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Journal of Drug Targeting Volume 3, 1995 - Issue 1
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Research Article

Aspects of the Design and Delivery of Microparticles for Vaccine Applications

P. G. Jenkins Proteus Molecular Design Ltd, Proteus House, Lyme Green Business Park Macclesfield, Cheshire, SK10 2UL
,
A. G. A. Coombes Vaccine Research Group, Dept. Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD
,
M. K. Yeh Vaccine Research Group, Dept. Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD
,
N. W. Thomas Dept. Human Morphology, University Medical School Nottingham, Queens Medical Centre, Nottingham, NG7 2UH
&
S. S. Davis Vaccine Research Group, Dept. Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD
Pages 79-81 | Received 17 Aug 1994, Accepted 01 Sep 1994, Published online: 28 Sep 2008

References

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  • Challacombe S. J., Rhaman D., Jeffery H., Davis S. S., O'Hagan D. T. Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen. Immunol (1992); 76: 164–168
  • Douglas R. G. The Childrens Vaccine Initiative—Will it work?. J. Infect. Dis (1993); 168: 269–274
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  • Jenkins P. G., Howard K. A., Blackhall N. W., Thomas N. W., Davis S. S., O'Hagan D. T. The quantitation of the absorption of microparticles into the intestinal lymph of Wistar rats. Int. J. Pharm (1994a); 102: 261–266
  • Jenkins P. G., Howard K. A., Blackhall N. W., Thomas N. W., Davis S. S., O'Hagan D. T. Microparticulate absorption form the rat intestine. J. Contr. Rel (1994b); 29: 339–350
  • Jenkins P. G., Coombes A. G. A., Yeh M. K., Blackhall N. W., Thomas N. W., Davis S. S. Antigen targeting for immunotherapy. Immunocontraception. Ares‐Serono Publications, StockholmSweden (1995), (in press)
  • Jani P., Halbert G. W., Langridge J., Florence A. T. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol (1990); 42: 821–826
  • McGhee J. R., Mestecky J., Dertzbaugh M. T., Eldridge J. H., Hirasawa M., Kiyono H. The mucosal immune system: from fundamental concepts to vaccine design. Vaccine (1992); 10: 75–85
  • McGhee J. R., Kiyono H. Perspectives in vaccine development: Mucosal immunity to infections. Inf. Agents. Dis (1993); 2: 55–73
  • O'Hagan D. T. Oral delivery of vaccines: Formulation and clinical pharmacokinetic considerations. Clin. Pharmacokinet (1992); 22: 1–10
  • Sass W., Dreyer H. ‐P., Seifert J. Rapid insorption of small particles in the gut. Am. J. Gastroenterol (1990); 85: 255–260
  • Yeh M. K., Jenkins P. G., Davis S. S., Coombes A. G.A. Improving the antigen delivery capacity of microparticle systems using blends of Poly (DL lactide co‐glycolide) and Poly (ethylene glycol). J. Contr. Rel (1994a), In Press
  • Yeh M. K., Coombes A. G. A., Jenkins P. G., Davis S. S. Increasing the protein payload in biodegradable microparticles for vaccine and drug delivery. J. Contr. Rel (1994b), In Press

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