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Research Articles

Oral bioavailability enhancement of vinpocetine using self-microemulsifying drug delivery system containing long chain triglycerides: Preparation and in vitro/in vivo evaluation

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Pages 97-107 | Received 27 Apr 2010, Accepted 10 Jun 2010, Published online: 14 Jul 2010

References

  • Tang B, Cheng G, Gu JC, Xu CH. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discov Today 2008;13:606–612.
  • Bendas ER, Mohamed MI, Mahmoud EA. Preparation and evaluation of self-nanoemulsifying tablets of carvedilol. AAPS PharmSciTech 2009;10:183–192.
  • Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 2000;50:179–188.
  • Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 2004;58:173–182.
  • El-Laithy HM. Self-nanoemulsifying drug delivery system for enhanced bioavailability and improved hepatoprotective activity of biphenyl dimethyl dicarboxylate. Curr Drug Deliv 2008;5:170–176.
  • Grovea M, Müllertzb A, Nielsenc JL, Pedersen GP. Bioavailability of seocalcitol II: development and characterization of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides. Eur J Pharm Sci 2006;28:233–242.
  • Caliph SM, Charman WN, Porter CJ. Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats. J Pharm Sci 2000;89:1073–1084.
  • Wu W, Wang Y, Que L. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system. Eur J Pharm Biopharm 2006;63:288–294.
  • Abdalla A, Mader K. Preparation and characterization of a self emulsifying pellet formulation. Eur J Pharm Biopharm 2007;66:220–226.
  • Patil P, Paradkar A. Porous polystyrene beads as carriers for Self-Emulsifying System (SES) containing a lipophilic drug, loratadine. AAPS PharmSciTech 2006;7: Article 28.
  • Attama AA, Mpamaugo VE. Pharmacodynamics of piroxicam from self-emulsifying lipospheres formulated with homolipids extracted from Capra hircus. Drug Deliv 2006;13:133–137.
  • Jannin V, Musakhanian J, Marchaud D. Approaches for the development of solid and semi-solid lipid-based formulations. Adv Drug Deliv Rev 2008;60:734–746.
  • Cole ET, Cadé D, Benameur H. Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration. Adv Drug Deliv Rev 2008;60:747–756.
  • Kontny MJ, Mulski CA. Gelatin capsule brittleness as a function of relative humidity at room temperature. Int J Pharm 1989;54:79–85.
  • Ito K, Kaga S, Takeya Y. Studies on hard gelatin capsules. I. Water vapor transfer between capsules and powders. Chem Pharm Bull 1969;17:1134–1137.
  • Subhan Z, Hindmarch I. Psychopharmacological effects of vinpocetine in normal healthy volunteers. Eur J Clin Pharmacol 1985;28:567–571.
  • Szakall S, Boros I, Balkay L, Emri M. Cerebral effects of a single dose of intravenous vinpocetine in chronic stroke patients: a PET study. J Neuroimaging 1998;8:197–204.
  • Feigin VL, Doronin BM, Popova TF, Gribatcheva EV, Tchernov  DV. Vinpocetine treatment in acute ischaemic stoke: a pilot single-blind randomized clinical trial. Eur J Neurol 2001;8:81–85.
  • Grandt R, Beitinger R. Vinpocetine pharmacokinetics in elderly subjects. Arzneim-Forsch/Drug Res 1989;39:1599–1602.
  • Kata M, Lukacs M. Enhancement of solubility of vinpocetine base with γ3;-cyclodextrin. Pharmazie 1986;41:151–152.
  • Ribeiro L, Veiga F. Complexation of vinpocetine with cyclodextrins in the presence or absence of polymers. Binary and ternary complexes preparation and characterization. J Incl Phenom Macro 2002;44:251–256.
  • Hua L, Weisan P, Jiayu L, Ying Z. Preparation, evaluation, and NMR characterization of vinpocetine microemulsion for transdermal delivery. Drug Dev Ind Pharm 2004;30:657–666.
  • Aburahma MH, EL-Laithy HM, Hamza YE. Preparation and in vitro/in vivo characterization of porous sublingual tablets containing ternary kneaded solid system of vinpocetine with β-cyclodextrin and hydroxy acid. Sci Pharm 2010;78:363–379.
  • Chen Y, Li G, Wu X, Chen Z, Hang J, Qin B, Chen S, Wang R. Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine: formulation development and in vivo assessment. Biol Pharm Bull 2008;31:118–125.
  • Cui SX, Nie SF, Li L, Wang CG, Pan WS, Sun JP. Preparation and evaluation of self-microemulsifying drug delivery system containing vinpocetine. Drug Dev Ind Pharm 2009;35:603–611.
  • Abd Elbary A, Foda N, El-Gazayerly O, El Khatib M. Reversed phase liquid chromatographic determination of vinpocetine in human plasma and its pharmacokinetic application. Anal Lett 2002;35:1041–1054.
  • Khoo S-M Humberstone, AJ, Porter CJH, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine. Int J Pharm 1998;167:155–164.
  • Nyqvist H. Saturated salt solutions for maintaining specified relative humidities. Int J Pharm Tech & Prod Mfr 1983;4:47–48.
  • Meshali M, El-Sabbagh H, Foda A. Effect of encapsulation of flufenamic acid with acrylic resins on its bioavailability and gastric ulcerogenic activity in rats. Acta Pharm Technol 1983;29:217.
  • Malmary MF, Houti I, Labat C, Batalla A, Moussamih S, Bouguettaya D, Oustrin J, Houin G. Chronopharmacokinetics of cyclosporine A following a single i.v. dose in the Wistar rat. Eur J Pharm Sci 1995;3:49–56.
  • Shah VP, Midha KK, Dighe S, McGilveray IJ, Skelly JP, Yacobi A, Layloff T, Viswanathan CT, Cook CE, McDowall RD. Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies. Eur J Drug Metab Pharmacokinet 1991;16:249–255.
  • Subramanian N, Ray S, Kumar S, Bhadra R, Priya S. Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib. Biol Pharm Bull 2004;27:1993–1999.
  • Charman WN, Stella VJ. Estimating the maximum potential for intestinal lymphatic transport of lipophilic drug molecules. Int J Pharm 1986;34:175–178.
  • Pouton CW. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci 2006;29:278–287
  • Gao ZG, Choi HG, Shin HJ, Park KM, Lim SJ, Hwang KJ, Kim  CK. Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporine A. Int J Pharm 1998;161:75–86.
  • Nerurkar MM, Burton PS, Borchardt RT. The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm Res 1996;13:528–534.
  • Shen H, Zhong M. Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J Pharm Pharmacol 2006;58:1183–1191.
  • Pouton CW. Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification. Int J Pharm 1985;27:335–348.
  • Pouton CW. Effects of inclusion of a model drug on the performance of self-emulsifying formulations. J Pharm Pharmacol 1985;37:1–11.
  • Nazzal S, Khan MA. Response surface methodology for the optimization of Ubiquinone self-nanoemulsified drug delivery system. AAPS Pharm Sci Tech 2002;3: Article 3.
  • Iranloye TA, Pilpel N, Groves MJ. Some factors affecting the droplet size and charge of dilute oil-in-water emulsions prepared by self-emulsification. J Disp Sci Technol 1983;4:109–121.
  • Craig DQM, Barker SA, Banning D, Booth SW. An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int J Pharm 1995;114:103–110.
  • Wei L, Sun P, Nie S, Pan W. Preparation and evaluation of SEDDS and SMEDDS containing carvedilol. Drug Dev Ind Pharm 2005;31:785–794.
  • Srinath P, Vyas SP, Prakash, V. Preparation and pharmacodynamic evaluation of liposomes of indomethacin. Drug Dev Ind Pharm 2000;2:313–321.
  • Tarr BD, Yalkowsky SH. Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size. Pharm Res 1989;6:40–43.
  • Gursoy N, Garrigue JS, Razafindratsita A, Lambert G, Benita S. Excipient effects on in vitro cytotoxicity of a novel paclitaxel self emulsifying drug delivery system. J Pharm Sci 2003;92:2420–2427.
  • Patil P, Joshi P, Paradkar A. Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery system (SEDDS) of ketoprofen. AAPS Pharm Sci Tech 2004;5: Article 42.
  • Costa P, Sousa Lobo JM. Modeling and comparing dissolution profiles. Eur J Pharm Sci 2001;13:123–133.
  • Gao P, Witt MJ, Haskell RJ, Zamora KM, Shifflett JR. Application of a mixture experimental design in the optimization of a self-emulsifying formulation with a high drug load. Pharm Dev Tech 2004;9:301–309.
  • Sh X, Yan G, Wu Y, Li J, Fang X. Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. Eur J Pharm Sci 2005;24:477–486.
  • Nosalova V, Machova J, Babulova A. Protective action of vinpocetine against experimentally induced gastric damage in rats. Arzneim-Forsch/Drug Res 1993;43:981–985.
  • Kang BK, Lee JS. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm 2004;271:65–73.
  • Haus DJ, Mehta SC, Radebaugh GW. Targeting lymphatic transport and modified systemic distribution of CI-976, a lipophilic lipid-regulator drug, via a formulation approach. Int J Pharm 1994;108:85–93.
  • Charman WN, Stella VJ. Transport of lipophilic molecules by the intestinal lymphatic system. Adv Drug Deliv Rev 1991;7:1–14.
  • Swenson ES, Curatolo WJ. Means to enhance penetration. Adv Drug Deliv Rev 1992;8:39–42.
  • Lindmark T, Nikkila T, Artursson P. Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 monolayers. J Pharmacol Exp Ther 1995;275:958–964.
  • Cui S, Zhao C, Tang X, Chen D, He Z. Study on the bioavailability of puerarin from pueraria lobata isoflavone self- microemulsifying drug-delivery systems and tablets in rabbits by liquid chromatography– mass spectrometry. Biomed Chromatogr 2005;19:375–378.

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