyosarcoma. Nature Genet 1993; 5: 230–235
   PubMed Web of Science ®Google Scholar
• Davis R. J., D'Cruz C. M., Lovell M. A., Biegel J. A., Barr F. G. Fusion of PAX-7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. Cancer Res 1994; 54: 2869–2872
   PubMed Web of Science ®Google Scholar
• Scheidler S., Fredericks W. J., Rauscher I II F. J., Barr F. G., Vogt P. K. The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture. Proc Natl Acad Sci USA 1996; 93: 9805–9809
   PubMed Web of Science ®Google Scholar
• Bernasconi M., Remppis A., Fredericks W. J., Rauscher I II, Schafer B. W. Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. Proc Natl Acad Sci USA 1996; 93: 13164–13169
   PubMed Web of Science ®Google Scholar
• Sublett J. E., Jeon I-S., Shapiro D. N. The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator. Oncogene 1995; 11: 545–552
   PubMed Web of Science ®Google Scholar
• Eccles M. R., Wallis L. J., Fidler A. E., Spurr N. K., Goodfellow P. J., Reeve A. E. Expression of the PAX-2 gene in human fetal kidney and Wilms' tumor. Cell Grow Diff 1992; 3: 279–289
   PubMedGoogle Scholar
• Kozmik Z., Sure U., Ruedi D., Busslinger M., Aguzzi A. Deregulated expression of PAX-5 in medulloblastoma. Proc Natl Acad Sci USA 1995; 92: 5709–5713
   PubMed Web of Science ®Google Scholar
• Wakatsuki Y., Neurath M. E, Max E. E., Strober W. The B cell-specific transcription factor BSAP regulates B cell proliferation. J Exp Med 1994; 179: 1099–1108
   PubMed Web of Science ®Google Scholar
• Usui T., Wakatsuki Y., Matsunaga Y., Kaneko S., Kosek H., Kita T. Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype. J Immunol 1997; 158(7)3197–3204
   PubMed Web of Science ®Google Scholar
• Stuart E. T., Haffner R., Oren M., Grass P. Loss of p53 function through PAX-mediated transcriptional repression. EMBO J 1995; 14: 5638–5645
   PubMedGoogle Scholar