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Original Article

BCL2 Overexpression in Diffuse Large B-Cell Lymphoma

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Pages 45-52 | Received 30 Sep 1998, Published online: 01 Jul 2009

References

  • Harris N. L., Jaffe E. S., Stein H., Banks P. M., Chan J. K. C., Cleary M. L., Delsol G., De Wolf-Peeters C., Falini B., Gatter K. C., Grogan T. M., Isaacson P. G., Knowles D. M., Mason D. Y., Muller-Hermelink H. K., Pileri S. A., Piris M. A., Ralfkiaer E., Warnke R. A. A revised European-American classification of lymphoid neoplasms: A proposal from the international lymphoma study group. Blood 1994; 84: 1361–1392
  • Stansfeld A. G., Diebold J., Kapanci Y., Kelenyi G., Lennert K., Mioduszewska O., Noel H., Rilke F., Sundström C., Van Unnik J. A. M., Wright D. H. Updated Kiel classification for lymphomas. Lancet 1988; 1: 292–293
  • Lukes R. J., Collins R. D. Immunologic characterization of human malignant lymphomas. Cancer 1974; 34: 1488–1503
  • Klimo P., Connors J. M. MACOP-B chemotherapy for the treatment of diffuse large cell lymphoma. Annals of Internal Medicine 1985; 102: 596–602
  • Fisher R. I., Gaynor E. R., Dahlberg S., Oken M. M., Grogan T. M., Mize E. M., Glick I. H., Coltman C. A., Miller T. P. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. New England Journal of Medicine 1993; 328: 1002–1006
  • Offit K., Jhanwar S. C., Ladanyi M., Filippa D. A., Chaganti R. S. K. Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: Correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment. Genes Chromosomes and Cancer 1991; 3: 189–201
  • Heim S., Mitelman E. Malignant lymphomas. Cancer cytogenetics. Wiley-Liss, New York 1995; 266–309
  • Weiss L. M., Warnke R. A., Sklar J., Cleary M. L. Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas. New England Journal of Medicine 1987; 317: 1185–1189
  • Dalla-Favera R., Ye B. H., Lo Coco F., Gaidano G., Lista F., Knowles D. M., Louie D. C., Offit K., Chaganti R. S. Identification of genetic lesions associated with diffuse large-cell lymphoma. Annals of Oncology 1994; 5: S55–S60
  • Hockenbery D., Nunez G., Milliman C., Schreiber R. D., Korsmeyer S. J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348: 334–336
  • Graninger W. B., Seto M., Boutain B., Goldman P., Korsmeyer S. J. Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells. Journal of Clinical Investigation 1987; 80: 1512–1515
  • Tsujimoto Y., Finger L. R., Yunis J., Nowell P. C., Croce C. M. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 1984; 226: 1097–1099
  • Tsujimoto Y., Cossman J., Jaffe E., Croce C. M. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985; 228: 1440–1443
  • Bakhshi A., Jensen J. P., Goldman P., Wright J. J., McBride O. W., Epstein A. L., Korsmeyer S. J. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 1985; 41: 899–906
  • Cleary M. L., Smith S. D., Sklar J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 1986; 47: 19–28
  • Ngan B. Y., Chen-Levy Z., Weiss L. M., Warnke R. A., Cleary M. L. Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation. New England Journal of Medicine 1988; 318: 1638–1644
  • Tsujimoto Y., Gorham J., Cossman J., Jaffe E., Croce C. M. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 1985; 229: 1390–1393
  • Cleary M. L., Sklar J. Nucleotide sequence of a t(14;18) chromosome breakpoint in follicular lymphoma and demonstration of a breakpoint cluster region near a transcriptionally active locus on chromosome 18. Proceedings of the National Academy of Science of the United States of America 1985; 82: 7439–7443
  • Cleary M. L., Galili N., Sklar J. Detection of a second t(14;18) breakpoint cluster region in follicular lymphomas. Journal of Experimental Medicine 1986; 164: 315–320
  • Klefstrom J., Franssila K., Peltomäki P., Kaartinen M., Solin M.-L., Knuutila S. Major and minor breakpoint sites of chromosomal translocation t(14;18) in subtypes of non-Hodgkin's lymphoma. Leukemia Research 1994; 18: 245–250
  • Jacobson J. O., Wilkes B. M., Kwiatkowski D. J., Medeiros L. J., Aisenberg A. C., Harris N. L. bcl-2 rearrangements in de novo diffuse large cell lymphoma. Association with distinctive clinical features. Cancer 1993; 72: 231–236
  • Pezzella F., Tse A. G. D., Cordell J. L., Pulford K. A. R., Gatter K. C., Mason D. Y. Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. American Journal of Pathology 1990; 137: 225–232
  • Zutter M., Hockenbery D., Silverman G. A., Korsmeyer S. J. Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms. Blood 1991; 78: 1062–1068
  • Kondo E., Nakamura S., Onoue H., Matsuo Y., Yoshino T., Aoki H., Hayashi K., Takahashi K., Minowada J., Nomura S., Akagi T. Detection of BCL-2 protein and BCL-2 messenger RNA in normal and neoplastic lymphoid tissues by immunohistochemistry and in situ hybridization. Blood 1992; 80: 2044–2051
  • Tang S. C., Visser L., Hepperle B., Hanson J., Poppema S. Clinical significance of bcl-2-MBR gene rearrangement and protein expression in diffuse large-cell non-Hodgkin's lymphoma: an analysis of 83 cases. Journal of Clinical Oncology 1994; 12: 149–154
  • Hill M. E., MacLennan K. A., Cunningham D. C., Vaughan Hudson B., Burke M., Clarke P., Di Stefano F., Anderson L., Vaughan Hudson G., Mason D., Selby P., Linch D. C. Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study. Blood 1996; 88: 1046–1051
  • Lee M. S., Blick M. B., Pathak S., Trujillo J. M., Butler J. J., Katz R. L., McLaughlin P., Hagemeister F. B., Velasquez W. S., Goodacre A., Cork A., Gutterman J. U., Cabanillas R. The gene located at chromosome 18 band q21 is rearranged in uncultured diffuse lymphomas as well as follicular lymphomas. Blood 1987; 70: 90–95
  • Alitalo K., Mäkelä T. P., Saksela K., Koskinen P., Hirvonen H. Oncogene amplification: Analysis of myc oncoproteins. Marcel Dekker, New York 1992; 371
  • Mitelman R. Catalog of chromosome aberrations in cancer, 5th edn. Wiley-Liss, New York 1994
  • Knuutila S., Björkqvist A. M., Autio K., Tarkkanen M., Wolf M., Monni O., Szymanska J., Larramendy M. L., Tapper J., Pere H., El-Rifai W., Hemmer S., Wasenius V.-M., Vidgren V., Zhu Y. DNA copy number amplifications in human neoplasms. Review of comparative genomic hybridization studies. American Journal of Pathology 1998; 152: 1107–1123
  • Monni O., El-Rifai W., Larramendy M. L., Knuutila S. Deletions and amplifications detected by comparative genomic hybridization (CGH) in hematological malignancies. Reviews in Clinical and Experimental Hematology 1997; 4: 56–69
  • Kallioniemi A., Kallioniemi O. P., Sudar D., Rutovitz D., Gray J. W., Waldman F., Pinkel D. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 1992; 258: 818–821
  • Kallioniemi O. P., Kallioniemi A., Piper J., Isola J., Waldman P. M., Gray J. W., Pinkel D. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosomes and Cancer 1994; 10: 231–243
  • Monni O., Joensuu H., Franssila K., Knuutila S. DNA copy number changes in diffuse large B-cell lymphoma-comparative genomic hybridization study. Blood 1996; 87: 5269–5278
  • Monni O., Joensuu H., Franssila K., Klefstrom J., Alitalo K., Knuutila S. BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood 1997; 90: 1168–1174
  • Dierlamm J., Rosenberg C., Stul M., Pittaluga S., Wlodarska I., Michaux L., Dehaen M., Verhoef G., Thomas J., De Kelver W., Bakker-Schut T., Cassiman J. J., Raap A. K., De Wolf-Peeters C., Van den Berghe H., Hagemeijer A. Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization. Leukemia 1997; 11: 747–758
  • Werner C. A., Döhner H., Joos S., Trumper L. H., Baudis M., Barth T. F. E., Ott G., Möller P., Lichter P., Bentz M. High-level DNA amplifications are common genetic aberrations in B-cell neoplasms. American Journal of Pathology 1997; 151: 335–342
  • Rao P. H., Houldsworth J., Dyomina K., Parsa N. Z., Cidugosa J. C., Louie D. C., Popplewell L., Offit K., Jhanwar S. C., Chaganti R. S. K. Chromosomal and gene amplification in diffuse large B-cell lymphoma. Blood 1998; 92: 234–240
  • Ben-Yehuda D., Houldsworth J., Parsa N. Z., Chaganti R. S. K. Gene amplification in non-Hodgkin's lymphoma. British Journal of Haematology 1994; 86: 792–797
  • Taniwaki M., Silverman G. A., Nishida K., Horiike S., Misawa S., Shimazaki C., Miura I., Nagai M., Abe M., Fukuhara S., Kashima K. Translocations and amplification of the BCL2 gene are detected in interphase nuclei of non-Hodgkin's lymphoma by in situ hybridization with yeast artificial chromosome clones. Blood 1995; 86: 1481–1486
  • Pettersson M., Jernberg-Wiklund H., Larsson L. G., Sundström C., Givol I., Tsujimoto Y., Nilsson K. Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells. Blood 1992; 79: 495–502
  • Seto M., Jaeger U., Hockett R. D., Graninger W., Bennett S., Goldman P., Korsmeyer S. J. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO Journal 1988; 7: 123–131
  • Tanaka S., Louie D. C., Kant J. A., Reed J. C. Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. Blood 1992; 79: 229–237
  • Reed J. C., Tanaka S. Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: Implications for mechanisms of tumor progression. Leukemia and Lymphoma 1993; 10: 157–163
  • Matolcsy A., Casali P., Warnke R. A., Knowles D. M. Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene. Blood 1996; 88: 3937–3944
  • McDonnell T. J., Deane N., Piatt F. M., Nunez G., Jaeger U., McKearn J. P., Korsmeyer S. J. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989; 57: 79–88
  • Yin X. M., Oltvai Z. N., Korsmeyer S. J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apophysis and heterodimerization with Bax. Nature 1994; 369: 321–323
  • Levine E. G., Arthur D. C., Frizzera G., Peterson B. A., Hurd D. D., Bloomfield C. D. Cytogenetic abnormalities predict clinical outcome in non-Hodgkin's lymphoma. Annals of Internal Medicine 1988; 108: 14–20
  • Pezzella E, Jones M, Ralfldaer E., Ersboll J., Gatter K. C., Mason D. Y. Evaluation of bcl-2 protein expression and 14; 18 translocation as prognostic markers in follicular lymphoma. British Journal of Cancer 1992; 65: 87–89
  • Romaguera J. E., Pugh W., Luthra R., Goodacre A., Cabanillas F. The clinical relevance of t(14;18)/BCL-2 rearrangement and DEL 6q in diffuse large cell lymphoma and immunoblastic lymphoma. Annals of Oncology 1993; 4: 51–54
  • Gascoyne R. D., Adomat S. A., Krajewski S., Krajewska M., Horsman D. E., Tolcher A. W., O'Reilly S. E., Hoskins P., Coldman A. J., Reed J. C., Connors J. M. Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Blood 1997; 90: 244–251
  • Yunis J. J., Mayer M. G., Arnesen M. A., Aeppli D. P., Oken M. M., Frizzera G. Bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma. New England Journal of Medicine 1989; 320: 1047–1054
  • Offit K., Koduru P. R. K., Hollis R., Filippa D. A., Jhanwar S. C., Clarkson B. C., Chaganti R. S. K. 18q21 rearrangement in diffuse large cell lymphoma: Incidence and clinical significance. British Journal of Haematology 1989; 72: 178–183
  • Piris M. A., Pezzella F., Martinez-Montero J. C., Orradre J. L., Villuendas R., Sanchez-Beato M., Cuena R., Cruz M. A., Martinez B., Garrido M. C., Gatter K., Aiello A., Delia D., Giardini R., Rilke F. p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time. British Journal of Cancer 1994; 69: 337–341
  • Hermine O., Haioun C., Lepage E., D'Agay M. R., Briere J., Lavignac C., Fillet G., Salles G., Marolleau J. P., Die-Bold J., Reyes E., Gaulard P. Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma, for the Groupe d'Etude des Lymphomas de l'Adulte (GELA). Blood 1996; 87: 265–272
  • Oltvai Z. N., Milliman C. L., Korsmeyer S. J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609–619
  • Gascoyne R. D., Krajewska M., Krajewski S., Connors J. M., Reed J. C. Prognostic significance of Bax protein expression in diffuse aggressive non-Hodgkin's lymphoma. Blood 1997; 90: 3173–3178
  • Louie D. C., Kant J. A., Brooks J. J., Reed J. C. Absence of t(14;18) major and minor breakpoints and of Bcl-2 protein overproduction in Reed-Sternberg cells of Hodgkin's disease. American Journal of Pathology 1991; 139: 1231–1237
  • Lambrechts A. C., Looijenga L. H. J., Van't Veer M. B., Van Echten J., Timens W., Oosterhuis J. W. Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study. British Journal of Cancer 1995; 71: 73–77
  • Tannapfel H., Kuhn R., Kessler H., Wittekind C. Expression of c-erbB2 oncogene product in different tumours and its standardised evaluation. Analytical Cellular Pathology 1996; 10: 149–160

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