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Research Article

Antioxidant effect of carnosine treatment on renal oxidative stress in streptozotocin-induced diabetic rats

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Pages 552-557 | Accepted 30 Jan 2014, Published online: 19 May 2014

References

  • Ansurudeen I, Sunkari VG, Grünler J, Peters V, Schmitt CP, Catrina SB, Brismar K, Forsberg EA (2012) Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes. Amino Acids 43: 127–134.
  • Armstrong D, Al-Awadi F (1991) Lipid peroxidation and retinopathy in streptozotocin induced diabetes. Free Rad. Biol. Med. 11: 433–436.
  • Aydogan S, Yapislar H, Artis S, Aydogan B (2008) Impaired erythrocytes deformability in H(2)O(2)-induced oxidative stress: protective effect of L-carnosine. Clin. Hemorheol. Microcirc. 39: 93–98.
  • Baynes JW, Thorpe SR (1999) Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48: 1–9.
  • Browmlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813–820.
  • Ceriello A (2000) Oxidative stress and glycemic regulation. Metabolism 49: 27–29.
  • Dellamea BS, Leitão CB, Friedman R, Canani LH (2014) Nitric oxide system and diabetic nephropathy. Diabetol. Metab. Syndrome 6: 17–22.
  • Eleftheriadis T, Antoniadi G, Pissas G, Liakopoulos V, Stefanidis I (2013) The renal endothelium in diabetic nephropathy. Ren. Fail. 35: 592–599.
  • Fioretto P, Mauer M (2007) Histopathology of diabetic nephropathy. Semin. Nephrol. 27: 195–207.
  • Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Xu J, McDonough C, Janssen B, Yard BA, van der Woude FJ, Bowden DW (2007) A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans. Nephrol. Dial. Transplant. 22: 1131–1135.
  • Gang JK, Young SK, Sang YH, Mi Hwa L, Hye K, Kum H, Dae R (2008) Lioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Nephrol. Dial. Transplant. 23: 2750–2760.
  • Ha H, Kim KH (1999) Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C. Diabetes Res. Clin. Pract. 45: 147–151.
  • Ha H, Lee SH, Kim KH (1997) Effects of rebamipide in a model of experimental diabetes and on the synthesis of transforming growth factor-b and fibronectin, lipid peroxidation induced by high glucose in cultured mesangial cells. J. Pharmacol. Exp. Ther. 281: 1457–1462.
  • Hipkiss AR, Brownson C, Carrier MJ (2001) Carnosine, the anti-aging, antioxidant dipeptide, may react with protein carbonyl groups. Mech. Ageing Dev. 122: 1431–1445.
  • Ibrahim HN, Hostetter TH (1997) Diabetic nephropathy. J. Am. Soc. Nephrol. 8: 487–493.
  • Isermann B, Vinnikov IA, Madhusudhan T, Herzog S, Kashif M, Blautzik J, Corat MA, Zeier M, Blessing E, Oh J, Gerlitz B, Berg DT, Grinnell BW, Chavakis T, Esmon CT, Weiler H, Bierhaus A, Nawroth PP (2007) Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat. Med. 13: 1349–1358.
  • Janssen B, Hohenadel D, Brinkkoetter P, Peters V, Rind N, Fischer C, Rychlik I, Cerna M, Romzova M, de Heer E, Baelde H, Bakker SJ, Zirie M, Rondeau E, Mathieson P, Saleem MA, Meyer J, Köppel H, Sauerhoefer S, Bartram CR, Nawroth P, Hammes HP, Yard BA, Zschocke J, van der Woude FJ (2005) Carnosine as a protective factor in diabetic nephropathy. Diabetes 54: 2320–2327.
  • Kalousová M, Skrha J, Zima T (2002) Advanced glycation end products and advanced oxidation protein products in patients with diabetes mellitus. Physiol. Res. 51: 597–604.
  • Lee YT, Hsu CC, Lin MH, Liu KS, Yin MC (2005) Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation. Eur. J. Pharmacol. 513: 145–150.
  • Mensah-Brown EP, Obineche EN, Galadari S, Chandranath E, Shahin A, Ahmed I, Patel SM, Adem A (2005) Streptozotocin-induced diabetic nephropathy in rats: the role of inflammatory cytokines. Cytokine 31: 180–190.
  • Mojica-Villegas MA, Izquierdo-Vega JA, Chamorro-Cevallos G, and Sánchez-Gutiérrez M (2014) Protective effect of resveratrol on biomarkers of oxidative stress induced by iron/ascorbate in mouse spermatozoa. Nutrients 6: 489–503.
  • Nobrega MA, Fleming S, Roman RJ, Shiozawa M, Schlick N, Lazar J, Jacob HJ (2004) Initial characterization of a rat model of diabetic nephropathy. Diabetes 53: 735–742.
  • Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M (1995) Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res. Clin. Pract. 28: 103–117.
  • Ozbek E (2012) Induction of oxidative stress in kidney. Int. J. Nephrol. 2012: 465897.
  • Pall M (2013) The NO/ONOO-cycle as the central cause of heart failure. Int. J. Mol. Sci. 14: 22274–22330.
  • Pitocco D, Zaccardi F, Di Stasio E, Romitelli F, Santini SA, Zuppi C, Ghirlanda G (2010 ) Oxidative stress, nitric oxide, and diabetes. Rev. Diabet. Stud. 7: 15–25.
  • Rashid I, van Reyk DM, Davies MJ (2007) Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro. FEBS Lett. 581: 1067–070.
  • Riedl E, Pfister F, Braunagel M, Brinkkötter P, Sternik P, Deinzer M, Bakker SJ, Henning RH, van den Born J, Krämer BK, Navis G, Hammes HP, Yard B, Koeppel H (2011) Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats. Cell Physiol. Biochem. 28: 279–288.
  • Ruiz-Munoz LM, Vidal VF, Lamreabe I (1997) Enaraplilat inhibits hydrogen peroxide production by murine mesangial cells exposed to high glucose concentrations. Nephrol. Dial. Transplant. 12: 456–464.
  • Sauerhöfer S, Yuan G, Braun GS, Deinzer M, Neumaier M, Gretz N, Floege J, Kriz W, van der Woude F, Moeller MJ (2007) L-carnosine, a substrate of carnosinase-1, influences glucose metabolism. Diabetes 56: 2425–2432.
  • Severina IS, Bussygina OG, Pyatakova NV (2000) Carnosine as a regulator of soluble guanylate cyclase. Biochemistry (Moscow) 65: 921–927.
  • Shah SV, Baliga R, Rajapurkar M, Fonseca VA (2007) Oxidants in Chronic Kidney Disease. J. Am. Soc. Nephrol. 18: 16–28.
  • Sugano M, Yamato H, Hayashi T, Ochiai H, Kakuchi J, Goto S, Nishijima F, Iino N, Kazama JJ, Takeuchi T, Mokuda O, Ishikawa T, Okazaki R (2006) High-fat diet in low dose streptozotocin-treated heminephrectomized rats induced all features of human type 2 diabetic nephropathy: a new rat model of diabetic nephropathy. Nutr. Metab. Cardiovasc. Dis. 16: 477–484.
  • Sun L, Halaihel N, Zhang W, Rogers T, Levi M (2002) Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus. J. Biol. Chem. 277: 18919–18927.
  • Suzuki S, Hinokio Y, Komatu K, Ohtomo M, Onoda M, Hirai S, Hirai M, Hirai A, Chiba M, Kasuga S, Akai H, Toyota T (1999) Oxidative damage to mitochondrial DNA and its relationship to diabetic complications. Diabetes Res. Clin. Pract. 45: 161–168.
  • Yapislar H, Aydogan S (2012) Effect of carnosine on erythrocyte deformability in diabetic rats. Arch. Physiol. Biochem. 118: 265–272.
  • Yusong Y, Rajendra S, Abha S, Sanjay A, Yogesh CA (2003) Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Biochim. Polon. 50: 319–336.

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