166
Views
33
CrossRef citations to date
0
Altmetric
Research Article

Novel nanoemulsion for minimizing variations in bioavailability of ezetimibe

, &
Pages 506-519 | Received 27 Sep 2009, Accepted 08 Dec 2009, Published online: 13 Jan 2010

References

  • Ahmed M, Ramadan W, Rambhu D, Shakeel F. (2008). Potential of nanoemulsions for intravenous delivery of rifampicin. Pharmazie, 63: 806–811.
  • Ambike AA, Mahadik KR, Paradkar A. (2005). Spray-dried amorphous solid dispersions of simvastatin, a low tg drug: in vitro and in vivo evaluations. Pharm Res, 22: 990–998.
  • Attwood D, Mallon C, Taylor CJ. (1992). Phase studies on oil-in-water phospholipid microemulsions. Int J Pharm, 84: R5–R8.
  • Basha SJ, Naveed SA, Tiwari NK, Shashikumar D, Muzeeb S, Kumar TR, Kumar NV, Rao NP, Srinivas N, Mullangi R, Srinivas NR. (2007). Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile. J Chromatogr B Analyt Technol Biomed Life Sci, 853: 88–96.
  • Bolkent S, Yanardag R, Karabulut-Bulan O, Yesilyaprak B. (2005). Protective role of Melissa officinalis L. extract on liver of hyperlipidemic rats: a morphological and biochemical study. J Ethnopharmacol, 99: 391–398.
  • Constantinides PP. (1995). Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res, 12: 1561–1572.
  • Dixit RP, Nagarsenker MS. (2008a). Self-nanoemulsifying granules of ezetimibe: design, optimization and evaluation. Eur J Pharm Sci, 35: 183–192.
  • Dixit RP, Nagarsenker MS. (2008b). Formulation and in vivo evaluation of self-nanoemulsifying granules for oral delivery of a combination of ezetimibe and simvastatin. Drug Dev Ind Pharm, 34: 1285–1296.
  • Doshi AS, Kachhadia PK, Joshi HS. (2008). Validation of a stability-indicating LC method for assay of ezetimibe in tablets and for determination of content uniformity. Chromatographia, 67: 137–142.
  • Ezzet F, Krishna G, Wexler DB, Statkevich P, Kosoglou T, Batra VK. (2001). A population pharmacokinetic model that describes multiple peaks due to enterohepatic recirculation of ezetimibe. Clin Ther, 23: 871–885.
  • Freireich EJ, Gehan EA, Rall DP, Schmidt LH, Skipper HE. (1966). Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep, 50: 219–244.
  • Ghosh MN, ed. (2005). Fundamentals of Experimental Pharmacology (p. 192). Chapter 30. Toxicity studies. Kolkata: Hilton and Company Publishers.
  • Ghosh PK, Murthy RS. (2006). Microemulsions: a potential drug delivery system. Curr Drug Deliv, 3: 167–180.
  • Jeu L, Cheng JW. (2003). Pharmacology and therapeutics of ezetimibe (SCH 58235), a cholesterol-absorption inhibitor. Clin Ther, 25: 2352–2387.
  • Kang BK, Lee JS, Chon SK, Jeong SY, Yuk SH, Khang G, Lee HB, Cho SH. (2004). Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm, 274: 65–73.
  • Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB. (2005). Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet, 44: 467–494.
  • Lawrence MJ, Rees GD. (2000). Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev, 45: 89–121.
  • Lipka LJ. (2003). Ezetimibe: a first-in-class, novel cholesterol absorption inhibitor. Cardiovasc Drug Rev, 21: 293–312.
  • Nerurkar MM, Burton PS, Borchardt RT. (1996). The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm Res, 13: 528–534.
  • Patel R, Bhimani D, Patel J, Patel D. (2008). Solid-state characterization and dissolution properties of ezetimibe–cyclodextrins inclusion complexes. J Incl Phenom Macro, 60: 241–251.
  • Patel AR, Vavia PR. (2007). Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. AAPS J, 9: E344–E352.
  • Patrick JE, Kosoglou T, Stauber KL, Alton KB, Maxwell SE, Zhu Y, Statkevich P, Iannucci R, Chowdhury S, Affrime M, Cayen MN. (2002). Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects. Drug Metab Dispos, 30: 430–437.
  • Pouton CW. (1997). Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev, 25: 47–58.
  • Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. (2007). Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm, 66: 227–243.
  • Sistla R, Tata VS, Kashyap YV, Chandrasekar D, Diwan PV. (2005). Development and validation of a reversed-phase HPLC method for the determination of ezetimibe in pharmaceutical dosage forms. J Pharm Biomed Anal, 39: 517–522.
  • Vyas SP, Khar RK, eds. (2002). Targeted and Controlled Drug Delivery (p. 280). Chapter 7. Submicronemulsions. New Delhi: CBS Publishers.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.